CY1117518T1 - Προτυποποιημενα μορια και μεθοδοι για χρηση τετοιων μοριων - Google Patents

Προτυποποιημενα μορια και μεθοδοι για χρηση τετοιων μοριων

Info

Publication number
CY1117518T1
CY1117518T1 CY20161100420T CY161100420T CY1117518T1 CY 1117518 T1 CY1117518 T1 CY 1117518T1 CY 20161100420 T CY20161100420 T CY 20161100420T CY 161100420 T CY161100420 T CY 161100420T CY 1117518 T1 CY1117518 T1 CY 1117518T1
Authority
CY
Cyprus
Prior art keywords
mills
standardized
finished
methods
templated
Prior art date
Application number
CY20161100420T
Other languages
English (en)
Inventor
Henrik Pedersen
Alex Haahr Gouilaev
Christian Klarner Sams
Frank Abilgaard Sløk
Per-Ola Freskgård
Anette Holtmann
Olsen Eva Kampmann
Gitte Nystrup Husemoen
Jakob Felding
Thomas Franch
Thomas Thisted
Lene Hyldtoft
Mads Nørregaard-Madsen
Michael Anders Godskesen
Glad Sanne Schrøder
Original Assignee
Nuevolution A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nuevolution A/S filed Critical Nuevolution A/S
Publication of CY1117518T1 publication Critical patent/CY1117518T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1062—Isolating an individual clone by screening libraries mRNA-Display, e.g. polypeptide and encoding template are connected covalently
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1068—Template (nucleic acid) mediated chemical library synthesis, e.g. chemical and enzymatical DNA-templated organic molecule synthesis, libraries prepared by non ribosomal polypeptide synthesis [NRPS], DNA/RNA-polymerase mediated polypeptide synthesis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1075—Isolating an individual clone by screening libraries by coupling phenotype to genotype, not provided for in other groups of this subclass
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/30—Nucleotides
    • C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/04—Methods of creating libraries, e.g. combinatorial synthesis using dynamic combinatorial chemistry techniques
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/06—Biochemical methods, e.g. using enzymes or whole viable microorganisms
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00452—Means for the recovery of reactants or products
    • B01J2219/00454—Means for the recovery of reactants or products by chemical cleavage from the solid support
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00702—Processes involving means for analysing and characterising the products
    • B01J2219/00707—Processes involving means for analysing and characterising the products separated from the reactor apparatus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00722—Nucleotides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00729—Peptide nucleic acids [PNA]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/11—Compounds covalently bound to a solid support

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biophysics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

Τα βιολογικά συστήματα επιτρέπουν κατευθυνόμενη από εκμαγείο σύνθεση α-πεπτιδίων. Η παρούσα εφεύρεση επιτρέπει ένα σύστημα που επιτρέπει κατευθυνόμενη από εκμαγείο σύνθεση άλλων τύπων πολυμερών καθώς επίσης α-πεπτιδίων. Η παρούσα εφεύρεση αφορά σε προτυποποιημένα μόρια και προτυποποιημένα μόρια που συνδέονται προς προσδιορισμένο εκ των προτέρων εκμαγείο. Τα προτυποποιημένα μόρια περιλαμβάνουν μία αλληλουχία λειτουργικών ομάδων που συνδέονται μαζί. Εκάστη λειτουργική ομάδα συνδέεται αρχικώς προς ένα στοιχείο ικανό συμπλήρωσης ενός προσδιορισμένου εκ των προτέρων κωδικοποιητικού στοιχείου του εκμαγείου. Μετά τη συμπλήρωση ενός κωδικοποιητικού στοιχείου, είτε την συμπλήρωση μίας πλειονότητας κωδικοποιητικών στοιχείων, οι προσαρτώμενες λειτουργικές ομάδες συνδέονται και σχηματίζεται το προτυποποιημένο μόριο.
CY20161100420T 2001-06-20 2016-05-13 Προτυποποιημενα μορια και μεθοδοι για χρηση τετοιων μοριων CY1117518T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA200100962 2001-06-20
DKPA200200415 2002-03-15
EP07114663.3A EP1905829B1 (en) 2001-06-20 2002-06-20 Templated molecules and methods for using such molecules

Publications (1)

Publication Number Publication Date
CY1117518T1 true CY1117518T1 (el) 2017-04-26

Family

ID=26069037

Family Applications (2)

Application Number Title Priority Date Filing Date
CY20161100420T CY1117518T1 (el) 2001-06-20 2016-05-13 Προτυποποιημενα μορια και μεθοδοι για χρηση τετοιων μοριων
CY20161100419T CY1117517T1 (el) 2001-06-20 2016-05-13 Προτυποποιημενα μορια και μεθοδοι για χρηση τετοιων μοριων

Family Applications After (1)

Application Number Title Priority Date Filing Date
CY20161100419T CY1117517T1 (el) 2001-06-20 2016-05-13 Προτυποποιημενα μορια και μεθοδοι για χρηση τετοιων μοριων

Country Status (14)

Country Link
EP (3) EP1905829B1 (el)
JP (1) JP2004535193A (el)
CN (1) CN1539014A (el)
AT (1) ATE371026T1 (el)
CA (1) CA2451524A1 (el)
CY (2) CY1117518T1 (el)
DE (1) DE60221986D1 (el)
DK (3) DK1905829T3 (el)
ES (2) ES2571835T3 (el)
IL (1) IL159268A0 (el)
NO (1) NO20035226L (el)
NZ (1) NZ530098A (el)
RU (1) RU2004101289A (el)
WO (1) WO2002103008A2 (el)

