IL163958A0 - Anxiolytic agents with reduced sedative and ataxideffects - Google Patents
Anxiolytic agents with reduced sedative and ataxideffectsInfo
- Publication number
- IL163958A0 IL163958A0 IL16395803A IL16395803A IL163958A0 IL 163958 A0 IL163958 A0 IL 163958A0 IL 16395803 A IL16395803 A IL 16395803A IL 16395803 A IL16395803 A IL 16395803A IL 163958 A0 IL163958 A0 IL 163958A0
- Authority
- IL
- Israel
- Prior art keywords
- ataxideffects
- anxiolytic agents
- reduced sedative
- sedative
- reduced
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/12—1,5-Benzodiazepines; Hydrogenated 1,5-benzodiazepines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/20—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/24—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/06—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US36840802P | 2002-03-28 | 2002-03-28 | |
PCT/US2003/009587 WO2003082832A2 (fr) | 2002-03-28 | 2003-03-28 | Agents anxiolytiques a effets sedatifs et ataxiques reduits |
Publications (1)
Publication Number | Publication Date |
---|---|
IL163958A0 true IL163958A0 (en) | 2005-12-18 |
Family
ID=28675480
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL16395803A IL163958A0 (en) | 2002-03-28 | 2003-03-28 | Anxiolytic agents with reduced sedative and ataxideffects |
Country Status (16)
Country | Link |
---|---|
US (6) | US7119196B2 (fr) |
EP (1) | EP1490344B1 (fr) |
JP (1) | JP2005525392A (fr) |
KR (2) | KR100865410B1 (fr) |
CN (1) | CN1642924A (fr) |
AT (1) | ATE389640T1 (fr) |
AU (1) | AU2003230754B2 (fr) |
BR (1) | BR0308918A (fr) |
CA (1) | CA2480869A1 (fr) |
DE (1) | DE60319812T2 (fr) |
DK (1) | DK1490344T3 (fr) |
ES (1) | ES2300576T3 (fr) |
IL (1) | IL163958A0 (fr) |
MX (1) | MXPA04009332A (fr) |
NZ (1) | NZ535517A (fr) |
WO (1) | WO2003082832A2 (fr) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
USRE47475E1 (en) * | 2002-03-28 | 2019-07-02 | Wisys Technology Foundation, Inc. | Selective agents for pain suppression |
AU2005260650A1 (en) | 2004-06-30 | 2006-01-12 | Wisys Technology Foundation, Inc. | Stereospecific anxiolytic and anticonvulsant agents with reduced muscle-relaxant, sedative-hypnotic and ataxic effects |
US8119629B2 (en) * | 2007-10-03 | 2012-02-21 | Bristol-Meyers Squibb Company | Carboxamide GABAA α2 modulators |
ES2388708T3 (es) * | 2008-01-22 | 2012-10-17 | Eli Lilly And Company | Antagonista selectivo del receptor opioide kappa |
US20100261711A1 (en) * | 2009-03-20 | 2010-10-14 | Wisys Technology Foundation | Selective anticonvulsant agents and their uses |
JP2013209292A (ja) * | 2010-07-23 | 2013-10-10 | Nippon Chemiphar Co Ltd | P2x4受容体拮抗剤 |
US9006233B2 (en) | 2011-04-28 | 2015-04-14 | Uwm Research Foundation, Inc. | Gabaergic receptor subtype selective ligands and their uses |
US20150374705A1 (en) | 2012-02-14 | 2015-12-31 | Shanghai Institues for Biological Sciences | Substances for treatment or relief of pain |
US9879020B2 (en) | 2012-09-21 | 2018-01-30 | Uwm Research Foundation, Inc. | GABAA agonists and methods of using to control airway hyperresponsiveness and inflammation in asthma |
FR3010785B1 (fr) * | 2013-09-18 | 2015-08-21 | Snecma | Procede de controle de la densite d'energie d'un faisceau laser par analyse d'image et dispositif correspondant |
CA3222584A1 (fr) | 2016-01-27 | 2017-08-03 | Universitat Zurich | Utilisation de modulateurs des recepteurs gabaa pour le traitement des demangeaisons |
PL3439665T3 (pl) | 2016-03-18 | 2023-01-16 | Uwm Research Foundation, Inc. | Leczenie objawów poznawczych i nastroju w zaburzeniach neurodegeneracyjnych i neuropsychiatrycznych za pomocą agonistów receptora gabaa zawierających alfa5 |
JP7013446B2 (ja) | 2016-08-16 | 2022-02-15 | ユーダブリューエム・リサーチ・ファウンデーション,インコーポレーテッド | Gaba(a)受容体モジュレーター、及び、喘息における気道過敏及び炎症を抑制するための方法 |
