IL181083A0 - Synthetic hyperglycosylated protease-resistant polypeptide variants, oral formulations and methods of using the same - Google Patents
Synthetic hyperglycosylated protease-resistant polypeptide variants, oral formulations and methods of using the sameInfo
- Publication number
- IL181083A0 IL181083A0 IL181083A IL18108307A IL181083A0 IL 181083 A0 IL181083 A0 IL 181083A0 IL 181083 A IL181083 A IL 181083A IL 18108307 A IL18108307 A IL 18108307A IL 181083 A0 IL181083 A0 IL 181083A0
- Authority
- IL
- Israel
- Prior art keywords
- hyperglycosylated
- protease
- synthetic
- methods
- same
- Prior art date
Links
- 108091005804 Peptidases Proteins 0.000 title 1
- 239000004365 Protease Substances 0.000 title 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 title 1
- 238000009472 formulation Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
- A61K38/212—IFN-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/14—Peptides containing saccharide radicals; Derivatives thereof, e.g. bleomycin, phleomycin, muramylpeptides or vancomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Physical Education & Sports Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60013404P | 2004-08-09 | 2004-08-09 | |
| US60020204P | 2004-08-09 | 2004-08-09 | |
| US60441504P | 2004-08-24 | 2004-08-24 | |
| US60428004P | 2004-08-24 | 2004-08-24 | |
| PCT/US2005/028165 WO2006020580A2 (en) | 2004-08-09 | 2005-08-08 | Synthetic hyperglycosylated, protease-resistant polypeptide variants, oral formulations and methods of using the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL181083A0 true IL181083A0 (en) | 2007-07-04 |
Family
ID=35908080
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL181083A IL181083A0 (en) | 2004-08-09 | 2007-01-31 | Synthetic hyperglycosylated protease-resistant polypeptide variants, oral formulations and methods of using the same |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US20060182716A1 (enExample) |
| EP (1) | EP1789074A4 (enExample) |
| JP (1) | JP2008513356A (enExample) |
| KR (1) | KR20070085227A (enExample) |
| AU (1) | AU2005273968A1 (enExample) |
| CA (1) | CA2576030A1 (enExample) |
| IL (1) | IL181083A0 (enExample) |
| MX (1) | MX2007001589A (enExample) |
| WO (1) | WO2006020580A2 (enExample) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004022593A2 (en) | 2002-09-09 | 2004-03-18 | Nautilus Biotech | Rational evolution of cytokines for higher stability, the cytokines and encoding nucleic acid molecules |
| AU2005269265B2 (en) * | 2004-08-02 | 2012-01-12 | Zenyth Operations Pty Ltd | A method of treating cancer comprising a VEGF-B antagonist |
| US7597884B2 (en) | 2004-08-09 | 2009-10-06 | Alios Biopharma, Inc. | Hyperglycosylated polypeptide variants and methods of use |
| EP1877434A2 (en) * | 2005-05-04 | 2008-01-16 | Nautilus Biotech | Modified interferon-gamma polypeptides and methods for using modified interferon-gamma polypeptides |
| EP1909822B1 (en) * | 2005-06-29 | 2013-09-25 | Yeda Research And Development Co., Ltd. | Recombinant interferon alpha 2 (ifn alpha 2) mutants |
| US8007790B2 (en) | 2006-04-03 | 2011-08-30 | Stowers Institute For Medical Research | Methods for treating polycystic kidney disease (PKD) or other cyst forming diseases |
| TW200804416A (en) | 2006-06-19 | 2008-01-16 | Nautilus Technology Llc | Modified coagulation factor IX polypeptides and use thereof for treatment |
