IL217112A0 - Regioselective preparation of 2-amino-5- trifluoromethylpyrimidine derivatives - Google Patents
Regioselective preparation of 2-amino-5- trifluoromethylpyrimidine derivativesInfo
- Publication number
- IL217112A0 IL217112A0 IL217112A IL21711211A IL217112A0 IL 217112 A0 IL217112 A0 IL 217112A0 IL 217112 A IL217112 A IL 217112A IL 21711211 A IL21711211 A IL 21711211A IL 217112 A0 IL217112 A0 IL 217112A0
- Authority
- IL
- Israel
- Prior art keywords
- amino
- regioselective preparation
- trifluoromethylpyrimidine
- derivatives
- trifluoromethylpyrimidine derivatives
- Prior art date
Links
- OUVVCECMELPNNT-UHFFFAOYSA-N 5-(trifluoromethyl)pyrimidin-2-amine Chemical class NC1=NC=C(C(F)(F)F)C=N1 OUVVCECMELPNNT-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09167934 | 2009-08-14 | ||
| PCT/EP2010/061840 WO2011018518A1 (en) | 2009-08-14 | 2010-08-13 | Regioselective preparation of 2 -amino-5-trifluoromethylpyrimidine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL217112A0 true IL217112A0 (en) | 2012-02-29 |
Family
ID=42712695
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL217112A IL217112A0 (en) | 2009-08-14 | 2011-12-21 | Regioselective preparation of 2-amino-5- trifluoromethylpyrimidine derivatives |
Country Status (17)
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UY31714A (es) * | 2008-03-20 | 2009-11-10 | Boehringer Ingelheim Int | Preparación selectiva de pirimidinas sustituidas |
| US8372974B2 (en) * | 2008-03-20 | 2013-02-12 | Boehringer Ingelheim International Gmbh | Regioselective preparation of substituted pyrimidines |
| JP5539518B2 (ja) | 2009-08-14 | 2014-07-02 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ２−アミノ−５−トリフルオロメチルピリミジン誘導体の位置選択的調製 |
| US8933227B2 (en) | 2009-08-14 | 2015-01-13 | Boehringer Ingelheim International Gmbh | Selective synthesis of functionalized pyrimidines |
| CN102887860B (zh) * | 2012-09-29 | 2015-07-01 | 上海泰坦科技有限公司 | 4-氯-6-三氟甲基嘧啶类化合物的制备方法 |
| JP6391985B2 (ja) * | 2014-05-16 | 2018-09-19 | 東ソー・ファインケム株式会社 | ２−置換−４−（２，２，２−トリフルオロエトキシ）−５−（トリフルオロメチル）ピリミジン誘導体及びその製造方法 |
| JP6391988B2 (ja) * | 2014-05-21 | 2018-09-19 | 東ソー・ファインケム株式会社 | ５−（トリフルオロメチル）ピリミジン誘導体の製造方法及び新規５−（トリフルオロメチル）ピリミジン誘導体 |
| JP6262079B2 (ja) * | 2014-06-02 | 2018-01-17 | 東ソー・ファインケム株式会社 | ４−（２，２，２−トリフルオロエトキシ）−５−（トリフルオロメチル）ピリミジン誘導体及びその製造方法 |
| JP6431294B2 (ja) * | 2014-06-16 | 2018-11-28 | 東ソー・ファインケム株式会社 | ５−（トリフルオロメチル）ピリミジン誘導体及びその製造法 |
| JP6479486B2 (ja) * | 2015-01-16 | 2019-03-06 | 東ソー・ファインケム株式会社 | ４−アルコキシ−５−（トリフルオロメチル）ピリミジン誘導体及びその製造方法 |
Family Cites Families (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6262A (ja) | 1986-03-05 | 1987-01-06 | Ishihara Sangyo Kaisha Ltd | ベンゾイルウレア系化合物の製造方法 |
| GB0016877D0 (en) | 2000-07-11 | 2000-08-30 | Astrazeneca Ab | Chemical compounds |
| WO2003030909A1 (en) | 2001-09-25 | 2003-04-17 | Bayer Pharmaceuticals Corporation | 2- and 4-aminopyrimidines n-substtituded by a bicyclic ring for use as kinase inhibitors in the treatment of cancer |
| UY27487A1 (es) | 2001-10-17 | 2003-05-30 | Boehringer Ingelheim Pharma | Derivados de pirimidina, medicamentos que contienen estos compuestos, su empleo y procedimiento para su preparación |
| DE10161763A1 (de) | 2001-12-15 | 2003-07-17 | Bayer Cropsience Ltd | Neues herbizides Verfahren |
| GB0206215D0 (en) | 2002-03-15 | 2002-05-01 | Novartis Ag | Organic compounds |