CN109906220A (zh) * | 2016-11-01 | 2019-06-18 | 豪夫迈·罗氏有限公司 | 用于治疗cns相关疾病的1,3-二氢-1,4-苯并二氮杂*-2-硫酮化合物 |
CN107056760A (zh) * | 2017-01-22 | 2017-08-18 | 苏州楚凯药业有限公司 | 5,7位取代的1H‑苯并[e][1,4]二氮杂‑2(3H)‑酮衍生物的制备方法 |
CN107325101B (zh) * | 2017-06-29 | 2019-03-26 | 上海合全药物研发有限公司 | 6-羟甲基-6,7-二氢-5h,9h-咪唑并二氮杂卓-8-羧酸叔丁酯的合成方法 |
CN107216332B (zh) * | 2017-06-29 | 2019-04-30 | 上海药明康德新药开发有限公司 | 叔丁基-7-羟甲基-7,8-二氢4h吡唑并二氮杂卓5(6h)甲酸基酯的合成方法 |
US20200316087A1 (en) | 2017-10-03 | 2020-10-08 | Uwm Research Foundation, Inc. | Novel combination therapy for anxiety disorders, epilepsy, and pain |
WO2021198124A1 (fr) | 2020-03-31 | 2021-10-07 | F. Hoffmann-La Roche Ag | Dérivés de benzodiazépine en tant que pams gaba a gamma1 |
AR127127A1 (es) * | 2021-09-24 | 2023-12-20 | Hoffmann La Roche | NUEVOS DERIVADOS DE PIRIDODIAZEPINAS COMO PAM DE GABAA g1 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2893992A (en) | 1959-07-07 | I ii i i | ||
US3886141A (en) * | 1971-10-07 | 1975-05-27 | Hoffmann La Roche | Preparation of 5-pyridyl benzodiazepine utilizing hexamethylenetetramine |
US4440685A (en) * | 1974-09-11 | 1984-04-03 | Hoffmann-La Roche Inc. | Imidazodiazepines and processes therefor |
US4280957A (en) | 1974-09-11 | 1981-07-28 | Hoffmann-La Roche Inc. | Imidazodiazepines and processes therefor |
US4401597A (en) | 1978-05-15 | 1983-08-30 | Hoffmann-La Roche Inc. | Imidazodiazepines and processes therefor |
DE3435973A1 (de) * | 1984-10-01 | 1986-04-10 | Boehringer Ingelheim KG, 6507 Ingelheim | Diazepine enthaltende pharmazeutische zusammensetzungen mit paf-antagonistischer wirkung |
ES2037013T3 (es) * | 1986-01-21 | 1993-06-16 | Boehringer Ingelheim Kg | Procedimiento para preparar tieno-1,4-diazepinas. |
MC1999A1 (fr) | 1987-12-18 | 1990-01-26 | Hoffmann La Roche | Composes tricycliques |
US4959361A (en) * | 1987-12-18 | 1990-09-25 | Hoffmann-La Roche Inc. | Triazolo(4,3-A)(1,4)benzodiazepines and thieno (3,2-F)(1,2,4)triazolo(4,3-A)(1,4)diazepine compounds which have useful activity as platelet activating factor (PAF) antagonists |
US5968176A (en) * | 1997-05-29 | 1999-10-19 | 3Com Corporation | Multilayer firewall system |
KR100566171B1 (ko) * | 2001-04-12 | 2006-03-29 | 에프. 호프만-라 로슈 아게 | mGluR2 길항제 Ⅱ인디하이드로-벤조[b][1,4]디아제핀-2-온 유도체 |
US7161904B2 (en) * | 2002-06-04 | 2007-01-09 | Fortinet, Inc. | System and method for hierarchical metering in a virtual router based network switch |
US7415723B2 (en) * | 2002-06-11 | 2008-08-19 | Pandya Ashish A | Distributed network security system and a hardware processor therefor |
-
2003
- 2003-03-28 WO PCT/US2003/009587 patent/WO2003082832A2/fr active Application Filing
- 2003-03-28 DK DK03723846T patent/DK1490344T3/da active
- 2003-03-28 ES ES03723846T patent/ES2300576T3/es not_active Expired - Lifetime
- 2003-03-28 DE DE60319812T patent/DE60319812T2/de not_active Expired - Lifetime
- 2003-03-28 MX MXPA04009332A patent/MXPA04009332A/es active IP Right Grant
- 2003-03-28 US US10/402,538 patent/US7119196B2/en not_active Expired - Lifetime
- 2003-03-28 IL IL16395803A patent/IL163958A0/xx unknown
- 2003-03-28 NZ NZ535517A patent/NZ535517A/en not_active IP Right Cessation
- 2003-03-28 KR KR1020047015305A patent/KR100865410B1/ko not_active IP Right Cessation
- 2003-03-28 EP EP03723846A patent/EP1490344B1/fr not_active Expired - Lifetime
- 2003-03-28 JP JP2003580300A patent/JP2005525392A/ja active Pending
- 2003-03-28 AT AT03723846T patent/ATE389640T1/de not_active IP Right Cessation
- 2003-03-28 CN CNA038073439A patent/CN1642924A/zh active Pending
- 2003-03-28 KR KR1020087012062A patent/KR20080060286A/ko not_active Application Discontinuation
- 2003-03-28 CA CA002480869A patent/CA2480869A1/fr not_active Abandoned