| AR078117A1 (es) | 2006-06-20 | 2011-10-19 | Protech Pharma S A | Una muteina recombinante del interferon alfa humano glicosilado, un gen que codifica para dicha muteina, un metodo de produccion de dicho gen, un metodo para obtener una celula eucariota productora de dicha muteina, un metodo para producir dicha muteina, un procedimiento para purificar dicha muteina |
| CN104645328A (zh) * | 2006-10-03 | 2015-05-27 | 建新公司 | TGF-β拮抗物治疗具有罹患支气管肺发育不良风险的婴儿的用途 |
| US7802280B2 (en) | 2007-04-03 | 2010-09-21 | Google Inc. | Approving transcoded advertisements in advertisement front end |
| US7625555B2 (en) | 2007-06-18 | 2009-12-01 | Novagen Holding Corporation | Recombinant human interferon-like proteins |
| PT2910570T (pt) | 2008-03-18 | 2017-01-24 | Novo Nordisk As | Análogos de insulina acilados, estabilizados contra proteases |
| CN102159250B (zh) | 2008-08-11 | 2014-08-06 | 尼克塔治疗公司 | 多臂的聚合烷酸酯偶联物 |
| US9410891B2 (en) | 2010-02-19 | 2016-08-09 | Pacific Biosciences Of California, Inc. | Optics collection and detection system and method |
| US10894087B2 (en) | 2010-12-22 | 2021-01-19 | Nektar Therapeutics | Multi-arm polymeric prodrug conjugates of cabazitaxel-based compounds |
| US20130331443A1 (en) | 2010-12-22 | 2013-12-12 | Nektar Therapeutics | Multi-arm polymeric prodrug conjugates of taxane-based compounds |
| CN109134642A (zh) | 2011-10-01 | 2019-01-04 | 株式会社糖锁工学研究所 | 加成糖链的多肽及含有该多肽的医药组合物 |
| WO2013059885A2 (en) * | 2011-10-28 | 2013-05-02 | Cephalon Australia Pty Ltd | Polypeptide constructs and uses thereof |
| EP3799880A3 (en) * | 2012-03-03 | 2021-06-23 | ImmunGene, Inc. | Engineered antibody-interferon mutant fusion molecules |
| BR112014025132A2 (pt) | 2012-04-11 | 2017-07-11 | Novo Nordisk As | formulações de insulina |
| US10053499B2 (en) | 2013-03-29 | 2018-08-21 | Glytech, Inc. | Polypeptide having sialylated sugar chains attached thereto |
| KR101432714B1 (ko) * | 2014-02-21 | 2014-08-25 | 순천향대학교 산학협력단 | 벤조안트라센 오염 검출을 위한 마커 및 키트 |
| WO2015148512A1 (en) | 2014-03-24 | 2015-10-01 | Qt Holdings Corp | Shaped articles including hydrogels and methods of manufacture and use thereof |
| US9790467B2 (en) * | 2015-09-22 | 2017-10-17 | Qt Holdings Corp | Methods and compositions for activation or expansion of T lymphocytes |
| PT3554534T (pt) | 2016-12-16 | 2021-11-05 | Novo Nordisk As | Composições farmacêuticas contendo insulina |
| CA3071534A1 (en) * | 2017-08-02 | 2019-02-07 | Northwestern University | Substituted fused pyrimidine compounds and uses thereof |
| CN112616315A (zh) * | 2018-03-29 | 2021-04-06 | 赫尔辛基大学 | C末端的cdnf和manf片段、包含它们的药物组合物及其用途 |
| AU2019276776B2 (en) * | 2018-06-01 | 2025-12-11 | ILC Therapeutics Limited | Compositions and methods relating to the treatment of diseases |
| BR112022002962A2 (pt) * | 2019-08-16 | 2022-07-05 | Applied Molecular Transport Inc | Composições, formulações e produção e purificação de interleucina |
| AR117715A1 (es) * | 2019-12-17 | 2021-08-25 | Univ Nacional Del Litoral Unl | Interferón hiperglicosilado con inmunogenicidad reducida |
| EP3901168A1 (en) * | 2020-04-21 | 2021-10-27 | Universität Duisburg-Essen | Interferon alpha 2 variants and uses thereof |
Family Cites Families (107)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3720760A (en) * | 1968-09-06 | 1973-03-13 | Pharmacia Ab | Method for determining the presence of reagin-immunoglobulins(reagin-ig)directed against certain allergens,in aqueous samples |
| DE2031216A1 (de) * | 1969-06-19 | 1971-01-14 | Citizen Watch Co Ltd , Tokio | Tag und Datum Stellvorrichtung fur Uhren mit Kalender |
