IL159268A0 - Templated molecules and methods for using such molecules - Google Patents
Templated molecules and methods for using such moleculesInfo
- Publication number
- IL159268A0 IL159268A0 IL15926802A IL15926802A IL159268A0 IL 159268 A0 IL159268 A0 IL 159268A0 IL 15926802 A IL15926802 A IL 15926802A IL 15926802 A IL15926802 A IL 15926802A IL 159268 A0 IL159268 A0 IL 159268A0
- Authority
- IL
- Israel
- Prior art keywords
- molecules
- templated
- methods
- templated molecules
- intion
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1062—Isolating an individual clone by screening libraries mRNA-Display, e.g. polypeptide and encoding template are connected covalently
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1068—Template (nucleic acid) mediated chemical library synthesis, e.g. chemical and enzymatical DNA-templated organic molecule synthesis, libraries prepared by non ribosomal polypeptide synthesis [NRPS], DNA/RNA-polymerase mediated polypeptide synthesis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1075—Isolating an individual clone by screening libraries by coupling phenotype to genotype, not provided for in other groups of this subclass
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/30—Nucleotides
- C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
- C40B50/04—Methods of creating libraries, e.g. combinatorial synthesis using dynamic combinatorial chemistry techniques
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
- C40B50/06—Biochemical methods, e.g. using enzymes or whole viable microorganisms
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00452—Means for the recovery of reactants or products
- B01J2219/00454—Means for the recovery of reactants or products by chemical cleavage from the solid support
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00596—Solid-phase processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/0068—Means for controlling the apparatus of the process
- B01J2219/00702—Processes involving means for analysing and characterising the products
- B01J2219/00707—Processes involving means for analysing and characterising the products separated from the reactor apparatus
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00718—Type of compounds synthesised
- B01J2219/0072—Organic compounds
- B01J2219/00722—Nucleotides
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00718—Type of compounds synthesised
- B01J2219/0072—Organic compounds
- B01J2219/00729—Peptide nucleic acids [PNA]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/11—Compounds covalently bound to a solid support
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Bioinformatics & Computational Biology (AREA)
- Biophysics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DKPA200100962 | 2001-06-20 | ||
DKPA200200415 | 2002-03-15 | ||
PCT/DK2002/000419 WO2002103008A2 (fr) | 2001-06-20 | 2002-06-20 | Molecules a matrice et procedes d'utilisation de ces dernieres |
Publications (1)
Publication Number | Publication Date |
---|---|
IL159268A0 true IL159268A0 (en) | 2004-06-01 |
Family
ID=26069037
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL15926802A IL159268A0 (en) | 2001-06-20 | 2002-06-20 | Templated molecules and methods for using such molecules |
Country Status (14)
Country | Link |
---|---|
EP (3) | EP1905829B1 (fr) |
JP (1) | JP2004535193A (fr) |
CN (1) | CN1539014A (fr) |
AT (1) | ATE371026T1 (fr) |
CA (1) | CA2451524A1 (fr) |
CY (2) | CY1117517T1 (fr) |
DE (1) | DE60221986D1 (fr) |
DK (3) | DK1402024T3 (fr) |
ES (2) | ES2571835T3 (fr) |
IL (1) | IL159268A0 (fr) |
NO (1) | NO20035226L (fr) |
NZ (1) | NZ530098A (fr) |
RU (1) | RU2004101289A (fr) |
WO (1) | WO2002103008A2 (fr) |
Families Citing this family (60)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2332896A3 (fr) | 2001-03-19 | 2012-09-26 | President and Fellows of Harvard College | Evolution d'une nouvelle fonction moléculaire |
WO2002102820A1 (fr) | 2001-06-20 | 2002-12-27 | Nuevolution A/S | Derives nucleosidiques pour elaboration de bibliotheque combinatoire |
ES2571933T3 (es) * | 2002-03-15 | 2016-05-27 | Nuevolution As | Método mejorado para sintetizar moléculas modeladas |
AU2003214031A1 (en) | 2002-03-15 | 2003-09-29 | Nuevolution A/S | An improved method for synthesising templated molecules |
TWI332956B (en) * | 2002-04-26 | 2010-11-11 | Gilead Sciences Inc | Cellular accumulation of phosphonate analogs of hiv protease inhibitor compounds |
WO2004013070A2 (fr) * | 2002-08-01 | 2004-02-12 | Nuevolution A/S | Synthese en plusieurs etapes de molecules synthetisees |
CN102838654B (zh) | 2002-10-30 | 2016-05-18 | 纽韦卢森公司 | 合成双功能复合物的方法 |
AU2011226815B2 (en) * | 2002-10-30 | 2014-09-25 | Nuevolution A/S | Enzymatic encoding |
AU2003291964A1 (en) * | 2002-12-19 | 2004-07-14 | Nuevolution A/S | Quasirandom structure and function guided synthesis methods |
US20070026397A1 (en) * | 2003-02-21 | 2007-02-01 | Nuevolution A/S | Method for producing second-generation library |
US20060269920A1 (en) * | 2003-02-21 | 2006-11-30 | Nuevolution A/S | Method for obtaining structural information about an encoded molecule |
EP1608748B1 (fr) * | 2003-03-20 | 2009-03-04 | Nuevolution A/S | Codage par ligature de petites molecules |
US7432261B2 (en) | 2003-04-25 | 2008-10-07 | Gilead Sciences, Inc. | Anti-inflammatory phosphonate compounds |
WO2005002626A2 (fr) | 2003-04-25 | 2005-01-13 | Gilead Sciences, Inc. | Composes de phosphonate therapeutiques |
US7470724B2 (en) | 2003-04-25 | 2008-12-30 | Gilead Sciences, Inc. | Phosphonate compounds having immuno-modulatory activity |
US7407965B2 (en) | 2003-04-25 | 2008-08-05 | Gilead Sciences, Inc. | Phosphonate analogs for treating metabolic diseases |
WO2004096285A2 (fr) | 2003-04-25 | 2004-11-11 | Gilead Sciences, Inc. | Analogues anti-infectieux du phosphonate |
AU2004233897A1 (en) | 2003-04-25 | 2004-11-11 | Gilead Sciences, Inc. | Kinase inhibitor phosphonate conjugates |
US7452901B2 (en) | 2003-04-25 | 2008-11-18 | Gilead Sciences, Inc. | Anti-cancer phosphonate analogs |
SG182849A1 (en) | 2003-04-25 | 2012-08-30 | Gilead Sciences Inc | Antiviral phosphonate analogs |
WO2004096287A2 (fr) | 2003-04-25 | 2004-11-11 | Gilead Sciences, Inc. | Composes de phosphonate inhibiteurs de l'inosine monophosphate deshydrogenase |
WO2004110964A2 (fr) * | 2003-06-16 | 2004-12-23 | Nuevolution A/S | Molecules codees par traduction genetique (emt) |
EP1533385A1 (fr) * | 2003-09-05 | 2005-05-25 | Nuevolution A/S | Composés à matrice pour la génération de molécules codées et procédés dirigés utilisant ces derniers |
DK1670939T3 (da) | 2003-09-18 | 2010-03-01 | Nuevolution As | Fremgangsmåde til opnåelse af strukturel information om et kodet molekyle og fremgangsmåde til udvælgelse af forbindelser |
AU2004286238A1 (en) | 2003-10-24 | 2005-05-12 | Gilead Sciences, Inc. | Methods and compositions for identifying therapeutic compounds |
WO2005044279A1 (fr) | 2003-10-24 | 2005-05-19 | Gilead Sciences, Inc. | Conjugues phosphonate / inhibiteur de purine nucleoside phosphorylase |
US7432273B2 (en) | 2003-10-24 | 2008-10-07 | Gilead Sciences, Inc. | Phosphonate analogs of antimetabolites |