Families Citing this family (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1423400T4 (da) 2001-03-19 2013-09-02 Harvard College Evolution af hidtil ukendt molekylfunktion
WO2002102820A1 (en) 2001-06-20 2002-12-27 Nuevolution A/S Nucleoside derivatives for library preparation
ES2571933T3 (es) * 2002-03-15 2016-05-27 Nuevolution As Método mejorado para sintetizar moléculas modeladas
IL163822A0 (en) * 2002-03-15 2005-12-18 Nuevolution As An improved method for synthesising templated molecules
AU2003231766A1 (en) * 2002-04-26 2003-11-10 Gilead Sciences, Inc. Non nucleoside reverse transcriptase inhibitors
US10730906B2 (en) * 2002-08-01 2020-08-04 Nuevolutions A/S Multi-step synthesis of templated molecules
PT1558744E (pt) * 2002-10-30 2011-09-22 Nuevolution As Codificação enzimática
AU2011226815B2 (en) * 2002-10-30 2014-09-25 Nuevolution A/S Enzymatic encoding
ATE450609T1 (de) * 2002-12-19 2009-12-15 Nuevolution As Durch quasizufallsstrukturen und funktionen geführte synthesemethode
US20070026397A1 (en) 2003-02-21 2007-02-01 Nuevolution A/S Method for producing second-generation library
US20060269920A1 (en) * 2003-02-21 2006-11-30 Nuevolution A/S Method for obtaining structural information about an encoded molecule
ATE424455T1 (de) 2003-03-20 2009-03-15 Nuevolution As Ligationsvermittelnde codierung von kleinen molekülen
WO2004096285A2 (en) 2003-04-25 2004-11-11 Gilead Sciences, Inc. Anti-infective phosphonate conjugates
CA2522845A1 (en) 2003-04-25 2004-11-11 Gilead Sciences, Inc. Kinase inhibitor phosphonate conjugates
US7432261B2 (en) 2003-04-25 2008-10-07 Gilead Sciences, Inc. Anti-inflammatory phosphonate compounds
US7407965B2 (en) 2003-04-25 2008-08-05 Gilead Sciences, Inc. Phosphonate analogs for treating metabolic diseases
WO2005002626A2 (en) 2003-04-25 2005-01-13 Gilead Sciences, Inc. Therapeutic phosphonate compounds
EP1628685B1 (en) 2003-04-25 2010-12-08 Gilead Sciences, Inc. Antiviral phosphonate analogs
US7452901B2 (en) 2003-04-25 2008-11-18 Gilead Sciences, Inc. Anti-cancer phosphonate analogs
US7470724B2 (en) 2003-04-25 2008-12-30 Gilead Sciences, Inc. Phosphonate compounds having immuno-modulatory activity
WO2004096287A2 (en) 2003-04-25 2004-11-11 Gilead Sciences, Inc. Inosine monophosphate dehydrogenase inhibitory phosphonate compounds
WO2004110964A2 (en) * 2003-06-16 2004-12-23 Nuevolution A/S Encoded molecules by translation (emt)
EP1533385A1 (en) * 2003-09-05 2005-05-25 Nuevolution A/S Templated compounds for generation of encoded molecules and directional methods using such compounds
ATE447626T1 (de) 2003-09-18 2009-11-15 Nuevolution As Methode zur gewinnung struktureller informationen kodierter moleküle und zur selektion von verbindungen
AU2004290298A1 (en) 2003-10-24 2005-05-26 Gilead Sciences, Inc. Methods and compositions for identifying therapeutic compounds
US7432273B2 (en) 2003-10-24 2008-10-07 Gilead Sciences, Inc. Phosphonate analogs of antimetabolites
WO2005044279A1 (en) 2003-10-24 2005-05-19 Gilead Sciences, Inc. Purine nucleoside phosphonate conjugates
CA2549386C (en) 2003-12-17 2014-07-29 Praecis Pharmaceuticals, Inc. Methods for synthesis of encoded libraries
US7972994B2 (en) 2003-12-17 2011-07-05 Glaxosmithkline Llc Methods for synthesis of encoded libraries
BRPI0417988A (pt) 2003-12-22 2007-04-27 Gilead Sciences Inc análogos de fosfonato antivirais
US20090239211A1 (en) 2004-02-17 2009-09-24 Nuevolution A/S Method For Enrichment Involving Elimination By Mismatch Hybridisation
