IL166027A0 - Bisarylsulfonamide compounds and their use in cancer therapy - Google Patents
Bisarylsulfonamide compounds and their use in cancer therapyInfo
- Publication number
- IL166027A0 IL166027A0 IL16602704A IL16602704A IL166027A0 IL 166027 A0 IL166027 A0 IL 166027A0 IL 16602704 A IL16602704 A IL 16602704A IL 16602704 A IL16602704 A IL 16602704A IL 166027 A0 IL166027 A0 IL 166027A0
- Authority
- IL
- Israel
- Prior art keywords
- sub
- sup
- group
- compounds
- cancer therapy
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 238000011275 oncology therapy Methods 0.000 title 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- -1 imidazothiazolyl Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 102100032257 E3 ubiquitin-protein ligase Mdm2 Human genes 0.000 abstract 1
- 108050002772 E3 ubiquitin-protein ligase Mdm2 Proteins 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 238000003556 assay Methods 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- 125000001041 indolyl group Chemical group 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002062 proliferating effect Effects 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 125000000168 pyrrolyl group Chemical group 0.000 abstract 1
- 125000000335 thiazolyl group Chemical group 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
Classifications
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/70—Sulfur atoms
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
- A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
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- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A61K31/5375—1,4-Oxazines, e.g. morpholine
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- C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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- C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/42—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms with nitro or nitroso radicals directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
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- Chemical & Material Sciences (AREA)
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- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Engineering & Computer Science (AREA)
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- Urology & Nephrology (AREA)
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- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
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- Oncology (AREA)
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- Pulmonology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Pyridine Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0215650.3A GB0215650D0 (en) | 2002-07-05 | 2002-07-05 | Bisarylsufonamide compounds |
| PCT/GB2003/002923 WO2004005278A1 (en) | 2002-07-05 | 2003-07-07 | Bisarylsulfonamide compounds and their use in cancer therapy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL166027A0 true IL166027A0 (en) | 2006-01-15 |
Family
ID=9939950
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL16602704A IL166027A0 (en) | 2002-07-05 | 2004-12-02 | Bisarylsulfonamide compounds and their use in cancer therapy |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20050215548A1 (de) |
| EP (1) | EP1519932B1 (de) |
| JP (1) | JP2006508906A (de) |
| CN (1) | CN1665802A (de) |
| AT (1) | ATE374763T1 (de) |
| AU (1) | AU2003244847A1 (de) |
| CA (1) | CA2488816A1 (de) |
| DE (1) | DE60316686T2 (de) |
| GB (1) | GB0215650D0 (de) |
| IL (1) | IL166027A0 (de) |
| NZ (1) | NZ536494A (de) |
| WO (1) | WO2004005278A1 (de) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0012528D0 (en) * | 2000-05-23 | 2000-07-12 | Univ Palackeho | Triterpenoid derivatives |
| JP4324480B2 (ja) | 2002-03-26 | 2009-09-02 | ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド | グルココルチコイドミメティクス、その製法、医薬組成物、及び使用 |
| HRP20050185A2 (en) * | 2002-08-29 | 2006-05-31 | Boehringer Ingelheim Pharmaceuticals Inc. | -3 (sulfonamidoethyl)-indole derivatives for use as glucocorticoid mimetics in the treatment of inflammatory, allergic and proliferative diseases |
