JP6071886B2 - 脳損傷のバイオマーカー - Google Patents

脳損傷のバイオマーカー Download PDF

Info

Publication number
JP6071886B2
JP6071886B2 JP2013534031A JP2013534031A JP6071886B2 JP 6071886 B2 JP6071886 B2 JP 6071886B2 JP 2013534031 A JP2013534031 A JP 2013534031A JP 2013534031 A JP2013534031 A JP 2013534031A JP 6071886 B2 JP6071886 B2 JP 6071886B2
Authority
JP
Japan
Prior art keywords
gfap
sci
patient
biomarker
level
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2013534031A
Other languages
English (en)
Japanese (ja)
Other versions
JP2013545087A5 (enExample
JP2013545087A (ja
Inventor
アラン デイル エヴェレット
アラン デイル エヴェレット
ジェイムズ フランシス カセラ
ジェイムズ フランシス カセラ
エイク ジェニファー ヴァン
エイク ジェニファー ヴァン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Johns Hopkins University
Original Assignee
Johns Hopkins University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45938999&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JP6071886(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Johns Hopkins University filed Critical Johns Hopkins University
Publication of JP2013545087A publication Critical patent/JP2013545087A/ja
Publication of JP2013545087A5 publication Critical patent/JP2013545087A5/ja
Application granted granted Critical
Publication of JP6071886B2 publication Critical patent/JP6071886B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2871—Cerebrovascular disorders, e.g. stroke, cerebral infarct, cerebral haemorrhage, transient ischemic event

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
JP2013534031A 2010-10-14 2011-10-14 脳損傷のバイオマーカー Active JP6071886B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US39300910P 2010-10-14 2010-10-14
US61/393,009 2010-10-14
US201161436955P 2011-01-27 2011-01-27
US201161436956P 2011-01-27 2011-01-27
US61/436,956 2011-01-27
US61/436,955 2011-01-27
PCT/US2011/056338 WO2012051519A2 (en) 2010-10-14 2011-10-14 Biomarkers of brain injury

Publications (3)

Publication Number Publication Date
JP2013545087A JP2013545087A (ja) 2013-12-19
JP2013545087A5 JP2013545087A5 (enExample) 2014-12-04
JP6071886B2 true JP6071886B2 (ja) 2017-02-01

Family

ID=45938999

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2013534031A Active JP6071886B2 (ja) 2010-10-14 2011-10-14 脳損傷のバイオマーカー

Country Status (5)