EP1730277B1 (en) 2004-03-22 2009-10-28 Nuevolution A/S Ligational encoding using building block oligonucleotides
ME03423B (me) 2004-07-27 2020-01-20 Gilead Sciences Inc Fosfonatni analozi jedinjenja hiv inhibitora
WO2006053571A2 (en) 2004-11-22 2006-05-26 Peter Birk Rasmussen Template directed split and mix systhesis of small molecule libraries
DE602006007819D1 (de) * 2005-01-21 2009-08-27 Harvard College Verwendung freier reaktanten bei der nukleinsäuretemplatgesteuerten synthese
ATE461279T1 (de) * 2005-06-07 2010-04-15 Harvard College Geordnete mehrschrittsynthese mittels nukleinsäurevermittelter chemie
SI1910538T1 (sl) 2005-06-09 2011-09-30 Praecis Pharm Inc POSTOPKI ZA SINTEZO KODIRANIH KNJIĹľNIC
WO2007011722A2 (en) 2005-07-15 2007-01-25 President And Fellows Of Harvard College Reaction discovery system
EP2368868A1 (en) 2005-10-28 2011-09-28 Praecis Pharmaceuticals Inc. Methods for identifying compounds of interest using encoded libraries
DK3305900T3 (da) 2005-12-01 2021-10-25 Nuevolution As Enzymatic encoding methods for efficient synthesis of large libraries
WO2009085328A1 (en) * 2008-01-03 2009-07-09 Helicos Biosciences Corporation Molecules and methods for nucleic acid sequencing
JP4777373B2 (ja) 2008-02-14 2011-09-21 独立行政法人科学技術振興機構 光応答性核酸の製造方法
BRPI0915878A2 (pt) 2008-07-08 2015-11-03 Gilead Sciences Inc sais ou hidratos de compostos inibidores de hiv, seu uso e composição farmacêutica que os compreende
JP4621926B2 (ja) * 2008-07-24 2011-02-02 国立大学法人九州大学 酵素基質修飾ヌクレオシド三リン酸、核酸プローブ、マルチラベル化核酸プローブ、マルチラベル化核酸プローブの製造方法および標的核酸の検出方法
AU2010209508C1 (en) * 2009-01-30 2017-10-19 Oxford Nanopore Technologies Limited Hybridization linkers
ES2638324T3 (es) 2009-02-13 2017-10-19 X-Chem, Inc. Métodos de creación y examen de bibliotecas codificadas por ADN
LT2558577T (lt) 2010-04-16 2019-03-12 Nuevolution A/S Bifunkciniai kompleksai ir tokių kompleksų gamybos ir naudojimo būdai
EP2622073B1 (en) 2010-09-27 2018-04-18 Vipergen A method for making an enriched library
AU2012304387B2 (en) 2011-09-07 2017-03-16 X-Chem, Inc. Methods for tagging DNA-encoded libraries
US8669314B2 (en) 2012-02-03 2014-03-11 Sabic Innovative Plastics Ip B.V. Hydrolytic stability in polycarbonate compositions
NZ739931A (en) 2012-07-13 2019-08-30 X Chem Inc Dna-encoded libraries having encoding oligonucleotide linkages not readable by polymerases
EP3000898B1 (en) 2013-05-21 2020-11-18 Hitgen Inc. Drug target capturing method
GB201322692D0 (en) 2013-12-20 2014-02-05 Philochem Ag Production of encoded chemical libraries
EP3218479A1 (en) 2014-11-11 2017-09-20 Nanocore ApS Method for identification of molecules with desired characteristics
CN105461632B (zh) * 2016-01-04 2018-01-09 湖北泓肽生物科技有限公司 一种n‑乙酰‑l‑肌肽的制备方法
US10326855B2 (en) 2016-07-28 2019-06-18 International Business Machines Corporation Trending topic driven cache eviction management
WO2018166532A1 (en) * 2017-03-17 2018-09-20 Hitgen Ltd. Methods and compositions for synthesis of encoded libraries
WO2018191582A1 (en) * 2017-04-13 2018-10-18 The Board Of Trustees Of The University Of Illinois Assay for quantifying polyphosphates
EP3661937B1 (en) 2017-08-01 2021-07-28 Gilead Sciences, Inc. Crystalline forms of ethyl ((s)-((((2r,5r)-5-(6-amino-9h-purin-9-yl)-4-fluoro-2,5-dihydrofuran-2-yl)oxy)methyl)(phenoxy)phosphoryl)-l-alaninate (gs-9131) for treating viral infections
SG11202107913VA (en) 2019-01-22 2021-08-30 Vipergen Aps A method for screening of an in vitro display library within a cell

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4863857A (en) 1985-03-01 1989-09-05 Board Of Regents, The University Of Texas System Polypeptide complementary to peptides or proteins having an amino acid sequence or nucleotide coding sequence at least partially known
US5506337A (en) 1985-03-15 1996-04-09 Antivirals Inc. Morpholino-subunit combinatorial library and method
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
DE3688920T4 (de) 1985-07-03 1995-08-31 Genencor Int Hybride Polypeptide und Verfahren zu deren Herstellung.
US5162218A (en) 1988-11-18 1992-11-10 The Regents Of The University Of California Conjugated polypeptides and methods for their preparation
ES2118066T3 (es) 1989-10-05 1998-09-16 Optein Inc Sintesis y aislamiento, exentos de celulas, de nuevos genes y polipeptidos.
US5660985A (en) 1990-06-11 1997-08-26 Nexstar Pharmaceuticals, Inc. High affinity nucleic acid ligands containing modified nucleotides
US5843701A (en) 1990-08-02 1998-12-01 Nexstar Pharmaceticals, Inc. Systematic polypeptide evolution by reverse translation
AU8498091A (en) 1990-08-02 1992-03-02 Regents Of The University Of Colorado, The Systematic polypeptide evolution by reverse translation
US6140496A (en) 1990-10-09 2000-10-31 Benner; Steven Albert Precursors for deoxyribonucleotides containing non-standard nucleosides
US6037120A (en) 1995-10-12 2000-03-14 Benner; Steven Albert Recognition of oligonucleotides containing non-standard base pairs
US5641625A (en) 1992-05-22 1997-06-24 Isis Pharmaceuticals, Inc. Cleaving double-stranded DNA with peptide nucleic acids
US5719262A (en) 1993-11-22 1998-02-17 Buchardt, Deceased; Ole Peptide nucleic acids having amino acid side chains
US5539082A (en) 1993-04-26 1996-07-23 Nielsen; Peter E. Peptide nucleic acids
AU2313392A (en) * 1991-08-01 1993-03-02 University Research Corporation Systematic polypeptide evolution by reverse translation
ATE163308T1 (de) 1991-08-28 1998-03-15 Boehringer Mannheim Gmbh Primer für matrizenabhängige enzymatische nukleinsäuresynthesen
AU669489B2 (en) 1991-09-18 1996-06-13 Affymax Technologies N.V. Method of synthesizing diverse collections of oligomers
US5639603A (en) 1991-09-18 1997-06-17 Affymax Technologies N.V. Synthesizing and screening molecular diversity
US5270170A (en) 1991-10-16 1993-12-14 Affymax Technologies N.V. Peptide library and screening method
US5573905A (en) 1992-03-30 1996-11-12 The Scripps Research Institute Encoded combinatorial chemical libraries
US5721099A (en) 1992-10-01 1998-02-24 Trustees Of Columbia University In The City Of New York Complex combinatorial chemical libraries encoded with tags
US5840485A (en) 1993-05-27 1998-11-24 Selectide Corporation Topologically segregated, encoded solid phase libraries
US5922545A (en) 1993-10-29 1999-07-13 Affymax Technologies N.V. In vitro peptide and antibody display libraries
DE4343591A1 (de) 1993-12-21 1995-06-22 Evotec Biosystems Gmbh Verfahren zum evolutiven Design und Synthese funktionaler Polymere auf der Basis von Formenelementen und Formencodes
US6127154A (en) 1994-02-10 2000-10-03 Mosbach; Klaus Methods for direct synthesis of compounds having complementary structure to a desired molecular entity and use thereof
US5597697A (en) 1994-09-30 1997-01-28 Diamond; Paul Screening assay for inhibitors and activators of RNA and DNA-dependent nucleic acid polymerases
DE19646372C1 (de) * 1995-11-11 1997-06-19 Evotec Biosystems Gmbh Genotyp und Phänotyp koppelnde Verbindung
US5846839A (en) 1995-12-22 1998-12-08 Glaxo Group Limited Methods for hard-tagging an encoded synthetic library
US5998140A (en) 1996-07-31 1999-12-07 The Scripps Research Institute Complex formation between dsDNA and oligomer of cyclic heterocycles
DE69739163D1 (de) * 1996-10-17 2009-01-22 Mitsubishi Chem Corp Molekül, welches Genotyp und Phänotyp zusammenführt und dessen Anwendungen
US5958703A (en) 1996-12-03 1999-09-28 Glaxo Group Limited Use of modified tethers in screening compound libraries
US6080826A (en) 1997-01-06 2000-06-27 California Institute Of Technology Template-directed ring-closing metathesis and ring-opening metathesis polymerization of functionalized dienes
US6261804B1 (en) 1997-01-21 2001-07-17 The General Hospital Corporation Selection of proteins using RNA-protein fusions
WO1998031700A1 (en) 1997-01-21 1998-07-23 The General Hospital Corporation Selection of proteins using rna-protein fusions
US6969584B2 (en) * 1997-06-12 2005-11-29 Rigel Pharmaceuticals, Inc. Combinatorial enzymatic complexes
US6175001B1 (en) 1998-10-16 2001-01-16 The Scripps Research Institute Functionalized pyrimidine nucleosides and nucleotides and DNA's incorporating same
AU1318400A (en) * 1998-10-19 2000-05-08 Board Of Trustees Of The Leland Stanford Junior University Dna-templated combinatorial library chemistry
WO2000032823A1 (en) * 1998-12-02 2000-06-08 Phylos, Inc. Dna-protein fusions and uses thereof
EP1208219A1 (en) * 1999-04-08 2002-05-29 Pavel Sergeev Synthesis of biologically active compounds in cells
MXPA02002163A (es) 1999-09-01 2004-04-21 Yeda Res & Dev Polimerizacion de acido nucleico dependiente de molde usando bloques de construccion de oligonucleotidos trifosfato.
DK1423400T4 (da) * 2001-03-19 2013-09-02 Harvard College Evolution af hidtil ukendt molekylfunktion