US7972994B2 (en) | 2003-12-17 | 2011-07-05 | Glaxosmithkline Llc | Methods for synthesis of encoded libraries |
WO2005058479A2 (fr) | 2003-12-17 | 2005-06-30 | Praecis Pharmaceuticals, Inc. | Procedes de synthese de bibliotheques codees |
ATE424400T1 (de) | 2003-12-22 | 2009-03-15 | Gilead Sciences Inc | 4'-substituierte carbovir- und abacavir-derivate sowie verwandte verbindungen mit hiv- und hcv- antiviraler wirkung |
EP1723255B1 (fr) | 2004-02-17 | 2010-12-29 | Nuevolution A/S | Methode d'elimination visant a un enrichissement par hybridation de mesappariements |
EP1730277B1 (fr) * | 2004-03-22 | 2009-10-28 | Nuevolution A/S | Codage par ligature utilisant des oligonucleotides motifs structuraux |
ATE505196T1 (de) | 2004-07-27 | 2011-04-15 | Gilead Sciences Inc | Nukleosid phosphonat konjugate als anti hiv mittel |
DE602005012319D1 (de) | 2004-11-22 | 2009-02-26 | Peter Birk Rasmussen | Matrizengerichtete split-and-mix-synthese von bibliotheken kleiner moleküle |
CA2595590C (fr) * | 2005-01-21 | 2015-04-21 | President And Fellows Of Harvard College | Utilisation de reactif libre dans la synthese faisant appel a une matrice d'acide nucleique |
ATE461279T1 (de) * | 2005-06-07 | 2010-04-15 | Harvard College | Geordnete mehrschrittsynthese mittels nukleinsäurevermittelter chemie |
DK2258870T3 (da) | 2005-06-09 | 2013-03-18 | Glaxosmithkline Llc | Fremgangsmåde til at identificere forbindelser der binder til et biologisk target-molekyle |
WO2007011722A2 (fr) | 2005-07-15 | 2007-01-25 | President And Fellows Of Harvard College | Systeme de decouverte de reaction |
WO2007053358A2 (fr) | 2005-10-28 | 2007-05-10 | Praecis Pharmaceuticals, Inc. | Procedes d'identification de composes etudies, par recours a des bibliotheques codees |
SI3305900T1 (sl) | 2005-12-01 | 2022-02-28 | Nuevolution A/S | Postopki encimskega kodiranja za učinkovito sintezo velikih knjižnic |
WO2009085328A1 (fr) * | 2008-01-03 | 2009-07-09 | Helicos Biosciences Corporation | Molécules et procédés pour le séquençage d'un acide nucléique |
JP4777373B2 (ja) * | 2008-02-14 | 2011-09-21 | 独立行政法人科学技術振興機構 | 光応答性核酸の製造方法 |
ES2393962T3 (es) | 2008-07-08 | 2013-01-03 | Gilead Sciences, Inc. | Sales de compuestos inhibidores del VIH. |
JP4621926B2 (ja) | 2008-07-24 | 2011-02-02 | 国立大学法人九州大学 | 酵素基質修飾ヌクレオシド三リン酸、核酸プローブ、マルチラベル化核酸プローブ、マルチラベル化核酸プローブの製造方法および標的核酸の検出方法 |
WO2010086603A1 (fr) * | 2009-01-30 | 2010-08-05 | Oxford Nanopore Technologies Limited | Enzyme mutante |
US9359601B2 (en) | 2009-02-13 | 2016-06-07 | X-Chem, Inc. | Methods of creating and screening DNA-encoded libraries |
SI2558577T1 (sl) | 2010-04-16 | 2019-05-31 | Nuevolution A/S | Bifunkcionalni kompleksi in metode za pripravo in uporabo takšnih kompleksov |
EP3399035B1 (fr) | 2010-09-27 | 2021-02-17 | Vipergen | Procédé de préparation d'une banque enrichie |
IN2014CN02574A (fr) | 2011-09-07 | 2015-06-26 | Chem Inc X | |
US8669314B2 (en) | 2012-02-03 | 2014-03-11 | Sabic Innovative Plastics Ip B.V. | Hydrolytic stability in polycarbonate compositions |
AU2013289993B2 (en) | 2012-07-13 | 2018-05-10 | X-Chem, Inc. | DNA-encoded libraries having encoding oligonucleotide linkages not readable by polymerases |
WO2014187314A1 (fr) | 2013-05-21 | 2014-11-27 | 成都先导药物开发有限公司 | Procédé de capture de cibles de médicaments |
GB201322692D0 (en) | 2013-12-20 | 2014-02-05 | Philochem Ag | Production of encoded chemical libraries |
EP3218479A1 (fr) | 2014-11-11 | 2017-09-20 | Nanocore ApS | Procédé d'identification de molécules présentant des caractéristiques souhaitées |
