IL175965A0 - Montelukast free acid polymorphs - Google Patents

Montelukast free acid polymorphs

Info

Publication number
IL175965A0
IL175965A0 IL175965A IL17596506A IL175965A0 IL 175965 A0 IL175965 A0 IL 175965A0 IL 175965 A IL175965 A IL 175965A IL 17596506 A IL17596506 A IL 17596506A IL 175965 A0 IL175965 A0 IL 175965A0
Authority
IL
Israel
Prior art keywords
free acid
montelukast free
acid polymorphs
polymorphs
montelukast
Prior art date
Application number
IL175965A
Other languages
English (en)
Original Assignee
Teva Pharma
Aronhime Judith
Chen Kobi
Niddam Valerie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Pharma, Aronhime Judith, Chen Kobi, Niddam Valerie filed Critical Teva Pharma
Publication of IL175965A0 publication Critical patent/IL175965A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
IL175965A 2004-01-30 2006-05-28 Montelukast free acid polymorphs IL175965A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US54084004P 2004-01-30 2004-01-30
US58223704P 2004-06-22 2004-06-22
PCT/US2005/002898 WO2005074935A1 (fr) 2004-01-30 2005-01-31 Polymorphes d'acide sans montelukast

Publications (1)

Publication Number Publication Date
IL175965A0 true IL175965A0 (en) 2006-10-05

Family

ID=34841113

Family Applications (1)

Application Number Title Priority Date Filing Date
IL175965A IL175965A0 (en) 2004-01-30 2006-05-28 Montelukast free acid polymorphs

Country Status (8)

