NO20035226L - Templatinkluderende molekyler og fremgangsmater til anvendelse av slike molekyler - Google Patents
Templatinkluderende molekyler og fremgangsmater til anvendelse av slike molekylerInfo
- Publication number
- NO20035226L NO20035226L NO20035226A NO20035226A NO20035226L NO 20035226 L NO20035226 L NO 20035226L NO 20035226 A NO20035226 A NO 20035226A NO 20035226 A NO20035226 A NO 20035226A NO 20035226 L NO20035226 L NO 20035226L
- Authority
- NO
- Norway
- Prior art keywords
- molecules
- template
- inclusive
- methods
- templated
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1062—Isolating an individual clone by screening libraries mRNA-Display, e.g. polypeptide and encoding template are connected covalently
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1068—Template (nucleic acid) mediated chemical library synthesis, e.g. chemical and enzymatical DNA-templated organic molecule synthesis, libraries prepared by non ribosomal polypeptide synthesis [NRPS], DNA/RNA-polymerase mediated polypeptide synthesis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1075—Isolating an individual clone by screening libraries by coupling phenotype to genotype, not provided for in other groups of this subclass
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/30—Nucleotides
- C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
- C40B50/04—Methods of creating libraries, e.g. combinatorial synthesis using dynamic combinatorial chemistry techniques
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
- C40B50/06—Biochemical methods, e.g. using enzymes or whole viable microorganisms
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00452—Means for the recovery of reactants or products
- B01J2219/00454—Means for the recovery of reactants or products by chemical cleavage from the solid support
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00596—Solid-phase processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/0068—Means for controlling the apparatus of the process
- B01J2219/00702—Processes involving means for analysing and characterising the products
- B01J2219/00707—Processes involving means for analysing and characterising the products separated from the reactor apparatus
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00718—Type of compounds synthesised
- B01J2219/0072—Organic compounds
- B01J2219/00722—Nucleotides
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00718—Type of compounds synthesised
- B01J2219/0072—Organic compounds
- B01J2219/00729—Peptide nucleic acids [PNA]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/11—Compounds covalently bound to a solid support
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DKPA200100962 | 2001-06-20 | ||
DKPA200200415 | 2002-03-15 | ||
PCT/DK2002/000419 WO2002103008A2 (en) | 2001-06-20 | 2002-06-20 | Templated molecules and methods for using such molecules |
Publications (2)
Publication Number | Publication Date |
---|---|
NO20035226D0 NO20035226D0 (no) | 2003-11-24 |
NO20035226L true NO20035226L (no) | 2004-02-16 |
Family
ID=26069037
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20035226A NO20035226L (no) | 2001-06-20 | 2003-11-24 | Templatinkluderende molekyler og fremgangsmater til anvendelse av slike molekyler |
Country Status (14)
Country | Link |
---|---|
EP (3) | EP1402024B1 (no) |
JP (1) | JP2004535193A (no) |
CN (1) | CN1539014A (no) |
AT (1) | ATE371026T1 (no) |
CA (1) | CA2451524A1 (no) |
CY (2) | CY1117518T1 (no) |
DE (1) | DE60221986D1 (no) |
DK (3) | DK1402024T3 (no) |
ES (2) | ES2571835T3 (no) |
IL (1) | IL159268A0 (no) |
NO (1) | NO20035226L (no) |
NZ (1) | NZ530098A (no) |
