DE602006021580D1 - Verfahren zur synthese codierter bibliotheken - Google Patents

Verfahren zur synthese codierter bibliotheken

Info

Publication number
DE602006021580D1
DE602006021580D1 DE602006021580T DE602006021580T DE602006021580D1 DE 602006021580 D1 DE602006021580 D1 DE 602006021580D1 DE 602006021580 T DE602006021580 T DE 602006021580T DE 602006021580 T DE602006021580 T DE 602006021580T DE 602006021580 D1 DE602006021580 D1 DE 602006021580D1
Authority
DE
Germany
Prior art keywords
synthesis
coded libraries
libraries
coded
tag
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602006021580T
Other languages
English (en)
Inventor
Barry Morgan
Stephen Hale
Christopher C Arico-Muendel
Matthew Clark
Richard Wagner
Malcolm J Kavarana
Steffen Phillip Creaser
George J Franklin
Paolo A Centrella
David I Israel
Malcolm L Gefter
Dennis Benjamin
Nils Jakob Vest Hansen
Raksha A Acharya
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Praecis Pharmaceuticals Inc
Original Assignee
Praecis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36930432&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE602006021580(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Praecis Pharmaceuticals Inc filed Critical Praecis Pharmaceuticals Inc
Publication of DE602006021580D1 publication Critical patent/DE602006021580D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B61/00—Other general methods
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1068—Template (nucleic acid) mediated chemical library synthesis, e.g. chemical and enzymatical DNA-templated organic molecule synthesis, libraries prepared by non ribosomal polypeptide synthesis [NRPS], DNA/RNA-polymerase mediated polypeptide synthesis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Saccharide Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Polyurethanes Or Polyureas (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE602006021580T 2005-06-09 2006-06-09 Verfahren zur synthese codierter bibliotheken Active DE602006021580D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US68946605P 2005-06-09 2005-06-09
US73104105P 2005-10-28 2005-10-28
PCT/US2006/022555 WO2006135786A2 (en) 2005-06-09 2006-06-09 Methods for synthesis of encoded libraries

Publications (1)

Publication Number Publication Date
DE602006021580D1 true DE602006021580D1 (de) 2011-06-09

Family

ID=36930432

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602006021580T Active DE602006021580D1 (de) 2005-06-09 2006-06-09 Verfahren zur synthese codierter bibliotheken

Country Status (24)

