IL155213A0 - Ketone compounds and compositions for cholesterol management and related uses - Google Patents

Ketone compounds and compositions for cholesterol management and related uses

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Publication number
IL155213A0
IL155213A0 IL15521301A IL15521301A IL155213A0 IL 155213 A0 IL155213 A0 IL 155213A0 IL 15521301 A IL15521301 A IL 15521301A IL 15521301 A IL15521301 A IL 15521301A IL 155213 A0 IL155213 A0 IL 155213A0
Authority
IL
Israel
Prior art keywords
compositions
ketone compounds
related uses
cholesterol management
cholesterol
Prior art date
Application number
IL15521301A
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English (en)
Original Assignee
Esperion Therapeutics Inc
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Publication date
Application filed by Esperion Therapeutics Inc filed Critical Esperion Therapeutics Inc
Publication of IL155213A0 publication Critical patent/IL155213A0/xx

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IL15521301A 2000-10-11 2001-10-11 Ketone compounds and compositions for cholesterol management and related uses IL155213A0 (en)

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US23923200P 2000-10-11 2000-10-11
PCT/US2001/031872 WO2002030860A2 (fr) 2000-10-11 2001-10-11 Composes de fonction cetone et compositions pour la regulation du taux de cholesterol, et utilisations associees

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Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8568766B2 (en) 2000-08-24 2013-10-29 Gattadahalli M. Anantharamaiah Peptides and peptide mimetics to treat pathologies associated with eye disease
US20040122091A1 (en) * 2000-10-11 2004-06-24 Esperion Therapeutics, Inc. Sulfoxide and bis-sulfoxide compounds and compositions for cholesterol management and related uses
US7304093B2 (en) * 2000-10-11 2007-12-04 Esperion Therapeutics, Inc. Ketone compounds and compositions for cholesterol management and related uses
US20050003041A1 (en) * 2001-05-01 2005-01-06 Gerhard Kamil Application of fluid bed technology in brewing
US20030236212A1 (en) * 2002-04-10 2003-12-25 Jean-Louis Dasseux Functionalized long chain derivatives as acyl coenzyme-A mimics, compositions thereof, and methods of cholesterol management and related uses
US20040148013A1 (en) * 2002-04-18 2004-07-29 Epstein Stephen E Stent-based delivery statins to prevent restenosis
US20040048910A1 (en) * 2002-08-22 2004-03-11 Bove Susan Elizabeth Method of treating osteoarthritis
MXPA05007674A (es) * 2003-01-23 2005-09-22 Esperion Therapeutics Inc Compuestos de hidroxilo y composiciones para el manejo del colesterol y usos relacionados.
BR0318685A (pt) 2003-12-24 2006-12-19 Esperion Therapeutics Inc compostos de cetona e composições para controle de colesterol e usos relacionados
EP1890715A4 (fr) 2005-04-29 2009-10-28 Univ California Peptides et mimetiques de peptides destines a traiter les pathologies caracterisees par une reaction inflammatoire
CA2659655A1 (fr) 2006-08-08 2008-02-21 Alan M. Fogelman Les salicylanilides renforcent l'administration par voie orale de peptides therapeutiques
IL181577A0 (en) * 2007-02-26 2007-07-04 Jacob Bar Tana Combination therapy composition and methods for the treatment of cardiovascular disorders and immune-related disorders
WO2009032693A2 (fr) 2007-08-28 2009-03-12 Uab Research Foundation Polypeptides de synthèse imitant l'apolipoprotéine e et leurs procédés d'utilisation
US8557767B2 (en) 2007-08-28 2013-10-15 Uab Research Foundation Synthetic apolipoprotein E mimicking polypeptides and methods of use
US8815508B2 (en) * 2008-08-12 2014-08-26 Zinfandel Pharmaceuticals, Inc. Method of identifying disease risk factors
US8846315B2 (en) 2008-08-12 2014-09-30 Zinfandel Pharmaceuticals, Inc. Disease risk factors and methods of use
EP2334188A4 (fr) * 2008-08-15 2012-08-08 Burnham Inst Medical Research Composition et procédés utilisables en vue de la conception et du développement d'inhibiteurs des métalloenzymes
WO2011143362A1 (fr) 2010-05-11 2011-11-17 Esperion Therapeutics, Inc. Variants d'apolipoprotéine a1 résistants à l'oxydation dimères
RU2013118021A (ru) 2010-09-20 2014-10-27 Кареус Терапьютикс, Са Способы и композиции для лечения сахарного диабета и дислипидемии
UA114704C2 (uk) 2011-01-10 2017-07-25 Зінфандел Фармасьютікалз, Інк. Способи та лікарські засоби для лікування хвороби альцгеймера
DE102011078416A1 (de) * 2011-06-30 2013-01-03 Henkel Ag & Co. Kgaa Photolabile Duftspeicherstoffe
EP3137899A2 (fr) 2014-05-02 2017-03-08 Cerenis Therapeutics Holding SA Marqueurs de thérapie hdl
EP3189069B1 (fr) 2014-07-31 2024-10-23 UAB Research Foundation Peptides e-mimétiques d'apo ayant une puissance supérieure afin de dégager le taux de cholestérol plasmatique
CN107530307A (zh) 2015-03-13 2018-01-02 艾斯柏伦治疗公司 包含etc1002和依泽替米贝的固定剂量组合和制剂以及治疗心血管疾病或降低心血管疾病风险的方法
MA41793A (fr) 2015-03-16 2018-01-23 Esperion Therapeutics Inc Associations de doses fixes comprenant du etc1002 et une ou plusieurs statines permettant de traiter ou de réduire un risque cardiovasculaire
KR101772440B1 (ko) 2015-08-31 2017-08-30 한국식품연구원 4-(4-하이드록시-4-메틸펜틸)-3-사이클로-헥센-1-카복스알데하이드를 포함하는 신생혈관형성 촉진용 조성물
GB201522302D0 (en) * 2015-12-17 2016-02-03 Mars Inc Food product for regulating lipid metabolites
CN107118098B (zh) * 2016-02-25 2020-07-14 中国科学院上海药物研究所 一类脂肪酸类化合物、其制备方法及其用途
WO2020141419A2 (fr) * 2018-12-31 2020-07-09 Lupin Limited Nouveaux sels et formes polymorphes d'acide bempedoïque
EP3986860A1 (fr) 2019-06-21 2022-04-27 Esperion Therapeutics, Inc. Formes salines d'acide bempedoïque et leurs procédés d'utilisation
CN114126593B (zh) 2019-07-26 2024-07-26 埃斯佩尔维塔治疗股份有限公司 可用于预防或治疗疾病的官能化的长链烃一元和二元羧酸
WO2021252607A1 (fr) * 2020-06-12 2021-12-16 Novomer, Inc. Composés de bêta-propiolactone et composés de bêta-propiolactone à cycle ouvert et leurs utilisations
TW202245804A (zh) 2021-01-25 2022-12-01 美商艾斯佩維他治療學公司 官能化長鏈烴單羧酸及二羧酸及其衍生物以及其於預防或治療疾病之用途
WO2022159808A2 (fr) * 2021-01-25 2022-07-28 Espervita Therapeutics, Inc. Acides monocarboxyliques et dicarboxyliques à chaîne longue fonctionnalisés et leurs dérivés, et leur utilisation pour la prévention ou le traitement d'une maladie
AU2022381258A1 (en) * 2021-11-03 2024-05-02 Tuojie Biotech (Shanghai) Co., Ltd. Substituted phenylpropionic acid derivative and use thereof
WO2024199070A1 (fr) * 2023-03-24 2024-10-03 上海京新生物医药有限公司 Dérivé d'amine cyclique, composition et utilisation associées

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3441605A (en) 1965-02-17 1969-04-29 Wallace & Tiernan Inc Diketo-dicarboxylic acids and salts and preparation thereof by alkaline oxidation
US3773946A (en) 1969-09-02 1973-11-20 Parke Davis & Co Triglyceride-lowering compositions and methods
US3930024A (en) 1969-09-02 1975-12-30 Parke Davis & Co Pharmaceutical compositions and methods
JPS5522636A (en) 1978-08-04 1980-02-18 Takeda Chem Ind Ltd Thiazoliding derivative
JPS5639033A (en) 1979-09-04 1981-04-14 Kao Corp Alpha-mono(methyl-branched alkyl glyceryl ether and skin cosmetic containing the same
IL64542A0 (en) 1981-12-15 1982-03-31 Yissum Res Dev Co Long-chain alpha,omega-dicarboxylic acids and derivatives thereof and pharmaceutical compositions containing them
IT1164254B (it) 1983-05-30 1987-04-08 Luso Farmaco Inst 3-(3-idrossibutossi)-1-butanolo e suo metodo di preparazione
JPS60136512A (ja) 1983-12-26 1985-07-20 Eisai Co Ltd 脂質代謝改善剤
DE3423166A1 (de) 1984-06-22 1986-01-02 Epis S.A., Zug Alpha-, omega-dicarbonsaeuren, verfahren zu ihrer herstellung und arzneimittel, die diese verbindungen enthalten
JP2999579B2 (ja) 1990-07-18 2000-01-17 武田薬品工業株式会社 Dnaおよびその用途
US5254589A (en) 1991-10-15 1993-10-19 Warner-Lambert Company Sulfonyl urea and carbamate ACAT inhibitors
IL109431A (en) 1993-05-14 2001-01-11 Warner Lambert Co Pharmaceutical compositions containing n-acyl sulfamic acid esters (or thioesters), n-acyl sulfonamides, and n-sulfonyl carbamic acid esters (or thioesters), for regulating plasma cholesterol concentration, and certain such novel compounds
US5420339A (en) 1993-11-22 1995-05-30 Warner-Lambert Company Alpha-aryl or heteroaryl-substituted amide ester ACAT inhibitors
US5504073A (en) 1994-07-01 1996-04-02 Warner-Lambert Company PLA2 inhibitors and their use for inhibition of intestinal cholesterol absorption
US5578639A (en) 1994-07-01 1996-11-26 Warner-Lambert Company PLA2 inhibitors and their use for inhibition of intestinal cholesterol absorption
US5648387A (en) 1995-03-24 1997-07-15 Warner-Lambert Company Carboxyalkylethers, formulations, and treatment of vascular diseases
EA000514B1 (ru) 1995-11-02 1999-10-28 Варнер-Ламберт Компани Способ нормализации липопротеидного профиля плазмы крови у млекопитающего и фармацевтическая композиция для его осуществления
US5807846A (en) 1996-11-14 1998-09-15 Warner-Lambert Company Phosphonamide ACAT inhibitors
IL119971A (en) 1997-01-07 2003-02-12 Yissum Res Dev Co Pharmaceutical compositions containing dicarboxylic acids and derivatives thereof and some novel dicarboxylic acids
US6093744A (en) 1997-04-21 2000-07-25 Warner-Lambert Company N-acyl sulfamic acid esters useful as hypocholesterolemic agents
IL121165A0 (en) 1997-06-26 1997-11-20 Yissum Res Dev Co Pharmaceutical compositions containing carboxylic acids and derivatives thereof
ATE298343T1 (de) 1999-04-28 2005-07-15 Univ Georgetown Ligande für metabotropische glutamat-rezeptoren
WO2001046110A2 (fr) * 1999-12-23 2001-06-28 The University Of Georgia Research Foundation, Inc. Chalcone et ses analogues comme agents inhibiteurs de l'angiogenese et des etats pathologiques associes

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WO2002030860A2 (fr) 2002-04-18
WO2002030860A3 (fr) 2002-08-15
IL155213A (en) 2011-12-29
CN1283610C (zh) 2006-11-08
US20030078239A1 (en) 2003-04-24
AU1313602A (en) 2002-04-22
AU2002213136B2 (en) 2007-01-04
BRPI0114622B1 (pt) 2016-07-05
US6699910B2 (en) 2004-03-02
BRPI0114622B8 (pt) 2021-05-25
BR0114622A (pt) 2004-06-29
MXPA03003020A (es) 2003-07-14
CN1962596A (zh) 2007-05-16
CA2425311A1 (fr) 2002-04-18
CA2425311C (fr) 2011-06-14
CN1479712A (zh) 2004-03-03
EP1326822A2 (fr) 2003-07-16
JP2004511453A (ja) 2004-04-15
HK1063461A1 (en) 2004-12-31
WO2002030860A9 (fr) 2003-02-20

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