| WO2003095448A1 (en) | 2002-05-06 | 2003-11-20 | Bayer Pharmaceuticals Corporation | Pyridinyl amino pyrimidine derivatives useful for treating hyper-proliferative disorders |
| AR037647A1 (es) | 2002-05-29 | 2004-12-01 | Novartis Ag | Derivados de diarilurea utiles para el tratamiento de enfermedades dependientes de la cinasa de proteina |
| RS20050363A (sr) | 2002-11-28 | 2007-11-15 | Schering Aktiengesellschaft, | Chk-,Pdk- I Akt-INHIBITORNI PIRIMIDINI, NJIHOVA PROIZVODNJA I UPOTREBA KAO FARMACEUTSKIH SREDSTAVA |
| UA80767C2 (en) | 2002-12-20 | 2007-10-25 | Pfizer Prod Inc | Pyrimidine derivatives for the treatment of abnormal cell growth |
| DE60331479D1 (de) | 2002-12-20 | 2010-04-08 | Pfizer Prod Inc | Pyrimidin-derivate zur behandlung von anormalem zellwachstum |
| PT1663991E (pt) | 2003-09-05 | 2007-02-28 | Pfizer Prod Inc | Síntese selectiva de pirimidinas substituídas com cf-3 |
| US20070105839A1 (en) | 2003-09-18 | 2007-05-10 | Patricia Imbach | 2, 4-Di (phenylamino) pyrimidines useful in the treatment of proliferative disorders |
| MY141220A (en) | 2003-11-17 | 2010-03-31 | Astrazeneca Ab | Pyrazole derivatives as inhibitors of receptor tyrosine kinases |
| KR100886990B1 (ko) | 2004-05-14 | 2009-03-04 | 화이자 프로덕츠 인크. | 비정상적인 세포성장의 치료를 위한 피리미딘 유도체 |
| EP1598343A1 (de) | 2004-05-19 | 2005-11-23 | Boehringer Ingelheim International GmbH | 2-Arylaminopyrimidine als PLK Inhibitoren |
| WO2006014482A1 (en) | 2004-07-08 | 2006-02-09 | Boehringer Ingelheim Pharmaceuticals, Inc. | Pyrimidine derivatives useful as inhibitors of pkc-theta |
| US7521457B2 (en) | 2004-08-20 | 2009-04-21 | Boehringer Ingelheim International Gmbh | Pyrimidines as PLK inhibitors |
| US7776869B2 (en) | 2004-10-18 | 2010-08-17 | Amgen Inc. | Heteroaryl-substituted alkyne compounds and method of use |
| ATE519759T1 (de) | 2004-12-30 | 2011-08-15 | Exelixis Inc | Pyrimidinderivate als kinasemodulatoren und anwendungsverfahren |
| US7323447B2 (en) | 2005-02-08 | 2008-01-29 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| WO2006091737A1 (en) | 2005-02-24 | 2006-08-31 | Kemia, Inc. | Modulators of gsk-3 activity |
| EP1705177A1 (en) | 2005-03-23 | 2006-09-27 | Schering Aktiengesellschaft | N-aryl-sulfoximine-substituted pyrimidines as CDK- and/or VEGF inhibitors, their production and use as pharmaceutical agents |
| JP2008540391A (ja) | 2005-05-05 | 2008-11-20 | アストラゼネカ アクチボラグ | ピラゾリルアミノ置換ピリミジン、および癌の処置におけるそれらの使用 |
| US20070203161A1 (en) | 2006-02-24 | 2007-08-30 | Rigel Pharmaceuticals, Inc. | Compositions and methods for inhibition of the jak pathway |
| US20070032514A1 (en) | 2005-07-01 | 2007-02-08 | Zahn Stephan K | 2,4-diamino-pyrimidines as aurora inhibitors |
| KR20080063846A (ko) | 2005-10-28 | 2008-07-07 | 아스트라제네카 아베 | 암 치료에서 티로신 키나제 억제제로 사용하기 위한4-(3-아미노피라졸)피리미딘 유도체 |
| WO2007063384A2 (en) | 2005-12-01 | 2007-06-07 | Pfizer Products Inc. | Pyrimidine derivatives for the treatment of abnormal cell growth |
| RS20080272A (sr) | 2005-12-21 | 2009-07-15 | Pfizer Products Inc., | Derivati pirimidina za tretman neprirodnog rasta ćelija |
| TW200804364A (en) | 2006-02-22 | 2008-01-16 | Boehringer Ingelheim Int | New compounds |
| CA2648170A1 (en) | 2006-04-10 | 2007-10-18 | Boehringer Ingelheim International Gmbh | 2, 4-diaminopyrimidine derivatives and their use for the treatment of cancer |
| PE20120006A1 (es) | 2006-05-15 | 2012-02-02 | Boehringer Ingelheim Int | Compuestos derivados de pirimidina como inhibidores de la quinasa aurora |