| US3940475A (en) * | 1970-06-11 | 1976-02-24 | Biological Developments, Inc. | Radioimmune method of assaying quantitatively for a hapten |
| US4211771A (en) * | 1971-06-01 | 1980-07-08 | Robins Ronald K | Treatment of human viral diseases with 1-B-D-ribofuranosyl-1,2,4-triazole-3-carboxamide |
| CA1049411A (en) * | 1972-12-18 | 1979-02-27 | Affiliated Medical Research | N-substituted pyridone and general method for preparing pyridones |
| USRE30985E (en) * | 1978-01-01 | 1982-06-29 | Serum-free cell culture media | |
| US6936694B1 (en) * | 1982-05-06 | 2005-08-30 | Intermune, Inc. | Manufacture and expression of large structural genes |
| US4657866A (en) * | 1982-12-21 | 1987-04-14 | Sudhir Kumar | Serum-free, synthetic, completely chemically defined tissue culture media |
| US4767704A (en) * | 1983-10-07 | 1988-08-30 | Columbia University In The City Of New York | Protein-free culture medium |
| US4683202A (en) * | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4683195A (en) * | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US4737456A (en) * | 1985-05-09 | 1988-04-12 | Syntex (U.S.A.) Inc. | Reducing interference in ligand-receptor binding assays |
| US4810643A (en) * | 1985-08-23 | 1989-03-07 | Kirin- Amgen Inc. | Production of pluripotent granulocyte colony-stimulating factor |
| US4927762A (en) * | 1986-04-01 | 1990-05-22 | Cell Enterprises, Inc. | Cell culture medium with antioxidant |
| US4810804A (en) * | 1987-03-26 | 1989-03-07 | Allergan, Inc. | Acetylenes disubstituted with a phenyl group and a heterobicyclic group having retinoid-like activity |
| EP0407401B1 (en) * | 1988-02-26 | 1993-04-21 | Genentech, Inc. | Human relaxin formulation |
| US5270198A (en) * | 1988-05-20 | 1993-12-14 | Genentech, Inc. | DNA molecules encoding variants of tissue plasminogen activators, vectors, and host cells |
| US5534617A (en) * | 1988-10-28 | 1996-07-09 | Genentech, Inc. | Human growth hormone variants having greater affinity for human growth hormone receptor at site 1 |
| US5240848A (en) * | 1988-11-21 | 1993-08-31 | Monsanto Company | Dna sequences encoding human vascular permeability factor having 189 amino acids |
| US5571714A (en) * | 1988-12-22 | 1996-11-05 | Celtrix Pharmaceuticals, Inc. | Monoclonal antibodies which bind both transforming growth factors β1 and β2 and methods of use |
| US5514646A (en) * | 1989-02-09 | 1996-05-07 | Chance; Ronald E. | Insulin analogs modified at position 29 of the B chain |
| US5332671A (en) * | 1989-05-12 | 1994-07-26 | Genetech, Inc. | Production of vascular endothelial cell growth factor and DNA encoding same |
| DE69024261T2 (de) * | 1989-05-24 | 1996-07-18 | Merck & Co Inc | Reinigung und Charakterisierung eines von einem Glioma abstammenden Wachstumsfaktors |
| US5194596A (en) * | 1989-07-27 | 1993-03-16 | California Biotechnology Inc. | Production of vascular endothelial cell growth factor |
| US5395760A (en) * | 1989-09-05 | 1995-03-07 | Immunex Corporation | DNA encoding tumor necrosis factor-α and -β receptors |
| US5605690A (en) * | 1989-09-05 | 1997-02-25 | Immunex Corporation | Methods of lowering active TNF-α levels in mammals using tumor necrosis factor receptor |
| US5518729A (en) * | 1989-11-22 | 1996-05-21 | Margolin; Solomon B. | Compositions and methods for reparation and prevention of fibrotic lesions |