Country Link
US (2) US9746481B2 (enExample)
EP (1) EP2628013B1 (enExample)
JP (1) JP6071886B2 (enExample)
IL (1) IL225731B (enExample)
WO (1) WO2012051519A2 (enExample)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2009282117B2 (en) 2008-08-11 2016-05-12 Banyan Biomarkers, Inc. Biomarker detection process and assay of neurological condition
US12601749B2 (en) 2008-08-11 2026-04-14 Banyan Biomarkers, Inc. Biomarker detection process and assay of neurological condition
US9709573B2 (en) 2012-03-13 2017-07-18 The Johns Hopkins University Citrullinated brain and neurological proteins as biomarkers of brain injury or neurodegeneration
US9378551B2 (en) * 2013-01-03 2016-06-28 Siemens Aktiengesellschaft Method and system for lesion candidate detection
WO2015009907A1 (en) 2013-07-17 2015-01-22 The Johns Hopkins University A multi-protein biomarker assay for brain injury detection and outcome
JP6312302B2 (ja) * 2014-01-06 2018-04-18 公益財団法人ヒューマンサイエンス振興財団 脳梗塞の診断マーカー
EP2896702A1 (en) * 2014-01-16 2015-07-22 University College Cork, National University Of Irland Cork A method of identifying a neonate at risk of having or developing hypoxic-ischaemic encephalopathy (HIE)
WO2016007762A1 (en) * 2014-07-09 2016-01-14 Duke University Compositions and methods for the repair of myelin
CN107003317B (zh) * 2014-10-06 2019-04-19 日内瓦大学 生物标记及其在脑损伤中的应用
US12422442B2 (en) 2014-10-06 2025-09-23 Universite De Geneve Markers and their use in brain injury
WO2016125148A1 (en) 2015-02-05 2016-08-11 Immunarray Ltd. Methods and compositions for diagnosing brain injury or neurodegeneration
JP6839854B2 (ja) 2015-05-05 2021-03-17 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニアＴｈｅ Ｒｅｇｅｎｔｓ Ｏｆ Ｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｃａｌｉｆｏｒｎｉａ 星状細胞トラウマトーム（ｔｒａｕｍａｔｏｍｅ）および神経外傷のバイオマーカー
EP4521116A3 (en) * 2016-10-03 2025-05-28 Abbott Laboratories Improved methods of assessing uch-l1 status in patient samples
EP3532496A1 (en) 2016-10-28 2019-09-04 Banyan Biomarkers, Inc. Antibodies to ubiquitin c-terminal hydrolase l1 (uch-l1) and glial fibrillary acidic protein (gfap) and related methods
CN110100182A (zh) * 2016-12-23 2019-08-06 苏珊娜·潘格拉茨-菲雷尔 α-B晶状体蛋白在诊断新生儿脑损伤中的作用
CN106645755B (zh) * 2016-12-30 2018-09-25 深圳大学 一种ad生物标记物及其检测方法
EP3568138B1 (en) 2017-01-13 2025-03-05 Duke University Compositions and methods for the treatment of myelin related and inflammation related diseases or disorders
CA3261113A1 (en) 2017-03-23 2025-10-27 Abbott Laboratories Methods for aiding in the diagnosis and determination of the extent of traumatic brain injury in a human subject using the early biomarker ubiquitin carboxy-terminal hydrolase l1
CN110546513A (zh) 2017-04-15 2019-12-06 雅培实验室 使用早期生物标记物帮助超急性诊断和确定人类受试者中的创伤性脑损伤的方法
ES3053676T3 (en) 2017-04-28 2026-01-23 Abbott Lab Methods for aiding in the hyperacute diagnosis and determination of traumatic brain injury using early biomarkers on at least two samples from the same human subject
US11709168B2 (en) 2017-05-23 2023-07-25 Brainbox Solutions, Inc. Biomarker levels and neuroimaging for detecting, monitoring and treating brain injury or trauma
AU2018272054B2 (en) 2017-05-25 2024-10-31 Abbott Laboratories Methods for aiding in the determination of whether to perform imaging on a human subject who has sustained or may have sustained an injury to the head using early biomarkers
JP7269182B2 (ja) 2017-05-30 2023-05-08 アボット・ラボラトリーズ 心臓トロポニンｉ及び早期バイオマーカーを使用する、ヒト対象における軽度外傷性脳損傷を診断及び査定する一助となるための方法
CA3068041C (en) 2017-07-03 2024-06-25 Abbott Laboratories Improved methods for measuring ubiquitin carboxy-terminal hydrolase l1 levels in blood
WO2019112863A1 (en) * 2017-12-06 2019-06-13 FloTBI Inc. Assay and point of care device utilizing saliva for diagnosis and treatment of neurological conditions affected brain health
US11022617B2 (en) 2017-12-09 2021-06-01 Abbott Laboratories Methods for aiding in the diagnosis and evaluation of a subject who has sustained an orthopedic injury and that has or may have sustained an injury to the head, such as mild traumatic brain injury (TBI), using glial fibrillary acidic protein (GFAP) and/or ubiquitin carboxy-terminal hydrolase L1 (UCH-L1)
EP3721234A1 (en) 2017-12-09 2020-10-14 Abbott Laboratories Methods for aiding in diagnosing and evaluating a traumatic brain injury in a human subject using a combination of gfap and uch-l1
AU2018395255B2 (en) 2017-12-29 2025-02-20 Abbott Laboratories Novel biomarkers and methods for diagnosing and evaluating traumatic brain injury
CN108872589B (zh) * 2018-01-03 2021-09-03 深圳市人民医院 脑梗死外周血标志物及其应用
US20210041468A1 (en) * 2018-03-30 2021-02-11 National Center Of Neurology And Psychiatry Neonatal hypoxic-ischemic encephalopathy severity determining method and prognosis predicting method
CA3119938A1 (en) * 2018-11-14 2020-05-22 Mark Evans Method and apparatus for reducing the risk of neonatal neurological injury
US20220016221A1 (en) * 2018-12-05 2022-01-20 Ipsen Biopharm Limited Treatment of symptoms of traumatic brain injury
CN110261617B (zh) * 2019-05-14 2022-07-01 深圳市人民医院 脑出血外周血标志物及其应用
CN110907422B (zh) * 2019-12-16 2021-07-06 吉林大学 基于Ti3C2的凝血酶适体传感器及其制备方法
US20230088509A1 (en) * 2020-05-20 2023-03-23 St. Jude Children's Research Hospital Detection of alzheimer's disease using specific biomarkers
US20230250480A1 (en) * 2020-07-09 2023-08-10 University Of Florida Research Foundation, Incorporated Biofluid-based protein and mirna biomarkers for neonatal hypoxic-ischemic encephalopathy
EP3982123A1 (en) * 2020-10-08 2022-04-13 Fundació Hospital Universitari Vall d'Hebron - Institut de Recerca Markers and their use in brain injury
US12582345B2 (en) * 2021-02-01 2026-03-24 The University Of Chicago Systems and methods for identifying progression of hypoxic-ischemic brain injury

