IL180894A - 1-alpha-halo-2,2-difluoro-2-deoxy-d-ribofuranose derivatives and processes for the preparation thereof - Google Patents

1-alpha-halo-2,2-difluoro-2-deoxy-d-ribofuranose derivatives and processes for the preparation thereof

Info

Publication number
IL180894A
IL180894A IL180894A IL18089407A IL180894A IL 180894 A IL180894 A IL 180894A IL 180894 A IL180894 A IL 180894A IL 18089407 A IL18089407 A IL 18089407A IL 180894 A IL180894 A IL 180894A
Authority
IL
Israel
Prior art keywords
formula
compound
halide
derivative
mixture
Prior art date
Application number
IL180894A
Other languages
English (en)
Other versions
IL180894A0 (en
Original Assignee
Hanmi Holdings Co Ltd
Hanmi Pharm Ind Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/KR2005/001922 external-priority patent/WO2006011713A1/en
Application filed by Hanmi Holdings Co Ltd, Hanmi Pharm Ind Co Ltd filed Critical Hanmi Holdings Co Ltd
Publication of IL180894A0 publication Critical patent/IL180894A0/en
Publication of IL180894A publication Critical patent/IL180894A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/08—Deoxysugars; Unsaturated sugars; Osones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL180894A 2004-07-29 2007-01-23 1-alpha-halo-2,2-difluoro-2-deoxy-d-ribofuranose derivatives and processes for the preparation thereof IL180894A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR20040059623 2004-07-29
KR1020050041278A KR100699099B1 (ko) 2004-07-29 2005-05-17 1-α-할로-2,2-다이플루오로-2-데옥시-Ｄ-라이보퓨라노스유도체 및 이의 제조방법
PCT/KR2005/001922 WO2006011713A1 (en) 2004-07-29 2005-06-21 1-α-HALO-2,2-DIFLUORO-2-DEOXY-D-RIBOFURANOSE DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF

Publications (2)

Publication Number Publication Date
IL180894A0 IL180894A0 (en) 2007-07-04
IL180894A true IL180894A (en) 2011-09-27

Family

ID=37149831

Family Applications (1)

Application Number Title Priority Date Filing Date
IL180894A IL180894A (en) 2004-07-29 2007-01-23 1-alpha-halo-2,2-difluoro-2-deoxy-d-ribofuranose derivatives and processes for the preparation thereof

Country Status (7)

Country Link
JP (1) JP4691101B2 (ko)
KR (1) KR100699099B1 (ko)
CN (1) CN1989148B (ko)
HK (1) HK1100946A1 (ko)
IL (1) IL180894A (ko)
MX (1) MX2007000959A (ko)
RU (1) RU2346948C2 (ko)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5349342B2 (ja) 2007-03-23 2013-11-20 ドンウ シンテック カンパニー リミテッド ２’−デオキシ−２’，２’−ジフルオロシチジンの製造方法
KR100858842B1 (ko) * 2007-03-23 2008-09-22 동우신테크 주식회사 키랄아민을 이용한 광학활성 옥소라이보스유도체의제조방법
CN101628927B (zh) * 2009-08-07 2012-10-10 卡硼瑞（北京）科技有限公司 以1,3,5-三-O-苯甲酰基-α-D-呋喃核糖为原料立体选择性制备β-二氟胞苷盐酸盐的方法
CN103897008A (zh) * 2012-12-28 2014-07-02 石药集团中奇制药技术（石家庄）有限公司 一种地西他滨及其中间体的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2039403A1 (en) * 1990-04-04 1991-10-05 Gerald Saischek Process for the manufacture of 2-deoxy-d-threo-pentofuranosides, intermediates for their manufacture and their use
ATE153669T1 (de) * 1992-06-22 1997-06-15 Lilly Co Eli Verfahren zur herstellung von mit alpha-anomeren angereicherten 1-halogen-2-deoxy-2,2-difluor-d- ribofuranosyl-derivaten
AU720451B2 (en) * 1997-01-24 2000-06-01 Conpharma As Gemcitabine derivatives
JP2003055364A (ja) * 2001-06-07 2003-02-26 Mitsui Chemicals Inc ２，３−ジデオキシ−２，３−デヒドロペントフラノース誘導体に関する新規製造法

Also Published As

Publication number Publication date
MX2007000959A (es) 2007-04-16
HK1100946A1 (en) 2007-10-05
JP4691101B2 (ja) 2011-06-01
RU2007107607A (ru) 2008-09-10
JP2008508261A (ja) 2008-03-21
KR20060047970A (ko) 2006-05-18
RU2346948C2 (ru) 2009-02-20
KR100699099B1 (ko) 2007-03-22
IL180894A0 (en) 2007-07-04
CN1989148B (zh) 2010-05-12
CN1989148A (zh) 2007-06-27

Similar Documents

Publication Publication Date Title
AU2005320374B2 (en) Method for the preparation of 2'-deoxy-2',2'-difluorocytidine
JP2008531680A (ja) βアノマーが富化された２１−デオキシ−２１，２１−ジフルオロ−Ｄ−リボフラノシルヌクレオシドの調製のための中間体と方法
KR100329525B1 (ko) 2',3'-디데히드로-3'-데옥시티미딘(d4t)의대단위제조를위한5-메틸우리딘공정
US8193354B2 (en) Process for preparation of Gemcitabine hydrochloride
EP2160397B1 (en) A novel and highly stereoselective process for preparing gemcitabine and intermediates thereof
WO2006070985A1 (en) METHOD FOR THE PREPARATION OF 2#-DEOXY-2#,2#-DIFLUOROCYTIDINE
IL180894A (en) 1-alpha-halo-2,2-difluoro-2-deoxy-d-ribofuranose derivatives and processes for the preparation thereof
US7858761B2 (en) 1-α-halo-2,2-difluoro-2-deoxy-D-ribofuranose derivatives and process for the preparation thereof
KR100908363B1 (ko) 트라이-Ｏ-아세틸-5-데옥시-β-Ｄ-라이보퓨라노즈의입체선택적 제조방법 및 이의 분리방법
US5262531A (en) Process for preparing 2'-deoxy-β-adenosine
US5608049A (en) Preparation of d4T from 5-methyluridine
US20090131651A1 (en) Synthesis of 2-substituted adenosines
EP1537134B1 (en) Process for producing a ribofuranose
KR101357409B1 (ko) 2′-데옥시-2′,2′-디플루오로시티딘의 제조방법
SK131092A3 (en) Method of production of 4-demethylepipodophylotoxinglucoside- -4-phosphates
JPS60215685A (ja) ２’−デオキシアリステロマイシン誘導体およびその用途
WO2012115578A1 (en) Synthesis of flg
KR20070119422A (ko) 신규한 ｄ-에리트로-2-데옥시-2,2-디플루오로-1-옥소리보스화합물 및 그 제조방법

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees