HK1063461A1 - Ketone compounds and compositions for cholesterolhmanagement and related uses - Google Patents
Ketone compounds and compositions for cholesterolhmanagement and related usesInfo
- Publication number
- HK1063461A1 HK1063461A1 HK04106257A HK04106257A HK1063461A1 HK 1063461 A1 HK1063461 A1 HK 1063461A1 HK 04106257 A HK04106257 A HK 04106257A HK 04106257 A HK04106257 A HK 04106257A HK 1063461 A1 HK1063461 A1 HK 1063461A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- cholesterolhmanagement
- compositions
- ketone compounds
- related uses
- ketone
- Prior art date
Links
- -1 Ketone compounds Chemical class 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
Classifications
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- C07C49/743—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups having unsaturation outside the rings, e.g. humulones, lupulones
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- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/44—Amides thereof
- C07F9/4403—Amides thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4423—Amides of poly (thio)phosphonic acids
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Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US23923200P | 2000-10-11 | 2000-10-11 | |
PCT/US2001/031872 WO2002030860A2 (en) | 2000-10-11 | 2001-10-11 | Ketone compounds and compositions for cholesterol management and related uses |
Publications (1)
Publication Number | Publication Date |
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HK1063461A1 true HK1063461A1 (en) | 2004-12-31 |
Family
ID=22901210
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK04106257A HK1063461A1 (en) | 2000-10-11 | 2004-08-20 | Ketone compounds and compositions for cholesterolhmanagement and related uses |
Country Status (11)
Country | Link |
---|---|
US (1) | US6699910B2 (xx) |
EP (1) | EP1326822A2 (xx) |
JP (1) | JP2004511453A (xx) |
CN (2) | CN1283610C (xx) |
AU (2) | AU1313602A (xx) |
BR (1) | BRPI0114622B8 (xx) |
CA (1) | CA2425311C (xx) |
HK (1) | HK1063461A1 (xx) |
IL (2) | IL155213A0 (xx) |
MX (1) | MXPA03003020A (xx) |
WO (1) | WO2002030860A2 (xx) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8568766B2 (en) | 2000-08-24 | 2013-10-29 | Gattadahalli M. Anantharamaiah | Peptides and peptide mimetics to treat pathologies associated with eye disease |
US7304093B2 (en) * | 2000-10-11 | 2007-12-04 | Esperion Therapeutics, Inc. | Ketone compounds and compositions for cholesterol management and related uses |
US20040122091A1 (en) * | 2000-10-11 | 2004-06-24 | Esperion Therapeutics, Inc. | Sulfoxide and bis-sulfoxide compounds and compositions for cholesterol management and related uses |
AU2002244732A2 (en) * | 2001-05-01 | 2002-11-11 | Gerhard Kamil | Application of fluid bed technology in brewing |
US20030236213A1 (en) * | 2002-04-10 | 2003-12-25 | Jean-Louis Dasseux | Mimics of acyl coenzyme-A comprising pantolactone and pantothenic acid derivatives, compositions thereof, and methods of cholesterol management and related uses |
US20040148013A1 (en) * | 2002-04-18 | 2004-07-29 | Epstein Stephen E | Stent-based delivery statins to prevent restenosis |
