IL188404A - Use of taci-fusion molecules in the preparation of a pharmaceutical composition for the treatment of multiple myeloma - Google Patents
Use of taci-fusion molecules in the preparation of a pharmaceutical composition for the treatment of multiple myelomaInfo
- Publication number
- IL188404A IL188404A IL188404A IL18840407A IL188404A IL 188404 A IL188404 A IL 188404A IL 188404 A IL188404 A IL 188404A IL 18840407 A IL18840407 A IL 18840407A IL 188404 A IL188404 A IL 188404A
- Authority
- IL
- Israel
- Prior art keywords
- taci
- patient
- dose
- patients
- fusion molecule
- Prior art date
Links
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Classifications
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US70688805P | 2005-08-09 | 2005-08-09 | |
| PCT/US2006/031274 WO2007019573A2 (en) | 2005-08-09 | 2006-08-09 | Methods for the treatment and prevention of abnormal cell proliferation using taci-fusion molecules |
Publications (2)
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| IL188404A0 IL188404A0 (en) | 2008-08-07 |
| IL188404A true IL188404A (en) | 2011-10-31 |
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| IL188404A IL188404A (en) | 2005-08-09 | 2007-12-25 | Use of taci-fusion molecules in the preparation of a pharmaceutical composition for the treatment of multiple myeloma |
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| Country | Link |
|---|---|
| US (1) | US8808696B2 (https=) |
| EP (1) | EP1922079A2 (https=) |
| JP (1) | JP5118037B2 (https=) |
| AR (1) | AR059025A1 (https=) |
| AU (1) | AU2006278227B2 (https=) |
| CA (1) | CA2618763A1 (https=) |
| IL (1) | IL188404A (https=) |
| NO (1) | NO20081152L (https=) |
| WO (1) | WO2007019573A2 (https=) |
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| US7833529B1 (en) | 1999-01-07 | 2010-11-16 | Zymogenetics, Inc. | Methods for inhibiting B lymphocyte proliferation with soluble ztnf4 receptor |
| AU2006278229B2 (en) | 2005-08-09 | 2011-10-27 | Ares Trading S.A. | Methods for treating B-cell malignancies using TACI-Ig fusion molecule |
| EP1922079A2 (en) | 2005-08-09 | 2008-05-21 | ZymoGenetics, Inc. | Methods for the treatment and prevention of abnormal cell proliferation using taci-fusion molecules |
| JP2009537563A (ja) | 2006-05-15 | 2009-10-29 | アレス トレーディング ソシエテ アノニム | Ｔａｃｉ融合分子を使用する自己免疫疾患を治療するための方法 |
| CN101323643B (zh) * | 2007-06-15 | 2010-12-01 | 烟台荣昌生物工程有限公司 | 优化的TACI-Fc融合蛋白 |
| US20170247462A1 (en) | 2014-07-03 | 2017-08-31 | Oklahoma Medical Research Foundation | Treatment of multiple sclerosis and neuromyelitis optica |
| JP7748393B2 (ja) | 2020-05-08 | 2025-10-02 | アルパイン イミューン サイエンシズ インコーポレイテッド | Ａｐｒｉｌおよびｂａｆｆ阻害免疫調節タンパク質、ならびにその使用方法 |
| JP2024514077A (ja) * | 2021-03-31 | 2024-03-28 | 江▲蘇▼恒瑞医▲薬▼股▲フン▼有限公司 | 切断したｔａｃｉポリペプチド及びその融合タンパク質並びに使用 |
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| US4331647A (en) | 1980-03-03 | 1982-05-25 | Goldenberg Milton David | Tumor localization and therapy with labeled antibody fragments specific to tumor-associated markers |
| IE54046B1 (en) | 1981-08-25 | 1989-05-24 | Celltech Ltd | Expression vectors |
| US4579821A (en) | 1981-11-23 | 1986-04-01 | University Patents, Inc. | Control of DNA sequence transcription |
| US4656134A (en) | 1982-01-11 | 1987-04-07 | Board Of Trustees Of Leland Stanford Jr. University | Gene amplification in eukaryotic cells |
| US4486533A (en) | 1982-09-02 | 1984-12-04 | St. Louis University | Filamentous fungi functional replicating extrachromosomal element |
| US4599311A (en) | 1982-08-13 | 1986-07-08 | Kawasaki Glenn H | Glycolytic promotersfor regulated protein expression: protease inhibitor |
| US4977092A (en) | 1985-06-26 | 1990-12-11 | Amgen | Expression of exogenous polypeptides and polypeptide products including hepatitis B surface antigen in yeast cells |
| US4601978A (en) | 1982-11-24 | 1986-07-22 | The Regents Of The University Of California | Mammalian metallothionein promoter system |
| US4713339A (en) | 1983-01-19 | 1987-12-15 | Genentech, Inc. | Polycistronic expression vector construction |
| US4661454A (en) | 1983-02-28 | 1987-04-28 | Collaborative Research, Inc. | GAL1 yeast promoter linked to non galactokinase gene |
| US5139936A (en) | 1983-02-28 | 1992-08-18 | Collaborative Research, Inc. | Use of the GAL1 yeast promoter |
| US4870008A (en) | 1983-08-12 | 1989-09-26 | Chiron Corporation | Secretory expression in eukaryotes |
| US4931373A (en) | 1984-05-25 | 1990-06-05 | Zymogenetics, Inc. | Stable DNA constructs for expression of α-1 antitrypsin |
| US4766073A (en) | 1985-02-25 | 1988-08-23 | Zymogenetics Inc. | Expression of biologically active PDGF analogs in eucaryotic cells |
| US4990446A (en) | 1984-12-06 | 1991-02-05 | Labofina, S.A. | Promoters for the expression of foreign genes in yeast, plasmids comprising them, and use thereof for the production of polypeptides |
| US4751181A (en) | 1984-12-31 | 1988-06-14 | Duke University | Methods and compositions useful in the diagnosis and treatment of autoimmune diseases |
| GR860984B (en) | 1985-04-17 | 1986-08-18 | Zymogenetics Inc | Expression of factor vii and ix activities in mammalian cells |
| US4882279A (en) | 1985-10-25 | 1989-11-21 | Phillips Petroleum Company | Site selective genomic modification of yeast of the genus pichia |
| US4935349A (en) | 1986-01-17 | 1990-06-19 | Zymogenetics, Inc. | Expression of higher eucaryotic genes in aspergillus |
| GB8611832D0 (en) | 1986-05-15 | 1986-06-25 | Holland I B | Polypeptide |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US5063154A (en) | 1987-06-24 | 1991-11-05 | Whitehead Institute For Biomedical Research | Pheromone - inducible yeast promoter |
| US5637677A (en) | 1987-07-16 | 1997-06-10 | The Trustees Of The University Of Pennsylvania | Biologically active compounds and methods of constructing and using the same |
| DE68926888T2 (de) | 1988-01-22 | 1997-01-09 | Zymogenetics Inc | Verfahren zur Herstellung von sekretierten Rezeptoranalogen |
| US5567584A (en) | 1988-01-22 | 1996-10-22 | Zymogenetics, Inc. | Methods of using biologically active dimerized polypeptide fusions to detect PDGF |
| US4956288A (en) | 1988-04-22 | 1990-09-11 | Biogen, Inc. | Method for producing cells containing stably integrated foreign DNA at a high copy number, the cells produced by this method, and the use of these cells to produce the polypeptides coded for by the foreign DNA |
| US5037743A (en) | 1988-08-05 | 1991-08-06 | Zymogenetics, Inc. | BAR1 secretion signal |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| US5162228A (en) | 1988-12-28 | 1992-11-10 | Takeda Chemical Industries, Ltd. | Gylceraldehyde-3-phosphate dehydrogenase gene and promoter |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5162222A (en) | 1989-07-07 | 1992-11-10 | Guarino Linda A | Use of baculovirus early promoters for expression of foreign genes in stably transformed insect cells or recombinant baculoviruses |
| SG46445A1 (en) | 1990-01-26 | 1998-02-20 | Immunomedics Inc | Vaccines against cancer and infectious diseases |
| CA2075182C (en) | 1990-02-09 | 2003-03-25 | David J. Mangelsdorf | Retinoid receptor compositions and methods |
| US5208146A (en) | 1990-11-05 | 1993-05-04 | The Regents Of The University Of California | Murine monoclonal anti-idiotype antibodies |
| WO1994006463A1 (en) | 1992-09-14 | 1994-03-31 | Pfizer Inc | Immortalized cells and uses therefor |
| WO1994009137A1 (en) | 1992-10-15 | 1994-04-28 | Genentech, Inc. | Antibodies against type 2 tumor necrosis factor receptor |
| US5595721A (en) | 1993-09-16 | 1997-01-21 | Coulter Pharmaceutical, Inc. | Radioimmunotherapy of lymphoma using anti-CD20 |
| US5650550A (en) | 1993-10-01 | 1997-07-22 | The United States Of America As Represented By The Department Of Health And Human Services | Mutant mice having a deficit of functional estrogen receptors |
| US5523227A (en) | 1994-06-17 | 1996-06-04 | The Board Of Trustees Of The Leland Stanford Junior Univ. | DNA encoding calcium-signal modulating cyclophilin ligand |
| DE69535634T2 (de) | 1994-12-15 | 2008-08-28 | Yeda Research And Development Co., Ltd. | Modulatoren der funktion des fas/ap01 rezeptors |
| US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| US5739277A (en) | 1995-04-14 | 1998-04-14 | Genentech Inc. | Altered polypeptides with increased half-life |
| DE19533447C1 (de) | 1995-09-09 | 1996-12-05 | Bbs Kraftfahrzeugtechnik | Verfahren und Vorrichtung zum Befüllen eines Gießwerkzeugs mit einer Metallschmelze |
| JP2000500014A (ja) | 1995-11-09 | 2000-01-11 | ザイモジェネティクス，インコーポレイティド | ピヒア・メタノリカ中で異種ポリペプチドを生産するための組成物と方法 |
| US5716808A (en) | 1995-11-09 | 1998-02-10 | Zymogenetics, Inc. | Genetic engineering of pichia methanolica |
| DK0897390T3 (da) | 1996-03-14 | 2004-03-08 | Human Genome Sciences Inc | Human tumornekrosefaktor-delta og -epsilon |
| CA2261020C (en) | 1996-07-17 | 2004-06-08 | Zymogenetics, Inc. | Preparation of pichia methanolica auxotrophic mutants |
| CA2261151C (en) | 1996-07-17 | 2003-09-16 | Zymogenetics, Inc. | Transformation of pichia methanolica |
| US5736383A (en) | 1996-08-26 | 1998-04-07 | Zymogenetics, Inc. | Preparation of Pichia methanolica auxotrophic mutants |
| US6689579B1 (en) | 1996-10-25 | 2004-02-10 | Human Genome Sciences, Inc. | Polynucleotides encoding neutrokine-α |
| ES2248823T5 (es) | 1996-10-25 | 2011-11-03 | Human Genome Sciences, Inc. | Neutroquina alfa. |
| AU5705898A (en) | 1996-12-17 | 1998-07-15 | Schering Corporation | Mammalian cell surface antigens; related reagents |
| US5969102A (en) | 1997-03-03 | 1999-10-19 | St. Jude Children's Research Hospital | Lymphocyte surface receptor that binds CAML, nucleic acids encoding the same and methods of use thereof |
| CA2232743A1 (en) | 1997-04-02 | 1998-10-02 | Smithkline Beecham Corporation | A tnf homologue, tl5 |
| JP2002517977A (ja) | 1997-06-06 | 2002-06-18 | リジェネロン ファーマシューティカルズ，インコーポレイテッド | Ｔｎｆリガンドファミリーのｎｔｎ−２メンバー |
| IL133315A0 (en) | 1997-06-06 | 2001-04-30 | Regeneron Pharma | Ntn-2 member of tnf ligand family |