| US7915293B2 (en) * | 2003-05-30 | 2011-03-29 | Rigel Pharmaceuticals, Inc. | Ubiquitin ligase inhibitors |
| UY28526A1 (es) | 2003-09-24 | 2005-04-29 | Boehringer Ingelheim Pharma | Miméticos de glucocorticoides, métodos de preparación composiciones farmacéuticas y usos de los mismos |
| US7795272B2 (en) | 2004-03-13 | 2010-09-14 | Boehringer Ingelheim Pharmaceutical, Inc. | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions and uses thereof |
| JP2007531757A (ja) * | 2004-03-30 | 2007-11-08 | カイロン コーポレイション | 抗癌剤としての置換チオフェン誘導体 |
| EP1758873A1 (de) * | 2004-06-22 | 2007-03-07 | Rigel Pharmaceuticals, Inc. | Ubiquitinligasehemmer |
| HRP20100561T1 (hr) | 2004-09-22 | 2010-11-30 | Janssen Pharmaceutica Nv | Inhibitori interakcije između mdm2 i p53 |
| US7635711B2 (en) | 2004-12-27 | 2009-12-22 | Boehringer-Ingelheim Pharmaceuticals, Inc. | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof |
| EP2527337A1 (de) * | 2005-04-14 | 2012-11-28 | Bristol-Myers Squibb Company | Hemmer des 11-Beta-Hydroxysteroid-Dehydrogenase-1-Enzyms |
| EP1945202A2 (de) * | 2005-11-11 | 2008-07-23 | Licentia OY | Säugetier-hedgehog-signalhemmer |
| CA2644643C (en) | 2006-03-22 | 2015-05-19 | Janssen Pharmaceutica N.V. | Inhibitors of the interaction between mdm2 and p53 |
| US8088795B2 (en) | 2006-03-22 | 2012-01-03 | Janssen Pharmaceutica N.V. | Cyclic-alkylamine derivatives as inhibitors of the interaction between MDM2 and p53 |
| CN101405285B (zh) * | 2006-03-22 | 2012-10-10 | 詹森药业有限公司 | 作为mdm2和p53间相互作用的抑制剂的环状-烷基胺衍生物 |
| US8470785B2 (en) | 2006-07-28 | 2013-06-25 | St. Jude Children's Research Hospital | Method for treating ocular cancer |
| US8614192B2 (en) | 2006-07-28 | 2013-12-24 | Leiden University Medical Center | Method for treating ocular cancer |
| JP2010512331A (ja) | 2006-12-06 | 2010-04-22 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | グルココルチコイド模倣薬、それらの製造方法、医薬組成物、及びこれらの使用 |
| EP2103619A4 (de) * | 2006-12-14 | 2011-11-23 | Daiichi Sankyo Co Ltd | Imidazothiazolderivate |
| JP2010523476A (ja) * | 2007-03-08 | 2010-07-15 | ザ ボード オブ トラスティーズ オブ ザ リーランド スタンフォード ジュニア ユニバーシティ | ミトコンドリアアルデヒドデヒドロゲナーゼ−2モジュレーター及びその使用方法 |
| KR101506750B1 (ko) | 2007-04-06 | 2015-03-27 | 뉴로크린 바이오사이언시즈 인코퍼레이티드 | 고나도트로핀-방출 호르몬 수용체 길항제 및 그와 관련된 방법 |
| US8263588B2 (en) * | 2007-04-06 | 2012-09-11 | Neurocrine Biosciences, Inc. | Gonadotropin-releasing hormone receptor antagonists and methods relating thereto |
| ES2534899T3 (es) | 2007-08-06 | 2015-04-30 | Janssen Pharmaceutica, N.V. | Fenilendiaminas sustituidas como inhibidores de la interacción entre MDM2 y p53 |
| US8039493B2 (en) * | 2007-09-27 | 2011-10-18 | Hoffmann-La Roche Inc. | Biaryl sulfonamide derivatives |
| WO2009070650A1 (en) * | 2007-11-26 | 2009-06-04 | The Research Foundation Of State University Of New York | Small molecule cancer treatments that cause necrosis in cancer cells but do not affect normal cells |
| EP2116547A1 (de) * | 2008-05-09 | 2009-11-11 | Laboratorios Del. Dr. Esteve, S.A. | Substituierte n-Imidazo[2,1-b]thiazol-5-sulfonamid-Derivative als 5-TH6-Liganden |
| DK2300472T3 (da) | 2008-06-06 | 2012-04-10 | Boehringer Ingelheim Int | Glucocorticoidmimetika, fremgangsmåder til disses fremstilling, farmaceutiske sammensætninger samt anvendelser deraf |
| JPWO2009151069A1 (ja) * | 2008-06-12 | 2011-11-17 | 第一三共株式会社 | 4,7−ジアザスピロ[2.5]オクタン環構造を有するイミダゾチアゾール誘導体 |
| US8354435B2 (en) | 2008-09-08 | 2013-01-15 | The Board Of Trustees Of The Leland Stanford Junior University | Modulators of aldehyde dehydrogenase activity and methods of use thereof |
| WO2010062308A1 (en) | 2008-10-28 | 2010-06-03 | The Board Of Trustees Of The Leland Stanford Junior University | Modulators of aldehyde dehydrogenase and methods of use thereof |
| SG173495A1 (en) | 2009-02-04 | 2011-09-29 | Janssen Pharmaceutica Nv | Indole derivatives as anticancer agents |
| KR102001418B1 (ko) * | 2009-05-26 | 2019-07-19 | 애브비 아일랜드 언리미티드 컴퍼니 | 암,면역 질환 및 자가면역 질환의 치료를 위한 아폽토시스-유도제 |
| WO2011137089A1 (en) | 2010-04-29 | 2011-11-03 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Activators of human pyruvate kinase |