US20040048910A1 (en) * | 2002-08-22 | 2004-03-11 | Bove Susan Elizabeth | Method of treating osteoarthritis |
US7335799B2 (en) | 2003-01-23 | 2008-02-26 | Esperion Therapeutics, Inc. | Hydroxyl compounds and compositions for cholesterol management and related uses |
CA2549995C (en) * | 2003-12-24 | 2011-11-15 | Esperion Therapeutics, Inc. | Ketone compounds and compositions for cholesterol management and related uses |
EP2269623A1 (en) | 2005-04-29 | 2011-01-05 | The Regents of The University of California | Peptides and peptide mimetics to treat pathologies characterized by an inflammatory response |
CA2659655A1 (en) | 2006-08-08 | 2008-02-21 | Alan M. Fogelman | Salicylanilides enhance oral delivery of therapeutic peptides |
IL181577A0 (en) * | 2007-02-26 | 2007-07-04 | Jacob Bar Tana | Combination therapy composition and methods for the treatment of cardiovascular disorders and immune-related disorders |
DK2195331T3 (da) | 2007-08-28 | 2014-02-03 | Uab Research Foundation | Syntetiske polypeptider, der efterligner apolipoprotein e, og anvendelsesmetoder |
US8557767B2 (en) | 2007-08-28 | 2013-10-15 | Uab Research Foundation | Synthetic apolipoprotein E mimicking polypeptides and methods of use |
EP2789695B1 (en) | 2008-08-12 | 2019-10-30 | Zinfandel Pharmaceuticals, Inc. | Anti-Alzheimer's disease treatment of subjects identified by detecting the presence of a genetic variant in the TOMM40 gene at rs 10524523 |
US8846315B2 (en) | 2008-08-12 | 2014-09-30 | Zinfandel Pharmaceuticals, Inc. | Disease risk factors and methods of use |
JP2012500222A (ja) * | 2008-08-15 | 2012-01-05 | バーンハム インスティテュート フォー メディカル リサーチ | 金属酵素阻害剤の設計および開発のための組成物および方法 |
WO2011143362A1 (en) | 2010-05-11 | 2011-11-17 | Esperion Therapeutics, Inc. | Dimeric oxidation-resistant apolipoprotein a1 variants |
WO2012040177A1 (en) | 2010-09-20 | 2012-03-29 | Kareus Therapeutics, Sa | Methods and compositions for treatment of diabetes and dyslipidemia |
GEP201706786B (en) | 2011-01-10 | 2017-12-11 | Takeda Pharmaceuticals Co | Methods and drug products for treating alzheimer's disease |
DE102011078416A1 (de) * | 2011-06-30 | 2013-01-03 | Henkel Ag & Co. Kgaa | Photolabile Duftspeicherstoffe |
RU2016144908A (ru) | 2014-05-02 | 2018-06-05 | Серени Терапеутикс Холдинг Са | Маркеры hdl-терапии |
EP3189069A4 (en) | 2014-07-31 | 2018-03-07 | UAB Research Foundation | Apoe mimetic peptides and higher potency to clear plasma cholesterol |
CA2978204A1 (en) | 2015-03-13 | 2016-09-22 | Esperion Therapeutics, Inc. | Fixed dose combinations and formulations comprising etc1002 and ezetimibe and methods of treating or reducing the risk of cardiovascular disease |
MA41793A (fr) | 2015-03-16 | 2018-01-23 | Esperion Therapeutics Inc | Associations de doses fixes comprenant du etc1002 et une ou plusieurs statines permettant de traiter ou de réduire un risque cardiovasculaire |
KR101772440B1 (ko) | 2015-08-31 | 2017-08-30 | 한국식품연구원 | 4-(4-하이드록시-4-메틸펜틸)-3-사이클로-헥센-1-카복스알데하이드를 포함하는 신생혈관형성 촉진용 조성물 |
GB201522302D0 (en) * | 2015-12-17 | 2016-02-03 | Mars Inc | Food product for regulating lipid metabolites |
