IL154949A0 - Imidazole derivatives as raf kinase inhibitors - Google Patents

Imidazole derivatives as raf kinase inhibitors

Info

Publication number
IL154949A0
IL154949A0 IL15494901A IL15494901A IL154949A0 IL 154949 A0 IL154949 A0 IL 154949A0 IL 15494901 A IL15494901 A IL 15494901A IL 15494901 A IL15494901 A IL 15494901A IL 154949 A0 IL154949 A0 IL 154949A0
Authority
IL
Israel
Prior art keywords
kinase inhibitors
raf kinase
imidazole derivatives
migraine
pain
Prior art date
Application number
IL15494901A
Other languages
English (en)
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0023197A external-priority patent/GB0023197D0/en
Priority claimed from GB0023193A external-priority patent/GB0023193D0/en
Priority claimed from GB0023196A external-priority patent/GB0023196D0/en
Priority claimed from GB0023208A external-priority patent/GB0023208D0/en
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of IL154949A0 publication Critical patent/IL154949A0/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/001Preparation for luminescence or biological staining
    • A61K49/0013Luminescence
    • A61K49/0017Fluorescence in vivo
    • A61K49/0019Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL15494901A 2000-09-21 2001-09-19 Imidazole derivatives as raf kinase inhibitors IL154949A0 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0023197A GB0023197D0 (en) 2000-09-21 2000-09-21 Compounds
GB0023193A GB0023193D0 (en) 2000-09-21 2000-09-21 Compounds
GB0023196A GB0023196D0 (en) 2000-09-21 2000-09-21 Compouds
GB0023208A GB0023208D0 (en) 2000-09-21 2000-09-21 Compounds
PCT/GB2001/004195 WO2002024680A1 (en) 2000-09-21 2001-09-19 Imidazole derivatives as raf kinase inhibitors

Publications (1)

Publication Number Publication Date
IL154949A0 true IL154949A0 (en) 2003-10-31

Family

ID=27447885

Family Applications (1)

Application Number Title Priority Date Filing Date
IL15494901A IL154949A0 (en) 2000-09-21 2001-09-19 Imidazole derivatives as raf kinase inhibitors

Country Status (21)

Country Link
US (2) US7199137B2 (zh)
EP (1) EP1318992B1 (zh)
JP (1) JP2004509882A (zh)
KR (1) KR20030030027A (zh)
CN (1) CN1471523A (zh)
AT (1) ATE300529T1 (zh)
AU (1) AU2001287901A1 (zh)
BR (1) BR0114023A (zh)
CA (1) CA2423154A1 (zh)
CY (1) CY1105251T1 (zh)
CZ (1) CZ2003793A3 (zh)
DE (1) DE60112312T2 (zh)
DK (1) DK1318992T3 (zh)
ES (1) ES2242767T3 (zh)
HU (1) HUP0301181A2 (zh)
IL (1) IL154949A0 (zh)
MX (1) MXPA03002449A (zh)
NO (1) NO20031270L (zh)
PL (1) PL361397A1 (zh)
PT (1) PT1318992E (zh)
WO (1) WO2002024680A1 (zh)

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WO2003022837A1 (en) * 2001-09-05 2003-03-20 Smithkline Beecham P.L.C. Heterocycle-carboxamide derivatives as raf kinase inhibitors
GB0121488D0 (en) * 2001-09-05 2001-10-24 Smithkline Beecham Plc Compounds
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BRPI0814423B1 (pt) 2007-07-17 2022-04-19 Plexxikon, Inc Compostos que modulam quinase e composição farmacêutica compreendendo os mesmos
EP2181987B9 (en) 2007-08-23 2014-09-03 Takeda Pharmaceutical Company Limited 2-Carbonylaminobenzothiazoles and their use for the prophylaxis and treatment of cancer
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Also Published As

Publication number Publication date
NO20031270D0 (no) 2003-03-19
HUP0301181A2 (en) 2007-02-28
US7199137B2 (en) 2007-04-03
EP1318992A1 (en) 2003-06-18
CY1105251T1 (el) 2010-03-03
US20070135433A1 (en) 2007-06-14
CZ2003793A3 (cs) 2004-04-14
ES2242767T3 (es) 2005-11-16
PL361397A1 (en) 2004-10-04
BR0114023A (pt) 2004-02-03
DE60112312T2 (de) 2005-12-29
PT1318992E (pt) 2005-11-30
CA2423154A1 (en) 2002-03-28
NO20031270L (no) 2003-05-19
DK1318992T3 (da) 2005-11-21
CN1471523A (zh) 2004-01-28
MXPA03002449A (es) 2003-06-19
JP2004509882A (ja) 2004-04-02
KR20030030027A (ko) 2003-04-16
AU2001287901A1 (en) 2002-04-02
US20040038964A1 (en) 2004-02-26
EP1318992B1 (en) 2005-07-27
WO2002024680A1 (en) 2002-03-28
DE60112312D1 (de) 2005-09-01
ATE300529T1 (de) 2005-08-15

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