| US5716632A (en) * | 1989-11-22 | 1998-02-10 | Margolin; Solomon B. | Compositions and methods for reparation and prevention of fibrotic lesions |
| US5310562A (en) * | 1989-11-22 | 1994-05-10 | Margolin Solomon B | Composition and method for reparation and prevention of fibrotic lesions |
| US5726152A (en) * | 1990-09-21 | 1998-03-10 | Merck & Co., Inc. | Vascular endothelial cell growth factor II |
| US5122469A (en) * | 1990-10-03 | 1992-06-16 | Genentech, Inc. | Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins |
| TW197439B (enExample) * | 1991-04-04 | 1993-01-01 | Ueno Pharmaceutics Applic Res Co Ltd | |
| US5736371A (en) * | 1991-06-04 | 1998-04-07 | A Et S Biovecteurs | Biodegradable particulate vector for transporting molecules having biological activity |
| US5283253A (en) * | 1991-09-23 | 1994-02-01 | Florida State University | Furyl or thienyl carbonyl substituted taxanes and pharmaceutical compositions containing them |
| US5200534A (en) * | 1992-03-13 | 1993-04-06 | University Of Florida | Process for the preparation of taxol and 10-deacetyltaxol |
| US5521184A (en) * | 1992-04-03 | 1996-05-28 | Ciba-Geigy Corporation | Pyrimidine derivatives and processes for the preparation thereof |
| US5780676A (en) * | 1992-04-22 | 1998-07-14 | Ligand Pharmaceuticals Incorporated | Compounds having selective activity for Retinoid X Receptors, and means for modulation of processes mediated by Retinoid X Receptors |
| US5711968A (en) * | 1994-07-25 | 1998-01-27 | Alkermes Controlled Therapeutics, Inc. | Composition and method for the controlled release of metal cation-stabilized interferon |
| US5686268A (en) * | 1992-06-19 | 1997-11-11 | Pfizer Inc. | Fused proteins |
| US5294637A (en) * | 1992-07-01 | 1994-03-15 | Bristol-Myers Squibb Company | Fluoro taxols |
| US5202448A (en) * | 1992-08-14 | 1993-04-13 | Napro Biotherapeutics, Inc. | Processes of converting taxanes into baccatin III |
| CA2141602A1 (en) * | 1992-08-26 | 1994-03-03 | Philip Leder | Use of the cytokine ip-10 as an anti-tumor agent |
| FR2696458B1 (fr) * | 1992-10-05 | 1994-11-10 | Rhone Poulenc Rorer Sa | Procédé de préparation de dérivés du taxane. |
| US6214542B1 (en) * | 1992-10-20 | 2001-04-10 | The United States Of America As Represented By The Department Of Health And Human Services | Quantification of indicators of fibrosis |
| US5279949A (en) * | 1992-12-07 | 1994-01-18 | Board Of Trustees Operating Michigan State University | Process for the isolation and purification of taxol and taxanes from Taxus spp |
| WO1995000645A2 (en) * | 1993-06-21 | 1995-01-05 | Genentech, Inc. | Process for producing relaxin |
| JP3220331B2 (ja) * | 1993-07-20 | 2001-10-22 | エチコン・インコーポレーテツド | 非経口投与用の吸収性液体コポリマー類 |
| US5728377A (en) * | 1993-07-20 | 1998-03-17 | Board Of Regents, The University Of Texas System | Methods and compositions incorporating IP-10 |
| US5426098A (en) * | 1993-09-02 | 1995-06-20 | Celtrix Pharmaceuticals, Inc. | Increase in hematopoietic progenitor cells in peripheral blood by transforming growth factor beta |
| US5643575A (en) * | 1993-10-27 | 1997-07-01 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
| US5415869A (en) * | 1993-11-12 | 1995-05-16 | The Research Foundation Of State University Of New York | Taxol formulation |
| EP0662515B1 (en) * | 1993-12-10 | 2000-11-15 | Korea Institute Of Science And Technology | Signal sequences for secretion of heterologous proteins from yeast |
| US5861499A (en) * | 1994-02-10 | 1999-01-19 | Imclone Systems Incorporated | Nucleic acid molecules encoding the variable or hypervariable region of a monoclonal antibody that binds to an extracellular domain |
| US5536249A (en) * | 1994-03-09 | 1996-07-16 | Visionary Medical Products, Inc. | Pen-type injector with a microprocessor and blood characteristic monitor |
| US5461031A (en) * | 1994-06-16 | 1995-10-24 | Eli Lilly And Company | Monomeric insulin analog formulations |
| US5504188A (en) * | 1994-06-16 | 1996-04-02 | Eli Lilly And Company | Preparation of stable zinc insulin analog crystals |
| US5484720A (en) * | 1994-09-08 | 1996-01-16 | Genentech, Inc. | Methods for calcium phosphate transfection |
| US5547929A (en) * | 1994-09-12 | 1996-08-20 | Eli Lilly And Company | Insulin analog formulations |
| US5693609A (en) * | 1994-11-17 | 1997-12-02 | Eli Lilly And Company | Acylated insulin analogs |
| US5770383A (en) * | 1994-12-30 | 1998-06-23 | Ligand Pharmaceuticals, Inc. | Tricyclic retinoids, methods for their production and use |
| US5770382A (en) * | 1994-12-30 | 1998-06-23 | Ligand Pharmaceuticals, Inc. | Tricyclic retinoids, methods for their production and use |
| US5770378A (en) * | 1994-12-30 | 1998-06-23 | Ligand Pharmaceuticals, Inc. | Tricyclic retinoids, methods for their production and use |
| US6090822A (en) * | 1995-03-03 | 2000-07-18 | Margolin; Solomon B. | Treatment of cytokine growth factor caused disorders |
| US5811395A (en) * | 1995-06-07 | 1998-09-22 | Medical University Of South Carolina | Relaxin analogs and derivatives methods and uses thereof |
| US6020473A (en) * | 1995-08-25 | 2000-02-01 | Genentech, Inc. | Nucleic acids encoding variants of vascular endothelial cell growth factor |
| US6066318A (en) * | 1995-10-05 | 2000-05-23 | G.D. Searle & Co. | Multi-functional hematopoietic fusion proteins between sequence rearranged C-MPL receptor agonists and other hematopoietic factors |
| US6100071A (en) * | 1996-05-07 | 2000-08-08 | Genentech, Inc. | Receptors as novel inhibitors of vascular endothelial growth factor activity and processes for their production |
| DE69736860T2 (de) * | 1996-09-24 | 2007-05-16 | Merck & Co., Inc. | Verbindungen zur hemmung der angiogenese durch gentherapie |
| IL129326A0 (en) * | 1996-10-09 | 2000-02-17 | Boehringer Mannheim Pharm Corp | Method for inhibiting stress-activated protein kinases |
| SI20024A (sl) * | 1996-10-16 | 2000-02-29 | Icn Pharmaceuticals, Inc. | Purinovi L-nukleozidi, analogi in uporaba od teh |
| CN1133649C (zh) * | 1996-10-18 | 2004-01-07 | 沃泰克斯药物股份有限公司 | 丝氨酸蛋白酶、特别是丙型肝炎病毒ns3蛋白酶的抑制剂 |
| ZA984697B (en) * | 1997-06-13 | 1999-12-01 | Lilly Co Eli | Stable insulin formulations. |
| TW517055B (en) * | 1997-07-02 | 2003-01-11 | Smithkline Beecham Corp | Novel substituted imidazole compounds |
| GEP20022707B (en) * | 1997-07-18 | 2002-06-25 | Infimed Inc Us | Biodegrading Macromers for the Controlled Release of Biologically Active Substances |
| US6168784B1 (en) * | 1997-09-03 | 2001-01-02 | Gryphon Sciences | N-terminal modifications of RANTES and methods of use |
| JP2001526033A (ja) * | 1997-12-08 | 2001-12-18 | ジェネンテク・インコーポレイテッド | ヒトインターフェロン−イプシロンというi型インターフェロン |
| ZA9811070B (en) * | 1997-12-08 | 2000-07-03 | Genentech Inc | Type I interferons. |
| AR014621A1 (es) * | 1997-12-12 | 2001-03-28 | Macromed Inc | Un poli (etilenglicol) con forma de estrella, heterofuncional, biocompatible, metodo para su obtencion y metodo para conjugarlo con una proteina |