Country Link
US (1) US20050187243A1 (fr)
EP (1) EP1708708A1 (fr)
JP (1) JP2007518826A (fr)
KR (1) KR20060117356A (fr)
CA (1) CA2554572A1 (fr)
IL (1) IL175965A0 (fr)
MX (1) MXPA06008584A (fr)
WO (1) WO2005074935A1 (fr)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE522507T1 (de) * 2003-10-10 2011-09-15 Synhton B V Montelukast in fester phase
CA2554789A1 (fr) * 2004-01-30 2005-08-18 Teva Pharmaceutical Industries, Ltd. Montelukast de sodium polymorphe
JP2007532686A (ja) * 2004-04-21 2007-11-15 テバ ファーマシューティカル インダストリーズ リミティド モンテルカストナトリウムを調製する方法
WO2006064269A2 (fr) * 2004-12-17 2006-06-22 Cipla Limited Sels d'antagoniste de leukotriene
JP2008510840A (ja) * 2005-07-05 2008-04-10 テバ ファーマシューティカル インダストリーズ リミティド モンテルカストの精製
AR057909A1 (es) * 2005-11-18 2007-12-26 Synthon Bv Proceso para preparar montelukast y compuestos relacionados, que utiliza un compuesto intermediario derivado de un ester sulfonico.
EA021960B1 (ru) * 2005-12-30 2015-10-30 Крка, Товарна Здравил, Д.Д., Ново Место Таблетка, содержащая фармацевтически приемлемую соль монтелукаста в аморфной форме, и способ ее получения
EP1803457A1 (fr) * 2005-12-30 2007-07-04 Krka Tovarna Zdravil, D.D., Novo Mesto Composition pharmaceutique contenant du montelukast
PT1818057E (pt) * 2006-02-09 2010-06-18 Teva Pharma Formulações farmacêuticas estáveis de montelucaste de sódio
WO2007107297A1 (fr) * 2006-03-17 2007-09-27 Synthon B.V. Sel d'amantadine de montélukast
EP1886997A1 (fr) * 2006-08-09 2008-02-13 Esteve Quimica, S.A. Procédé de purification de montelukast
EP1886998A1 (fr) * 2006-08-09 2008-02-13 Esteve Quimica, S.A. Procédés de purification du montelukast et ses sels d'amine
US7700776B2 (en) * 2006-10-24 2010-04-20 Formosa Laboratories, Inc. Compounds and preparation for montelukast sodium
PL205444B1 (pl) 2007-05-02 2010-04-30 Zak & Lstrok Ady Farmaceutyczn Sposób wytwarzania soli sodowej kwasu 1-(((1(R)-(3-(2-(7--chloro-2- chinolinylo)-etenylo)fenylo)-3-(2-(1-hydroksy-1- metyloetylo)fenylo)propylo)sulfanylo)metylo)-cyklopropanooctowego
CZ302518B6 (cs) * 2007-07-09 2011-06-29 Zentiva, A. S. Zpusob izolace a cištení montelukastu
KR101072896B1 (ko) * 2007-10-09 2011-10-17 한미홀딩스 주식회사 이온성 액체 매개체를 이용한 몬테루카스트산의 제조 방법
CN102046602A (zh) * 2008-04-25 2011-05-04 斯索恩有限公司 制备孟鲁司特中间体的方法
KR101123292B1 (ko) * 2008-09-26 2012-03-19 주식회사 엘지생명과학 몬테루카스트 나트륨염의 제조방법
WO2010112222A1 (fr) 2009-03-31 2010-10-07 Krka, D.D., Novo Mesto Cristallisation progressive en émulsion
EP2287154A1 (fr) 2009-07-14 2011-02-23 KRKA, D.D., Novo Mesto Synthèse efficace pour la préparation de montelukast
WO2011121091A1 (fr) 2010-03-31 2011-10-06 Krka, D.D., Novo Mesto Synthèse efficace pour la préparation de montélukast et nouvelle forme cristalline d'intermédiaires dans celle-ci
KR102495018B1 (ko) 2013-11-15 2023-02-06 아케비아 테라퓨틱스 인코포레이티드 ｛[5-(3-클로로페닐)-3-하이드록시피리딘-2-카보닐]아미노｝아세트산의 고체형, 이의 조성물 및 용도
IT201900008340A1 (it) 2019-06-07 2020-12-07 Genetic S P A Sali di montelukast e loro composizioni farmaceutiche
AU2021215849B2 (en) 2020-02-03 2023-08-03 Taro Pharmaceutical Industries Ltd. Topical montelukast formulations
CN116509810B (zh) * 2023-05-18 2024-03-29 牡丹江恒远药业股份有限公司 一种孟鲁司特钠片剂及其制备方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0480717T3 (da) * 1990-10-12 1999-02-08 Merck Frosst Canada Inc Umættede hydroxyalkylquinolinsyrer som leukotrienantagonister
EP0480716A1 (fr) * 1990-10-12 1992-04-15 Merck Frosst Canada Inc. Acides hydroxyalkylquinoliniques saturés comme antagonistes de leukotriène
US5565473A (en) * 1990-10-12 1996-10-15 Merck Frosst Canada, Inc. Unsaturated hydroxyalkylquinoline acids as leukotriene antagonists
TW416948B (en) * 1993-12-28 2001-01-01 Merck & Co Inc Process for the preparation of leukotriene antagonists
US5523477A (en) * 1995-01-23 1996-06-04 Merck & Co., Inc. Process for the preparation of 1-(thiomethyl)-cyclopropaneacetic acid
GB9812413D0 (en) * 1998-06-10 1998-08-05 Glaxo Group Ltd Compound and its use
WO2003066598A1 (fr) * 2002-02-07 2003-08-14 Dr. Reddy's Laboratories Ltd. Nouvelles formes amorphes anhydres de sel de sodium de montelukast
US20050107612A1 (en) * 2002-12-30 2005-05-19 Dr. Reddy's Laboratories Limited Process for preparation of montelukast and its salts
EP1633357A4 (fr) * 2003-04-15 2010-02-10 Merck & Co Inc Forme polymorphe de sodium de montelukast
CA2528228C (fr) * 2003-06-06 2011-09-20 Morepen Laboratories Limited Une methode de preparation d'un sel sodique de montelukast sous forme amorphe
ATE522507T1 (de) * 2003-10-10 2011-09-15 Synhton B V Montelukast in fester phase
US7189853B2 (en) * 2004-04-15 2007-03-13 Dr. Reddy's Laboratories Limited Process for the preparation of [R-(E)-1-[[[1-[3-[2-[7-chloro-2-quinolinyl]ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic acid (Montelukast) and its pharmaceutically acceptable salts
JP2007532686A (ja) * 2004-04-21 2007-11-15 テバ ファーマシューティカル インダストリーズ リミティド モンテルカストナトリウムを調製する方法

Also Published As

Publication number Publication date
US20050187243A1 (en) 2005-08-25
JP2007518826A (ja) 2007-07-12
KR20060117356A (ko) 2006-11-16
CA2554572A1 (fr) 2005-08-18
WO2005074935A1 (fr) 2005-08-18
EP1708708A1 (fr) 2006-10-11
MXPA06008584A (es) 2007-04-16

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