IL162866A0 - Streptomyces a vermitilis gene directing the ratioof b2:b1 avermectins - Google Patents

Streptomyces a vermitilis gene directing the ratioof b2:b1 avermectins

Info

Publication number
IL162866A0
IL162866A0 IL16286603A IL16286603A IL162866A0 IL 162866 A0 IL162866 A0 IL 162866A0 IL 16286603 A IL16286603 A IL 16286603A IL 16286603 A IL16286603 A IL 16286603A IL 162866 A0 IL162866 A0 IL 162866A0
Authority
IL
Israel
Prior art keywords
vermitilis
ratioof
avermectins
streptomyces
gene directing
Prior art date
Application number
IL16286603A
Other languages
English (en)
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of IL162866A0 publication Critical patent/IL162866A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • C12P19/623—Avermectin; Milbemycin; Ivermectin; C-076

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Detergent Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL16286603A 2002-02-12 2003-01-31 Streptomyces a vermitilis gene directing the ratioof b2:b1 avermectins IL162866A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35622202P 2002-02-12 2002-02-12
PCT/IB2003/000348 WO2003068955A2 (en) 2002-02-12 2003-01-31 Streptomyces avermitilis gene directing the ratio of b2:b1 avermectins

Publications (1)

Publication Number Publication Date
IL162866A0 true IL162866A0 (en) 2005-11-20

Family

ID=27734621

Family Applications (3)

Application Number Title Priority Date Filing Date
IL16286603A IL162866A0 (en) 2002-02-12 2003-01-31 Streptomyces a vermitilis gene directing the ratioof b2:b1 avermectins
IL162866A IL162866A (en) 2002-02-12 2004-07-05 A gene of Streptomyces avermitilis that directs the ratio of Avermectins B2: B1
IL192371A IL192371A (en) 2002-02-12 2008-06-22 POLYNUCLEOTIDE SEQUENCES TO A STREPTOMYCES AVERMITILIS aveC ALLELE PRODUCING A REDUCED CLASS 2:1 RATIO OF AVERMECTINS

Family Applications After (2)

Application Number Title Priority Date Filing Date
IL162866A IL162866A (en) 2002-02-12 2004-07-05 A gene of Streptomyces avermitilis that directs the ratio of Avermectins B2: B1
IL192371A IL192371A (en) 2002-02-12 2008-06-22 POLYNUCLEOTIDE SEQUENCES TO A STREPTOMYCES AVERMITILIS aveC ALLELE PRODUCING A REDUCED CLASS 2:1 RATIO OF AVERMECTINS

Country Status (26)

Country Link
US (2) US7388085B2 (de)
EP (2) EP2050815B1 (de)
JP (1) JP2005517406A (de)
KR (1) KR100718378B1 (de)
CN (2) CN102392028B (de)
AR (1) AR038405A1 (de)
AT (2) ATE530645T1 (de)
AU (1) AU2003245052B2 (de)
BR (1) BRPI0307620B8 (de)
CA (1) CA2475214C (de)
CY (2) CY1110454T1 (de)
DE (1) DE60326824D1 (de)
DK (2) DK2050815T3 (de)
ES (2) ES2373629T3 (de)
HK (2) HK1074644A1 (de)
IL (3) IL162866A0 (de)
ME (1) ME00472B (de)
MX (1) MXPA04007777A (de)
PL (1) PL211693B1 (de)
PT (2) PT2050815E (de)
RS (1) RS50813B (de)
RU (1) RU2293117C2 (de)
SI (2) SI2050815T1 (de)
TW (1) TWI341330B (de)
WO (1) WO2003068955A2 (de)
ZA (1) ZA200405345B (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2373629T3 (es) 2002-02-12 2012-02-07 Pfizer Products Inc. Gen de streptomyces avemitilis que dirige la proporción de avermectinas b2:b1.
CN102241750B (zh) * 2010-05-14 2014-05-28 中国科学院微生物研究所 一种生产阿维菌素的基因工程方法及其专用菌株
CN102093997B (zh) * 2010-12-01 2013-03-13 中国科学院上海有机化学研究所 一种改造除虫链霉菌产生多拉菌素的方法
CN109576196B (zh) * 2019-01-25 2022-01-04 北大方正集团有限公司 一种生产多拉菌素的发酵培养基及多拉菌素的生产方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE434277B (sv) 1976-04-19 1984-07-16 Merck & Co Inc Sett att framstella nya antihelmintiskt verkande foreningar genom odling av streptomyces avermitilis
US4429042A (en) 1978-09-08 1984-01-31 Merck & Co., Inc. Strain of Streptomyces for producing antiparasitic compounds
IN167980B (de) 1987-01-23 1991-01-19 Pfizer
US5252474A (en) 1989-03-31 1993-10-12 Merck & Co., Inc. Cloning genes from Streptomyces avermitilis for avermectin biosynthesis and the methods for their use
JP2761296B2 (ja) * 1993-10-05 1998-06-04 フアイザー・インコーポレイテツド ドラメクチンの製造方法および駆虫性中間体
US5605793A (en) 1994-02-17 1997-02-25 Affymax Technologies N.V. Methods for in vitro recombination
US5837458A (en) 1994-02-17 1998-11-17 Maxygen, Inc. Methods and compositions for cellular and metabolic engineering
US6117679A (en) 1994-02-17 2000-09-12 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
CN1297485A (zh) * 1998-02-13 2001-05-30 辉瑞产品公司 介导除虫菌素b2:b1比例的除虫链霉菌基因
US6248579B1 (en) 1998-02-13 2001-06-19 Pfizer Inc Streptomyces avermitilis gene directing the ratio of B2:B1 avermectins
US6197591B1 (en) 1998-09-14 2001-03-06 Pfizer Inc. Streptomyces avermitilis regulatory genes for increased avermectin production
CN1222520C (zh) 1999-08-12 2005-10-12 沃泰克斯药物股份有限公司 c－JUN N－末端激酶(JNK)和其它蛋白激酶的抑制剂
IL147563A0 (en) * 1999-08-12 2002-08-14 Pfizer Prod Inc Streptomyces avermitilis gene directing the ratio of b2:b1 avermectins
ES2373629T3 (es) 2002-02-12 2012-02-07 Pfizer Products Inc. Gen de streptomyces avemitilis que dirige la proporción de avermectinas b2:b1.