| US6387879B1 (en) * | 1997-12-15 | 2002-05-14 | Dgi Biotechnologies, Inc. | Compounds that bind growth to hormone receptor |
| US6423695B1 (en) * | 1998-01-13 | 2002-07-23 | Ribapharm, Inc. | Cytokine related treatments of disease |
| EP1051157B1 (en) * | 1998-01-30 | 2002-01-02 | Scios Inc. | Controlled release delivery of peptide or protein |
| US5961495A (en) * | 1998-02-20 | 1999-10-05 | Becton, Dickinson And Company | Medication delivery pen having a priming mechanism |
| US6221053B1 (en) * | 1998-02-20 | 2001-04-24 | Becton, Dickinson And Company | Multi-featured medication delivery pen |
| US6248095B1 (en) * | 1998-02-23 | 2001-06-19 | Becton, Dickinson And Company | Low-cost medication delivery pen |
| WO1999061437A1 (en) * | 1998-05-22 | 1999-12-02 | Smithkline Beecham Corporation | Novel 2-alkyl substituted imidazole compounds |
| US6685933B1 (en) * | 1998-07-28 | 2004-02-03 | The United States Of America As Represented By The Department Of Health And Human Services | Interferon α hybrids |
| US6323180B1 (en) * | 1998-08-10 | 2001-11-27 | Boehringer Ingelheim (Canada) Ltd | Hepatitis C inhibitor tri-peptides |
| US6211144B1 (en) * | 1998-10-16 | 2001-04-03 | Novo Nordisk A/S | Stable concentrated insulin preparations for pulmonary delivery |
| IT1303736B1 (it) * | 1998-11-11 | 2001-02-23 | San Raffaele Centro Fond | Peptidi derivati da rantes con attivita' anti-hiv. |
| EP1016414B1 (en) * | 1998-12-17 | 2004-09-08 | Applied Research Systems ARS Holding N.V. | Human growth hormone to stimulate hematopoiesis and immune reconstitution after hematopoietic stem cell transplantation in humans |
| US6703225B1 (en) * | 1999-01-12 | 2004-03-09 | Sumitomo Pharmaceuticals Company, Limited | Interferon-α |
| MXPA01010208A (es) * | 1999-04-09 | 2003-07-21 | Johnson & Johnson | Composiciones farmaceuticas de eritropoyetina. |
| US6492497B1 (en) * | 1999-04-30 | 2002-12-10 | Cambridge Antibody Technology Limited | Specific binding members for TGFbeta1 |
| US6531122B1 (en) * | 1999-08-27 | 2003-03-11 | Maxygen Aps | Interferon-β variants and conjugates |
| US20040002474A1 (en) * | 1999-10-07 | 2004-01-01 | Maxygen Inc. | IFN-alpha homologues |
| US6586398B1 (en) * | 2000-04-07 | 2003-07-01 | Amgen, Inc. | Chemically modified novel erythropoietin stimulating protein compositions and methods |
| US6346269B1 (en) * | 2000-05-08 | 2002-02-12 | Standard Chem. & Pharm. Co., Ltd. | Method for preparing an oral formulation containing acid-sensitive drugs and oral formulation made thereby |
| EP1712239A3 (en) * | 2000-05-12 | 2007-08-22 | Immunex Corporation | Interleukin-1 inhibitors in the treatment of diseases |
| US6673580B2 (en) * | 2000-10-27 | 2004-01-06 | Genentech, Inc. | Identification and modification of immunodominant epitopes in polypeptides |
| US6958388B2 (en) * | 2001-04-06 | 2005-10-25 | Maxygen, Aps | Interferon gamma polypeptide variants |
| PL366705A1 (en) * | 2001-04-06 | 2005-02-07 | Maxygen Holdings Ltd. | Interferon gamma polypeptide variants |
| AU2002338286A1 (en) * | 2001-04-10 | 2002-10-28 | Leo Pharma A/S | Novel aminophenyl ketone derivatives |
| US6585398B1 (en) * | 2001-06-22 | 2003-07-01 | Genlyte Thomas Group, Llc | Post top deck light fixture |
| JP2005519946A (ja) * | 2002-03-12 | 2005-07-07 | マキシジェン エーピーエス | 発作の処置のためのインターフェロンβ様分子 |
| KR20040020817A (ko) * | 2002-08-31 | 2004-03-09 | 씨제이 주식회사 | 당쇄화된 사람 인터페론 알파 동종체 |
| WO2004022593A2 (en) * | 2002-09-09 | 2004-03-18 | Nautilus Biotech | Rational evolution of cytokines for higher stability, the cytokines and encoding nucleic acid molecules |
