IL155590A0 - Acyl and sulfonyl derivatives of 6,9-disubstituted 2-(trans-1,4-diaminocyclohexyl)-purines and their use as antiproliferative agents - Google Patents
Acyl and sulfonyl derivatives of 6,9-disubstituted 2-(trans-1,4-diaminocyclohexyl)-purines and their use as antiproliferative agentsInfo
- Publication number
- IL155590A0 IL155590A0 IL15559001A IL15559001A IL155590A0 IL 155590 A0 IL155590 A0 IL 155590A0 IL 15559001 A IL15559001 A IL 15559001A IL 15559001 A IL15559001 A IL 15559001A IL 155590 A0 IL155590 A0 IL 155590A0
- Authority
- IL
- Israel
- Prior art keywords
- diaminocyclohexyl
- purines
- disubstituted
- acyl
- trans
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Vascular Medicine (AREA)
- Obesity (AREA)
- Transplantation (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Urology & Nephrology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24456700P | 2000-10-31 | 2000-10-31 | |
| GBGB0117075.2A GB0117075D0 (en) | 2000-10-31 | 2001-07-13 | Acyl and sulfonyl derivatives of 6, 9-distributed 2-(trans-1, 4-diaminocyclohexyl)-purines and their use as antiproliferative agents |
| PCT/US2001/044835 WO2002042303A2 (fr) | 2000-10-31 | 2001-10-31 | Dérivés acyle et sulfonyle de 2-(trans-1,4-diaminocyclohexyl)-purines 6,9-disubstituées et leur utilisation comme antiproliférants |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL155590A0 true IL155590A0 (en) | 2003-11-23 |
Family
ID=26246308
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL15559001A IL155590A0 (en) | 2000-10-31 | 2001-10-31 | Acyl and sulfonyl derivatives of 6,9-disubstituted 2-(trans-1,4-diaminocyclohexyl)-purines and their use as antiproliferative agents |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP1377579B1 (fr) |
| JP (1) | JP4348081B2 (fr) |
| AT (1) | ATE426603T1 (fr) |
| AU (2) | AU2002239388B2 (fr) |
| BR (1) | BR0115080A (fr) |
| CA (1) | CA2427338C (fr) |
| DE (1) | DE60138140D1 (fr) |
| DK (1) | DK1377579T3 (fr) |
| ES (1) | ES2324763T3 (fr) |
| IL (1) | IL155590A0 (fr) |
| MX (1) | MXPA03003774A (fr) |
| NO (1) | NO20031939L (fr) |
| NZ (1) | NZ525264A (fr) |
| WO (1) | WO2002042303A2 (fr) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7563810B2 (en) * | 2002-11-06 | 2009-07-21 | Celgene Corporation | Methods of using 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myeloproliferative diseases |
| FR2851248B1 (fr) * | 2003-02-18 | 2005-04-08 | Aventis Pharma Sa | Nouveaux derives de la purine, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation |
| CN1805951A (zh) * | 2003-06-12 | 2006-07-19 | 诺沃挪第克公司 | 取代的哌啶氨基甲酸酯用作激素敏感性脂酶抑制剂 |
| ATE531372T1 (de) * | 2008-04-07 | 2011-11-15 | Amgen Inc | Gem-disubstituierte und spirocyclische aminopyridine/pyrimidine als zellcyclus- inhibitoren |
| EP2519517B1 (fr) | 2009-12-29 | 2015-03-25 | Dana-Farber Cancer Institute, Inc. | Inhibiteurs de kinase raf de type ii |
| JP6106685B2 (ja) | 2011-11-17 | 2017-04-05 | ダナ−ファーバー キャンサー インスティテュート， インコーポレイテッド | Ｃ−ｊｕｎ−ｎ−末端キナーゼ（ｊｎｋ）の阻害剤 |
| EP3057956B1 (fr) | 2013-10-18 | 2021-05-05 | Dana-Farber Cancer Institute, Inc. | Inhibiteurs polycycliques de la kinase cycline-dépendante 7 (cdk7) |
| US10870651B2 (en) | 2014-12-23 | 2020-12-22 | Dana-Farber Cancer Institute, Inc. | Inhibitors of cyclin-dependent kinase 7 (CDK7) |
| JP6861166B2 (ja) * | 2015-03-27 | 2021-04-21 | ダナ−ファーバー キャンサー インスティテュート， インコーポレイテッド | サイクリン依存性キナーゼの阻害剤 |
| JP7028766B2 (ja) | 2015-09-09 | 2022-03-02 | ダナ－ファーバー キャンサー インスティテュート， インコーポレイテッド | サイクリン依存性キナーゼの阻害剤 |
| US11066404B2 (en) | 2018-10-11 | 2021-07-20 | Incyte Corporation | Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors |
| US11384083B2 (en) | 2019-02-15 | 2022-07-12 | Incyte Corporation | Substituted spiro[cyclopropane-1,5′-pyrrolo[2,3-d]pyrimidin]-6′(7′h)-ones as CDK2 inhibitors |
| TW202100520A (zh) | 2019-03-05 | 2021-01-01 | 美商英塞特公司 | 作為cdk2 抑制劑之吡唑基嘧啶基胺化合物 |
| WO2020205560A1 (fr) | 2019-03-29 | 2020-10-08 | Incyte Corporation | Composés sulfonylamides utilisés comme inhibiteurs de la cdk2 |
| WO2020223469A1 (fr) | 2019-05-01 | 2020-11-05 | Incyte Corporation | Dérivés de n-(1-(méthylsulfonyl)pipéridin-4-yl)-4,5-di hydro-1h-imidazo[4,5-h]quinazolin-8-amine et composés apparentés utilisés en tant qu'inhibiteurs de kinase 2 dépendante des cyclines (cdk2) pour le traitement du cancer |
| WO2020223558A1 (fr) | 2019-05-01 | 2020-11-05 | Incyte Corporation | Composés aminés tricycliques en tant qu'inhibiteurs de cdk2 |
| CR20220066A (es) | 2019-08-14 | 2022-11-28 | Incyte Corp | Compuestos de imidazolil pirimidinilamina como inhibidores de cdk2 |
| CN115298177A (zh) | 2019-10-11 | 2022-11-04 | 因赛特公司 | 作为cdk2抑制剂的双环胺 |
| US11981671B2 (en) | 2021-06-21 | 2024-05-14 | Incyte Corporation | Bicyclic pyrazolyl amines as CDK2 inhibitors |
| US11976073B2 (en) | 2021-12-10 | 2024-05-07 | Incyte Corporation | Bicyclic amines as CDK2 inhibitors |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SK12912000A3 (sk) * | 1998-02-26 | 2001-08-06 | Aventis Pharmaceuticals Inc. | 6,9-disubstituované 2-[trans-(4-aminocyklohexyl)amino]puríny, farmaceutické prostriedky obsahujúce tieto zlúčeniny a použitie |
| US6479487B1 (en) * | 1998-02-26 | 2002-11-12 | Aventis Pharmaceuticals Inc. | 6, 9-disubstituted 2-[trans-(4-aminocyclohexyl)amino] purines |
| FR2793794B1 (fr) * | 1999-05-21 | 2001-07-27 | Hoechst Marion Roussel Inc | Nouveaux derives de la purine, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation |
| CA2394646A1 (fr) * | 1999-12-17 | 2001-06-21 | Ariad Pharmaceuticals, Inc. | Nouvelles purines |
| CZ20022353A3 (cs) * | 2000-01-07 | 2003-02-12 | Universitaire Instelling Antwerpen | Deriváty purinu, způsob jejich přípravy a jejich použití |
-
2001
- 2001-10-31 DE DE60138140T patent/DE60138140D1/de not_active Expired - Lifetime
- 2001-10-31 BR BR0115080-4A patent/BR0115080A/pt not_active Application Discontinuation
- 2001-10-31 AU AU2002239388A patent/AU2002239388B2/en not_active Expired
- 2001-10-31 ES ES01987144T patent/ES2324763T3/es not_active Expired - Lifetime
- 2001-10-31 EP EP01987144A patent/EP1377579B1/fr not_active Expired - Lifetime
- 2001-10-31 MX MXPA03003774A patent/MXPA03003774A/es active IP Right Grant
- 2001-10-31 AT AT01987144T patent/ATE426603T1/de active
- 2001-10-31 NZ NZ525264A patent/NZ525264A/en not_active IP Right Cessation
- 2001-10-31 AU AU3938802A patent/AU3938802A/xx active Pending
- 2001-10-31 WO PCT/US2001/044835 patent/WO2002042303A2/fr active Application Filing
- 2001-10-31 JP JP2002544437A patent/JP4348081B2/ja not_active Expired - Lifetime
- 2001-10-31 IL IL15559001A patent/IL155590A0/xx unknown
- 2001-10-31 DK DK01987144T patent/DK1377579T3/da active
- 2001-10-31 CA CA002427338A patent/CA2427338C/fr not_active Expired - Lifetime
-
2003
- 2003-04-29 NO NO20031939A patent/NO20031939L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2002042303A2 (fr) | 2002-05-30 |
| JP2004517075A (ja) | 2004-06-10 |
| CA2427338A1 (fr) | 2002-05-30 |
| DK1377579T3 (da) | 2009-08-31 |
| NO20031939L (no) | 2003-06-19 |
| EP1377579A2 (fr) | 2004-01-07 |
| NZ525264A (en) | 2005-12-23 |
| CA2427338C (fr) | 2008-06-10 |
| AU2002239388B2 (en) | 2006-05-25 |
| EP1377579B1 (fr) | 2009-03-25 |
| ES2324763T3 (es) | 2009-08-14 |
| MXPA03003774A (es) | 2003-07-28 |
| JP4348081B2 (ja) | 2009-10-21 |
| NO20031939D0 (no) | 2003-04-29 |
| DE60138140D1 (de) | 2009-05-07 |
| BR0115080A (pt) | 2003-09-23 |
| WO2002042303A3 (fr) | 2003-10-30 |
| ATE426603T1 (de) | 2009-04-15 |
| AU3938802A (en) | 2002-06-03 |
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