RU (1) | RU2004101289A (no) |
WO (1) | WO2002103008A2 (no) |
Families Citing this family (60)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002074929A2 (en) | 2001-03-19 | 2002-09-26 | President And Fellows Of Harvard College | Evolving new molecular function |
WO2002102820A1 (en) | 2001-06-20 | 2002-12-27 | Nuevolution A/S | Nucleoside derivatives for library preparation |
SI2186897T1 (sl) * | 2002-03-15 | 2016-06-30 | Nuevolution A/S | Izboljšan postopek za sintetiziranje matričnih molekul |
US7413854B2 (en) * | 2002-03-15 | 2008-08-19 | Nuevolution A/S | Method for synthesising templated molecules |
CA2481449A1 (en) * | 2002-04-26 | 2003-11-06 | Gilead Sciences, Inc. | Method and compositions for identifying anti-hiv therapeutic compounds |
US10730906B2 (en) * | 2002-08-01 | 2020-08-04 | Nuevolutions A/S | Multi-step synthesis of templated molecules |
AU2011226815B2 (en) * | 2002-10-30 | 2014-09-25 | Nuevolution A/S | Enzymatic encoding |
EP3299463B1 (en) * | 2002-10-30 | 2020-10-21 | Nuevolution A/S | Enzymatic encoding |
WO2004056994A2 (en) * | 2002-12-19 | 2004-07-08 | Nuevolution A/S | Quasirandom structure and function guided synthesis methods |
EP1597394A2 (en) * | 2003-02-21 | 2005-11-23 | Nuevolution A/S | A method for obtaining structural information about an encoded molecule |
WO2004074429A2 (en) * | 2003-02-21 | 2004-09-02 | Nuevolution A/S | Method for producing second-generation library |
DE602004019764D1 (de) | 2003-03-20 | 2009-04-16 | Nuevolution As | Ligationsvermittelnde codierung von kleinen molekülen |
US7407965B2 (en) | 2003-04-25 | 2008-08-05 | Gilead Sciences, Inc. | Phosphonate analogs for treating metabolic diseases |
NZ542342A (en) | 2003-04-25 | 2009-05-31 | Gilead Sciences Inc | Antiviral phosphonate analogs |
US7427636B2 (en) | 2003-04-25 | 2008-09-23 | Gilead Sciences, Inc. | Inosine monophosphate dehydrogenase inhibitory phosphonate compounds |
US7452901B2 (en) | 2003-04-25 | 2008-11-18 | Gilead Sciences, Inc. | Anti-cancer phosphonate analogs |
WO2005002626A2 (en) | 2003-04-25 | 2005-01-13 | Gilead Sciences, Inc. | Therapeutic phosphonate compounds |
US7432261B2 (en) | 2003-04-25 | 2008-10-07 | Gilead Sciences, Inc. | Anti-inflammatory phosphonate compounds |
WO2004096285A2 (en) | 2003-04-25 | 2004-11-11 | Gilead Sciences, Inc. | Anti-infective phosphonate conjugates |
US7273716B2 (en) | 2003-04-25 | 2007-09-25 | Gilead Sciences, Inc. | Methods and compositions for identifying therapeutic compounds with GS-7340 ester hydrolase |
EP1620109A2 (en) | 2003-04-25 | 2006-02-01 | Gilead Sciences, Inc. | Kinase inhibitor phosphonate conjugates |
US7470724B2 (en) | 2003-04-25 | 2008-12-30 | Gilead Sciences, Inc. | Phosphonate compounds having immuno-modulatory activity |
WO2004110964A2 (en) * | 2003-06-16 | 2004-12-23 | Nuevolution A/S | Encoded molecules by translation (emt) |
EP1533385A1 (en) * | 2003-09-05 | 2005-05-25 | Nuevolution A/S | Templated compounds for generation of encoded molecules and directional methods using such compounds |
WO2005026387A1 (en) * | 2003-09-18 | 2005-03-24 | Nuevolution A/S | A method for obtaining structural information concerning an encoded molecule and method for selecting compounds |
WO2005044308A1 (en) | 2003-10-24 | 2005-05-19 | Gilead Sciences, Inc. | Phosphonate analogs of antimetabolites |
WO2005044279A1 (en) | 2003-10-24 | 2005-05-19 | Gilead Sciences, Inc. | Purine nucleoside phosphonate conjugates |
NZ547723A (en) | 2003-12-17 | 2009-09-25 | Praecis Pharm Inc | Methods for synthesis of encoded libraries |
US7972994B2 (en) | 2003-12-17 | 2011-07-05 | Glaxosmithkline Llc | Methods for synthesis of encoded libraries |
