IL160060A0 - Piperidine derivatives useful as ccr5 antagonists - Google Patents
Piperidine derivatives useful as ccr5 antagonistsInfo
- Publication number
- IL160060A0 IL160060A0 IL16006002A IL16006002A IL160060A0 IL 160060 A0 IL160060 A0 IL 160060A0 IL 16006002 A IL16006002 A IL 16006002A IL 16006002 A IL16006002 A IL 16006002A IL 160060 A0 IL160060 A0 IL 160060A0
- Authority
- IL
- Israel
- Prior art keywords
- derivatives useful
- piperidine derivatives
- ccr5 antagonists
- ccr5
- antagonists
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Virology (AREA)
- Dermatology (AREA)
- Pulmonology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- AIDS & HIV (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Molecular Biology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31568301P | 2001-08-29 | 2001-08-29 | |
| PCT/US2002/027389 WO2003020716A1 (en) | 2001-08-29 | 2002-08-28 | Piperidine derivatives useful as ccr5 antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL160060A0 true IL160060A0 (en) | 2004-06-20 |
Family
ID=23225580
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL16006002A IL160060A0 (en) | 2001-08-29 | 2002-08-28 | Piperidine derivatives useful as ccr5 antagonists |
Country Status (24)
| Country | Link |
|---|---|
| US (4) | US20040010008A1 (pl) |
| EP (1) | EP1421075B1 (pl) |
| JP (2) | JP4223950B2 (pl) |
| KR (1) | KR20040029057A (pl) |
| CN (1) | CN1304389C (pl) |
| AR (1) | AR036366A1 (pl) |
| AT (1) | ATE328879T1 (pl) |
| BR (1) | BR0212108A (pl) |
| CA (1) | CA2457861A1 (pl) |
| CY (1) | CY1105198T1 (pl) |
| DE (1) | DE60212146T2 (pl) |
| DK (1) | DK1421075T3 (pl) |
| EC (1) | ECSP044993A (pl) |
| ES (1) | ES2264491T3 (pl) |
| HK (1) | HK1061563A1 (pl) |
| HU (1) | HUP0402019A3 (pl) |
| IL (1) | IL160060A0 (pl) |
| MX (1) | MXPA04001886A (pl) |
| NO (1) | NO20041266L (pl) |
| PL (1) | PL368827A1 (pl) |
| PT (1) | PT1421075E (pl) |
| RU (1) | RU2004109510A (pl) |
| WO (1) | WO2003020716A1 (pl) |
| ZA (1) | ZA200401594B (pl) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0108876D0 (en) * | 2001-04-09 | 2001-05-30 | Novartis Ag | Organic Compounds |
| WO2003004487A1 (en) | 2001-07-02 | 2003-01-16 | Astrazeneca Ab | Piperidine derivatives useful as modulators of chemokine receptor activity |
| SE0200843D0 (sv) | 2002-03-19 | 2002-03-19 | Astrazeneca Ab | Chemical compounds |
| SE0200844D0 (sv) | 2002-03-19 | 2002-03-19 | Astrazeneca Ab | Chemical compounds |
| GB0223223D0 (en) | 2002-10-07 | 2002-11-13 | Novartis Ag | Organic compounds |
| US20040082612A1 (en) * | 2002-10-15 | 2004-04-29 | Baxter Ellen W | Benzyl substituted (piperidin-4-yl)aminobenzamido derivatives |
| SE0300957D0 (sv) | 2003-04-01 | 2003-04-01 | Astrazeneca Ab | Chemical compounds |
| JP4757802B2 (ja) * | 2003-11-03 | 2011-08-24 | シェーリング コーポレイション | ケモカインレセプターの阻害剤として有用なビピペリジニル誘導体 |
| RU2006120084A (ru) * | 2003-11-10 | 2008-01-10 | Шеринг Акциенгезельшафт (De) | Бензилэфирамины, полезные как антагонисты ccr-5 |
| CA2562235C (en) | 2004-04-13 | 2013-09-24 | Incyte Corporation | Piperazinylpiperidine derivatives as chemokine receptor antagonists |
| US7635698B2 (en) | 2004-12-29 | 2009-12-22 | Millennium Pharmaceuticals, Inc. | Compounds useful as chemokine receptor antagonists |
| WO2006071875A1 (en) * | 2004-12-29 | 2006-07-06 | Millennium Pharmaceuticals, Inc. | Compounds useful as chemokine receptor antagonists |
| WO2006077499A1 (en) * | 2005-01-20 | 2006-07-27 | Pfizer Limited | Chemical compounds |
| PE20061074A1 (es) * | 2005-02-23 | 2006-11-08 | Schering Corp | Derivados de piperidinil piperidina como inhibidores de receptores de quimioquinas |
| US20070010565A1 (en) * | 2005-04-25 | 2007-01-11 | Olaf Prien | New thiazolidinones without basic nitrogen, their production and use as pharmaceutical agents |
| EP1912941B1 (en) | 2005-07-21 | 2012-11-14 | AstraZeneca AB | Piperidine derivatives |
| US8119661B2 (en) * | 2007-09-11 | 2012-02-21 | Astrazeneca Ab | Piperidine derivatives and their use as muscarinic receptor modulators |
| WO2009043747A2 (en) * | 2007-10-01 | 2009-04-09 | F. Hoffmann-La Roche Ag | N-heterocyclic biaryl carboxamides as ccr receptor antagonists |
| AU2009259496A1 (en) * | 2008-06-18 | 2009-12-23 | F. Hoffmann-La Roche Ag | Novel heteroaryl carboxamide derivatives |
