IL160706A0 - Peptides acting as both glp-1 receptor agonists and their pharmacological methods of use - Google Patents

Peptides acting as both glp-1 receptor agonists and their pharmacological methods of use

Info

Publication number
IL160706A0
IL160706A0 IL16070602A IL16070602A IL160706A0 IL 160706 A0 IL160706 A0 IL 160706A0 IL 16070602 A IL16070602 A IL 16070602A IL 16070602 A IL16070602 A IL 16070602A IL 160706 A0 IL160706 A0 IL 160706A0
Authority
IL
Israel
Prior art keywords
glp
receptor agonists
pharmacological methods
peptides acting
peptides
Prior art date
Application number
IL16070602A
Other languages
English (en)
Original Assignee
Bayer Pharmaceuticals Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Pharmaceuticals Corp filed Critical Bayer Pharmaceuticals Corp
Publication of IL160706A0 publication Critical patent/IL160706A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Obesity (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL16070602A 2001-10-05 2002-10-04 Peptides acting as both glp-1 receptor agonists and their pharmacological methods of use IL160706A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32773001P 2001-10-05 2001-10-05
PCT/US2002/031693 WO2003040309A2 (en) 2001-10-05 2002-10-04 Peptides acting as both glp-1 receptor agonists and glucagon receptor antagonists and their pharmacological methods of use

Publications (1)

Publication Number Publication Date
IL160706A0 true IL160706A0 (en) 2004-08-31

Family

ID=23277790

Family Applications (1)

Application Number Title Priority Date Filing Date
IL16070602A IL160706A0 (en) 2001-10-05 2002-10-04 Peptides acting as both glp-1 receptor agonists and their pharmacological methods of use

Country Status (27)

Country Link
US (6) US7399745B2 (pl)
EP (1) EP1436330A4 (pl)
JP (1) JP2005508639A (pl)
KR (1) KR20050034580A (pl)
CN (1) CN1326876C (pl)
AR (1) AR036711A1 (pl)
BR (1) BR0213132A (pl)
CA (1) CA2462462A1 (pl)
CO (1) CO5570710A2 (pl)
DO (1) DOP2002000475A (pl)
EC (2) ECSP024346A (pl)
HN (1) HN2002000282A (pl)
HR (1) HRP20040327A2 (pl)
HU (1) HUP0401797A2 (pl)
IL (1) IL160706A0 (pl)
MA (1) MA26228A1 (pl)
MX (1) MXPA04002140A (pl)
MY (1) MY138267A (pl)
NO (1) NO20041792L (pl)
NZ (1) NZ532685A (pl)
PE (1) PE20030850A1 (pl)
PL (1) PL368760A1 (pl)
RU (1) RU2334761C2 (pl)
SG (2) SG158736A1 (pl)
UY (1) UY27469A1 (pl)
WO (1) WO2003040309A2 (pl)
ZA (1) ZA200403322B (pl)

Families Citing this family (65)