Also Published As

Publication number Publication date
ATE371026T1 (de) 2007-09-15
NZ530098A (en) 2006-02-24
EP1402024A2 (en) 2004-03-31
EP1905829A3 (en) 2009-06-24
WO2002103008A2 (en) 2002-12-27
EP1905829B1 (en) 2016-02-17
DK2305808T3 (en) 2016-05-23
ES2571835T3 (es) 2016-05-27
DK1402024T3 (da) 2007-12-27
WO2002103008A3 (en) 2003-11-27
JP2004535193A (ja) 2004-11-25
NO20035226L (no) 2004-02-16
RU2004101289A (ru) 2005-07-10
DK1905829T3 (en) 2016-05-23
CY1117517T1 (el) 2017-04-26
EP2305808B1 (en) 2016-03-02
IL159268A0 (en) 2004-06-01
EP2305808A1 (en) 2011-04-06
CN1539014A (zh) 2004-10-20
NO20035226D0 (no) 2003-11-24
CA2451524A1 (en) 2002-12-27
EP1402024B1 (en) 2007-08-22
EP1905829A2 (en) 2008-04-02
DE60221986D1 (de) 2007-10-04
ES2571945T3 (es) 2016-05-27

Similar Documents

Publication Publication Date Title
CY1117517T1 (el) Προτυποποιημενα μορια και μεθοδοι για χρηση τετοιων μοριων
DK1487978T3 (da) Forbedret fremgangsmåde til syntese af templatemolekyler
DK1944040T3 (da) Analysefremgangsmåde for Alzheimers sygdom
DE60330400D1 (de) Sprachsynthesesystem, Sprachsyntheseverfahren und Rechnerprogramm
CY1116776T1 (el) Αντισωματα ειδικα για τα διαλυτα πρωτοϊνιδια των πεπτιδιων β-αμυλοειδους και χρησεις αυτων
DE602004030869D1 (de) Dekodierverfahren, dekodiervorrichtung, programm, aufzeichnungs-/wiedergabevorrichtung und -verfahren, und wiedergabevorrichtung und -verfahren
CY1112507T1 (el) Μορια αντισωματος που εχουν ειδικοτητα για την ανθρωπινη ιl-1β
DE60325191D1 (de) Verfahren, vorrichtung und computerprogramm zur sprachsynthese
DE60336419D1 (de) Selektive synthese von organophosphiten
WO2006138659A3 (en) Intranasal red light probe for treating alzheimers disease
IL186333A0 (en) Method for treating dementia or alzheimer's disease with a cd20 antibody
IL166619A0 (en) Method of comparing x-ray diffraction patterns using the fundamental parameter method
IS8447A (is) Aðferð til að framleiða gamma-karboxýleruð prótín
NO20034282D0 (no) Fremgangsmåte og anordning for fremstilling av syntesegass
DE60232972D1 (de) Strickverfahren für intarsienware und entsprechendes strickprogramm erzeugende vorrichtung
DE60221462D1 (de) Vorrichtung und Verfahren zur High-Level Synthese, Verfahren zur Produktion von logischen Schaltungen unter Verwendung des Verfahrens zur High-Level Synthese und Aufzeichnungsmedium
AT5708U3 (de) Maschine zur aufnahme von schwellen eines gleises
DK1419992T3 (da) Anlæg og fremgangsmåde til at fremstille syntesegas
DE50203015D1 (de) Technische syntheseverfahren zur herstellung von tropenol
NO20035799L (no) Integrert fremgangsmåte for hydrokarbonsyntese
ATE319668T1 (de) Verfahren zur synthese von (2s)-indolin-2- carbonsäure, und verwendung in der synthese von perindopril
DE50307382D1 (de) Piezoaktor und verfahren zum herstellen des piezoaktors
DE60031338D1 (de) Verfahren und Vorrichtung zum Mischen und für die Wiedergabe von Toninformationen aus zwei Quellen, sowie Computerprogramm für die Durchführung des Verfahrens
DE50201045D1 (de) Verfahren zum katalytischen erzeugen von ammoniak aus synthesegas
NO20031122D0 (no) Tannprotesebase, fremgangsmåte for å fremstille den og instrument benyttettil dette