| GB201017345D0 (en) | 2010-10-14 | 2010-11-24 | Proximagen Ltd | Receptor antagonists |
| CN105980374A (zh) | 2013-12-19 | 2016-09-28 | 拜耳制药股份公司 | 取代的哌啶基四氢喹啉 |
| JOP20200052A1 (ar) | 2013-12-19 | 2017-06-16 | Bayer Pharma AG | بيبريدينيل تتراهيدرو كوينولينات مستبدلة واستخدامها كمعضدات مستقبل أدريني ألفا- 2c |
| CA2934132A1 (en) | 2013-12-19 | 2015-06-25 | Bayer Pharma Aktiengesellschaft | Substituted bipiperidinyl derivatives as adrenoreceptor alpha 2c antagonists |
| JP2017503778A (ja) * | 2013-12-19 | 2017-02-02 | バイエル ファーマ アクチエンゲゼルシャフト | アドレナリン受容体α２Ｃ拮抗薬としての置換されたビピペリジニル誘導体 |
| EP3277284B1 (en) | 2015-04-02 | 2020-08-05 | Proximagen, Llc | Novel therapies for cancer |
| US11629196B2 (en) | 2020-04-27 | 2023-04-18 | Incelldx, Inc. | Method of treating SARS-CoV-2-associated hypercytokinemia by administering a human monoclonal antibody (PRO-140) that inhibits CCR5/CCL5 binding interactions |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4588722A (en) * | 1984-01-09 | 1986-05-13 | Janssen Pharmaceutica N.V. | N-(4-piperidinyl) bicyclic condensed 2-imidazolamine derivatives |
| TW531537B (en) * | 1995-12-27 | 2003-05-11 | Janssen Pharmaceutica Nv | 1-(1,2-disubstituted piperidinyl)-4-substituted piperidine derivatives |
| US5952349A (en) * | 1996-07-10 | 1999-09-14 | Schering Corporation | Muscarinic antagonists for treating memory loss |
| ES2182104T3 (es) * | 1996-07-10 | 2003-03-01 | Schering Corp | Piperidinas 1,4-disustituidas como antagonistas muscarinicos. |
| IL145742A0 (en) * | 1999-05-04 | 2002-07-25 | Schering Corp | Piperidine derivatives useful as ccr5 antagonists |
| WO2001030348A1 (en) * | 1999-10-25 | 2001-05-03 | Janssen Pharmaceutica N.V. | Use of substance p antagonists for influencing the circadian timing system |
| AR033517A1 (es) * | 2000-04-08 | 2003-12-26 | Astrazeneca Ab | Derivados de piperidina, proceso para su preparacion y uso de estos derivados en la fabricacion de medicamentos |
| GB0108876D0 (en) * | 2001-04-09 | 2001-05-30 | Novartis Ag | Organic Compounds |
-
2002
- 2002-08-27 AR ARP020103217A patent/AR036366A1/es unknown
- 2002-08-28 DK DK02766142T patent/DK1421075T3/da active
- 2002-08-28 PT PT02766142T patent/PT1421075E/pt unknown
- 2002-08-28 IL IL16006002A patent/IL160060A0/xx unknown
- 2002-08-28 CN CNB028166795A patent/CN1304389C/zh not_active Expired - Fee Related
- 2002-08-28 RU RU2004109510/04A patent/RU2004109510A/ru not_active Application Discontinuation
- 2002-08-28 KR KR10-2004-7002835A patent/KR20040029057A/ko not_active Application Discontinuation
- 2002-08-28 CA CA002457861A patent/CA2457861A1/en not_active Abandoned
- 2002-08-28 AT AT02766142T patent/ATE328879T1/de not_active IP Right Cessation
- 2002-08-28 HU HU0402019A patent/HUP0402019A3/hu unknown
- 2002-08-28 US US10/229,466 patent/US20040010008A1/en not_active Abandoned
- 2002-08-28 DE DE60212146T patent/DE60212146T2/de not_active Expired - Lifetime
- 2002-08-28 EP EP02766142A patent/EP1421075B1/en not_active Expired - Lifetime
- 2002-08-28 ES ES02766142T patent/ES2264491T3/es not_active Expired - Lifetime
- 2002-08-28 BR BR0212108-5A patent/BR0212108A/pt not_active IP Right Cessation
- 2002-08-28 PL PL02368827A patent/PL368827A1/pl not_active Application Discontinuation
- 2002-08-28 JP JP2003524986A patent/JP4223950B2/ja not_active Expired - Fee Related
- 2002-08-28 MX MXPA04001886A patent/MXPA04001886A/es active IP Right Grant
- 2002-08-28 WO PCT/US2002/027389 patent/WO2003020716A1/en active IP Right Grant
-
2003
- 2003-07-29 US US10/629,466 patent/US7442703B2/en not_active Expired - Fee Related
- 2003-07-29 US US10/628,933 patent/US7384948B2/en not_active Expired - Fee Related
-
2004
- 2004-02-25 ZA ZA200401594A patent/ZA200401594B/en unknown
- 2004-02-27 EC EC2004004993A patent/ECSP044993A/es unknown
- 2004-03-26 NO NO20041266A patent/NO20041266L/no not_active Application Discontinuation
- 2004-06-19 HK HK04104463A patent/HK1061563A1/xx not_active IP Right Cessation
-
2006
- 2006-09-06 CY CY20061101271T patent/CY1105198T1/el unknown
-
2008
- 2008-04-17 US US12/104,914 patent/US8034933B2/en not_active Expired - Fee Related
- 2008-05-22 JP JP2008134844A patent/JP2008222722A/ja active Pending
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