IL152567A0 - Il-18 inhibitors in atherosclerosis - Google Patents

Il-18 inhibitors in atherosclerosis

Info

Publication number
IL152567A0
IL152567A0 IL15256701A IL15256701A IL152567A0 IL 152567 A0 IL152567 A0 IL 152567A0 IL 15256701 A IL15256701 A IL 15256701A IL 15256701 A IL15256701 A IL 15256701A IL 152567 A0 IL152567 A0 IL 152567A0
Authority
IL
Israel
Prior art keywords
atherosclerosis
inhibitors
Prior art date
Application number
IL15256701A
Other languages
English (en)
Original Assignee
Applied Research Systems
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Research Systems filed Critical Applied Research Systems
Publication of IL152567A0 publication Critical patent/IL152567A0/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Cardiology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Hospice & Palliative Care (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
IL15256701A 2000-05-05 2001-04-30 Il-18 inhibitors in atherosclerosis IL152567A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP00109606 2000-05-05
PCT/EP2001/004843 WO2001085201A2 (fr) 2000-05-05 2001-04-30 Utilisation d'inhibiteurs il-18 pour le traitement et/ou la prevention de l'atherosclerose

Publications (1)

Publication Number Publication Date
IL152567A0 true IL152567A0 (en) 2003-05-29

Family

ID=8168631

Family Applications (2)

Application Number Title Priority Date Filing Date
IL15256701A IL152567A0 (en) 2000-05-05 2001-04-30 Il-18 inhibitors in atherosclerosis
IL152567A IL152567A (en) 2000-05-05 2002-10-31 Il-18 inhibitors in atherosclerosis

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL152567A IL152567A (en) 2000-05-05 2002-10-31 Il-18 inhibitors in atherosclerosis

Country Status (33)

Country Link
US (1) US20040076628A1 (fr)
EP (1) EP1278540B1 (fr)
JP (1) JP5122053B2 (fr)
KR (2) KR100798545B1 (fr)
CN (2) CN1841066B (fr)
AR (1) AR035640A1 (fr)
AT (1) ATE395075T1 (fr)
AU (2) AU2001267390B2 (fr)
BG (1) BG65881B1 (fr)
BR (1) BRPI0110506B8 (fr)
CA (1) CA2407895C (fr)
CY (1) CY1110385T1 (fr)
CZ (1) CZ300792B6 (fr)
DE (1) DE60134009D1 (fr)
DK (1) DK1278540T3 (fr)
EA (2) EA007014B1 (fr)
EE (1) EE05056B1 (fr)
ES (1) ES2305082T3 (fr)
HK (2) HK1055681A1 (fr)
HR (1) HRP20020828A2 (fr)
HU (1) HU229375B1 (fr)
IL (2) IL152567A0 (fr)
ME (1) ME00554B (fr)
MX (1) MXPA02010895A (fr)
NO (1) NO329821B1 (fr)
PL (1) PL209371B1 (fr)
PT (1) PT1278540E (fr)
RS (1) RS50926B (fr)
SI (1) SI1278540T1 (fr)
SK (1) SK287761B6 (fr)
UA (2) UA87658C2 (fr)
WO (1) WO2001085201A2 (fr)
ZA (1) ZA200208228B (fr)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2332579A3 (fr) * 2000-02-10 2011-09-21 Abbott Laboratories Anticorps qui se lient à l'interleukine-18 humaine et procédés de fabrication et d'utilisation
ATE380558T1 (de) * 2001-01-29 2007-12-15 Serono Lab Verwendung von il-18 hemmern zur behandlung und/oder prävention von herzkrankheiten
KR20040030625A (ko) 2001-05-25 2004-04-09 아레스 트레이딩 에스.에이. Ｃｎｓ 손상을 치료하거나 예방하기 위한 ｉｌ-18저해물질의 용도
US6797727B2 (en) 2001-07-16 2004-09-28 Transition Therapeutics Inc. Use of rhein or diacerhein compounds for the treatment or prevention of vascular diseases
US8729124B2 (en) 2002-03-05 2014-05-20 Pronova Biopharma Norge As Use of EPA and DHA in secondary prevention
GB0210212D0 (en) * 2002-05-03 2002-06-12 Univ Southampton Effects of dietary N-3 and N-6 pufa intake on atheromatous plaque stability
SI1487541T1 (sl) 2002-03-22 2009-02-28 Serono Lab Uporaba inhibitorjev il-18 za zdravljenje in /alipreventivo bolezni perifernega oĺ˝ilja
BRPI0408246A (pt) * 2003-03-11 2006-03-01 Applied Research Systems vetores de expressão que compreendem o promotor ie2 do mcmv
ES2384241T3 (es) 2003-05-13 2012-07-02 Merck Serono Sa Variantes activas de la proteína que fija IL-18 y usos médicos de las mismas
US7968684B2 (en) 2003-11-12 2011-06-28 Abbott Laboratories IL-18 binding proteins
WO2005099744A1 (fr) * 2004-04-15 2005-10-27 Athera Biotechnologies Ab Utilisation de l'annexine v pour la prevention de l'atherothrombose et de la rupture de la plaque
CN101219208B (zh) * 2005-01-04 2010-08-11 健能隆医药技术（上海）有限公司 白介素-22的医药用途
ATE557038T1 (de) 2005-06-03 2012-05-15 Ares Trading Sa Herstellung von rekombinantem il-18 bindendem protein
EP1891088B1 (fr) 2005-06-10 2011-10-19 Ares Trading S.A. Procede pour la purification de la proteine liante de il-18
CA2805054A1 (fr) 2010-08-25 2012-03-01 F. Hoffmann-La Roche Ag Anticorps contre il-18r1 et leurs utilisations
JOP20200308A1 (ar) 2012-09-07 2017-06-16 Novartis Ag جزيئات إرتباط il-18
MD707Z (ro) * 2013-01-18 2014-07-31 Институт Зоологии Академии Наук Молдовы Metodă de identificare a secvenţelor polimorfe 4a/4b ale genei sintetazei endoteliale a oxidului nitric
SI3041864T1 (sl) 2013-09-05 2021-11-30 Ab2 Bio Sa IL-18-vezavni protein (IL-18BP) pri vnetnih boleznih
KR102511343B1 (ko) 2015-03-05 2023-03-17 에이비2 바이오 에스에이 염증성 질환에서 il-18 결합 단백질(ｉｌ-18ｂｐ) 및 항체
CN110273591B (zh) 2019-08-13 2023-12-12 上海杉脉电子科技发展有限公司 一种单动力微型智能锁
TW202233675A (zh) 2020-10-29 2022-09-01 瑞士商諾華公司 Ｉｌ－１８拮抗劑用於治療和／或預防異位性皮炎或相關病症之用途
CN112972655A (zh) * 2021-04-16 2021-06-18 武汉大学 白细胞介素12在制备预防、缓解和/或治疗主动脉瘤药物中的应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5985863A (en) * 1996-09-12 1999-11-16 Vertex Pharmaceuticals, Inc. Compositions and methods for decreasing IGIF and IFN-γ production by administering an ICE inhibitor
US5877197A (en) * 1996-12-16 1999-03-02 Karanewsky; Donald S. C-terminal modified (N-substituted)-2-indolyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases
IL121860A0 (en) * 1997-08-14 1998-02-22 Yeda Res & Dev Interleukin-18 binding proteins their preparation and use
CA2276216A1 (fr) * 1998-06-24 1999-12-24 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Peptide artificiel capable de neutraliser l'activite biologique de l'interleukine-18
EP0987552A3 (fr) * 1998-08-31 2000-06-07 Pfizer Products Inc. Protéines de liaison pour diarylsulfonylurée
WO2000012555A1 (fr) * 1998-09-01 2000-03-09 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Proteine de liaison de l'interleukine 18

Also Published As

Publication number Publication date
CN1841066B (zh) 2012-08-29
KR100798545B1 (ko) 2008-01-28
CA2407895A1 (fr) 2001-11-15
ZA200208228B (en) 2005-07-27
HUP0301991A3 (en) 2006-11-28
CZ20023644A3 (cs) 2003-03-12
KR20030016254A (ko) 2003-02-26
PT1278540E (pt) 2008-07-03
KR20070073989A (ko) 2007-07-10
NO329821B1 (no) 2010-12-27
DK1278540T3 (da) 2008-07-21
AU2001267390B2 (en) 2005-09-22
PL365697A1 (en) 2005-01-10
ME00554B (me) 2012-03-20
BG107218A (bg) 2003-06-30
CZ300792B6 (cs) 2009-08-12
HU229375B1 (en) 2013-11-28
MEP64008A (en) 2011-12-20
CY1110385T1 (el) 2015-04-29
EP1278540B1 (fr) 2008-05-14
CN1841066A (zh) 2006-10-04
SI1278540T1 (sl) 2008-10-31
BRPI0110506B1 (pt) 2015-05-19
NO20025307D0 (no) 2002-11-05
BG65881B1 (bg) 2010-04-30
CN1434722A (zh) 2003-08-06
EA200401183A1 (ru) 2004-12-30
HUP0301991A2 (hu) 2003-09-29
AR035640A1 (es) 2004-06-23
ES2305082T3 (es) 2008-11-01
US20040076628A1 (en) 2004-04-22
EA007014B1 (ru) 2006-06-30
RS50926B (sr) 2010-08-31
WO2001085201A3 (fr) 2002-05-10
JP5122053B2 (ja) 2013-01-16
AU6739001A (en) 2001-11-20
SK287761B6 (en) 2011-09-05
CA2407895C (fr) 2012-12-18
CN1250286C (zh) 2006-04-12
HK1094909A1 (en) 2007-04-13
HRP20020828A2 (en) 2004-12-31
PL209371B1 (pl) 2011-08-31
UA87658C2 (uk) 2009-08-10
BR0110506A (pt) 2003-04-01
WO2001085201A2 (fr) 2001-11-15
IL152567A (en) 2010-12-30
BRPI0110506B8 (pt) 2021-05-25
EA200201175A1 (ru) 2003-04-24
EE05056B1 (et) 2008-08-15
UA78492C2 (en) 2007-04-10
DE60134009D1 (de) 2008-06-26
ATE395075T1 (de) 2008-05-15
EA005410B1 (ru) 2005-02-24
YU82602A (sh) 2006-01-16
EE200200620A (et) 2004-06-15
HK1055681A1 (en) 2004-01-21
EP1278540A2 (fr) 2003-01-29
SK15562002A3 (sk) 2003-05-02
JP2003532685A (ja) 2003-11-05
NO20025307L (no) 2002-12-18
MXPA02010895A (es) 2003-03-27

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