Country Link
EP (4) EP1910538B1 (de)
JP (2) JP5508711B2 (de)
KR (1) KR101346432B1 (de)
CN (2) CN102392014A (de)
AT (1) ATE507292T1 (de)
AU (1) AU2006257915B2 (de)
BR (1) BRPI0613566B1 (de)
CA (1) CA2611512C (de)
CY (1) CY1112036T1 (de)
DE (1) DE602006021580D1 (de)
DK (4) DK2258870T3 (de)
ES (2) ES2365534T3 (de)
HK (2) HK1120546A1 (de)
HR (1) HRP20110528T1 (de)
IL (1) IL187977A (de)
NO (1) NO343698B1 (de)
NZ (1) NZ564545A (de)
PL (2) PL2258870T3 (de)
PT (2) PT1910538E (de)
RS (1) RS51868B (de)
RU (2) RU2459869C2 (de)
SI (1) SI1910538T1 (de)
WO (1) WO2006135786A2 (de)
ZA (2) ZA200800190B (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002102820A1 (en) 2001-06-20 2002-12-27 Nuevolution A/S Nucleoside derivatives for library preparation
IL163822A0 (en) 2002-03-15 2005-12-18 Nuevolution As An improved method for synthesising templated molecules
US10730906B2 (en) 2002-08-01 2020-08-04 Nuevolutions A/S Multi-step synthesis of templated molecules
PT1558744E (pt) 2002-10-30 2011-09-22 Nuevolution As Codificação enzimática
ATE450609T1 (de) 2002-12-19 2009-12-15 Nuevolution As Durch quasizufallsstrukturen und funktionen geführte synthesemethode
US20070026397A1 (en) 2003-02-21 2007-02-01 Nuevolution A/S Method for producing second-generation library
ATE447626T1 (de) 2003-09-18 2009-11-15 Nuevolution As Methode zur gewinnung struktureller informationen kodierter moleküle und zur selektion von verbindungen
SI1910538T1 (sl) 2005-06-09 2011-09-30 Praecis Pharm Inc POSTOPKI ZA SINTEZO KODIRANIH KNJIĹľNIC
DK3305900T3 (da) * 2005-12-01 2021-10-25 Nuevolution As Enzymatic encoding methods for efficient synthesis of large libraries
ES2638324T3 (es) * 2009-02-13 2017-10-19 X-Chem, Inc. Métodos de creación y examen de bibliotecas codificadas por ADN
LT2558577T (lt) 2010-04-16 2019-03-12 Nuevolution A/S Bifunkciniai kompleksai ir tokių kompleksų gamybos ir naudojimo būdai
AU2012304387B2 (en) * 2011-09-07 2017-03-16 X-Chem, Inc. Methods for tagging DNA-encoded libraries
NZ739931A (en) 2012-07-13 2019-08-30 X Chem Inc Dna-encoded libraries having encoding oligonucleotide linkages not readable by polymerases
WO2018166532A1 (en) * 2017-03-17 2018-09-20 Hitgen Ltd. Methods and compositions for synthesis of encoded libraries
WO2019149198A1 (zh) * 2018-01-31 2019-08-08 成都先导药物开发股份有限公司 一种dna编码化合物库及化合物筛选方法
GB201821109D0 (en) * 2018-12-21 2019-02-06 Philochem Ag Nucleic acid encoded chemical libraries
CN110041390B (zh) * 2019-04-26 2022-05-27 上海药明康德新药开发有限公司 DNA编码化合物库中On-DNA的1,2,3-三氮唑化合物的合成方法
CN112779606A (zh) * 2019-11-06 2021-05-11 成都先导药物开发股份有限公司 一种On-DNA曼尼希反应的方法
CN113089104B (zh) * 2019-12-23 2023-03-28 成都先导药物开发股份有限公司 一种On-DNA二胺化合物关环反应的合成方法
CN115506036B (zh) * 2021-06-22 2024-07-02 中国科学院上海药物研究所 Dna编码化合物文库起始片段及其制备和应用
DK4201951T3 (da) * 2021-12-21 2024-01-15 Bachem Holding Ag Fremgangsmåde til syntese af et peptid
CN114920791B (zh) * 2022-04-28 2024-06-18 康龙化成(宁波)科技发展有限公司 一种寡聚核酸-琥珀酰亚胺化合物的合成方法

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1545804A (en) 1924-12-26 1925-07-14 Warmerdam Nicholas Sash fastener
US4356270A (en) 1977-11-08 1982-10-26 Genentech, Inc. Recombinant DNA cloning vehicle
US4293652A (en) 1979-05-25 1981-10-06 Cetus Corporation Method for synthesizing DNA sequentially
US4458066A (en) 1980-02-29 1984-07-03 University Patents, Inc. Process for preparing polynucleotides
US4416988A (en) 1980-12-23 1983-11-22 Harvey Rubin Detection and isolation of enkephalin mRNA using a synthetic oligodeoxynucleotide
JPS60222842A (ja) 1984-04-19 1985-11-07 Fuji Photo Film Co Ltd ハロゲン化銀写真乳剤およびその製造方法
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4965188A (en) 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
US4800159A (en) 1986-02-07 1989-01-24 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences
US5360928A (en) 1989-10-23 1994-11-01 Research Corporation Technologies, Inc. Synthesis and use of amino acid fluorides as peptide coupling reagents
AU669489B2 (en) 1991-09-18 1996-06-13 Affymax Technologies N.V. Method of synthesizing diverse collections of oligomers
US5573905A (en) 1992-03-30 1996-11-12 The Scripps Research Institute Encoded combinatorial chemical libraries
US5565324A (en) * 1992-10-01 1996-10-15 The Trustees Of Columbia University In The City Of New York Complex combinatorial chemical libraries encoded with tags
JPH08504444A (ja) 1992-12-11 1996-05-14 カイロン コーポレイション コードされるポリマーの合成
US6537776B1 (en) * 1999-06-14 2003-03-25 Diversa Corporation Synthetic ligation reassembly in directed evolution
AU1318400A (en) 1998-10-19 2000-05-08 Board Of Trustees Of The Leland Stanford Junior University Dna-templated combinatorial library chemistry
DK1423400T4 (da) 2001-03-19 2013-09-02 Harvard College Evolution af hidtil ukendt molekylfunktion
CN1539014A (zh) 2001-06-20 2004-10-20 ŦΤ¬ɭ��˾ 模控分子和使用这种分子的方法
KR101138643B1 (ko) 2002-05-30 2012-04-26 더 스크립스 리서치 인스티튜트 구리 촉매 작용하에서의 아지드와 아세틸렌과의 리게이션
WO2004016767A2 (en) * 2002-08-19 2004-02-26 The President And Fellows Of Harvard College Evolving new molecular function
PT1558744E (pt) * 2002-10-30 2011-09-22 Nuevolution As Codificação enzimática
DE602004036672C5 (de) 2003-01-29 2012-11-29 454 Life Sciences Corporation Nukleinsäureamplifikation auf Basis von Kügelchenemulsion
GB0304433D0 (en) * 2003-02-27 2003-04-02 Xceleron Ltd Improvements relating to chemical libraries
ATE424455T1 (de) * 2003-03-20 2009-03-15 Nuevolution As Ligationsvermittelnde codierung von kleinen molekülen
ATE447626T1 (de) * 2003-09-18 2009-11-15 Nuevolution As Methode zur gewinnung struktureller informationen kodierter moleküle und zur selektion von verbindungen
CA2549386C (en) * 2003-12-17 2014-07-29 Praecis Pharmaceuticals, Inc. Methods for synthesis of encoded libraries
US7116036B2 (en) 2004-08-02 2006-10-03 General Electric Company Energy harvesting system, apparatus and method
WO2006053571A2 (en) * 2004-11-22 2006-05-26 Peter Birk Rasmussen Template directed split and mix systhesis of small molecule libraries
SI1910538T1 (sl) 2005-06-09 2011-09-30 Praecis Pharm Inc POSTOPKI ZA SINTEZO KODIRANIH KNJIĹľNIC