CN105461632B (zh) * | 2016-01-04 | 2018-01-09 | 湖北泓肽生物科技有限公司 | 一种n‑乙酰‑l‑肌肽的制备方法 |
US10326855B2 (en) | 2016-07-28 | 2019-06-18 | International Business Machines Corporation | Trending topic driven cache eviction management |
CN110325491B (zh) * | 2017-03-17 | 2022-04-19 | 成都先导药物开发股份有限公司 | 编码库的合成方法及组合物 |
WO2018191582A1 (fr) * | 2017-04-13 | 2018-10-18 | The Board Of Trustees Of The University Of Illinois | Analyse permettant de quantifier des polyphosphates |
ES2969496T3 (es) | 2017-08-01 | 2024-05-20 | Gilead Sciences Inc | Formas cristalinas de ((S)-((((2R,5R)-5-(6-amino-9H-purin-9-il)-4-fluoro-2,5-dihidrofuran-2- il)oxi)metil)(fenoxi)fosforil)-L-alaninato de etilo para tratar infecciones virales |
WO2020152028A1 (fr) | 2019-01-22 | 2020-07-30 | Vipergen Aps | Procédé de criblage d'une banque d'affichage in vitro dans une cellule |
Family Cites Families (41)
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US4863857A (en) | 1985-03-01 | 1989-09-05 | Board Of Regents, The University Of Texas System | Polypeptide complementary to peptides or proteins having an amino acid sequence or nucleotide coding sequence at least partially known |
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-
2002
- 2002-06-20 DE DE60221986T patent/DE60221986D1/de not_active Expired - Lifetime
- 2002-06-20 ES ES07114663T patent/ES2571835T3/es not_active Expired - Lifetime
- 2002-06-20 CA CA002451524A patent/CA2451524A1/fr not_active Abandoned
- 2002-06-20 EP EP07114663.3A patent/EP1905829B1/fr not_active Expired - Lifetime
- 2002-06-20 AT AT02740409T patent/ATE371026T1/de not_active IP Right Cessation
- 2002-06-20 CN CNA028154207A patent/CN1539014A/zh active Pending
- 2002-06-20 RU RU2004101289/04A patent/RU2004101289A/ru not_active Application Discontinuation
- 2002-06-20 DK DK02740409T patent/DK1402024T3/da active
- 2002-06-20 ES ES10184311T patent/ES2571945T3/es not_active Expired - Lifetime
- 2002-06-20 IL IL15926802A patent/IL159268A0/xx unknown
- 2002-06-20 DK DK07114663.3T patent/DK1905829T3/en active
- 2002-06-20 WO PCT/DK2002/000419 patent/WO2002103008A2/fr active Search and Examination
- 2002-06-20 EP EP10184311.8A patent/EP2305808B1/fr not_active Expired - Lifetime
- 2002-06-20 JP JP2003505331A patent/JP2004535193A/ja active Pending
- 2002-06-20 DK DK10184311.8T patent/DK2305808T3/en active
- 2002-06-20 EP EP02740409A patent/EP1402024B1/fr not_active Expired - Lifetime
- 2002-06-20 NZ NZ530098A patent/NZ530098A/en unknown
-
2003
- 2003-11-24 NO NO20035226A patent/NO20035226L/no not_active Application Discontinuation
-
2016
- 2016-05-13 CY CY20161100419T patent/CY1117517T1/el unknown
- 2016-05-13 CY CY20161100420T patent/CY1117518T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
JP2004535193A (ja) | 2004-11-25 |
CY1117518T1 (el) | 2017-04-26 |
EP1905829B1 (fr) | 2016-02-17 |
RU2004101289A (ru) | 2005-07-10 |
DK2305808T3 (en) | 2016-05-23 |
DK1905829T3 (en) | 2016-05-23 |
ATE371026T1 (de) | 2007-09-15 |
ES2571835T3 (es) | 2016-05-27 |
ES2571945T3 (es) | 2016-05-27 |
EP2305808A1 (fr) | 2011-04-06 |
EP2305808B1 (fr) | 2016-03-02 |
DK1402024T3 (da) | 2007-12-27 |
WO2002103008A2 (fr) | 2002-12-27 |
NO20035226D0 (no) | 2003-11-24 |
EP1905829A2 (fr) | 2008-04-02 |
NZ530098A (en) | 2006-02-24 |
DE60221986D1 (de) | 2007-10-04 |
EP1905829A3 (fr) | 2009-06-24 |
WO2002103008A3 (fr) | 2003-11-27 |
NO20035226L (no) | 2004-02-16 |
CY1117517T1 (el) | 2017-04-26 |
EP1402024B1 (fr) | 2007-08-22 |
CA2451524A1 (fr) | 2002-12-27 |
CN1539014A (zh) | 2004-10-20 |
EP1402024A2 (fr) | 2004-03-31 |
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