| CA2652397A1 (en) | 2006-05-18 | 2007-11-29 | Boehringer Ingelheim International Gmbh | Method of preparing chiral cyclic .beta.-aminocarboxamides |
| DE102006027156A1 (de) | 2006-06-08 | 2007-12-13 | Bayer Schering Pharma Ag | Sulfimide als Proteinkinaseinhibitoren |
| WO2008003766A2 (en) | 2006-07-06 | 2008-01-10 | Boehringer Ingelheim International Gmbh | 4-heter0cycl0alkylpyri(mi)dines, process for the preparation thereof and their use as medicaments |
| DE102006041382A1 (de) | 2006-08-29 | 2008-03-20 | Bayer Schering Pharma Ag | Carbamoyl-Sulfoximide als Proteinkinaseinhibitoren |
| WO2008040951A1 (en) | 2006-10-03 | 2008-04-10 | Astrazeneca Ab | Compounds |
| WO2008045978A1 (en) | 2006-10-10 | 2008-04-17 | Rigel Pharmaceuticals, Inc. | Pinane-substituted pyrimidinediamine derivatives useful as axl inhibitors |
| WO2008046216A1 (en) | 2006-10-18 | 2008-04-24 | Methylgene, Inc. | Kinase inhibitors and uses thereof |
| AU2007312390B2 (en) | 2006-10-19 | 2013-03-28 | F. Hoffmann-La Roche Ag | Aminomethyl-4-imidazoles |
| TWI432427B (zh) | 2006-10-23 | 2014-04-01 | Cephalon Inc | 作為ＡＬＫ及ｃ-ＭＥＴ抑制劑之２，４-二胺基嘧啶之融合雙環衍生物 |
| CA2671478C (en) | 2006-12-13 | 2015-02-17 | F. Hoffmann-La Roche Ag | Non-nucleoside reverse transcriptase inhibitors |
| US20100144732A1 (en) | 2006-12-19 | 2010-06-10 | Krueger Elaine B | Pyrimidine kinase inhibitors |
| EP1939185A1 (de) | 2006-12-20 | 2008-07-02 | Bayer Schering Pharma Aktiengesellschaft | Neuartige Hetaryl-Phenylendiamin-Pyrimidine als Proteinkinaseinhibitoren zur Behandlung von Krebs |
| TW200838517A (en) | 2006-12-21 | 2008-10-01 | Vertex Pharma | Compounds useful as protein kinases inhibitors |
| JP2010513406A (ja) | 2006-12-22 | 2010-04-30 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 癌治療のための細胞周期キナーゼ阻害剤としての２−［（フェニルアミノ）−ピリミジン−４−イルアミノ］−シクロペンタンカルボキサミド誘導体及び関連化合物 |
| AR065015A1 (es) | 2007-01-26 | 2009-05-13 | Smithkline Beecham Corp | Derivados de antranilamida, composiciones farmaceuticas que los contienen, y usos para el tratamiento del cancer |
| US7947698B2 (en) | 2007-03-23 | 2011-05-24 | Rigel Pharmaceuticals, Inc. | Compositions and methods for inhibition of the JAK pathway |
| WO2008129380A1 (en) | 2007-04-18 | 2008-10-30 | Pfizer Products Inc. | Sulfonyl amide derivatives for the treatment of abnormal cell growth |
| WO2009012421A1 (en) | 2007-07-17 | 2009-01-22 | Rigel Pharmaceuticals, Inc. | Cyclic amine substituted pyrimidinediamines as pkc inhibitors |
| WO2009017838A2 (en) | 2007-08-01 | 2009-02-05 | Exelixis, Inc. | Combinations of jak-2 inhibitors and other agents |
| AU2008296545B2 (en) | 2007-08-28 | 2011-09-29 | Irm Llc | 2 -biphenylamino-4 -aminopyrimidine derivatives as kinase inhibitors |
| WO2009063240A1 (en) | 2007-11-16 | 2009-05-22 | Arrow Therapeutics Limited | 2,4-diaminopyrimidine derivatives useful as inhibitors of aurora kinase |
| EP2231620A1 (en) | 2007-12-03 | 2010-09-29 | Boehringer Ingelheim International GmbH | Diaminopyridines for the treatment of diseases which are characterised by excessive or anomal cell proliferation |
| US8207178B2 (en) | 2007-12-14 | 2012-06-26 | Ardea Biosciences, Inc. | Fused pyrimidines as reverse transcriptase inhibitors |
| US8372974B2 (en) | 2008-03-20 | 2013-02-12 | Boehringer Ingelheim International Gmbh | Regioselective preparation of substituted pyrimidines |
| UY31714A (es) | 2008-03-20 | 2009-11-10 | Boehringer Ingelheim Int | Preparación selectiva de pirimidinas sustituidas |
