IL158819A0 - Encapsulation of nanosuspensions in liposomes and microspheres - Google Patents
Encapsulation of nanosuspensions in liposomes and microspheresInfo
- Publication number
- IL158819A0 IL158819A0 IL15881902A IL15881902A IL158819A0 IL 158819 A0 IL158819 A0 IL 158819A0 IL 15881902 A IL15881902 A IL 15881902A IL 15881902 A IL15881902 A IL 15881902A IL 158819 A0 IL158819 A0 IL 158819A0
- Authority
- IL
- Israel
- Prior art keywords
- nanosuspensions
- microspheres
- liposomes
- encapsulation
- Prior art date
Links
- 238000005538 encapsulation Methods 0.000 title 1
- 239000002502 liposome Substances 0.000 title 1
- 239000004005 microsphere Substances 0.000 title 1
- 239000006070 nanosuspension Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1277—Preparation processes; Proliposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dispersion Chemistry (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Psychiatry (AREA)
- Anesthesiology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Manufacturing Of Micro-Capsules (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29523301P | 2001-05-31 | 2001-05-31 | |
| PCT/US2002/017346 WO2002096368A2 (en) | 2001-05-31 | 2002-05-31 | Encapsulation of nanosuspensions in liposomes and microspheres |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL158819A0 true IL158819A0 (en) | 2004-05-12 |
Family
ID=23136814
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL15881902A IL158819A0 (en) | 2001-05-31 | 2002-05-31 | Encapsulation of nanosuspensions in liposomes and microspheres |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20030096000A1 (enExample) |
| EP (1) | EP1395243A2 (enExample) |
| JP (2) | JP2004532252A (enExample) |
| AU (2) | AU2002322024B2 (enExample) |
| CA (1) | CA2447990C (enExample) |
| IL (1) | IL158819A0 (enExample) |
| NZ (1) | NZ529544A (enExample) |
| WO (1) | WO2002096368A2 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050129753A1 (en) * | 2003-11-14 | 2005-06-16 | Gabizon Alberto A. | Method for drug loading in liposomes |
| US20060002994A1 (en) * | 2004-03-23 | 2006-01-05 | Thomas James L | Responsive liposomes for ultrasonic drug delivery |
| US20070059746A1 (en) * | 2005-09-14 | 2007-03-15 | Japan Science And Technology Agency | Substance carrier using hollow nanoparticle of hepatitis B virus protein and liposome, and method of introducing substance into cell |
| WO2009091531A2 (en) * | 2008-01-16 | 2009-07-23 | The General Hospital Corporation | Uniform-sized, multi-drug carrying and photosensitive liposomes for advance drug delivery |
| US20100260830A1 (en) * | 2009-04-08 | 2010-10-14 | Brian A Salvatore | Liposomal Formulations of Tocopheryl Amides |
| JP6043278B2 (ja) | 2010-04-09 | 2016-12-14 | パシラ ファーマシューティカルズ インコーポレーテッド | 多小胞リポソームを作製するための方法、大直径合成膜小胞を調製するための方法、および蒸発装置 |
| WO2012109387A1 (en) | 2011-02-08 | 2012-08-16 | Halozyme, Inc. | Composition and lipid formulation of a hyaluronan-degrading enzyme and the use thereof for treatment of benign prostatic hyperplasia |
| FR2987268B1 (fr) | 2012-02-28 | 2014-07-11 | Ammtek | Formulations liquides de sulfamides hypoglycemiants |
| RU2664700C2 (ru) | 2012-05-10 | 2018-08-21 | Пейнреформ Лтд. | Депо-составы местного анестетика и способы их получения |
| CA2926797A1 (en) * | 2013-10-14 | 2015-04-23 | Nanosphere Health Sciences, Llc | Nanoparticle compositions and methods as carriers of nutraceutical factors across cell membranes and biological barriers |
| DK3186281T3 (da) | 2014-08-28 | 2019-06-11 | Halozyme Inc | Kombinationsterapi med et hyaluronan-nedbrydende enzym og en immun-checkpoint-inhibitor |