* Cited by examiner, † Cited by third party
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US20050124550A1 (en) * 2003-06-18 2005-06-09 Peri Krishna G. Compounds that modulate the glucagon response and uses thereof
BRPI0417717A (pt) * 2003-12-18 2007-04-03 Novo Nordisk As composto, composição farmacêutica, e, uso de um composto
TW200643033A (en) * 2005-03-08 2006-12-16 Chugai Pharmaceutical Co Ltd Conjugate of water-soluble modified hyaluronic acid and glp-1 analogue
TWI372629B (en) 2005-03-18 2012-09-21 Novo Nordisk As Acylated glp-1 compounds
KR20070120112A (ko) 2005-03-18 2007-12-21 노보 노르디스크 에이/에스 연장형 ｇｌｐ-1 화합물
ES2507098T3 (es) 2005-11-07 2014-10-14 Indiana University Research And Technology Corporation Análogos de glucagón que muestran solubilidad y estabilidad fisiológicas
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WO2008086086A2 (en) * 2007-01-05 2008-07-17 Indiana University Research And Technology Corporation Glucagon analogs exhibiting enhanced solubility in physiological ph buffers
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WO2008098693A2 (en) * 2007-02-16 2008-08-21 Bayer Healthcare Ag Convergent synthesis of glp-1
JP5669582B2 (ja) 2007-10-30 2015-02-12 インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションＩｎｄｉａｎａ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐｏｒａｔｉｏｎ グルカゴンアンタゴニスト
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JP2011511778A (ja) * 2008-01-30 2011-04-14 インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーション エステルに基づいたペプチドプロドラッグ
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US8546327B2 (en) 2008-06-17 2013-10-01 Indiana University Research And Technology Corporation Glucagon/GLP-1 receptor co-agonists
KR20110039348A (ko) 2008-08-06 2011-04-15 노보 노르디스크 헬스 케어 악티엔게젤샤프트 연장된 생체내 효능을 가지는 콘쥬게이트된 단백질
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AR074811A1 (es) 2008-12-19 2011-02-16 Univ Indiana Res & Tech Corp Profarmaco de peptido de la superfamilia de glucagon basados en amida
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MX2011013625A (es) 2009-06-16 2012-01-20 Univ Indiana Res & Tech Corp Compuestos glucagon activo de receptor de gip.
JP6086528B2 (ja) 2009-08-06 2017-03-01 ノヴォ・ノルディスク・ヘルス・ケア・アーゲー 長期のインビボ有効性を有する成長ホルモン
GB0917072D0 (en) 2009-09-29 2009-11-11 Univ Ulster Peptide analogues of glucagon for diabetes therapy
WO2011075393A2 (en) 2009-12-18 2011-06-23 Indiana University Research And Technology Corporation Glucagon/glp-1 receptor co-agonists
EP2460527A1 (en) 2010-01-21 2012-06-06 Sanofi Pharmaceutical composition for treating a metabolic syndrome
JP5980689B2 (ja) 2010-01-22 2016-08-31 ノヴォ・ノルディスク・ヘルス・ケア・アーゲー 安定な成長ホルモン化合物
CN106139158B (zh) 2010-01-22 2024-06-21 诺沃—诺迪斯克保健股份有限公司 体内功效延长的生长激素
MX2012008603A (es) 2010-01-27 2013-01-25 Univ Indiana Res & Tech Corp Conjugados de antagonista de glucagon-agonista de gip y composiciones para el tratamiento de desordenes metabolicos y obesidad.
WO2011140176A1 (en) 2010-05-04 2011-11-10 Glaxosmithkline Llc Methods for treating or preventing cardiovascular disorders and providing cardiovascular protection
CN103179976A (zh) 2010-05-13 2013-06-26 印第安纳大学研究及科技有限公司 呈现g蛋白偶联受体活性的胰高血糖素超家族肽
CA2797095A1 (en) 2010-05-13 2011-11-17 Indiana University Research And Technology Corporation Glucagon superfamily peptides exhibiting nuclear hormone receptor activity
CA2796894A1 (en) 2010-06-24 2011-12-29 Indiana University Research And Technology Corporation Amide based glucagon superfamily peptide prodrugs
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Also Published As

Publication number Publication date
US7494978B2 (en) 2009-02-24
JP2005508639A (ja) 2005-04-07
RU2004114243A (ru) 2005-05-10
US20060003419A1 (en) 2006-01-05
US7399745B2 (en) 2008-07-15
HRP20040327A2 (en) 2007-11-30
MXPA04002140A (es) 2005-03-07
DOP2002000475A (es) 2003-06-30
EP1436330A2 (en) 2004-07-14
AR036711A1 (es) 2004-09-29
CN1564828A (zh) 2005-01-12
NZ532685A (en) 2006-02-24
CO5570710A2 (es) 2005-10-31
HUP0401797A2 (en) 2006-08-28
PL368760A1 (pl) 2005-04-04
HK1073117A1 (zh) 2005-09-23
WO2003040309A3 (en) 2003-12-18
US20050153890A1 (en) 2005-07-14
HN2002000282A (es) 2002-12-12
US20060003418A1 (en) 2006-01-05
NO20041792L (no) 2004-07-02
KR20050034580A (ko) 2005-04-14
US7488715B2 (en) 2009-02-10
ZA200403322B (en) 2005-05-03
EP1436330A4 (en) 2006-01-18
US7488714B2 (en) 2009-02-10
WO2003040309A2 (en) 2003-05-15
PE20030850A1 (es) 2003-10-31
BR0213132A (pt) 2004-10-19
CA2462462A1 (en) 2003-05-15
CN1326876C (zh) 2007-07-18
US7488716B2 (en) 2009-02-10
MY138267A (en) 2009-05-29
SG158736A1 (en) 2010-02-26
US20060003934A1 (en) 2006-01-05
SG149693A1 (en) 2009-02-27
US20060003417A1 (en) 2006-01-05
UY27469A1 (es) 2003-04-30
ECSP024346A (es) 2003-05-26
ECSP045094A (es) 2004-06-28
RU2334761C2 (ru) 2008-09-27
US20050288248A1 (en) 2005-12-29
MA26228A1 (fr) 2004-07-01

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