WO2005063751A1 (en) | 2003-12-22 | 2005-07-14 | Gilead Sciences, Inc. | 4’-substituted carbovir-and abacavir-derivatives as well as related compounds with hiv and hcv antiviral activity |
US20090239211A1 (en) | 2004-02-17 | 2009-09-24 | Nuevolution A/S | Method For Enrichment Involving Elimination By Mismatch Hybridisation |
EP1730277B1 (en) * | 2004-03-22 | 2009-10-28 | Nuevolution A/S | Ligational encoding using building block oligonucleotides |
AU2005330489B2 (en) | 2004-07-27 | 2011-08-25 | Gilead Sciences, Inc. | Nucleoside phosphonate conjugates as anti HIV agents |
DE602005012319D1 (de) | 2004-11-22 | 2009-02-26 | Peter Birk Rasmussen | Matrizengerichtete split-and-mix-synthese von bibliotheken kleiner moleküle |
AU2006206219B2 (en) * | 2005-01-21 | 2012-07-26 | President And Fellows Of Harvard College | Free reactant use in nucleic acid-templated synthesis |
WO2006133312A2 (en) * | 2005-06-07 | 2006-12-14 | President And Fellows Of Harvard College | Ordered multi-step synthesis by nucleic acid-mediated chemistry |
DE602006021580D1 (de) | 2005-06-09 | 2011-06-09 | Praecis Pharm Inc | Verfahren zur synthese codierter bibliotheken |
WO2007011722A2 (en) | 2005-07-15 | 2007-01-25 | President And Fellows Of Harvard College | Reaction discovery system |
EP1940755A2 (en) | 2005-10-28 | 2008-07-09 | Praecis Pharmaceuticals Inc. | Methods for identifying compounds of interest using encoded libraries |
LT3305900T (lt) | 2005-12-01 | 2021-11-10 | Nuevolution A/S | Fermentiniai kodavimo būdai didelių bibliotekų efektyviai sintezei |
WO2009085328A1 (en) * | 2008-01-03 | 2009-07-09 | Helicos Biosciences Corporation | Molecules and methods for nucleic acid sequencing |
JP4777373B2 (ja) | 2008-02-14 | 2011-09-21 | 独立行政法人科学技術振興機構 | 光応答性核酸の製造方法 |
WO2010005986A1 (en) | 2008-07-08 | 2010-01-14 | Gilead Sciences, Inc. | Salts of hiv inhibitor compounds |
JP4621926B2 (ja) | 2008-07-24 | 2011-02-02 | 国立大学法人九州大学 | 酵素基質修飾ヌクレオシド三リン酸、核酸プローブ、マルチラベル化核酸プローブ、マルチラベル化核酸プローブの製造方法および標的核酸の検出方法 |
WO2010086603A1 (en) * | 2009-01-30 | 2010-08-05 | Oxford Nanopore Technologies Limited | Enzyme mutant |
KR20170119729A (ko) | 2009-02-13 | 2017-10-27 | 엑스-켐, 인크. | Dna―코딩된 라이브러리의 생성 및 스크리닝 방법 |
US11225655B2 (en) | 2010-04-16 | 2022-01-18 | Nuevolution A/S | Bi-functional complexes and methods for making and using such complexes |
CA2808656C (en) | 2010-09-27 | 2019-12-03 | Vipergen | A method for making an enriched library |
WO2013036810A1 (en) | 2011-09-07 | 2013-03-14 | X-Chem, Inc. | Methods for tagging dna-encoded libraries |
US8669314B2 (en) | 2012-02-03 | 2014-03-11 | Sabic Innovative Plastics Ip B.V. | Hydrolytic stability in polycarbonate compositions |
IL236633B (en) | 2012-07-13 | 2022-07-01 | X Chem Inc | DNA-encoded libraries containing a conjugate containing conjugated oligonucleotide links |
WO2014187314A1 (zh) | 2013-05-21 | 2014-11-27 | 成都先导药物开发有限公司 | 一种药物靶标捕获方法 |
GB201322692D0 (en) | 2013-12-20 | 2014-02-05 | Philochem Ag | Production of encoded chemical libraries |
WO2016074683A1 (en) | 2014-11-11 | 2016-05-19 | Lundorf Pedersen Materials Aps | Method for identification of molecules with desired characteristics |
CN105461632B (zh) * | 2016-01-04 | 2018-01-09 | 湖北泓肽生物科技有限公司 | 一种n‑乙酰‑l‑肌肽的制备方法 |
US10326855B2 (en) | 2016-07-28 | 2019-06-18 | International Business Machines Corporation | Trending topic driven cache eviction management |
KR102222242B1 (ko) * | 2017-03-17 | 2021-03-04 | 히트젠 주식회사 | 코드 라이브러리 합성방법 및 조성물 |
US11519917B2 (en) | 2017-04-13 | 2022-12-06 | The Regents Of The University Of Michigan | Assay for quantifying polyphosphates |
SI3661937T1 (sl) | 2017-08-01 | 2021-11-30 | Gilead Sciences, Inc. | Kristalinične oblike etil((S)-((((2R,5R)-5-(6-amino-9H-purin-9-IL)-4- fluoro-2,5-dihidrofuran-2-IL)oksi)metil)(fenoksi)fosforil)-L-alaninata (GS-9131) za zdravljenje virusnih okužb |
EP3914704B9 (en) | 2019-01-22 | 2023-10-04 | Vipergen APS | A method for screening of an in vitro display library within a cell |
Family Cites Families (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4863857A (en) | 1985-03-01 | 1989-09-05 | Board Of Regents, The University Of Texas System | Polypeptide complementary to peptides or proteins having an amino acid sequence or nucleotide coding sequence at least partially known |
US5506337A (en) | 1985-03-15 | 1996-04-09 | Antivirals Inc. | Morpholino-subunit combinatorial library and method |
ATE93541T1 (de) | 1985-07-03 | 1993-09-15 | Genencor Int | Hybride polypeptide und verfahren zu deren herstellung. |
US5162218A (en) | 1988-11-18 | 1992-11-10 | The Regents Of The University Of California | Conjugated polypeptides and methods for their preparation |
ES2118066T3 (es) | 1989-10-05 | 1998-09-16 | Optein Inc | Sintesis y aislamiento, exentos de celulas, de nuevos genes y polipeptidos. |
US5660985A (en) | 1990-06-11 | 1997-08-26 | Nexstar Pharmaceuticals, Inc. | High affinity nucleic acid ligands containing modified nucleotides |
US5843701A (en) | 1990-08-02 | 1998-12-01 | Nexstar Pharmaceticals, Inc. | Systematic polypeptide evolution by reverse translation |
AU8498091A (en) | 1990-08-02 | 1992-03-02 | Regents Of The University Of Colorado, The | Systematic polypeptide evolution by reverse translation |
US6140496A (en) | 1990-10-09 | 2000-10-31 | Benner; Steven Albert | Precursors for deoxyribonucleotides containing non-standard nucleosides |
US6037120A (en) | 1995-10-12 | 2000-03-14 | Benner; Steven Albert | Recognition of oligonucleotides containing non-standard base pairs |
US5539082A (en) | 1993-04-26 | 1996-07-23 | Nielsen; Peter E. | Peptide nucleic acids |
US5641625A (en) | 1992-05-22 | 1997-06-24 | Isis Pharmaceuticals, Inc. | Cleaving double-stranded DNA with peptide nucleic acids |
US5719262A (en) | 1993-11-22 | 1998-02-17 | Buchardt, Deceased; Ole | Peptide nucleic acids having amino acid side chains |
AU2313392A (en) * | 1991-08-01 | 1993-03-02 | University Research Corporation | Systematic polypeptide evolution by reverse translation |
DE59209203D1 (de) | 1991-08-28 | 1998-03-26 | Boehringer Mannheim Gmbh | Primer für matrizenabhängige enzymatische nukleinsäuresynthesen |
AU669489B2 (en) | 1991-09-18 | 1996-06-13 | Affymax Technologies N.V. | Method of synthesizing diverse collections of oligomers |
US5639603A (en) | 1991-09-18 | 1997-06-17 | Affymax Technologies N.V. | Synthesizing and screening molecular diversity |
US5270170A (en) | 1991-10-16 | 1993-12-14 | Affymax Technologies N.V. | Peptide library and screening method |
US5573905A (en) | 1992-03-30 | 1996-11-12 | The Scripps Research Institute | Encoded combinatorial chemical libraries |
US5721099A (en) | 1992-10-01 | 1998-02-24 | Trustees Of Columbia University In The City Of New York | Complex combinatorial chemical libraries encoded with tags |
US5840485A (en) | 1993-05-27 | 1998-11-24 | Selectide Corporation | Topologically segregated, encoded solid phase libraries |
US5922545A (en) | 1993-10-29 | 1999-07-13 | Affymax Technologies N.V. | In vitro peptide and antibody display libraries |
DE4343591A1 (de) | 1993-12-21 | 1995-06-22 | Evotec Biosystems Gmbh | Verfahren zum evolutiven Design und Synthese funktionaler Polymere auf der Basis von Formenelementen und Formencodes |
US6127154A (en) | 1994-02-10 | 2000-10-03 | Mosbach; Klaus | Methods for direct synthesis of compounds having complementary structure to a desired molecular entity and use thereof |
US5597697A (en) | 1994-09-30 | 1997-01-28 | Diamond; Paul | Screening assay for inhibitors and activators of RNA and DNA-dependent nucleic acid polymerases |
DE19646372C1 (de) * | 1995-11-11 | 1997-06-19 | Evotec Biosystems Gmbh | Genotyp und Phänotyp koppelnde Verbindung |
US5846839A (en) | 1995-12-22 | 1998-12-08 | Glaxo Group Limited | Methods for hard-tagging an encoded synthetic library |
US5998140A (en) | 1996-07-31 | 1999-12-07 | The Scripps Research Institute | Complex formation between dsDNA and oligomer of cyclic heterocycles |
EP1477561B1 (en) * | 1996-10-17 | 2008-12-10 | Mitsubishi Chemical Corporation | Molecule assigning genotype to phenotype and use thereof |
US5958703A (en) | 1996-12-03 | 1999-09-28 | Glaxo Group Limited | Use of modified tethers in screening compound libraries |
US6080826A (en) | 1997-01-06 | 2000-06-27 | California Institute Of Technology | Template-directed ring-closing metathesis and ring-opening metathesis polymerization of functionalized dienes |
US6261804B1 (en) | 1997-01-21 | 2001-07-17 | The General Hospital Corporation | Selection of proteins using RNA-protein fusions |
WO1998031700A1 (en) | 1997-01-21 | 1998-07-23 | The General Hospital Corporation | Selection of proteins using rna-protein fusions |
US6969584B2 (en) * | 1997-06-12 | 2005-11-29 | Rigel Pharmaceuticals, Inc. | Combinatorial enzymatic complexes |
US6175001B1 (en) | 1998-10-16 | 2001-01-16 | The Scripps Research Institute | Functionalized pyrimidine nucleosides and nucleotides and DNA's incorporating same |
US7479472B1 (en) * | 1998-10-19 | 2009-01-20 | The Board Of Trustees Of The Leland Stanford Junior University | DNA-templated combinatorial library chemistry |
WO2000032823A1 (en) * | 1998-12-02 | 2000-06-08 | Phylos, Inc. | Dna-protein fusions and uses thereof |
EP1208219A1 (en) * | 1999-04-08 | 2002-05-29 | Pavel Sergeev | Synthesis of biologically active compounds in cells |
US7060440B1 (en) | 1999-09-01 | 2006-06-13 | Yeda Research And Development Co. Ltd. | Template-dependent nucleic acid polymerization using oligonucleotide triphosphates building blocks |
WO2002074929A2 (en) * | 2001-03-19 | 2002-09-26 | President And Fellows Of Harvard College | Evolving new molecular function |
-
2002
- 2002-06-20 AT AT02740409T patent/ATE371026T1/de not_active IP Right Cessation
- 2002-06-20 DE DE60221986T patent/DE60221986D1/de not_active Expired - Lifetime
- 2002-06-20 IL IL15926802A patent/IL159268A0/xx unknown
- 2002-06-20 RU RU2004101289/04A patent/RU2004101289A/ru not_active Application Discontinuation
- 2002-06-20 EP EP02740409A patent/EP1402024B1/en not_active Expired - Lifetime
- 2002-06-20 CA CA002451524A patent/CA2451524A1/en not_active Abandoned
- 2002-06-20 CN CNA028154207A patent/CN1539014A/zh active Pending
- 2002-06-20 EP EP10184311.8A patent/EP2305808B1/en not_active Expired - Lifetime
- 2002-06-20 WO PCT/DK2002/000419 patent/WO2002103008A2/en active Search and Examination
- 2002-06-20 DK DK02740409T patent/DK1402024T3/da active
- 2002-06-20 JP JP2003505331A patent/JP2004535193A/ja active Pending
- 2002-06-20 EP EP07114663.3A patent/EP1905829B1/en not_active Expired - Lifetime
- 2002-06-20 NZ NZ530098A patent/NZ530098A/en unknown
- 2002-06-20 ES ES07114663T patent/ES2571835T3/es not_active Expired - Lifetime
- 2002-06-20 ES ES10184311T patent/ES2571945T3/es not_active Expired - Lifetime
- 2002-06-20 DK DK10184311.8T patent/DK2305808T3/en active
- 2002-06-20 DK DK07114663.3T patent/DK1905829T3/en active
-
2003
- 2003-11-24 NO NO20035226A patent/NO20035226L/no not_active Application Discontinuation
-
2016
- 2016-05-13 CY CY20161100420T patent/CY1117518T1/el unknown
- 2016-05-13 CY CY20161100419T patent/CY1117517T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
CY1117517T1 (el) | 2017-04-26 |
EP1905829B1 (en) | 2016-02-17 |
CN1539014A (zh) | 2004-10-20 |
RU2004101289A (ru) | 2005-07-10 |
NO20035226D0 (no) | 2003-11-24 |
JP2004535193A (ja) | 2004-11-25 |
EP1905829A2 (en) | 2008-04-02 |
DK1402024T3 (da) | 2007-12-27 |
IL159268A0 (en) | 2004-06-01 |
DK1905829T3 (en) | 2016-05-23 |
EP1402024A2 (en) | 2004-03-31 |
EP1402024B1 (en) | 2007-08-22 |
DE60221986D1 (de) | 2007-10-04 |
CY1117518T1 (el) | 2017-04-26 |
EP1905829A3 (en) | 2009-06-24 |
ES2571945T3 (es) | 2016-05-27 |
ES2571835T3 (es) | 2016-05-27 |
WO2002103008A3 (en) | 2003-11-27 |
NZ530098A (en) | 2006-02-24 |
DK2305808T3 (en) | 2016-05-23 |
WO2002103008A2 (en) | 2002-12-27 |
EP2305808A1 (en) | 2011-04-06 |
CA2451524A1 (en) | 2002-12-27 |
EP2305808B1 (en) | 2016-03-02 |
ATE371026T1 (de) | 2007-09-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NO20035226L (no) | Templatinkluderende molekyler og fremgangsmater til anvendelse av slike molekyler | |
DK1487978T3 (da) | Forbedret fremgangsmåde til syntese af templatemolekyler | |
NO20034285D0 (no) | Fremgangsmåte for fremstilling av syntesegass | |
NO20050859D0 (no) | Katalysatorstruktur og fremgangsmate for fremstilling av syntesegass | |
NO20033913D0 (no) | Systemarkitektur og beslektede fremgangsmåter for dynamisk tilföyelse av programkomponenter, for å utvide systemprosessers funksjonalitet | |
DE602004030869D1 (de) | Dekodierverfahren, dekodiervorrichtung, programm, aufzeichnungs-/wiedergabevorrichtung und -verfahren, und wiedergabevorrichtung und -verfahren | |
PT1928882E (pt) | (s)-n-metilnaltrexona, processo para a sua síntese e sua utilização farmacêutica | |
NO20025318L (no) | Fremgangsmåte for rensing av syntesegass | |
DE602004013006D1 (de) | Wiedergabegerät, programm und wiedergabeverfahren | |
DE60111358D1 (de) | 3-(pyrolyllacton)-2-indolinon verbindungen zur verwendung als kinase-hemmstoffe | |
NO20076362L (no) | Fremgangsmåter for syntetisering av molekyl og kodete bibliotek | |
IS7368A (is) | Aðferð og tæki til nýmyndunar fylkinga DNA-þreifara | |
NO20034282L (no) | Fremgangsmate og anordning for fremstilling av syntesegass | |
NO20034283L (no) | Fremgangsmate og anordning for fremstilling av syntesegass | |
DK1916619T3 (da) | Hierarkiseret todimensionel kode, fremgangsmåde til frembringelse heraf, og fremgangsmåde til læsning heraf | |
DE60336419D1 (de) | Selektive synthese von organophosphiten | |
IS8447A (is) | Aðferð til að framleiða gamma-karboxýleruð prótín | |
NO20011753L (no) | Fremgangsmåte for fremstilling av syntesegass | |
DE60221462D1 (de) | Vorrichtung und Verfahren zur High-Level Synthese, Verfahren zur Produktion von logischen Schaltungen unter Verwendung des Verfahrens zur High-Level Synthese und Aufzeichnungsmedium | |
DK1419992T3 (da) | Anlæg og fremgangsmåde til at fremstille syntesegas | |
NO20044050L (no) | Fremgangsmate for syntese av chirale N-aryl-piperaziner | |
DE60303904D1 (de) | Verfahren zur Synthese von (2S)-Indolin-2-carbonsäure, und Verwendung in der Synthese von Perindopril | |
DE50201045D1 (de) | Verfahren zum katalytischen erzeugen von ammoniak aus synthesegas | |
DE602004008214D1 (de) | Verfahren und Vorrichtungen zur Kodierung/Dekodierung von Signalen, sowie Computerprogrammprodukt dafür | |
EA200400652A1 (ru) | Катализатор и способ получения углеводородов и их кислородсодержащих производных из синтез-газа |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC2A | Withdrawal, rejection or dismissal of laid open patent application |