| WO1999004001A1 (en) | 1997-07-21 | 1999-01-28 | Zymogenetics, Inc. | Tumor necrosis factor receptor ztnfr-5 |
| US6015801A (en) * | 1997-07-22 | 2000-01-18 | Merck & Co., Inc. | Method for inhibiting bone resorption |
| WO1999011791A2 (en) | 1997-09-05 | 1999-03-11 | University Of Washington | Tumor necrosis factor family receptors and ligands, encoding nucleic acids and related binding agents |
| CA2303424A1 (en) | 1997-09-12 | 1999-03-18 | Jurg Tschopp | Kay - a novel immune system protein |
| SK3542000A3 (en) | 1997-09-12 | 2000-08-14 | Apotech R & D Sa | Nucleic acid coding ligand april, a vector, a host cell, method for preparing ligand april, a polypeptide of ligand april, a pharmaceutical composition and an antibody, and use thereof |
| DE19831987A1 (de) | 1998-07-16 | 2000-01-20 | Bayer Ag | Diphenylimidazoline |
| GB9828628D0 (en) | 1998-12-23 | 1999-02-17 | Glaxo Group Ltd | Novel ligand |
| EP1141278B1 (en) * | 1998-12-30 | 2008-02-27 | Oligos Etc. Inc. | Therapeutic pde4d phosphodiesterase inhibitors |
| DE60043626D1 (de) * | 1999-01-07 | 2010-02-11 | Zymogenetics Inc | Verfahren zur therapeutischen Verwendung von löslichen rezeptoren BR43X2 |
| US20060067933A1 (en) | 1999-01-07 | 2006-03-30 | Gross Jane A | Soluble receptor BR43x2 and methods of using |
| US7833529B1 (en) | 1999-01-07 | 2010-11-16 | Zymogenetics, Inc. | Methods for inhibiting B lymphocyte proliferation with soluble ztnf4 receptor |
| BR0007719A (pt) | 1999-01-25 | 2001-11-13 | Biogen Inc | Baff, agentes de bloqueio relacionados e uso dosmesmos no estìmulo e na inibição de células b e deimunoglobulinas em respostas imunológicas |
| NZ513290A (en) | 1999-02-23 | 2004-05-28 | Human Genome Sciences Inc | Neutrokine-alpha and neutrokine-alpha splice variant |
| AU4363200A (en) | 1999-04-19 | 2000-11-02 | Immunex Corporation | Soluble tumor necrosis factor receptor treatment of medical desorders |
| US20030022233A1 (en) | 1999-04-30 | 2003-01-30 | Raymond G. Goodwin | Methods of use of the taci/taci-l interaction |
| DE60040147D1 (de) | 1999-05-28 | 2008-10-16 | Targeted Genetics Corp | Methoden und zusammensetzungen zur reduktion des tumor-nekrosis-faktor-spiegels (tnf) bei tnf-assoziierten erkrankungen |
| UA75049C2 (uk) | 1999-08-17 | 2006-03-15 | Байоджен Айдек Ма Інк. | Фармацевтична композиція, що містить поліпептид, який являє собою білковий фактор дозрівання в-клітин (всма), що зв'язується з фактором активації в-клітин (baff), спосіб інгібування росту в-клітин, спосіб лікування аутоімунного захворювання, спосіб лікування гіпертонії, спосіб інгібування запалення та спосіб модулювання імунної відповіді у ссавця за допомогою всма |
| UA74798C2 (uk) | 1999-10-06 | 2006-02-15 | Байоджен Айдек Ма Інк. | Спосіб лікування раку у ссавця за допомогою поліпептиду, що протидіє взаємодії april з його рецепторами |
| CA2396793A1 (en) | 2000-02-16 | 2001-08-23 | Genentech, Inc. | Uses of agonists and antagonists to modulate activity of tnf-related molecules |
| CN101289511A (zh) | 2000-04-11 | 2008-10-22 | 杰南技术公司 | 多价抗体及其应用 |
| US20040013674A1 (en) | 2001-04-27 | 2004-01-22 | Christine Ambrose | Taci as an anti-tumor agent |
| JP2004513876A (ja) * | 2000-04-27 | 2004-05-13 | バイオジェン インコーポレーテッド | 抗−腫瘍剤としてのｔａｃｉ |
| US20020086018A1 (en) | 2000-05-12 | 2002-07-04 | Theill Lars Eyde | Methods and compositions of matter concerning APRIL/G70, BCMA, BLYS/AGP-3, and TACI |
| WO2001094419A2 (en) * | 2000-06-07 | 2001-12-13 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw | Method to induce the th1 immune response |
| ES2329012T3 (es) | 2000-11-07 | 2009-11-20 | Zymogenetics, Inc. | Receptor del factor de necrosis tumoral humano. |
| US20030012783A1 (en) | 2001-02-20 | 2003-01-16 | Wayne Kindsvogel | Antibodies that bind both BCMA and TACI |
| BRPI0209933B8 (pt) | 2001-05-24 | 2021-05-25 | Zymogenetics Inc | proteína de fusão, e, molécula de ácido nucleico |
| BR0211614A (pt) | 2001-08-03 | 2006-10-31 | Genentech Inc | polipeptìdeo tacis e br3 e empregos dos mesmos |
| EP1556033A4 (en) | 2002-05-17 | 2006-05-31 | Celgene Corp | METHODS AND COMPOSITIONS USING CYTOKINE INHIBITOR SELECTIVE MEDICAMENTS FOR THE TREATMENT AND MANAGEMENT OF CANCERS AND OTHER DISEASES |
| US7090417B2 (en) | 2002-10-29 | 2006-08-15 | Eastman Kodak Company | Method of programming pages within a document to be printed on different output devices |
| US20050163775A1 (en) | 2003-06-05 | 2005-07-28 | Genentech, Inc. | Combination therapy for B cell disorders |
| PL1631313T3 (pl) | 2003-06-05 | 2015-08-31 | Genentech Inc | Terapia skojarzona zaburzeń z komórek B |
| AU2004285455A1 (en) | 2003-10-20 | 2005-05-12 | Biogen Idec Ma Inc. | Therapeutic regimens for BAFF antagonists |
| FR2884251B1 (fr) | 2005-04-08 | 2007-07-13 | Servier Lab | Derives de piperazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| EP1922079A2 (en) | 2005-08-09 | 2008-05-21 | ZymoGenetics, Inc. | Methods for the treatment and prevention of abnormal cell proliferation using taci-fusion molecules |
| AU2006278229B2 (en) | 2005-08-09 | 2011-10-27 | Ares Trading S.A. | Methods for treating B-cell malignancies using TACI-Ig fusion molecule |
| WO2009062960A1 (en) | 2007-11-12 | 2009-05-22 | Ares Trading S.A. | Formulations for taci-immunoglobulin fusion proteins |
-
2006
- 2006-08-09 EP EP06801191A patent/EP1922079A2/en not_active Withdrawn
- 2006-08-09 CA CA002618763A patent/CA2618763A1/en not_active Abandoned
- 2006-08-09 JP JP2008526210A patent/JP5118037B2/ja not_active Expired - Fee Related
- 2006-08-09 AU AU2006278227A patent/AU2006278227B2/en not_active Ceased
- 2006-08-09 US US11/501,999 patent/US8808696B2/en not_active Expired - Fee Related
- 2006-08-09 AR ARP060103487A patent/AR059025A1/es unknown
- 2006-08-09 WO PCT/US2006/031274 patent/WO2007019573A2/en not_active Ceased
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2007
- 2007-12-25 IL IL188404A patent/IL188404A/en not_active IP Right Cessation
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2008
- 2008-03-04 NO NO20081152A patent/NO20081152L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1922079A2 (en) | 2008-05-21 |
| JP5118037B2 (ja) | 2013-01-16 |
| NO20081152L (no) | 2008-03-04 |
| JP2009504668A (ja) | 2009-02-05 |
| AR059025A1 (es) | 2008-03-12 |
| AU2006278227A1 (en) | 2007-02-15 |
| IL188404A0 (en) | 2008-08-07 |
| WO2007019573A2 (en) | 2007-02-15 |
| AU2006278227A8 (en) | 2008-02-28 |
| US20070207156A1 (en) | 2007-09-06 |
| WO2007019573A3 (en) | 2007-08-16 |
| AU2006278227B2 (en) | 2011-10-20 |
| CA2618763A1 (en) | 2007-02-15 |
| US8808696B2 (en) | 2014-08-19 |
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