IL213246A - Processes and intermediates for the preparation of HCV macrocyclic protease inhibitor - Google Patents
Processes and intermediates for the preparation of HCV macrocyclic protease inhibitorInfo
- Publication number
- IL213246A IL213246A IL213246A IL21324611A IL213246A IL 213246 A IL213246 A IL 213246A IL 213246 A IL213246 A IL 213246A IL 21324611 A IL21324611 A IL 21324611A IL 213246 A IL213246 A IL 213246A
- Authority
- IL
- Israel
- Prior art keywords
- hcv
- intermediates
- preparing
- processes
- protease inhibitor
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/475—Preparation of carboxylic acid esters by splitting of carbon-to-carbon bonds and redistribution, e.g. disproportionation or migration of groups between different molecules
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/40—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/32—Oxygen atoms
- C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
- C07D453/04—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems having a quinolyl-4, a substituted quinolyl-4 or a alkylenedioxy-quinolyl-4 radical linked through only one carbon atom, attached in position 2, e.g. quinine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Virology (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Peptides Or Proteins (AREA)
- Furan Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08172691 | 2008-12-23 | ||
| PCT/EP2009/067715 WO2010072742A1 (en) | 2008-12-23 | 2009-12-22 | Processes and intermediates for preparing a macrocyclic protease inhibitor of hcv |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL213246A0 IL213246A0 (en) | 2011-07-31 |
| IL213246A true IL213246A (en) | 2017-10-31 |
Family
ID=40548041
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL213246A IL213246A (en) | 2008-12-23 | 2011-05-31 | Processes and intermediates for the preparation of HCV macrocyclic protease inhibitor |
Country Status (22)
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010072742A1 (en) | 2008-12-23 | 2010-07-01 | Ortho-Mcneil-Janssen Pharmaceuticals, Inc | Processes and intermediates for preparing a macrocyclic protease inhibitor of hcv |
| WO2013041655A1 (en) * | 2011-09-22 | 2013-03-28 | Janssen Pharmaceuticals, Inc. | Processes and intermediates for preparing a macrocyclic protease inhibitor of hcv |
| AU2012327934B2 (en) | 2011-10-28 | 2017-06-01 | Janssen Pharmaceuticals, Inc. | Improved process for preparing an intermediate of the macrocyclic protease inhibitor TMC 435 |
| CN103387509B (zh) * | 2012-05-11 | 2016-06-08 | 重庆博腾制药科技股份有限公司 | 一种hcv蛋白酶抑制剂中间体的制备方法 |
| US9090653B2 (en) * | 2012-06-08 | 2015-07-28 | Gilead Sciences, Inc. | Macrocyclic inhibitors of flaviviridae viruses |
| IN2014MN02652A (cg-RX-API-DMAC7.html) | 2012-06-08 | 2015-08-21 | Gilead Sciences Inc | |
| AR091279A1 (es) | 2012-06-08 | 2015-01-21 | Gilead Sciences Inc | Inhibidores macrociclicos de virus flaviviridae |
| UA119315C2 (uk) | 2012-07-03 | 2019-06-10 | Гіліад Фармассет Елелсі | Інгібітори вірусу гепатиту с |
| AU2014233390B2 (en) | 2013-03-15 | 2018-03-01 | Gilead Sciences, Inc. | Macrocyclic and bicyclic inhibitors of hepatitis C virus |
| CN105308043B (zh) * | 2014-05-29 | 2018-01-30 | 杭州普晒医药科技有限公司 | 丙型肝炎药物的晶型及其制备方法、其药物组合物和用途 |
| MA41812A (fr) | 2015-03-27 | 2018-01-30 | Janssen Pharmaceuticals Inc | Procédés et intermédiaires pour la préparation d'un inhibiteur de protéase macrocyclique du vhc |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL8300536A (nl) | 1983-02-14 | 1984-09-03 | Oce Andeno Bv | Optisch actief alfa-azido-p-hydroxyfenylazijnzuur en zijn zouten alsmede de bereiding daarvan. |
| JPS6124539A (ja) * | 1984-07-11 | 1986-02-03 | Sagami Chem Res Center | 光学活性（ｒ）−２，５，１２−トリヒドロキシ−１，２，３，４−テトラヒドロナフタセン−６，１１−ジオン−２−カルボン酸の取得方法 |
| JP4218040B2 (ja) * | 1997-12-26 | 2009-02-04 | 曽田香料株式会社 | 有機酸とアミンの複合塩の製造法 |
| JP3844112B2 (ja) * | 2000-08-23 | 2006-11-08 | 高砂香料工業株式会社 | ３，５，６−トリヒドロキシヘキサン酸アンモニウム塩誘導体、及びその製造方法 |
| PT1713823E (pt) * | 2004-01-30 | 2010-02-02 | Medivir Ab | Inibidores da protease ns-3 da serina do hcv |
| CN101146794A (zh) * | 2005-01-21 | 2008-03-19 | 阿斯泰克斯治疗有限公司 | 用于抑制cdk和gsk的吡唑衍生物 |
| MY139988A (en) * | 2005-07-29 | 2009-11-30 | Tibotec Pharm Ltd | Macrocylic inhibitors of hepatitis c virus |
| PE20070211A1 (es) | 2005-07-29 | 2007-05-12 | Medivir Ab | Compuestos macrociclicos como inhibidores del virus de hepatitis c |
| SI2121674T1 (sl) | 2007-02-01 | 2010-09-30 | Tibotec Pharm Ltd | Postopki in intermediati za pripravo makrocikličnega proteaznega inhibitorja HCV |
| BRPI0807482A2 (pt) * | 2007-02-08 | 2014-05-13 | Tibotec Pharm Ltd | Fenilcarbamatos macrocíclicos inibidores de hcv |
| WO2010072742A1 (en) | 2008-12-23 | 2010-07-01 | Ortho-Mcneil-Janssen Pharmaceuticals, Inc | Processes and intermediates for preparing a macrocyclic protease inhibitor of hcv |
-
2009
- 2009-12-22 WO PCT/EP2009/067715 patent/WO2010072742A1/en not_active Ceased
- 2009-12-22 PT PT09801447T patent/PT2382198E/pt unknown
- 2009-12-22 AU AU2009331530A patent/AU2009331530B2/en not_active Ceased
- 2009-12-22 TW TW98144049A patent/TWI461424B/zh not_active IP Right Cessation
- 2009-12-22 CA CA2745565A patent/CA2745565C/en not_active Expired - Fee Related
- 2009-12-22 HR HRP20130906AT patent/HRP20130906T1/hr unknown
- 2009-12-22 RU RU2016120007A patent/RU2016120007A/ru not_active Application Discontinuation
- 2009-12-22 ES ES09801447T patent/ES2429013T3/es active Active
- 2009-12-22 US US13/141,715 patent/US8927722B2/en not_active Expired - Fee Related
- 2009-12-22 CN CN200980152851.5A patent/CN102264715B/zh not_active Expired - Fee Related
- 2009-12-22 BR BRPI0923393-8A patent/BRPI0923393B1/pt not_active IP Right Cessation
- 2009-12-22 EP EP09801447.5A patent/EP2382198B1/en active Active
- 2009-12-22 KR KR1020117017333A patent/KR101734507B1/ko not_active Expired - Fee Related
- 2009-12-22 PL PL09801447T patent/PL2382198T3/pl unknown
- 2009-12-22 AR ARP090105059 patent/AR074863A1/es unknown
- 2009-12-22 MX MX2011006764A patent/MX2011006764A/es active IP Right Grant
- 2009-12-22 SI SI200930731T patent/SI2382198T1/sl unknown
- 2009-12-22 DK DK09801447.5T patent/DK2382198T3/da active
- 2009-12-22 JP JP2011541509A patent/JP5687631B2/ja not_active Expired - Fee Related
-
2011
- 2011-05-31 IL IL213246A patent/IL213246A/en not_active IP Right Cessation
-
2013
- 2013-10-10 SM SM201300116T patent/SMT201300116B/xx unknown
- 2013-10-10 CY CY20131100890T patent/CY1114488T1/el unknown
-
2014
- 2014-11-25 US US14/552,550 patent/US9115077B2/en not_active Expired - Fee Related
Also Published As
Similar Documents
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| EP2432318A4 (en) | NS3 PROTEASE INHIBITORS OF BIPACROCYCLIC HEPATITIS C VIRUS | |
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| IL221242A0 (en) | Processes and intermediates for preparing a macrocyclic protease inhibitor of hcv | |
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| SG2014011258A (en) | Hcv protease inhibitors |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |