IL211623A0 - Anti-notch2 antibodies and methods of use - Google Patents

Anti-notch2 antibodies and methods of use

Info

Publication number
IL211623A0
IL211623A0 IL211623A IL21162311A IL211623A0 IL 211623 A0 IL211623 A0 IL 211623A0 IL 211623 A IL211623 A IL 211623A IL 21162311 A IL21162311 A IL 21162311A IL 211623 A0 IL211623 A0 IL 211623A0
Authority
IL
Israel
Prior art keywords
methods
notch2 antibodies
notch2
antibodies
Prior art date
Application number
IL211623A
Other languages
English (en)
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41349057&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL211623(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of IL211623A0 publication Critical patent/IL211623A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3053—Skin, nerves, brain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
IL211623A 2008-10-01 2011-03-08 Anti-notch2 antibodies and methods of use IL211623A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10191708P 2008-10-01 2008-10-01
PCT/US2009/059028 WO2010039832A1 (en) 2008-10-01 2009-09-30 Anti-notch2 antibodies and methods of use

Publications (1)

Publication Number Publication Date
IL211623A0 true IL211623A0 (en) 2011-05-31

Family

ID=41349057

Family Applications (1)

Application Number Title Priority Date Filing Date
IL211623A IL211623A0 (en) 2008-10-01 2011-03-08 Anti-notch2 antibodies and methods of use

Country Status (18)

Country Link
US (5) US8404239B2 (https=)
EP (1) EP2334331B1 (https=)
JP (2) JP5710487B2 (https=)
KR (1) KR101712214B1 (https=)
CN (1) CN102170909B (https=)
AR (1) AR073717A1 (https=)
AU (1) AU2009298569A1 (https=)
BR (1) BRPI0913827A2 (https=)
CA (1) CA2736429A1 (https=)
CL (1) CL2011000711A1 (https=)
ES (1) ES2541726T3 (https=)
IL (1) IL211623A0 (https=)
MX (1) MX2011002928A (https=)
PE (1) PE20120080A1 (https=)
RU (1) RU2580029C2 (https=)
TW (1) TW201018484A (https=)
WO (1) WO2010039832A1 (https=)
ZA (1) ZA201101651B (https=)

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US7919092B2 (en) 2006-06-13 2011-04-05 Oncomed Pharmaceuticals, Inc. Antibodies to notch receptors
EP2125887A4 (en) 2007-01-24 2010-11-10 Oncomed Pharm Inc COMPOSITIONS AND METHODS OF TREATMENT AND DIAGNOSIS OF CANCER
US9132189B2 (en) 2008-07-08 2015-09-15 Oncomed Pharmaceuticals, Inc. Notch1 binding agents and methods of use thereof
CN104402998A (zh) 2008-07-08 2015-03-11 昂考梅德药品有限公司 分离的抗体
PE20120080A1 (es) * 2008-10-01 2012-02-17 Genentech Inc Anticuerpos anti-notch2 y metodos de uso
CN103429616B (zh) 2010-09-27 2016-08-10 詹森生物科技公司 结合人胶原ii的抗体
US8906649B2 (en) 2010-09-27 2014-12-09 Janssen Biotech, Inc. Antibodies binding human collagen II
US20130089562A1 (en) 2011-10-05 2013-04-11 Genenthech, Inc. Methods of treating liver conditions using notch2 antagonists
EP2849785A4 (en) * 2012-05-16 2015-12-16 Oncomed Pharm Inc METHOD FOR THE TREATMENT OF CANCER WITH NOTCH2 / 3 ANTIBODIES
CN104520328B (zh) 2012-08-13 2019-06-07 霍夫曼-拉罗奇有限公司 抗锯齿蛋白抗体及使用方法
US9944700B2 (en) * 2013-03-13 2018-04-17 Novartis Ag Notch2 binding molecules for treating respiratory diseases
SG10201706210WA (en) 2013-03-15 2017-09-28 Genentech Inc Compositions and methods for diagnosis and treatment of hepatic cancers
PL3105253T3 (pl) 2014-02-12 2018-12-31 F. Hoffmann-La Roche Ag Przeciwciała anty-Jagged1 i sposoby stosowania
CA2952315A1 (en) 2014-07-11 2016-01-14 Genentech, Inc. Notch pathway inhibition
US10716829B2 (en) * 2015-09-26 2020-07-21 National Health Research Institutes Method and composition for treatment of hair loss
GB201521447D0 (en) * 2015-12-04 2016-01-20 Ucb Biopharma Sprl De novo antibody design
US10858443B2 (en) 2017-05-31 2020-12-08 Trustees Of Boston University Synthetic notch protein for modulating gene expression
EP4182348A1 (en) * 2020-07-17 2023-05-24 Genentech, Inc. Anti-notch2 antibodies and methods of use
WO2024216505A1 (zh) * 2023-04-18 2024-10-24 上海洛启生物医药技术有限公司 抗Notch2纳米抗体及其应用
CN120441700B (zh) * 2023-11-21 2026-02-10 兰州大学第二医院 一种抗人notch2单链抗体、编码基因、试剂盒及其用途
WO2025149667A1 (en) 2024-01-12 2025-07-17 Pheon Therapeutics Ltd Antibody drug conjugates and uses thereof

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PE20120080A1 (es) * 2008-10-01 2012-02-17 Genentech Inc Anticuerpos anti-notch2 y metodos de uso
JP6059985B2 (ja) * 2009-06-18 2017-01-11 ファイザー・インク 抗ｎｏｔｃｈ−１抗体

Also Published As

Publication number Publication date
EP2334331B1 (en) 2015-04-29
KR101712214B1 (ko) 2017-03-03
CL2011000711A1 (es) 2012-07-20
US20170204175A9 (en) 2017-07-20
US20140314782A1 (en) 2014-10-23
CA2736429A1 (en) 2010-04-08
JP2015145379A (ja) 2015-08-13
RU2580029C2 (ru) 2016-04-10
WO2010039832A1 (en) 2010-04-08
US20150104461A1 (en) 2015-04-16
US20140037643A1 (en) 2014-02-06
TW201018484A (en) 2010-05-16
US20180057589A1 (en) 2018-03-01
EP2334331A1 (en) 2011-06-22
US20100080808A1 (en) 2010-04-01
US8404239B2 (en) 2013-03-26
CN102170909A (zh) 2011-08-31
MX2011002928A (es) 2011-04-11
ES2541726T3 (es) 2015-07-23
AU2009298569A1 (en) 2010-04-08
RU2011117237A (ru) 2012-11-10
PE20120080A1 (es) 2012-02-17
KR20110061600A (ko) 2011-06-09
ZA201101651B (en) 2012-06-27
JP2012504634A (ja) 2012-02-23
BRPI0913827A2 (pt) 2020-12-29
JP5710487B2 (ja) 2015-04-30
AR073717A1 (es) 2010-11-24
CN102170909B (zh) 2015-11-25

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