- 2003-03-28 AU AU2003230754A patent/AU2003230754B2/en not_active Ceased
- 2003-03-28 BR BR0308918-5A patent/BR0308918A/pt not_active IP Right Cessation
-
2006
- 2006-07-20 US US11/458,739 patent/US7235656B2/en not_active Expired - Fee Related
- 2006-07-20 US US11/458,855 patent/US20070049580A1/en not_active Abandoned
-
2007
- 2007-06-24 US US11/767,515 patent/US20070299058A1/en not_active Abandoned
- 2007-10-30 US US11/929,860 patent/US20080108605A1/en not_active Abandoned
-
2010
- 2010-01-08 US US12/684,845 patent/US20100130481A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20080108605A1 (en) | 2008-05-08 |
AU2003230754A1 (en) | 2003-10-13 |
US7119196B2 (en) | 2006-10-10 |
KR100865410B1 (ko) | 2008-10-24 |
MXPA04009332A (es) | 2005-12-12 |
US7235656B2 (en) | 2007-06-26 |
DE60319812D1 (de) | 2008-04-30 |
US20040082573A1 (en) | 2004-04-29 |
ES2300576T3 (es) | 2008-06-16 |
DE60319812T2 (de) | 2009-04-23 |
NZ535517A (en) | 2007-02-23 |
US20070049580A1 (en) | 2007-03-01 |
AU2003230754B2 (en) | 2007-10-25 |
US20070054881A1 (en) | 2007-03-08 |
EP1490344A2 (fr) | 2004-12-29 |
WO2003082832A2 (fr) | 2003-10-09 |
US20070299058A1 (en) | 2007-12-27 |
CN1642924A (zh) | 2005-07-20 |
DK1490344T3 (da) | 2008-06-16 |
CA2480869A1 (fr) | 2003-10-09 |
EP1490344B1 (fr) | 2008-03-19 |
KR20040098029A (ko) | 2004-11-18 |
KR20080060286A (ko) | 2008-07-01 |
BR0308918A (pt) | 2005-01-04 |
ATE389640T1 (de) | 2008-04-15 |
WO2003082832A3 (fr) | 2004-04-08 |
US20100130481A1 (en) | 2010-05-27 |
JP2005525392A (ja) | 2005-08-25 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL163958A0 (en) | Anxiolytic agents with reduced sedative and ataxideffects | |
HK1084602A1 (en) | Tricyclic parp inhibitors | |
HK1202114A1 (zh) | 短效苯並二氮雜䓬鹽及其多晶型 | |
WO2002044183A3 (fr) | Composes et leurs utilisations | |
MA27343A1 (fr) | 1-amino triazolo [4,3-a] quinazoline-5-ones et/ou -5-thiones inhibitrices de phosphodiesterases iv. | |
ZA200108204B (en) | Cyclo-alkyl substituted benzimidazoles and their use as PARP inhibitors. | |
DK1185529T3 (da) | Pyrazolbenzodiazepiner som CDK2-inhibitorer | |
GB0613693D0 (en) | Benzodiazepine salts (3) | |
MX2007005478A (es) | Formulaciones de derivados de [1,4]diazepino[6,7,1-ij]quinolina. | |
DK1315731T3 (da) | 2-pyridinyl-6,7,8,9-tetrahydropyrimido[1,2-a]pyrimidin-4-on og 7-pyridinyl-2,3-dihydroimidazo[1,2-a]pyrimidin-5(1H)on-derivater | |
EE05433B1 (et) | 4-(2-butlamino)-2,7-dimetl-8-(2-metl-6-metoksprid-3-l)[1,5-a]prasolo-1,3,5-triasiin, selle farmatseutiliselt vastuv?etavad eelravimid v?i farmatseutiliselt vastuv?etavad soolad ning nende kasutamine | |
CA2384037A1 (fr) | Pyrazolo[4,3-d]pyrimidines | |
DK1480981T3 (da) | 1-(Alkyl)-, 1-(heteroaryl)alkyl- og 1-[(aryl)alkyl]-7-(pyrimidin-4-yl) imidazo[1,2a]pyrimidin-5(1H)-onderivater | |
MY136822A (en) | Derivatives of [6, 7-dihydro-5h-imidazo[1,2-a]imidazole-3-sulfonylamino]-propionamide and their use as inhibitors upon the interaction of cams and leukointegrins | |
PL339073A1 (en) | Derivatives of benzoxazine and benzothiazine and their application in therapeutic agents | |
DK0900212T3 (da) | Chirale phenyldihydrofuranoner som PDE-IV inhibitorer | |
DE60319802D1 (de) | Sedierende nicht-benzodiazepin-formulierungen | |
PT1212119E (pt) | Utilizacao de ciamemazina no tratamento do desmame subito de benzodiazepinas | |
DK0937075T3 (da) | Hidtil ukendte imidazo- og oxazolopyridiner som phosphodiesteraseinhibitorer | |
TR200000473T1 (tr) | Adenozin reseptörüne bağlılık gösteren antikonvülsif ve antialerjik/antiastımatik pirazolo-[3,4-d] pirimidinler ve bunları hazırlama yöntemi. | |
PT1325010E (pt) | 3, 4-di-hidropirimido [1,2-a] pirimidinas e 3, 4-di-hidropirazino [1,2-a] pirimidinas substituidas |