ATE317395T1 - Aktivatoren für die oligonukleotidsynthese - Google Patents
Aktivatoren für die oligonukleotidsyntheseInfo
- Publication number
- ATE317395T1 ATE317395T1 AT02748994T AT02748994T ATE317395T1 AT E317395 T1 ATE317395 T1 AT E317395T1 AT 02748994 T AT02748994 T AT 02748994T AT 02748994 T AT02748994 T AT 02748994T AT E317395 T1 ATE317395 T1 AT E317395T1
- Authority
- AT
- Austria
- Prior art keywords
- activators
- oligonucleotide synthesis
- oligonucleotide
- synthesis
- Prior art date
Links
- 239000012190 activator Substances 0.000 title 1
- 238000002515 oligonucleotide synthesis Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
- C07D275/06—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
- C07D213/16—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing only one pyridine ring
- C07D213/18—Salts thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Pyridine Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30271701P | 2001-07-03 | 2001-07-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE317395T1 true ATE317395T1 (de) | 2006-02-15 |
Family
ID=23168928
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02748994T ATE317395T1 (de) | 2001-07-03 | 2002-07-01 | Aktivatoren für die oligonukleotidsynthese |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US7501505B2 (de) |
| EP (1) | EP1404696B1 (de) |
| JP (1) | JP4574167B2 (de) |
| KR (1) | KR100898083B1 (de) |
| CN (1) | CN100430411C (de) |
| AR (1) | AR036122A1 (de) |
| AT (1) | ATE317395T1 (de) |
| CA (1) | CA2452205C (de) |
| DE (1) | DE60209128T2 (de) |
| DK (1) | DK1404696T3 (de) |
| ES (1) | ES2258151T3 (de) |
| HU (1) | HUP0400151A2 (de) |
| IL (1) | IL159402A0 (de) |
| PL (1) | PL367623A1 (de) |
| RU (1) | RU2004102903A (de) |
| WO (1) | WO2003004512A1 (de) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR036122A1 (es) | 2001-07-03 | 2004-08-11 | Avecia Biotechnology Inc | Un complejo de sal que comprende un n-alquilimidazol y una 1,1-dioxo-1,2-dihidro-1l6-benzo [d]-isotiazol-3-ona y un metodo para sintetizar oligonucleotidos utilizando la quimica de fosforamidita |
| DE60313993T2 (de) * | 2002-10-15 | 2008-01-24 | Avecia Biotechnology, Inc., Milford | Verfahren zur phosphithylierung |
| GB0229443D0 (en) | 2002-12-18 | 2003-01-22 | Avecia Ltd | Process |
| US8569367B2 (en) | 2004-11-16 | 2013-10-29 | Allergan, Inc. | Ophthalmic compositions and methods for treating eyes |
| US7339052B2 (en) * | 2005-02-08 | 2008-03-04 | Honeywell International Inc. | Phosphoramidite activator for oligonucleotide synthesis |
| EP1874792B1 (de) | 2005-04-27 | 2016-04-13 | Sigma-Aldrich Co. LLC | Aktivatoren für die oligonukleotid- und phosphoramiditsynthese |
| WO2009007736A1 (en) * | 2007-07-12 | 2009-01-15 | Avecia Biotechnology Inc. | Oxidation process |
| KR200457843Y1 (ko) * | 2010-05-26 | 2012-01-10 | 김원제 | 향기 발산 기능을 가지는 악취 차단 커버 |
| CA2805546A1 (en) * | 2010-06-30 | 2012-01-05 | Girindus America, Inc. | A new method of using n-thio compounds for oligonucleotide synthesis |
| US9907826B2 (en) | 2011-12-07 | 2018-03-06 | Allergan, Inc. | Efficient lipid delivery to human tear film using a salt-sensitive emulsion system |
| CN104278030A (zh) * | 2013-07-05 | 2015-01-14 | 上海交通大学医学院 | 小分子化合物Antagomir-31制备方法及应用 |
| UA123995C2 (uk) | 2015-08-05 | 2021-07-07 | ЕЙСАЙ Ар ЕНД Ді МЕНЕДЖМЕНТ КО., ЛТД. | Хіральні реагенти для одержання гомогенних олігомерів |
| US10072261B1 (en) * | 2016-03-25 | 2018-09-11 | Agilent Technologies, Inc. | Double coupling method for oligonucleotide synthesis |
| CN110023321A (zh) | 2016-08-17 | 2019-07-16 | 索尔斯蒂斯生物有限公司 | 多核苷酸构建体 |
| US11597744B2 (en) | 2017-06-30 | 2023-03-07 | Sirius Therapeutics, Inc. | Chiral phosphoramidite auxiliaries and methods of their use |
| WO2019158007A1 (zh) * | 2018-02-13 | 2019-08-22 | 深圳华大生命科学研究院 | 合成寡核苷酸的方法及系统 |
| CN113993876B (zh) * | 2019-06-11 | 2024-06-14 | 豪夫迈·罗氏有限公司 | 使用改进的氧化方案制备寡核苷酸的方法 |
| JPWO2021141072A1 (de) * | 2020-01-08 | 2021-07-15 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US757650A (en) * | 1903-09-30 | 1904-04-19 | Wilfrid Chausse | Means for cleaning the third rails of electrical railways. |
| US3325475A (en) * | 1964-11-16 | 1967-06-13 | Maumee Chemical Company | Organic amine salts of saccharin |