| CA2970917C (en) | 2014-12-15 | 2019-09-17 | Nanosphere Health Sciences, Llc | Methods of treating inflammatory disorders and global inflammation with compositions comprising phospholipid nanoparticle encapsulations of nsaids |
| CA2979184C (en) | 2015-03-10 | 2020-09-08 | Nanosphere Health Sciences, Llc | Lipid nanoparticle compositions and methods as carriers of cannabinoids in standardized precision-metered dosage forms |
| US11344497B1 (en) | 2017-12-08 | 2022-05-31 | Quicksilver Scientific, Inc. | Mitochondrial performance enhancement nanoemulsion |
| US10722465B1 (en) | 2017-12-08 | 2020-07-28 | Quicksilber Scientific, Inc. | Transparent colloidal vitamin supplement |
| EP4272731A3 (en) | 2018-12-11 | 2024-02-14 | Disruption Labs Inc. | Compositions for the delivery of therapeutic agents and methods of use and making thereof |
| US11291702B1 (en) | 2019-04-15 | 2022-04-05 | Quicksilver Scientific, Inc. | Liver activation nanoemulsion, solid binding composition, and toxin excretion enhancement method |
| WO2021185343A1 (zh) * | 2020-03-20 | 2021-09-23 | 江苏恒瑞医药股份有限公司 | 格列本脲脂质体组合物及其制备方法 |
| CN114767658B (zh) * | 2022-04-22 | 2023-09-19 | 中国医学科学院医药生物技术研究所 | 一种imb16-4脂质体纳米粒的制备方法和药物 |
Family Cites Families (81)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4235871A (en) * | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
| US4588578A (en) * | 1983-08-08 | 1986-05-13 | The Liposome Company, Inc. | Lipid vesicles prepared in a monophase |
| US5169637A (en) * | 1983-03-24 | 1992-12-08 | The Liposome Company, Inc. | Stable plurilamellar vesicles |
| US5186941A (en) * | 1983-05-06 | 1993-02-16 | Vestar, Inc. | Vesicle formulation for the controlled release of therapeutic agents |
| US4725442A (en) * | 1983-06-17 | 1988-02-16 | Haynes Duncan H | Microdroplets of water-insoluble drugs and injectable formulations containing same |
| US4622219A (en) * | 1983-06-17 | 1986-11-11 | Haynes Duncan H | Method of inducing local anesthesia using microdroplets of a general anesthetic |
| JPS60100516A (ja) * | 1983-11-04 | 1985-06-04 | Takeda Chem Ind Ltd | 徐放型マイクロカプセルの製造法 |
| US4599342A (en) * | 1984-01-16 | 1986-07-08 | The Procter & Gamble Company | Pharmaceutical products providing enhanced analgesia |
| US4744989A (en) * | 1984-02-08 | 1988-05-17 | E. R. Squibb & Sons, Inc. | Method of preparing liposomes and products produced thereby |
| US5141674A (en) * | 1984-03-08 | 1992-08-25 | Phares Pharmaceutical Research N.V. | Methods of preparing pro-liposome dispersions and aerosols |
| JPH0753661B2 (ja) * | 1984-03-08 | 1995-06-07 | フアレス フアーマスーチカル リサーチ エヌブイ | プロ―リポソーム組成物及びリポソームの水性分散物を作る方法 |
| US4610868A (en) * | 1984-03-20 | 1986-09-09 | The Liposome Company, Inc. | Lipid matrix carriers for use in drug delivery systems |
| DE3576117D1 (de) * | 1984-09-24 | 1990-04-05 | Michael Mezei | Mehrphasige pharmazeutische zusammensetzung. |
| US4761288A (en) * | 1984-09-24 | 1988-08-02 | Mezei Associates Limited | Multiphase liposomal drug delivery system |
| ATE68968T1 (de) * | 1985-11-22 | 1991-11-15 | Takeda Chemical Industries Ltd | Liposomzusammensetzung. |
| US5244678A (en) * | 1986-01-14 | 1993-09-14 | Ire-Celltarg S.A. | Pharmaceutical composition containing a local anesthetic and/or centrally acting analgesic encapsulated in liposomes |
| JPH0751496B2 (ja) * | 1986-04-02 | 1995-06-05 | 武田薬品工業株式会社 | リポソ−ムの製造法 |
| EP0247497B1 (en) * | 1986-05-20 | 1992-03-04 | Wako Pure Chemical Industries, Ltd. | Novel functionalized liposomes and a process for production thereof |
| US4877619A (en) * | 1986-08-25 | 1989-10-31 | Vestar, Inc. | Liposomal vesicles for intraperitoneal administration of therapeutic agents |
| DK86988A (da) * | 1987-02-25 | 1988-08-26 | Takeda Chemical Industries Ltd | Liposompraeparat og anvendelse deraf |