Family Cites Families (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3234412A (en) * 1961-07-21 1966-02-08 Babcock & Wilcox Co Thermionic conversion nuclear reactor
SE462454B (sv) 1988-11-10 1990-06-25 Pharmacia Ab Maetyta foer anvaendning i biosensorer
US5707796A (en) 1990-06-11 1998-01-13 Nexstar Pharmaceuticals, Inc. Method for selecting nucleic acids on the basis of structure
US5683867A (en) 1990-06-11 1997-11-04 Nexstar Pharmaceuticals, Inc. Systematic evolution of ligands by exponential enrichment: blended SELEX
US5637459A (en) 1990-06-11 1997-06-10 Nexstar Pharmaceuticals, Inc. Systematic evolution of ligands by exponential enrichment: chimeric selex
US5567588A (en) 1990-06-11 1996-10-22 University Research Corporation Systematic evolution of ligands by exponential enrichment: Solution SELEX
US5496938A (en) 1990-06-11 1996-03-05 Nexstar Pharmaceuticals, Inc. Nucleic acid ligands to HIV-RT and HIV-1 rev
US5270163A (en) 1990-06-11 1993-12-14 University Research Corporation Methods for identifying nucleic acid ligands
KR970002255B1 (ko) 1990-06-11 1997-02-26 넥스스타 파아마슈티컬드, 인크. 핵산 리간드
US6011020A (en) 1990-06-11 2000-01-04 Nexstar Pharmaceuticals, Inc. Nucleic acid ligand complexes
US5660985A (en) 1990-06-11 1997-08-26 Nexstar Pharmaceuticals, Inc. High affinity nucleic acid ligands containing modified nucleotides
WO1994028418A1 (en) 1993-05-28 1994-12-08 Baylor College Of Medicine Method and apparatus for desorption and ionization of analytes
US5866434A (en) 1994-12-08 1999-02-02 Meso Scale Technology Graphitic nanotubes in luminescence assays
US6673533B1 (en) 1995-03-10 2004-01-06 Meso Scale Technologies, Llc. Multi-array multi-specific electrochemiluminescence testing
KR100449615B1 (ko) 1995-03-10 2004-12-08 메소 스케일 테크놀러지즈, 엘엘시 다-배열,다-특이적전기화학발광시험법
US6140045A (en) 1995-03-10 2000-10-31 Meso Scale Technologies Multi-array, multi-specific electrochemiluminescence testing
US6207369B1 (en) 1995-03-10 2001-03-27 Meso Scale Technologies, Llc Multi-array, multi-specific electrochemiluminescence testing
US6319670B1 (en) 1995-05-09 2001-11-20 Meso Scale Technology Llp Methods and apparatus for improved luminescence assays using microparticles
NZ516848A (en) 1997-06-20 2004-03-26 Ciphergen Biosystems Inc Retentate chromatography apparatus with applications in biology and medicine
US6413783B1 (en) 1997-09-18 2002-07-02 Meso Scale Technologies, Llc Assay sonication apparatus and methodology
EP1068356B8 (en) 1998-04-03 2007-01-03 Adnexus Therapeutics, Inc. Addressable protein arrays
US6406921B1 (en) 1998-07-14 2002-06-18 Zyomyx, Incorporated Protein arrays for high-throughput screening
US6780606B1 (en) 1999-02-26 2004-08-24 Synx Pharma, Inc. Method for diagnosing and distinguishing stroke and diagnostic devices for use therein
WO2000056934A1 (en) 1999-03-24 2000-09-28 Packard Bioscience Company Continuous porous matrix arrays
WO2001031580A2 (en) 1999-10-27 2001-05-03 Biowulf Technologies, Llc Methods and devices for identifying patterns in biological systems
AU2001280581A1 (en) 2000-07-18 2002-01-30 Correlogic Systems, Inc. A process for discriminating between biological states based on hidden patterns from biological data
WO2002024867A2 (en) 2000-09-22 2002-03-28 University Of Aarhus Novel compositions and methods for lymphoma and leukemia
US20020164576A1 (en) 2000-09-22 2002-11-07 Pedersen Finn Skou Methods for diagnosis and treatment of diseases associated with altered expression of Nrf2
WO2002042733A2 (en) 2000-11-16 2002-05-30 Ciphergen Biosystems, Inc. Method for analyzing mass spectra
WO2003016910A1 (en) * 2001-08-20 2003-02-27 Biosite, Inc. Diagnostic markers of stroke and cerebral injury and methods of use thereof
US7113896B2 (en) 2001-05-11 2006-09-26 Zhen Zhang System and methods for processing biological expression data
US6884591B2 (en) 2001-06-25 2005-04-26 The Cleveland Clinic Foundation Peripheral marker of blood brain barrier permeability
US7144708B2 (en) 2001-06-25 2006-12-05 The Cleveland Clinic Foundation Markers of blood barrier disruption and methods of using same
EP2420824B1 (en) 2001-06-29 2018-11-28 Meso Scale Technologies LLC Multi-well plate having an array of wells and kit for use in the conduct of an ECL assay
US8815577B2 (en) 2001-07-30 2014-08-26 Meso Scale Technologies, Llc Assay electrode having immobilized lipid/protein layers, methods of making the same and methods of using the same for luminescence test measurements
CA2932756C (en) 2001-09-10 2020-07-07 Meso Scale Technologies, Llc Assay buffer, compositions containing the same, and methods of using the same