| KR100781666B1 (ko) * | 2004-11-02 | 2007-12-03 | 신영기 | 인간 인터페론-베타 변이체 |
-
2005
- 2005-08-08 JP JP2007525713A patent/JP2008513356A/ja not_active Withdrawn
- 2005-08-08 MX MX2007001589A patent/MX2007001589A/es unknown
- 2005-08-08 EP EP05783926A patent/EP1789074A4/en not_active Withdrawn
- 2005-08-08 CA CA002576030A patent/CA2576030A1/en not_active Abandoned
- 2005-08-08 WO PCT/US2005/028165 patent/WO2006020580A2/en not_active Ceased
- 2005-08-08 AU AU2005273968A patent/AU2005273968A1/en not_active Abandoned
- 2005-08-08 KR KR1020077005432A patent/KR20070085227A/ko not_active Withdrawn
-
2006
- 2006-01-11 US US11/330,917 patent/US20060182716A1/en not_active Abandoned
-
2007
- 2007-01-31 IL IL181083A patent/IL181083A0/en unknown
-
2009
- 2009-10-19 US US12/581,723 patent/US20100099851A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2006020580A2 (en) | 2006-02-23 |
| US20100099851A1 (en) | 2010-04-22 |
| AU2005273968A2 (en) | 2006-02-23 |
| CA2576030A1 (en) | 2006-02-23 |
| AU2005273968A1 (en) | 2006-02-23 |
| KR20070085227A (ko) | 2007-08-27 |
| JP2008513356A (ja) | 2008-05-01 |
| WO2006020580A3 (en) | 2006-12-07 |
| MX2007001589A (es) | 2007-08-02 |
| US20060182716A1 (en) | 2006-08-17 |
| EP1789074A2 (en) | 2007-05-30 |
| EP1789074A4 (en) | 2009-08-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL181083A0 (en) | Synthetic hyperglycosylated protease-resistant polypeptide variants, oral formulations and methods of using the same | |
| IL172059A0 (en) | Stabilized radiopharmaceutical compositions and methods for the preparation thereof | |
| EP1695699A4 (en) | MEDICINAL GRAINS AND THE GRAINS CONTAINING SOLID PREPARATIONS | |
| EP1726008A4 (en) | BIS-PROPYLAMINE ANALOG AND COMPOSITION | |
| IL176385A0 (en) | Fused pyrrolocarbazoles and methods for the preparation thereof | |
| AU2003296369A8 (en) | Imminoamines and preparation thereof | |
| AU2003299825A8 (en) | Cosmetic prosthesis and methods for making the same | |
| EP1762216A4 (en) | COMPOSITION FOR COSMETIC PREPARATION AND COSMETIC PREPARATION | |
| IL172802A0 (en) | Aztreonam l-lysine and methods for the preparation thereof | |
| ZA200701496B (en) | Post-foaming dental mousse and methods utilizing the same | |
| AU2003252075A8 (en) | Human immunosuppressive protein | |
| IL173626A0 (en) | Small peptides and oral pharmaceutical compositions containing the same | |
| AU2003213146A8 (en) | Activated protein c formulations | |
| ZA200605668B (en) | Fused pyrrolocarbazoles and methods for the preparation thereof | |
| GB0218175D0 (en) | Chairs | |
| HK1125383A (en) | Synthetic hyperglycosylated, and hyperglycosylated protease-resistant polypeptide variants, oral formulations and methods of using the same | |
| EP1804608A4 (en) | ORAL BRUSHING DEVICES AND ASSOCIATED METHODS | |
| GB0710292D0 (en) | Cosmetic agents and methods for the preparation thereof | |
| EP1618125A4 (en) | Vitamin C derivatives with peptide, process for their preparation and composition containing them | |
| AU152848S (en) | Chair | |
| ZA200802235B (en) | Organoleptically acceptable ibuprofen oral dosage formulations, methods of making and using the same | |
| PL354667A1 (en) | Probiotic preparation | |
| HK1119066A (en) | Organoleptically acceptable ibuprofen oral dosage formulations, methods of making and using the same | |
| GB0319903D0 (en) | JR`s chair | |
| CA94484S (en) | Chair |