| US5628936A (en) * | 1987-03-13 | 1997-05-13 | Micro-Pak, Inc. | Hybrid paucilamellar lipid vesicles |
| JP2666345B2 (ja) * | 1987-04-16 | 1997-10-22 | 武田薬品工業株式会社 | リポソーム製剤およびその製造法 |
| JP3202705B2 (ja) * | 1987-11-06 | 2001-08-27 | リサーチ ディベロップメント ファンデーション | 医療用のリポソームおよび薬物含有リポソームのエアゾールの小粒子 |
| US4921644A (en) * | 1988-02-29 | 1990-05-01 | Technology Unlimited, Inc. | Mucin directed lipsome |
| US4937078A (en) * | 1988-08-26 | 1990-06-26 | Mezei Associates Limited | Liposomal local anesthetic and analgesic products |
| IL91664A (en) * | 1988-09-28 | 1993-05-13 | Yissum Res Dev Co | Ammonium transmembrane gradient system for efficient loading of liposomes with amphipathic drugs and their controlled release |
| US4906476A (en) * | 1988-12-14 | 1990-03-06 | Liposome Technology, Inc. | Novel liposome composition for sustained release of steroidal drugs in lungs |
| US5049392A (en) * | 1989-01-18 | 1991-09-17 | The Liposome Company, Inc. | Osmotically dependent vesicles |
| US5364632A (en) * | 1989-04-05 | 1994-11-15 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Medicinal emulsions |
| US5225212A (en) * | 1989-10-20 | 1993-07-06 | Liposome Technology, Inc. | Microreservoir liposome composition and method |
| US5013556A (en) * | 1989-10-20 | 1991-05-07 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| US5527528A (en) * | 1989-10-20 | 1996-06-18 | Sequus Pharmaceuticals, Inc. | Solid-tumor treatment method |
| US5227165A (en) * | 1989-11-13 | 1993-07-13 | Nova Pharmaceutical Corporation | Liposphere delivery systems for local anesthetics |
| US5123414A (en) * | 1989-12-22 | 1992-06-23 | Unger Evan C | Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same |
| US5580575A (en) * | 1989-12-22 | 1996-12-03 | Imarx Pharmaceutical Corp. | Therapeutic drug delivery systems |
| IS1685B (is) * | 1990-12-11 | 1998-02-24 | Bracco International B.V. | Aðferð við að búa til fitukúlur (liposomes) sem eru gæddar auknum hæfileika til að draga í sig og halda í sér aðskotaefnum |
| US5977326A (en) * | 1991-08-06 | 1999-11-02 | Salford Ultrafine Chemicals And Research Limited | Process for making morphine-6-glucuronide or substituted morphine-6-glucuronide |
| US5439967A (en) * | 1991-09-17 | 1995-08-08 | Micro Vesicular Systems, Inc. | Propylene glycol stearate vesicles |
| SE9200952D0 (sv) * | 1992-03-27 | 1992-03-27 | Kabi Pharmacia Ab | Pharmaceutical carrier system containing defined lipids |
| US5922340A (en) * | 1992-09-10 | 1999-07-13 | Children's Medical Center Corporation | High load formulations and methods for providing prolonged local anesthesia |
| JPH06247842A (ja) * | 1993-02-23 | 1994-09-06 | Green Cross Corp:The | リポソーム組成物の製造方法 |
| US5891842A (en) * | 1993-04-09 | 1999-04-06 | Trustees Of Tufts College | Methodology for eliciting an analgesic response in a living subject |
| US5853755A (en) * | 1993-07-28 | 1998-12-29 | Pharmaderm Laboratories Ltd. | Biphasic multilamellar lipid vesicles |
| GB9320668D0 (en) * | 1993-10-07 | 1993-11-24 | Secr Defence | Liposomes containing particulare materials |
| US5849763A (en) * | 1993-10-13 | 1998-12-15 | Darwin Discovery Limited | Use of levobupivacaine as an anesthetic agent |
| GB9321061D0 (en) * | 1993-10-13 | 1993-12-01 | Chiroscience Ltd | Analgestic agent and its use |
| ATE210982T1 (de) * | 1993-10-13 | 2002-01-15 | Darwin Discovery Ltd | Analgetisches mittel und dessen verwendung |
| US5451408A (en) * | 1994-03-23 | 1995-09-19 | Liposome Pain Management, Ltd. | Pain management with liposome-encapsulated analgesic drugs |
| SE518578C2 (sv) * | 1994-06-15 | 2002-10-29 | Gs Dev Ab | Lipidbaserad komposition |
| US5741516A (en) * | 1994-06-20 | 1998-04-21 | Inex Pharmaceuticals Corporation | Sphingosomes for enhanced drug delivery |