Also Published As

Publication number Publication date
BRPI0307620B1 (pt) 2015-08-11
KR100718378B1 (ko) 2007-05-14
US20090017508A1 (en) 2009-01-15
US7388085B2 (en) 2008-06-17
HK1168383A1 (en) 2012-12-28
IL162866A (en) 2009-11-18
CA2475214A1 (en) 2003-08-21
ES2373629T3 (es) 2012-02-07
TW200303918A (en) 2003-09-16
RS70004A (en) 2006-10-27
PL371320A1 (en) 2005-06-13
CY1110454T1 (el) 2015-04-29
CA2475214C (en) 2012-07-31
PL211693B1 (pl) 2012-06-29
PT2050815E (pt) 2012-01-02
EP1476539A2 (de) 2004-11-17
CN1630712A (zh) 2005-06-22
WO2003068955A2 (en) 2003-08-21
ME00472B (me) 2011-10-10
AR038405A1 (es) 2005-01-12
ZA200405345B (en) 2005-06-14
AU2003245052A1 (en) 2003-09-04
RU2293117C2 (ru) 2007-02-10
DE60326824D1 (de) 2009-05-07
SI2050815T1 (sl) 2012-01-31
CN102392028B (zh) 2013-08-14
US8008078B2 (en) 2011-08-30
HK1074644A1 (en) 2005-11-18
US20030166165A1 (en) 2003-09-04
BR0307620A (pt) 2004-12-07
BRPI0307620B8 (pt) 2016-09-13
SI1476539T1 (sl) 2009-06-30
RS50813B (sr) 2010-08-31
IL192371A (en) 2010-11-30
DK2050815T3 (da) 2011-12-12
MXPA04007777A (es) 2004-10-15
TWI341330B (en) 2011-05-01
KR20040081199A (ko) 2004-09-20
ATE530645T1 (de) 2011-11-15
IL192371A0 (en) 2008-12-29
AU2003245052B2 (en) 2008-07-31
EP1476539B1 (de) 2009-03-25
EP2050815A1 (de) 2009-04-22
ES2321827T3 (es) 2009-06-12
JP2005517406A (ja) 2005-06-16
WO2003068955A3 (en) 2003-11-13
DK1476539T3 (da) 2009-05-11
CN1630712B (zh) 2011-09-28
CN102392028A (zh) 2012-03-28
CY1112491T1 (el) 2015-12-09
EP2050815B1 (de) 2011-10-26
ATE426659T1 (de) 2009-04-15
PT1476539E (pt) 2009-04-09
RU2004124521A (ru) 2005-04-10

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