IL212580A0 - Cells modified to express lipid - linked oligosaccharide flippase activity, methods of producing the same and uses thereof - Google Patents

Cells modified to express lipid - linked oligosaccharide flippase activity, methods of producing the same and uses thereof

Info

Publication number
IL212580A0
IL212580A0 IL212580A IL21258011A IL212580A0 IL 212580 A0 IL212580 A0 IL 212580A0 IL 212580 A IL212580 A IL 212580A IL 21258011 A IL21258011 A IL 21258011A IL 212580 A0 IL212580 A0 IL 212580A0
Authority
IL
Israel
Prior art keywords
producing
methods
same
linked oligosaccharide
cells modified
Prior art date
Application number
IL212580A
Other languages
English (en)
Original Assignee
Lonza Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lonza Ag filed Critical Lonza Ag
Publication of IL212580A0 publication Critical patent/IL212580A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1081—Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/005—Glycopeptides, glycoproteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/99—Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
    • C12Y204/99018—Dolichyl-diphosphooligosaccharide—protein glycotransferase (2.4.99.18)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
IL212580A 2008-10-31 2011-04-28 Cells modified to express lipid - linked oligosaccharide flippase activity, methods of producing the same and uses thereof IL212580A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US19802308P 2008-10-31 2008-10-31
EP08400044 2008-10-31
PCT/EP2009/007816 WO2010049177A1 (en) 2008-10-31 2009-10-31 Novel tools for the production of glycosylated proteins in host cells

Publications (1)

Publication Number Publication Date
IL212580A0 true IL212580A0 (en) 2011-07-31

Family

ID=40386055

Family Applications (1)

Application Number Title Priority Date Filing Date
IL212580A IL212580A0 (en) 2008-10-31 2011-04-28 Cells modified to express lipid - linked oligosaccharide flippase activity, methods of producing the same and uses thereof

Country Status (9)

Country Link
US (1) US20110207214A1 (https=)
EP (1) EP2350123A1 (https=)
JP (1) JP2012506710A (https=)
CN (1) CN102203123A (https=)
AU (1) AU2009309925A1 (https=)
CA (1) CA2741964A1 (https=)
IL (1) IL212580A0 (https=)
TW (1) TW201028431A (https=)
WO (1) WO2010049177A1 (https=)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2252261T3 (es) * 2000-06-28 2006-05-16 Glycofi, Inc. Metodos para producir glicoproteinas modificadas.
RU2012140429A (ru) 2010-02-24 2014-03-27 Мерк Шарп Энд Домэ Корп. Способ увеличения занятости участков n-ликозилирования на терапевтических гликопротеинах, продуцируемых в p pastoris
EP2643456B1 (en) * 2010-11-24 2016-05-11 Novartis International Pharmaceutical Ltd. Fusion enzymes having n-acetylglucosaminyltransferase activity
CN102586316B (zh) * 2012-02-16 2013-08-07 中国科学院微生物研究所 人源糖基化改造的汉逊酵母
CN104105789A (zh) * 2012-02-16 2014-10-15 默沙东公司 降低酵母中甘露糖基转移酶活性的方法
CN102839157A (zh) * 2012-07-12 2012-12-26 扬州大学 稳定共表达hST3GalIV和β1-4GalT1的MDCK细胞系及构建方法和应用
JP6356229B2 (ja) * 2013-06-04 2018-07-11 アイコン ジェネティクス ゲーエムベーハー 植物産生糖タンパク質及び組換え糖タンパク質のｎ−グリコシル化部位占有率を調節する方法
CA2916899C (en) * 2013-07-10 2020-03-10 Novartis Ag Production of glycoproteins having increased n-glycosylation site occupancy
WO2015116315A1 (en) * 2014-01-29 2015-08-06 Amgen Inc. Overexpression of n-glycosylation pathway regulators to modulate glycosylation of recombinant proteins
SG11201700446XA (en) 2014-07-21 2017-02-27 Glykos Finland Oy Production of glycoproteins with mammalian-like n-glycans in filamentous fungi
CN105372214B (zh) * 2014-08-18 2019-06-28 中国科学院上海有机化学研究所 一种鉴定新红细胞生成刺激蛋白的n-连接寡糖结构的方法
CN104784754B (zh) * 2015-03-04 2017-05-10 重庆市畜牧科学院 一种蚕丝人工血管及制备方法
CN106867966B (zh) * 2015-12-11 2020-11-24 复旦大学 稳定表达核心α(1,3)岩藻糖基转移酶的脊椎动物细胞系及其制备方法
JP6757341B2 (ja) * 2018-01-26 2020-09-16 東洋紡株式会社 アスペルギルス属微生物が生産するタンパク質のｎ型糖鎖構造を改変する方法
CN108179160B (zh) * 2018-01-29 2021-05-11 江南大学 一种植烷醇连接的高甘露糖型寡糖的制备方法
EP3788164A4 (en) * 2018-05-01 2022-01-26 Conagen Inc. RECOMBINANT ORGANISMS AND METHODS FOR PRODUCTION OF HIGH GLYCAN OCCUPANCY GLYCOMOLECULES
CN110687035A (zh) * 2019-10-10 2020-01-14 沈阳万类生物科技有限公司 Annexin V-Light 650凋亡检测试剂盒
WO2022190022A1 (en) * 2021-03-11 2022-09-15 Dyadic International (Usa), Inc. Genetically-modified filamentous fungi for production of exogenous proteins having reduced or no n-linked glycosylation

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7507573B2 (en) * 2003-11-14 2009-03-24 Vib, Vzw Modification of protein glycosylation in methylotrophic yeast
AU2005269759A1 (en) * 2004-07-21 2006-02-09 Glycofi, Inc. Immunoglobulins comprising predominantly a GlcNAc2Man3GlcNAc2 glycoform

Also Published As

Publication number Publication date
WO2010049177A1 (en) 2010-05-06
US20110207214A1 (en) 2011-08-25
CN102203123A (zh) 2011-09-28
CA2741964A1 (en) 2010-05-06
EP2350123A1 (en) 2011-08-03
JP2012506710A (ja) 2012-03-22
AU2009309925A1 (en) 2010-05-06
TW201028431A (en) 2010-08-01

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