CN107118098B (zh) * | 2016-02-25 | 2020-07-14 | 中国科学院上海药物研究所 | 一类脂肪酸类化合物、其制备方法及其用途 |
WO2020141419A2 (en) * | 2018-12-31 | 2020-07-09 | Lupin Limited | Novel salts and polymorphic form of bempedoic acid |
EP3986859A1 (en) | 2019-06-21 | 2022-04-27 | Esperion Therapeutics, Inc. | Methods of making bempedoic acid and compositions of the same |
US11098002B2 (en) | 2019-07-26 | 2021-08-24 | Espervita Therapeutics, Inc. | Functionalized long-chain hydrocarbon mono- and di-carboxylic acids and their use for the prevention or treatment of disease |
WO2021252607A1 (en) * | 2020-06-12 | 2021-12-16 | Novomer, Inc. | Beta-propiolactone compounds and ring opened beta-propiolactone compounds and uses for same |
TW202245804A (zh) | 2021-01-25 | 2022-12-01 | 美商艾斯佩維他治療學公司 | 官能化長鏈烴單羧酸及二羧酸及其衍生物以及其於預防或治療疾病之用途 |
MX2023008567A (es) * | 2021-01-25 | 2023-08-28 | Espervita Therapeutics Inc | Acidos monocarboxilicos y dicarboxilicos de hidrocarburos de cadena larga funcionalizados y derivados de estos, y su uso para la prevencion o el tratamiento de enfermedades. |
KR20240091010A (ko) * | 2021-11-03 | 2024-06-21 | 투오지에 바이오텍 (상하이) 컴퍼니 리미티드 | 치환된 페닐프로피온산 유도체 및 이의 용도 |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3441605A (en) * | 1965-02-17 | 1969-04-29 | Wallace & Tiernan Inc | Diketo-dicarboxylic acids and salts and preparation thereof by alkaline oxidation |
US3773946A (en) | 1969-09-02 | 1973-11-20 | Parke Davis & Co | Triglyceride-lowering compositions and methods |
US3930024A (en) | 1969-09-02 | 1975-12-30 | Parke Davis & Co | Pharmaceutical compositions and methods |
JPS5522636A (en) | 1978-08-04 | 1980-02-18 | Takeda Chem Ind Ltd | Thiazoliding derivative |
JPS5639033A (en) | 1979-09-04 | 1981-04-14 | Kao Corp | Alpha-mono(methyl-branched alkyl glyceryl ether and skin cosmetic containing the same |
IL64542A0 (en) | 1981-12-15 | 1982-03-31 | Yissum Res Dev Co | Long-chain alpha,omega-dicarboxylic acids and derivatives thereof and pharmaceutical compositions containing them |
IT1164254B (it) | 1983-05-30 | 1987-04-08 | Luso Farmaco Inst | 3-(3-idrossibutossi)-1-butanolo e suo metodo di preparazione |
JPS60136512A (ja) | 1983-12-26 | 1985-07-20 | Eisai Co Ltd | 脂質代謝改善剤 |
DE3423166A1 (de) | 1984-06-22 | 1986-01-02 | Epis S.A., Zug | Alpha-, omega-dicarbonsaeuren, verfahren zu ihrer herstellung und arzneimittel, die diese verbindungen enthalten |
JP2999579B2 (ja) | 1990-07-18 | 2000-01-17 | 武田薬品工業株式会社 | Dnaおよびその用途 |
US5254589A (en) | 1991-10-15 | 1993-10-19 | Warner-Lambert Company | Sulfonyl urea and carbamate ACAT inhibitors |
IL109431A (en) | 1993-05-14 | 2001-01-11 | Warner Lambert Co | Pharmaceutical compositions containing n-acyl sulfamic acid esters (or thioesters), n-acyl sulfonamides, and n-sulfonyl carbamic acid esters (or thioesters), for regulating plasma cholesterol concentration, and certain such novel compounds |
US5420339A (en) | 1993-11-22 | 1995-05-30 | Warner-Lambert Company | Alpha-aryl or heteroaryl-substituted amide ester ACAT inhibitors |
US5504073A (en) | 1994-07-01 | 1996-04-02 | Warner-Lambert Company | PLA2 inhibitors and their use for inhibition of intestinal cholesterol absorption |
US5578639A (en) | 1994-07-01 | 1996-11-26 | Warner-Lambert Company | PLA2 inhibitors and their use for inhibition of intestinal cholesterol absorption |
US5648387A (en) | 1995-03-24 | 1997-07-15 | Warner-Lambert Company | Carboxyalkylethers, formulations, and treatment of vascular diseases |
CN1217656C (zh) | 1995-11-02 | 2005-09-07 | 沃尼尔·朗伯公司 | 用于调节脂浓度的方法和药物组合物 |
US5807846A (en) | 1996-11-14 | 1998-09-15 | Warner-Lambert Company | Phosphonamide ACAT inhibitors |
IL119971A (en) | 1997-01-07 | 2003-02-12 | Yissum Res Dev Co | Pharmaceutical compositions containing dicarboxylic acids and derivatives thereof and some novel dicarboxylic acids |
US6093744A (en) | 1997-04-21 | 2000-07-25 | Warner-Lambert Company | N-acyl sulfamic acid esters useful as hypocholesterolemic agents |
IL121165A0 (en) | 1997-06-26 | 1997-11-20 | Yissum Res Dev Co | Pharmaceutical compositions containing carboxylic acids and derivatives thereof |
US6479470B1 (en) * | 1999-04-28 | 2002-11-12 | Georgetown University | Ligands for metabotropic glutamate receptors and inhibitors of NAALAdase |
CA2395191A1 (en) * | 1999-12-23 | 2001-06-28 | Tedman Ehlers | Chalcone and its analogs as agents for the inhibition of angiogenesis and related disease states |
-
2001
- 2001-10-11 MX MXPA03003020A patent/MXPA03003020A/es active IP Right Grant
- 2001-10-11 BR BRPI0114622A patent/BRPI0114622B8/pt not_active IP Right Cessation
- 2001-10-11 CA CA2425311A patent/CA2425311C/en not_active Expired - Lifetime
- 2001-10-11 EP EP01981499A patent/EP1326822A2/en not_active Withdrawn
- 2001-10-11 CN CNB018202470A patent/CN1283610C/zh not_active Expired - Lifetime
- 2001-10-11 IL IL15521301A patent/IL155213A0/xx unknown
- 2001-10-11 AU AU1313602A patent/AU1313602A/xx active Pending
- 2001-10-11 JP JP2002534250A patent/JP2004511453A/ja not_active Withdrawn
- 2001-10-11 US US09/976,938 patent/US6699910B2/en not_active Expired - Lifetime
- 2001-10-11 WO PCT/US2001/031872 patent/WO2002030860A2/en active Application Filing
- 2001-10-11 AU AU2002213136A patent/AU2002213136B2/en not_active Expired
- 2001-10-11 CN CNA2006101540229A patent/CN1962596A/zh active Pending
-
2003
- 2003-04-03 IL IL155213A patent/IL155213A/en active IP Right Grant
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2004
- 2004-08-20 HK HK04106257A patent/HK1063461A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
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CN1962596A (zh) | 2007-05-16 |
IL155213A0 (en) | 2003-11-23 |
WO2002030860A3 (en) | 2002-08-15 |
AU1313602A (en) | 2002-04-22 |
CA2425311A1 (en) | 2002-04-18 |
JP2004511453A (ja) | 2004-04-15 |
BRPI0114622B1 (pt) | 2016-07-05 |
CA2425311C (en) | 2011-06-14 |
BRPI0114622B8 (pt) | 2021-05-25 |
BR0114622A (pt) | 2004-06-29 |
EP1326822A2 (en) | 2003-07-16 |
IL155213A (en) | 2011-12-29 |
CN1479712A (zh) | 2004-03-03 |
US6699910B2 (en) | 2004-03-02 |
AU2002213136B2 (en) | 2007-01-04 |
US20030078239A1 (en) | 2003-04-24 |
WO2002030860A9 (en) | 2003-02-20 |
CN1283610C (zh) | 2006-11-08 |
MXPA03003020A (es) | 2003-07-14 |
WO2002030860A2 (en) | 2002-04-18 |
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