| WO2012149106A1 (en) | 2011-04-29 | 2012-11-01 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for increasing proliferation of adult salivary stem cells |
| SG11201504041WA (en) | 2012-11-30 | 2015-06-29 | Novomedix Llc | Substituted biaryl sulfonamides and the use thereof |
| ES2707305T3 (es) | 2012-12-20 | 2019-04-03 | Merck Sharp & Dohme | Imidazopiridinas sustituidas como inhibidores de HDM2 |
| KR20150135332A (ko) | 2013-03-14 | 2015-12-02 | 더 보드 오브 트러스티스 오브 더 리랜드 스탠포드 쥬니어 유니버시티 | 미토콘드리아 알데히드 탈수소효소-2 조절인자들 및 이들의 사용 방법 |
| US10448637B2 (en) | 2014-10-03 | 2019-10-22 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Inhibitors of GRB2-associated binding protein 1 (GAB1) and methods of treating cancer using the same |
| WO2016112177A1 (en) * | 2015-01-08 | 2016-07-14 | Yale University | Novel Compositions Useful for Killing DNA Repair-Deficient Cancer Cells, and Methods Using Same |
| EP3412652A1 (de) * | 2017-06-06 | 2018-12-12 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Inhibitoren von rac1 und verwendungen zur behandlung von krebs |
| WO2019139869A1 (en) * | 2018-01-10 | 2019-07-18 | Cura Therapeutics Llc | Pharmaceutical compositions comprising phenylsulfonamides, and their therapeutic applications |
| CN112236162A (zh) | 2018-04-06 | 2021-01-15 | 昂科莱奇公司 | 用于裂解选择性癌细胞的组合物 |
| CN113056305A (zh) | 2018-11-23 | 2021-06-29 | 格雷沃尔夫治疗有限公司 | 化合物 |
| WO2021087096A1 (en) * | 2019-11-01 | 2021-05-06 | The Regents Of The University Of California | P53 modulators and uses thereof |
| CN117050053A (zh) * | 2023-08-11 | 2023-11-14 | 北京中医药大学 | 一种新型噻吩类抗肿瘤化合物及其制备方法与应用 |
| CN119462567B (zh) * | 2024-11-12 | 2025-11-07 | 中国药科大学 | N-苯基苯磺酰胺类化合物、制备方法和用途 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2402623A (en) * | 1943-06-24 | 1946-06-25 | Rohm & Haas | Nu-nitroaryl haloarylsulphonamides |
| CH362688A (de) * | 1957-09-10 | 1962-06-30 | Geigy Ag J R | Verfahren zur Herstellung von neuen Arylsulfonarylamiden |
| US3991081A (en) * | 1975-05-19 | 1976-11-09 | Chevron Research Company | Fungicidal 2-(N-haloalkylthiosulfonamido)thiophenes |
| JP3545461B2 (ja) * | 1993-09-10 | 2004-07-21 | エーザイ株式会社 | 二環式ヘテロ環含有スルホンアミド誘導体 |
| GB9819860D0 (en) * | 1998-09-12 | 1998-11-04 | Zeneca Ltd | Chemical compounds |
| WO2001012593A1 (en) * | 1999-08-17 | 2001-02-22 | Tularik Inc. | Arylsulfonanilide derivatives |
| US20040018192A1 (en) * | 2000-02-03 | 2004-01-29 | Toshiaki Wakabayashi | Integrin expression inhibitors |
| US7491718B2 (en) * | 2002-10-08 | 2009-02-17 | Abbott Laboratories | Sulfonamides having antiangiogenic and anticancer activity |
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2002
- 2002-07-05 GB GBGB0215650.3A patent/GB0215650D0/en not_active Ceased
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2003
- 2003-07-07 AU AU2003244847A patent/AU2003244847A1/en not_active Abandoned
- 2003-07-07 JP JP2004518989A patent/JP2006508906A/ja not_active Withdrawn
- 2003-07-07 NZ NZ536494A patent/NZ536494A/en unknown
- 2003-07-07 AT AT03738323T patent/ATE374763T1/de not_active IP Right Cessation
- 2003-07-07 CN CN038159481A patent/CN1665802A/zh active Pending
- 2003-07-07 EP EP03738323A patent/EP1519932B1/de not_active Expired - Lifetime
- 2003-07-07 WO PCT/GB2003/002923 patent/WO2004005278A1/en not_active Ceased
- 2003-07-07 CA CA002488816A patent/CA2488816A1/en not_active Abandoned
- 2003-07-07 DE DE60316686T patent/DE60316686T2/de not_active Expired - Fee Related
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2004
- 2004-11-12 US US10/988,388 patent/US20050215548A1/en not_active Abandoned
- 2004-12-02 IL IL16602704A patent/IL166027A0/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1519932A1 (de) | 2005-04-06 |
| WO2004005278A1 (en) | 2004-01-15 |
| CA2488816A1 (en) | 2004-01-15 |
| CN1665802A (zh) | 2005-09-07 |
| NZ536494A (en) | 2006-10-27 |
| DE60316686T2 (de) | 2008-01-24 |
| JP2006508906A (ja) | 2006-03-16 |
| AU2003244847A1 (en) | 2004-01-23 |
| EP1519932B1 (de) | 2007-10-03 |
| US20050215548A1 (en) | 2005-09-29 |
| GB0215650D0 (en) | 2002-08-14 |
| DE60316686D1 (de) | 2007-11-15 |
| ATE374763T1 (de) | 2007-10-15 |
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