IL166552A0 - Pyrimidine derivatives and their use as cb2 modulators - Google Patents
Pyrimidine derivatives and their use as cb2 modulatorsInfo
- Publication number
- IL166552A0 IL166552A0 IL16655205A IL16655205A IL166552A0 IL 166552 A0 IL166552 A0 IL 166552A0 IL 16655205 A IL16655205 A IL 16655205A IL 16655205 A IL16655205 A IL 16655205A IL 166552 A0 IL166552 A0 IL 166552A0
- Authority
- IL
- Israel
- Prior art keywords
- modulators
- pyrimidine derivatives
- pyrimidine
- derivatives
- Prior art date
Links
- 229940083082 pyrimidine derivative acting on arteriolar smooth muscle Drugs 0.000 title 1
- 150000003230 pyrimidines Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0219501A GB0219501D0 (en) | 2002-08-21 | 2002-08-21 | Compounds |
GB0309326A GB0309326D0 (en) | 2003-04-24 | 2003-04-24 | Compounds |
PCT/EP2003/009217 WO2004018433A1 (fr) | 2002-08-21 | 2003-08-19 | Derives de pyrimidine et leur utilisation en tant que modulateurs cb2 |
Publications (1)
Publication Number | Publication Date |
---|---|
IL166552A0 true IL166552A0 (en) | 2006-01-15 |
Family
ID=31948030
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL16655205A IL166552A0 (en) | 2002-08-21 | 2005-01-27 | Pyrimidine derivatives and their use as cb2 modulators |
IL185549A IL185549A0 (en) | 2002-08-21 | 2007-08-27 | Pyrimidine derivatives and their use as cb2 modulators |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL185549A IL185549A0 (en) | 2002-08-21 | 2007-08-27 | Pyrimidine derivatives and their use as cb2 modulators |
Country Status (35)
Country | Link |
---|---|
US (2) | US7635701B2 (fr) |
EP (2) | EP1539712B1 (fr) |
JP (1) | JP4583174B2 (fr) |
KR (1) | KR20050058367A (fr) |
CN (1) | CN100351239C (fr) |
AP (1) | AP2005003219A0 (fr) |
AR (1) | AR041016A1 (fr) |
AT (2) | ATE377591T1 (fr) |
AU (1) | AU2003264076B2 (fr) |
BR (1) | BR0313676A (fr) |
CA (1) | CA2495880C (fr) |
CY (1) | CY1107871T1 (fr) |
DE (2) | DE60317348T2 (fr) |
DK (1) | DK1539712T3 (fr) |
EA (2) | EA010130B1 (fr) |
EC (1) | ECSP055613A (fr) |
ES (1) | ES2295682T3 (fr) |
HK (1) | HK1079193A1 (fr) |
IL (2) | IL166552A0 (fr) |
IS (1) | IS7749A (fr) |
MA (1) | MA27428A1 (fr) |
MX (1) | MXPA05001960A (fr) |
MY (1) | MY137053A (fr) |
NO (1) | NO20051451D0 (fr) |
NZ (1) | NZ537886A (fr) |
OA (1) | OA12910A (fr) |
PE (1) | PE20040898A1 (fr) |
PL (1) | PL376047A1 (fr) |
PT (1) | PT1539712E (fr) |
SI (1) | SI1539712T1 (fr) |
TW (1) | TW200410946A (fr) |
UA (1) | UA83194C2 (fr) |
UY (1) | UY27939A1 (fr) |
WO (1) | WO2004018433A1 (fr) |
ZA (1) | ZA200500913B (fr) |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
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UY27939A1 (es) * | 2002-08-21 | 2004-03-31 | Glaxo Group Ltd | Compuestos |
WO2004029204A2 (fr) | 2002-09-27 | 2004-04-08 | Merck & Co., Inc. | Pyrimidines substituees |
TW200505902A (en) * | 2003-03-20 | 2005-02-16 | Schering Corp | Cannabinoid receptor ligands |
US20040259887A1 (en) * | 2003-06-18 | 2004-12-23 | Pfizer Inc | Cannabinoid receptor ligands and uses thereof |
GB0402355D0 (en) * | 2004-02-03 | 2004-03-10 | Glaxo Group Ltd | Novel compounds |
GB0402356D0 (en) * | 2004-02-03 | 2004-03-10 | Glaxo Group Ltd | Novel compounds |
WO2005096784A2 (fr) | 2004-04-08 | 2005-10-20 | Targegen, Inc. | Inhibiteurs benzotriazine de kinases |
AU2005276974B2 (en) | 2004-08-25 | 2012-08-02 | Targegen, Inc. | Heterocyclic compounds and methods of use |
GB0517188D0 (en) * | 2005-08-22 | 2005-09-28 | Glaxo Group Ltd | Compounds |
NZ592990A (en) | 2005-11-01 | 2013-01-25 | Targegen Inc | Bi-aryl meta-pyrimidine inhibitors of kinases |
US8133900B2 (en) | 2005-11-01 | 2012-03-13 | Targegen, Inc. | Use of bi-aryl meta-pyrimidine inhibitors of kinases |
US8604042B2 (en) | 2005-11-01 | 2013-12-10 | Targegen, Inc. | Bi-aryl meta-pyrimidine inhibitors of kinases |
JP2009519349A (ja) * | 2005-12-15 | 2009-05-14 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Cb2受容体を変調する化合物 |
JP2009536613A (ja) * | 2006-04-07 | 2009-10-15 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Cb2受容体を調節する化合物 |
WO2008014199A2 (fr) | 2006-07-28 | 2008-01-31 | Boehringer Ingelheim International Gmbh | Composés modulant le récepteur cb2 |
EP2070927A4 (fr) | 2006-09-13 | 2010-10-13 | Kyowa Hakko Kirin Co Ltd | Dérivé hétérocyclique fusionné |
CN101516839A (zh) | 2006-09-25 | 2009-08-26 | 贝林格尔.英格海姆国际有限公司 | 调节cb2受体的化合物 |
EP2076499B1 (fr) | 2006-10-04 | 2010-05-12 | F.Hoffmann-La Roche Ag | Dérivés de pyrazine-2-carboxamide en tant que modulateurs du récepteur cb2 |
WO2008048914A1 (fr) * | 2006-10-17 | 2008-04-24 | Boehringer Ingelheim International Gmbh | Composés qui modulent le récepteur cb2 |
WO2008075353A1 (fr) | 2006-12-19 | 2008-06-26 | Pharmos Corporation | Dérivés sulfonamides avec indications thérapeutiques |
GB0705803D0 (en) * | 2007-03-28 | 2007-05-02 | Glaxo Group Ltd | Novel compounds |
KR20100100858A (ko) * | 2007-11-06 | 2010-09-15 | 에모리 유니버시티 | 안전한 nmda 수용체 길항제의 식별 방법 |
CA2704684A1 (fr) | 2007-11-07 | 2009-05-14 | Boehringer Ingelheim International Gmbh | Composes modulant le recepteur cb2 |
JP5749162B2 (ja) | 2008-07-10 | 2015-07-15 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Cb2受容体を調節するスルホン化合物 |
EP2342200B1 (fr) | 2008-09-25 | 2013-01-23 | Boehringer Ingelheim International GmbH | Composés modulant sélectivement le récepteur cb2 |
TW201031650A (en) * | 2008-12-02 | 2010-09-01 | Organon Nv | 1-(biphenyl-4-ylmethyl)imidazolidine-2,4-dione |
TW201031649A (en) | 2008-12-02 | 2010-09-01 | Organon Nv | 1-(4-(pyridin-2-yl)benzyl)imidazolidine-2,4-dione derivatives |
AU2010231694A1 (en) * | 2009-03-30 | 2011-10-06 | Astellas Pharma Inc. | Pyrimidine compound |
US8299103B2 (en) | 2009-06-15 | 2012-10-30 | Boehringer Ingelheim International Gmbh | Compounds which selectively modulate the CB2 receptor |
EP2443107B1 (fr) | 2009-06-16 | 2018-08-08 | Boehringer Ingelheim International GmbH | Dérivés d'azétidine 2-carboxamide qui modulent le récepteur cb2 |
US8383651B2 (en) | 2009-09-22 | 2013-02-26 | Boehringer Ingelheim International Gmbh | Compounds which selectively modulate the CB2 receptor |
EP2523936A1 (fr) | 2010-01-15 | 2012-11-21 | Boehringer Ingelheim International GmbH | Composés qui modulent le récepteur cb2 |
EP2542539B1 (fr) | 2010-03-05 | 2014-02-26 | Boehringer Ingelheim International GmbH | Composés tétrazoles qui modulent sélectivement le récepteur cb2 |
JP5746764B2 (ja) | 2010-07-22 | 2015-07-08 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Cb2受容体を調節する化合物 |
WO2012014963A1 (fr) * | 2010-07-29 | 2012-02-02 | アステラス製薬株式会社 | Composé de pyridine à cycle condensé |
WO2012060847A1 (fr) | 2010-11-07 | 2012-05-10 | Targegen, Inc. | Compositions et procédés de traitement de la myélofibrose |
US20150261260A1 (en) * | 2013-03-15 | 2015-09-17 | Royce J. Nicholas | Method of water-proofing electronic components |
EP2803668A1 (fr) | 2013-05-17 | 2014-11-19 | Boehringer Ingelheim International Gmbh | Nouveau (cyano-dimethyl-methyl)-isoxazoles et - [1,3,4] thiadiazoles |
KR102313314B1 (ko) * | 2013-10-23 | 2021-10-19 | 아카데미아 시니카 | 신경퇴행성 질환 및 통증의 예방 및 치료에 사용하기 위한 화합물 |
WO2017185038A1 (fr) | 2016-04-22 | 2017-10-26 | Receptor Life Sciences | Composés médicinaux à base de plantes à action rapide, et suppléments nutritionnels |
EA201892396A1 (ru) | 2016-12-02 | 2019-04-30 | Ресептор Лайф Сайенсиз, Инк. | Быстродействующие растительные лекарственные соединения и биологически активные добавки |
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