Also Published As

Publication number Publication date
ES2365534T3 (es) 2011-10-06
BRPI0613566B1 (pt) 2020-01-07
DK201170734A (en) 2011-12-20
DK177345B1 (da) 2013-01-28
IL187977A0 (en) 2008-03-20
JP2008543289A (ja) 2008-12-04
ZA201004791B (en) 2012-06-27
DK1910538T3 (da) 2011-08-08
CN102392014A (zh) 2012-03-28
CY1112036T1 (el) 2015-11-04
RU2008100035A (ru) 2009-07-20
EP2311786A3 (de) 2014-04-02
AU2006257915A1 (en) 2006-12-21
HK1120546A1 (en) 2009-04-03
RU2011101778A (ru) 2012-07-27
HRP20110528T1 (hr) 2011-09-30
JP2014039550A (ja) 2014-03-06
HK1150454A1 (en) 2011-12-30
EP2258870A3 (de) 2011-11-30
BRPI0613566A2 (pt) 2011-01-18
DK2258870T3 (da) 2013-03-18
SI1910538T1 (sl) 2011-09-30
EP2338990A3 (de) 2011-10-19
EP2258870A2 (de) 2010-12-08
CN101233235B (zh) 2012-10-03
ES2401485T3 (es) 2013-04-22
PL2258870T3 (pl) 2013-05-31
KR101346432B1 (ko) 2014-02-14
RS51868B (en) 2012-02-29
ATE507292T1 (de) 2011-05-15
DK179064B1 (da) 2017-10-02
RU2459869C2 (ru) 2012-08-27
AU2006257915B2 (en) 2011-09-08
WO2006135786A3 (en) 2007-06-21
CN101233235A (zh) 2008-07-30
EP1910538A2 (de) 2008-04-16
KR20080036577A (ko) 2008-04-28
EP1910538B1 (de) 2011-04-27
EP2258870B1 (de) 2013-01-02
EP2311786A2 (de) 2011-04-20
EP2338990A2 (de) 2011-06-29
NZ564545A (en) 2011-03-31
CA2611512A1 (en) 2006-12-21
IL187977A (en) 2013-02-28
NO20076362L (no) 2008-03-07
NO343698B1 (no) 2019-05-13
DK200800005A (da) 2008-03-04
PL1910538T3 (pl) 2011-12-30
WO2006135786A2 (en) 2006-12-21
JP5508711B2 (ja) 2014-06-04
PT2258870E (pt) 2013-04-01
CA2611512C (en) 2018-05-22
PT1910538E (pt) 2011-07-28
ZA200800190B (en) 2010-11-24

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