| US6048545A (en) * | 1994-06-24 | 2000-04-11 | Biozone Laboratories, Inc. | Liposomal delivery by iontophoresis |
| US6066331A (en) * | 1994-07-08 | 2000-05-23 | Barenholz; Yechezkel | Method for preparation of vesicles loaded with biological structures, biopolymers and/or oligomers |
| SE9402453D0 (sv) * | 1994-07-12 | 1994-07-12 | Astra Ab | New pharmaceutical preparation |
| DE4430592A1 (de) * | 1994-08-20 | 1996-02-22 | Max Delbrueck Centrum | Liposomale Zubereitung, ihre Herstellung und ihre Verwendung |
| US5702722A (en) * | 1994-09-30 | 1997-12-30 | Bracco Research S.A. | Liposomes with enhanced entrapment capacity, method and use |
| US6333021B1 (en) * | 1994-11-22 | 2001-12-25 | Bracco Research S.A. | Microcapsules, method of making and their use |
| DE69603577T2 (de) * | 1995-02-10 | 1999-11-25 | Medtronic, Inc. | Verfahren und vorrichtung zur verabreichung von analgetika |
| KR0173089B1 (ko) * | 1996-01-30 | 1999-03-20 | 윤덕용 | N-이소프로필아크릴아미드/옥타데실아크릴레이트/아크릴산 공중합체로 피복된 방출온도 제어형 리포솜 및 그의 제조방법 |
| GB9605915D0 (en) * | 1996-03-21 | 1996-05-22 | Univ Bruxelles | Liposome encapsulated amphiphilic drug compositions |
| US6284267B1 (en) * | 1996-08-14 | 2001-09-04 | Nutrimed Biotech | Amphiphilic materials and liposome formulations thereof |
| US6046187A (en) * | 1996-09-16 | 2000-04-04 | Children's Medical Center Corporation | Formulations and methods for providing prolonged local anesthesia |
| NZ336538A (en) * | 1996-10-15 | 2001-11-30 | Liposome Co Inc | N-acyl phosphatidylethanolamine-mediated liposomal drug delivery |
| WO1998024415A1 (en) * | 1996-12-02 | 1998-06-11 | The Regents Of The University Of California | A bilayer structure which encapsulates multiple containment units and uses thereof |
| US6565889B2 (en) * | 1996-12-02 | 2003-05-20 | The Regents Of The University Of California | Bilayer structure which encapsulates multiple containment units and uses thereof |
| US5865184A (en) * | 1997-01-13 | 1999-02-02 | Takiguchi; Tetsuo | Combined spinal and epidural anesthesia |
| US5827533A (en) * | 1997-02-06 | 1998-10-27 | Duke University | Liposomes containing active agents aggregated with lipid surfactants |
| US6017540A (en) * | 1997-02-07 | 2000-01-25 | Fordham University | Prevention and treatment of primary and metastatic neoplastic diseases and infectious diseases with heat shock/stress protein-peptide complexes |
| GB9704351D0 (en) * | 1997-03-03 | 1997-04-23 | Chiroscience Ltd | Levobupivacaine and its use |
| GB9704352D0 (en) * | 1997-03-03 | 1997-04-23 | Chiroscience Ltd | Levobupivacaine and its use |
| WO1998040070A1 (en) * | 1997-03-13 | 1998-09-17 | Campbell James N | Compositions containing capsaicin or capsaicin analogues and a local anesthetic |
| WO1999001114A1 (en) * | 1997-07-02 | 1999-01-14 | Euro-Celtique, S.A. | Prolonged anesthesia in joints and body spaces |
| US6287587B2 (en) * | 1997-07-15 | 2001-09-11 | Takeda Chemical Industries, Ltd. | Process for producing sustained-release preparation by in-water drying |
| EP0998286A2 (en) * | 1997-07-21 | 2000-05-10 | Darwin Discovery Limited | Use of levobupivacaine |
| US20010004644A1 (en) * | 1997-07-21 | 2001-06-21 | Levin Bruce H. | Compositions, kits, apparatus, and methods for inhibiting cephalic inflammation |
| US6432986B2 (en) * | 1997-07-21 | 2002-08-13 | Bruce H. Levin | Compositions, kits, and methods for inhibiting cerebral neurovascular disorders and muscular headaches |
| WO1999004772A2 (en) * | 1997-07-22 | 1999-02-04 | Darwin Discovery Limited | Use of levobupivacaine |
| EP1014946B1 (en) * | 1997-09-18 | 2010-04-07 | Pacira Pharmaceuticals, Inc. | Sustained-release liposomal anesthetic compositions |
| ES2284266T3 (es) * | 1998-08-12 | 2007-11-01 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Composiciones terapeuticas liposomicas que se pueden obtener mediante el uso de un grandiente de sulfato amonico. |
| PE20001396A1 (es) * | 1999-01-18 | 2000-12-23 | Gruenenthal Chemie | Formulaciones medicamentosas retardadas que contienen una combinacion de un opioide o una sal fisiologicamente tolerables del mismo, un o-agonista |
| US6368620B2 (en) * | 1999-06-11 | 2002-04-09 | Abbott Laboratories | Formulations comprising lipid-regulating agents |
| AU2003304108B2 (en) * | 2002-10-30 | 2007-03-22 | Spherics, Inc. | Nanoparticulate bioactive agents |
-
2002
- 2002-05-31 IL IL15881902A patent/IL158819A0/xx unknown
- 2002-05-31 NZ NZ529544A patent/NZ529544A/en unknown
- 2002-05-31 WO PCT/US2002/017346 patent/WO2002096368A2/en not_active Ceased
- 2002-05-31 CA CA2447990A patent/CA2447990C/en not_active Expired - Fee Related
- 2002-05-31 US US10/161,969 patent/US20030096000A1/en not_active Abandoned
- 2002-05-31 JP JP2002592881A patent/JP2004532252A/ja not_active Withdrawn
- 2002-05-31 AU AU2002322024A patent/AU2002322024B2/en not_active Ceased
- 2002-05-31 EP EP02756110A patent/EP1395243A2/en not_active Withdrawn
-
2008
- 2008-08-08 AU AU2008203783A patent/AU2008203783A1/en not_active Abandoned
-
2009
- 2009-08-07 JP JP2009185294A patent/JP2009256383A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20030096000A1 (en) | 2003-05-22 |
| AU2002322024B2 (en) | 2008-05-08 |
| JP2009256383A (ja) | 2009-11-05 |
| EP1395243A2 (en) | 2004-03-10 |
| CA2447990A1 (en) | 2002-12-05 |
| WO2002096368A2 (en) | 2002-12-05 |
| WO2002096368A3 (en) | 2003-07-10 |
| NZ529544A (en) | 2006-11-30 |
| CA2447990C (en) | 2012-01-31 |
| JP2004532252A (ja) | 2004-10-21 |
| AU2008203783A1 (en) | 2008-08-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL158819A0 (en) | Encapsulation of nanosuspensions in liposomes and microspheres | |
| AU2002365162A8 (en) | Self-assembly and mineralization of peptide-amphiphile nanofibers | |
| PL348343A1 (en) | Method of obtaining prolonged-release microparticles and prolonged-release microparticles as such | |
| IL162737A (en) | Arrays of microparticles and methods of preparation thereof | |
| EP1405624A4 (en) | SURFACE-TREATED POWDER AND COSMETIC PREPARATION | |
| EP1463742A4 (en) | NEW PYRAZOLO AND PYRROLO PYRIMIDINES AND THEIR USES | |
| EP1291377A4 (en) | SILICONE COMPOUND AND COSMETIC PREPARATION | |
| AU2002359512A8 (en) | Belts and methods of use thereof | |
| AU2002346548A8 (en) | Regioisomerically pure oxochlorins and methods of synthesis | |
| HUP0400341A3 (en) | Cyano-substituted dihydropyrimidine compounds and their use | |
| HU0104832D0 (en) | Cosmetic composition and method | |
| IL154553A0 (en) | Urocortin-iii and uses thereof | |
| GB0106467D0 (en) | Cosmetic and personal care compositions | |
| AU2002363938A8 (en) | Methods and use of motoneuronotropic factors | |
| GB0200204D0 (en) | Cosmetic and related preparations | |
| EP1408985A4 (en) | NEW PYRIDOPYRIMIDONE AND ITS USES | |
| PL363290A1 (en) | 1k-polyurethane lacquer and use thereof | |
| IL161608A0 (en) | Synthesis of 2-aralkoxyadenosines and 2-alkoxyadenosines | |
| HK1064916A (en) | Encapsulation of nanosuspensions in liposomes and microspheres | |
| EP1367123A4 (en) | NEUROTONIN AND ITS USE | |
| EP1414427A4 (en) | KAVALACTONE COMPOSITIONS AND METHODS OF USE | |
| IL155713A0 (en) | Improved endosulfan formulation and methods of use thereof | |
| GB0200843D0 (en) | Benzodioxinopyrroles their preparation and use | |
| GB2363981B (en) | Assemblies of Case-holder and Case | |
| TW477214U (en) | Structure of pepper grinding can and grinding structure thereof |