| CN102203083A (zh) | 2008-06-25 | 2011-09-28 | Irm责任有限公司 | 作为激酶抑制剂的嘧啶衍生物 |
| UY31929A (es) | 2008-06-25 | 2010-01-05 | Irm Llc | Compuestos y composiciones como inhibidores de cinasa |
| AU2009262068C1 (en) | 2008-06-27 | 2015-07-02 | Celgene Car Llc | Heteroaryl compounds and uses thereof |
| EP2179992A1 (de) | 2008-10-21 | 2010-04-28 | Bayer Schering Pharma Aktiengesellschaft | Sulfonsubstituierte Anlinopyrimidinderivative als CDK-Inhibitoren, deren Herstellung und Verwendung als Arzneimittel |
| EP2179991A1 (de) | 2008-10-21 | 2010-04-28 | Bayer Schering Pharma Aktiengesellschaft | Sulfoximinsubstituierte Anilino-Pyrimidinderivate als CDK-Inhibitoren, deren Herstellung und Verwendung als Arzneimittel |
| UY32240A (es) | 2008-11-14 | 2010-06-30 | Boeringer Ingelheim Kg | Nuevas 2,4-diaminopirimidinas, sus sales farmacéuticamente aceptables, composiciones conteniéndolas y aplicaciones. |
| TW201024281A (en) | 2008-11-24 | 2010-07-01 | Boehringer Ingelheim Int | New compounds |
| TWI491605B (zh) | 2008-11-24 | 2015-07-11 | Boehringer Ingelheim Int | 新穎化合物 |
| JP5539518B2 (ja) | 2009-08-14 | 2014-07-02 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ２−アミノ−５−トリフルオロメチルピリミジン誘導体の位置選択的調製 |
| US8933227B2 (en) | 2009-08-14 | 2015-01-13 | Boehringer Ingelheim International Gmbh | Selective synthesis of functionalized pyrimidines |
-
2010
- 2010-08-10 US US12/853,732 patent/US8933227B2/en active Active
- 2010-08-13 EA EA201200282A patent/EA201200282A1/ru unknown
- 2010-08-13 CA CA2767965A patent/CA2767965A1/en not_active Abandoned
- 2010-08-13 TW TW099127176A patent/TW201124385A/zh unknown
- 2010-08-13 KR KR1020127003436A patent/KR20120046248A/ko not_active Withdrawn
- 2010-08-13 IN IN1342DEN2012 patent/IN2012DN01342A/en unknown
- 2010-08-13 CN CN2010800346368A patent/CN102471287A/zh active Pending
- 2010-08-13 AR ARP100103001A patent/AR077925A1/es unknown
- 2010-08-13 NZ NZ597538A patent/NZ597538A/en not_active IP Right Cessation
- 2010-08-13 JP JP2012524242A patent/JP5539519B2/ja active Active
- 2010-08-13 WO PCT/EP2010/061840 patent/WO2011018518A1/en not_active Ceased
- 2010-08-13 MX MX2012001469A patent/MX2012001469A/es not_active Application Discontinuation
- 2010-08-13 EP EP10744917.5A patent/EP2464634B1/en active Active
- 2010-08-13 BR BR112012002971A patent/BR112012002971A2/pt not_active IP Right Cessation
- 2010-08-13 AU AU2010283713A patent/AU2010283713A1/en not_active Abandoned
-
2011
- 2011-12-21 IL IL217112A patent/IL217112A0/en unknown
-
2012
- 2012-02-02 CL CL2012000278A patent/CL2012000278A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BR112012002971A2 (pt) | 2015-10-13 |
| NZ597538A (en) | 2014-05-30 |
| CN102471287A (zh) | 2012-05-23 |
| EP2464634A1 (en) | 2012-06-20 |
| US20110190499A1 (en) | 2011-08-04 |
| IN2012DN01342A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 2015-06-05 |
| EA201200282A1 (ru) | 2012-09-28 |
| TW201124385A (en) | 2011-07-16 |
| JP5539519B2 (ja) | 2014-07-02 |
| CA2767965A1 (en) | 2011-02-17 |
| KR20120046248A (ko) | 2012-05-09 |
| WO2011018518A1 (en) | 2011-02-17 |
| AU2010283713A1 (en) | 2012-02-02 |
| CL2012000278A1 (es) | 2012-10-12 |
| JP2013501759A (ja) | 2013-01-17 |
| AR077925A1 (es) | 2011-10-05 |
| MX2012001469A (es) | 2012-02-22 |
| EP2464634B1 (en) | 2016-11-30 |
| US8933227B2 (en) | 2015-01-13 |
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