IL159402A0 - Activators for oligonucleotide synthesis - Google Patents
Activators for oligonucleotide synthesisInfo
- Publication number
- IL159402A0 IL159402A0 IL15940202A IL15940202A IL159402A0 IL 159402 A0 IL159402 A0 IL 159402A0 IL 15940202 A IL15940202 A IL 15940202A IL 15940202 A IL15940202 A IL 15940202A IL 159402 A0 IL159402 A0 IL 159402A0
- Authority
- IL
- Israel
- Prior art keywords
- activators
- oligonucleotide synthesis
- oligonucleotide
- synthesis
- Prior art date
Links
- 239000012190 activator Substances 0.000 title 1
- 238000002515 oligonucleotide synthesis Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
- C07D275/06—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
- C07D213/16—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing only one pyridine ring
- C07D213/18—Salts thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US30271701P | 2001-07-03 | 2001-07-03 | |
PCT/GB2002/003029 WO2003004512A1 (fr) | 2001-07-03 | 2002-07-01 | Activateurs pour la synthese d'oligonucleotides |
Publications (1)
Publication Number | Publication Date |
---|---|
IL159402A0 true IL159402A0 (en) | 2004-06-01 |
Family
ID=23168928
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL15940202A IL159402A0 (en) | 2001-07-03 | 2002-07-01 | Activators for oligonucleotide synthesis |
Country Status (16)
Country | Link |
---|---|
US (2) | US7501505B2 (fr) |
EP (1) | EP1404696B1 (fr) |
JP (1) | JP4574167B2 (fr) |
KR (1) | KR100898083B1 (fr) |
CN (1) | CN100430411C (fr) |
AR (1) | AR036122A1 (fr) |
AT (1) | ATE317395T1 (fr) |
CA (1) | CA2452205C (fr) |
DE (1) | DE60209128T2 (fr) |
DK (1) | DK1404696T3 (fr) |
ES (1) | ES2258151T3 (fr) |
HU (1) | HUP0400151A2 (fr) |
IL (1) | IL159402A0 (fr) |
PL (1) | PL367623A1 (fr) |
RU (1) | RU2004102903A (fr) |
WO (1) | WO2003004512A1 (fr) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR036122A1 (es) | 2001-07-03 | 2004-08-11 | Avecia Biotechnology Inc | Un complejo de sal que comprende un n-alquilimidazol y una 1,1-dioxo-1,2-dihidro-1l6-benzo [d]-isotiazol-3-ona y un metodo para sintetizar oligonucleotidos utilizando la quimica de fosforamidita |
CN1329408C (zh) * | 2002-10-15 | 2007-08-01 | 艾夫西亚生物科技公司 | 亚磷酰化方法 |
GB0229443D0 (en) * | 2002-12-18 | 2003-01-22 | Avecia Ltd | Process |
US8569367B2 (en) | 2004-11-16 | 2013-10-29 | Allergan, Inc. | Ophthalmic compositions and methods for treating eyes |
US7339052B2 (en) * | 2005-02-08 | 2008-03-04 | Honeywell International Inc. | Phosphoramidite activator for oligonucleotide synthesis |
EP1874792B1 (fr) | 2005-04-27 | 2016-04-13 | Sigma-Aldrich Co. LLC | Activateurs destines a la synthese d'oligonucleotides et de phosphoramidites |
US8193337B2 (en) | 2007-07-12 | 2012-06-05 | Avecia Biotechnology, Inc. | Oxidation process |
KR200457843Y1 (ko) * | 2010-05-26 | 2012-01-10 | 김원제 | 향기 발산 기능을 가지는 악취 차단 커버 |
CA2805546A1 (fr) * | 2010-06-30 | 2012-01-05 | Girindus America, Inc. | Nouveau procede d'utilisation des composes n-thio pour la synthese d'oligonucleotides |
US9907826B2 (en) | 2011-12-07 | 2018-03-06 | Allergan, Inc. | Efficient lipid delivery to human tear film using a salt-sensitive emulsion system |
CN104278030A (zh) * | 2013-07-05 | 2015-01-14 | 上海交通大学医学院 | 小分子化合物Antagomir-31制备方法及应用 |
CN113461733A (zh) | 2015-08-05 | 2021-10-01 | 卫材R&D管理有限公司 | 用于制备均一低聚物的手性试剂 |
US10072261B1 (en) * | 2016-03-25 | 2018-09-11 | Agilent Technologies, Inc. | Double coupling method for oligonucleotide synthesis |
US11981703B2 (en) | 2016-08-17 | 2024-05-14 | Sirius Therapeutics, Inc. | Polynucleotide constructs |
US11597744B2 (en) | 2017-06-30 | 2023-03-07 | Sirius Therapeutics, Inc. | Chiral phosphoramidite auxiliaries and methods of their use |
CN111479818A (zh) * | 2018-02-13 | 2020-07-31 | 深圳华大生命科学研究院 | 合成寡核苷酸的方法及系统 |
EP3983421A1 (fr) * | 2019-06-11 | 2022-04-20 | F. Hoffmann-La Roche AG | Procédé de préparation d'oligonucléotides à l'aide d'un protocole d'oxydation modifié |
EP4089099A1 (fr) * | 2020-01-08 | 2022-11-16 | Nitto Denko Corporation | Procédé de synthèse d'acide nucléique utilisant un amidite de type segment |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US757650A (en) * | 1903-09-30 | 1904-04-19 | Wilfrid Chausse | Means for cleaning the third rails of electrical railways. |
US3325475A (en) * | 1964-11-16 | 1967-06-13 | Maumee Chemical Company | Organic amine salts of saccharin |
JPS4822628B1 (fr) * | 1967-04-15 | 1973-07-07 | ||
IT8148047A0 (it) * | 1981-03-18 | 1981-03-18 | Manetti & Roberts Italo Brit | Composti organici derivati da 2-ami no-5-(o-solfamidofenil)-1,3,4-tiadiazolo loro applicazione terapeutica e procedimento per la loro preparazione |
DE3430805A1 (de) * | 1984-03-08 | 1985-09-19 | Bayer Ag, 5090 Leverkusen | Mikrobizide mittel |
DE3639901A1 (de) * | 1986-11-22 | 1988-06-01 | Bayer Ag | Saccharin-salze von substituierten aminen |
US5034534A (en) | 1988-07-15 | 1991-07-23 | E. I. Du Pont De Nemours And Company | Process for producing saccharin, saccharin analogues or their salts |
JPH04330093A (ja) * | 1990-07-20 | 1992-11-18 | Takeda Chem Ind Ltd | オリゴリボヌクレオチドの製造法 |
US5639875A (en) * | 1995-02-01 | 1997-06-17 | Hybridon, Inc. | Methods for H-phosphonate syntheis of oligonucleotides using triphosgene |
AU4800197A (en) * | 1996-10-15 | 1998-05-11 | Nexstar Pharmaceuticals, Inc. | Improved coupling activators for oligonucleotide synthesis |
US5896999A (en) | 1996-10-16 | 1999-04-27 | United Parcel Service Of America, Inc. | Sorting system |
US5955600A (en) * | 1996-12-27 | 1999-09-21 | Isis Pharmaceuticals, Inc. | Method for the synthesis of nucleotide or oligonucleotide phosphoramidites |
US6096881A (en) * | 1997-05-30 | 2000-08-01 | Hybridon, Inc. | Sulfur transfer reagents for oligonucleotide synthesis |
US6274725B1 (en) * | 1998-06-02 | 2001-08-14 | Isis Pharmaceuticals, Inc. | Activators for oligonucleotide synthesis |
AR036122A1 (es) | 2001-07-03 | 2004-08-11 | Avecia Biotechnology Inc | Un complejo de sal que comprende un n-alquilimidazol y una 1,1-dioxo-1,2-dihidro-1l6-benzo [d]-isotiazol-3-ona y un metodo para sintetizar oligonucleotidos utilizando la quimica de fosforamidita |
CN1329408C (zh) * | 2002-10-15 | 2007-08-01 | 艾夫西亚生物科技公司 | 亚磷酰化方法 |
GB0229443D0 (en) * | 2002-12-18 | 2003-01-22 | Avecia Ltd | Process |
-
2002
- 2002-06-28 AR ARP020102444A patent/AR036122A1/es unknown
- 2002-07-01 AT AT02748994T patent/ATE317395T1/de not_active IP Right Cessation
- 2002-07-01 DK DK02748994T patent/DK1404696T3/da active
- 2002-07-01 JP JP2003510678A patent/JP4574167B2/ja not_active Expired - Lifetime
- 2002-07-01 EP EP02748994A patent/EP1404696B1/fr not_active Expired - Lifetime
- 2002-07-01 RU RU2004102903/04A patent/RU2004102903A/ru not_active Application Discontinuation
- 2002-07-01 HU HU0400151A patent/HUP0400151A2/hu unknown
- 2002-07-01 DE DE60209128T patent/DE60209128T2/de not_active Expired - Lifetime
- 2002-07-01 KR KR1020037016969A patent/KR100898083B1/ko active IP Right Grant
- 2002-07-01 ES ES02748994T patent/ES2258151T3/es not_active Expired - Lifetime
- 2002-07-01 CN CNB02817156XA patent/CN100430411C/zh not_active Expired - Lifetime
- 2002-07-01 WO PCT/GB2002/003029 patent/WO2003004512A1/fr active IP Right Grant
- 2002-07-01 US US10/482,441 patent/US7501505B2/en not_active Expired - Lifetime
- 2002-07-01 CA CA2452205A patent/CA2452205C/fr not_active Expired - Lifetime
- 2002-07-01 PL PL02367623A patent/PL367623A1/xx not_active Application Discontinuation
- 2002-07-01 IL IL15940202A patent/IL159402A0/xx unknown
-
2008
- 2008-10-06 US US12/287,116 patent/US8093397B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US7501505B2 (en) | 2009-03-10 |
ATE317395T1 (de) | 2006-02-15 |
US20090085006A1 (en) | 2009-04-02 |
AR036122A1 (es) | 2004-08-11 |
HUP0400151A2 (en) | 2007-08-28 |
EP1404696B1 (fr) | 2006-02-08 |
CA2452205A1 (fr) | 2003-01-16 |
RU2004102903A (ru) | 2005-07-10 |
PL367623A1 (en) | 2005-03-07 |
ES2258151T3 (es) | 2006-08-16 |
JP2004533488A (ja) | 2004-11-04 |
KR100898083B1 (ko) | 2009-05-18 |
EP1404696A1 (fr) | 2004-04-07 |
CN100430411C (zh) | 2008-11-05 |
CN1549820A (zh) | 2004-11-24 |
DK1404696T3 (da) | 2006-06-06 |
JP4574167B2 (ja) | 2010-11-04 |
CA2452205C (fr) | 2011-11-08 |
US8093397B2 (en) | 2012-01-10 |
KR20040015758A (ko) | 2004-02-19 |
DE60209128T2 (de) | 2006-10-05 |
DE60209128D1 (de) | 2006-04-20 |
WO2003004512A1 (fr) | 2003-01-16 |
US20060041114A1 (en) | 2006-02-23 |
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