US7063946B2 (en) 2001-09-10 2006-06-20 Meso Scale Technologies, Llc. Methods, reagents, kits and apparatus for protein function analysis
US20070098728A1 (en) 2001-09-24 2007-05-03 Pedersen Finn S Novel compositions and methods in cancer
DK1456668T3 (da) 2001-12-05 2007-09-10 Sense Proteomic Ltd Proteinarrays til alleliske varianter og anvendelser deraf
US20020193950A1 (en) 2002-02-25 2002-12-19 Gavin Edward J. Method for analyzing mass spectra
US7036946B1 (en) 2002-09-13 2006-05-02 Rockwell Collins, Inc. LCD backlight with UV light-emitting diodes and planar reactive element
CA3122193C (en) 2002-12-26 2025-05-06 Meso Scale Technologies, Llc. ANALYSIS CARTRIDGES AND THEIR METHODS OF USE
EP1519194A1 (en) 2003-09-24 2005-03-30 Roche Diagnostics GmbH Use of gfap for identification of intracerebral hemorrhage
US7981362B2 (en) 2003-11-04 2011-07-19 Meso Scale Technologies, Llc Modular assay plates, reader systems and methods for test measurements
ES2367311T3 (es) 2004-04-15 2011-11-02 University Of Florida Research Foundation, Inc. Productos de degradación proteolítica de map-2 como biomarcadores de diagnóstico para las lesiones neurales.
US20140303041A1 (en) 2004-04-15 2014-10-09 University Of Florida Research Foundation Inc. In vitro diagnostic devices for nervous system injury and other neural disorders
AU2005238446B2 (en) 2004-04-15 2009-07-30 Banyan Biomarkers Inc. Neural proteins as biomarkers for nervous system injury and other neural disorders
US8492107B2 (en) 2004-04-15 2013-07-23 University Of Florida Research Foundation, Inc. Neural proteins as biomarkers for nervous system injury and other neural disorders
US7776583B2 (en) 2004-06-03 2010-08-17 Meso Scale Technologies, Llc Methods and apparatuses for conducting assays
EP1774023B1 (en) 2004-06-25 2013-05-01 Washington University School Of Medicine Markers for brain damage
US20060257943A1 (en) 2005-01-25 2006-11-16 Cis Biotech, Inc. Ischemic biomarkers and their use to predict adverse neurological events from surgery
US7884260B2 (en) 2005-06-14 2011-02-08 University Of Chicago Cell-based screen for agents useful for reducing neuronal demyelination or promoting neuronal remyelination
GB2428240A (en) 2005-07-14 2007-01-24 Univ Gen Ve Diagnostic method for brain damage-related disorders
WO2007123976A2 (en) 2006-04-18 2007-11-01 The Board Of Trustees Of The Leland Stanford Junior University Antibody profiling for determination of patient responsiveness
WO2007136617A2 (en) 2006-05-18 2007-11-29 Walter Reed Army Institute Of Research (Wrair) Endothelial-monocyte activating polypeptide ii, a biomarker for use in diagnosis of brain injury
US8088584B2 (en) * 2006-10-16 2012-01-03 Bayer Schering Pharma Aktiengesellschaft LTBP2 as a biomarker and diagnostic target
WO2008097618A1 (en) 2007-02-06 2008-08-14 University Of Florida Research Foundation, Inc. Synaptotagmin and collapsin response mediator protein as biomarkers for traumatic brain injury
EP2015196A1 (en) 2007-06-28 2009-01-14 Siemens Aktiengesellschaft Programmer interface for manufacturing execution system
US8497078B2 (en) 2008-05-23 2013-07-30 The Johns Hopkins University Biomarkers for myocardial ischemia
EP2143735A1 (en) 2008-07-10 2010-01-13 Institut Pasteur Variable domains of camelid heavy-chain antibodies directed against glial fibrillary acidic proteins
AU2009282117B2 (en) 2008-08-11 2016-05-12 Banyan Biomarkers, Inc. Biomarker detection process and assay of neurological condition
US20140342381A1 (en) 2008-08-11 2014-11-20 Banyan Biomarkers, Inc. Devices and methods for biomarker detection process and assay of neurological condition
US20170315136A9 (en) 2009-06-19 2017-11-02 Banyan Biomarkers, Inc. Biomarker assay of neurological condition
HUE040281T2 (hu) 2009-09-14 2019-03-28 Banyan Biomarkers Inc Autoantitest markerek traumás agysérülés diagnózisára
GB201008541D0 (en) * 2010-05-21 2010-07-07 Univ Geneve Diagnostic methods
CN105823887B (zh) 2011-01-28 2018-06-12 西瑞斯实验室有限公司 用于检测肠和血脑屏障通透性的方法及其测试材料
JP2014518624A (ja) * 2011-05-12 2014-08-07 ザ・ジョンズ・ホプキンス・ユニバーシティー ニューログラニン診断キットのためのアッセイ試薬
WO2012170998A1 (en) 2011-06-10 2012-12-13 Cornell University Immobilized protein system for rapid and enhanced multiplexed diagnostics
US20150119273A1 (en) 2012-05-16 2015-04-30 Trustees Of Boston University Chronic Traumatic Encephalopathy in Blast-Exposed Individuals
WO2014194329A1 (en) 2013-05-31 2014-12-04 Banyan Biomarkers, Inc. NEURAL SPECIFIC S100β FOR BIOMARKER ASSAYS AND DEVICES FOR DETECTION OF A NEUROLOGICAL CONDITION
WO2015066211A1 (en) 2013-10-29 2015-05-07 Banyan Biomarkers, Inc. Uch-l1 isoforms, assays and devices for detection of a neurological condition

Also Published As

Publication number Publication date
IL225731B (en) 2018-01-31
WO2012051519A3 (en) 2012-09-20
EP2628013A4 (en) 2014-03-12
WO2012051519A2 (en) 2012-04-19
US9746481B2 (en) 2017-08-29
US20150051115A1 (en) 2015-02-19
IL225731A0 (en) 2013-06-27
EP2628013A2 (en) 2013-08-21
US20140045713A1 (en) 2014-02-13
EP2628013B1 (en) 2019-06-12
JP2013545087A (ja) 2013-12-19

Similar Documents

Publication Publication Date Title
JP2013545087A (ja) 脳損傷のバイオマーカー
JP6980291B2 (ja) 脳損傷の診断／予後判定／評価において有用な組成物及びキット
US20260063646A1 (en) Circulating biomarker levels for diagnosis and risk-stratification of traumatic brain injury
US20230314453A1 (en) Biomarker levels and neuroimaging for detecting, monitoring and treating brain injury or trauma
US20230238143A1 (en) Multimodality systems and methods for detection, prognosis, and monitoring of neurological injury and disease
US20250044303A1 (en) Protein biomarker indicators of neurological injury and/or disease and methods of use thereof
JP6707181B2 (ja) 早産のリスクがある妊娠女性を同定するためのキットまたはパッケージ、および、当該キットまたはパッケージの使用
CN103403549A (zh) 败血症的预后的预测方法
CN114341343A (zh) α-突触核蛋白测定
CN115884788A (zh) 作为用于神经退行性状况的生物标志物的激酶
WO2020228132A1 (zh) 脑出血外周血标志物及其应用
CN105026579A (zh) 用于测定中风症状发作的时间的生物标志物算法以及方法
Gao et al. [Retracted] Diagnostic Value of IGFBP‐2 in Predicting Preeclampsia before 20 Weeks of Pregnancy: A Prospective Nested Case‐Control Study
CN121713065A (zh) 使用无细胞核小体水平的诊断方法
US20200402609A1 (en) Computer implemented discovery of antibody signatures

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20130830

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20141011

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20141011

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20150709

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20150804

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20151021

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20160202

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20160719

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20161019

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20161206

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20161227

R150 Certificate of patent or registration of utility model

Ref document number: 6071886

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250