| JPS4822628B1 (de) * | 1967-04-15 | 1973-07-07 | ||
| IT8148047A0 (it) * | 1981-03-18 | 1981-03-18 | Manetti & Roberts Italo Brit | Composti organici derivati da 2-ami no-5-(o-solfamidofenil)-1,3,4-tiadiazolo loro applicazione terapeutica e procedimento per la loro preparazione |
| DE3430805A1 (de) * | 1984-03-08 | 1985-09-19 | Bayer Ag, 5090 Leverkusen | Mikrobizide mittel |
| DE3639901A1 (de) * | 1986-11-22 | 1988-06-01 | Bayer Ag | Saccharin-salze von substituierten aminen |
| US5034534A (en) * | 1988-07-15 | 1991-07-23 | E. I. Du Pont De Nemours And Company | Process for producing saccharin, saccharin analogues or their salts |
| JPH04330093A (ja) * | 1990-07-20 | 1992-11-18 | Takeda Chem Ind Ltd | オリゴリボヌクレオチドの製造法 |
| US5639875A (en) | 1995-02-01 | 1997-06-17 | Hybridon, Inc. | Methods for H-phosphonate syntheis of oligonucleotides using triphosgene |
| WO1998016540A1 (en) * | 1996-10-15 | 1998-04-23 | Proligo Llc | Improved coupling activators for oligonucleotide synthesis |
| US5896999A (en) | 1996-10-16 | 1999-04-27 | United Parcel Service Of America, Inc. | Sorting system |
| US5955600A (en) * | 1996-12-27 | 1999-09-21 | Isis Pharmaceuticals, Inc. | Method for the synthesis of nucleotide or oligonucleotide phosphoramidites |
| US6096881A (en) | 1997-05-30 | 2000-08-01 | Hybridon, Inc. | Sulfur transfer reagents for oligonucleotide synthesis |
| US6274725B1 (en) * | 1998-06-02 | 2001-08-14 | Isis Pharmaceuticals, Inc. | Activators for oligonucleotide synthesis |
| AR036122A1 (es) | 2001-07-03 | 2004-08-11 | Avecia Biotechnology Inc | Un complejo de sal que comprende un n-alquilimidazol y una 1,1-dioxo-1,2-dihidro-1l6-benzo [d]-isotiazol-3-ona y un metodo para sintetizar oligonucleotidos utilizando la quimica de fosforamidita |
| DE60313993T2 (de) * | 2002-10-15 | 2008-01-24 | Avecia Biotechnology, Inc., Milford | Verfahren zur phosphithylierung |
| GB0229443D0 (en) * | 2002-12-18 | 2003-01-22 | Avecia Ltd | Process |
-
2002
- 2002-06-28 AR ARP020102444A patent/AR036122A1/es unknown
- 2002-07-01 ES ES02748994T patent/ES2258151T3/es not_active Expired - Lifetime
- 2002-07-01 DK DK02748994T patent/DK1404696T3/da active
- 2002-07-01 PL PL02367623A patent/PL367623A1/xx not_active Application Discontinuation
- 2002-07-01 WO PCT/GB2002/003029 patent/WO2003004512A1/en active IP Right Grant
- 2002-07-01 EP EP02748994A patent/EP1404696B1/de not_active Expired - Lifetime
- 2002-07-01 IL IL15940202A patent/IL159402A0/xx unknown
- 2002-07-01 US US10/482,441 patent/US7501505B2/en not_active Expired - Lifetime
- 2002-07-01 CN CNB02817156XA patent/CN100430411C/zh not_active Expired - Lifetime
- 2002-07-01 KR KR1020037016969A patent/KR100898083B1/ko active IP Right Grant
- 2002-07-01 JP JP2003510678A patent/JP4574167B2/ja not_active Expired - Lifetime
- 2002-07-01 RU RU2004102903/04A patent/RU2004102903A/ru not_active Application Discontinuation
- 2002-07-01 DE DE60209128T patent/DE60209128T2/de not_active Expired - Lifetime
- 2002-07-01 HU HU0400151A patent/HUP0400151A2/hu unknown
- 2002-07-01 CA CA2452205A patent/CA2452205C/en not_active Expired - Lifetime
- 2002-07-01 AT AT02748994T patent/ATE317395T1/de not_active IP Right Cessation
-
2008
- 2008-10-06 US US12/287,116 patent/US8093397B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0400151A2 (en) | 2007-08-28 |
| DE60209128D1 (de) | 2006-04-20 |
| DE60209128T2 (de) | 2006-10-05 |
| US20060041114A1 (en) | 2006-02-23 |
| AR036122A1 (es) | 2004-08-11 |
| JP4574167B2 (ja) | 2010-11-04 |
| WO2003004512A1 (en) | 2003-01-16 |
| CA2452205C (en) | 2011-11-08 |
| IL159402A0 (en) | 2004-06-01 |
| ES2258151T3 (es) | 2006-08-16 |
| US20090085006A1 (en) | 2009-04-02 |
| US7501505B2 (en) | 2009-03-10 |
| CN1549820A (zh) | 2004-11-24 |
| CA2452205A1 (en) | 2003-01-16 |
| US8093397B2 (en) | 2012-01-10 |
| EP1404696B1 (de) | 2006-02-08 |
| KR100898083B1 (ko) | 2009-05-18 |
| PL367623A1 (en) | 2005-03-07 |
| KR20040015758A (ko) | 2004-02-19 |
| DK1404696T3 (da) | 2006-06-06 |
| JP2004533488A (ja) | 2004-11-04 |
| EP1404696A1 (de) | 2004-04-07 |
| CN100430411C (zh) | 2008-11-05 |
| RU2004102903A (ru) | 2005-07-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |