IL151238A0 - Process for the preparation of phosphorothioate triesters - Google Patents
Process for the preparation of phosphorothioate triestersInfo
- Publication number
- IL151238A0 IL151238A0 IL15123801A IL15123801A IL151238A0 IL 151238 A0 IL151238 A0 IL 151238A0 IL 15123801 A IL15123801 A IL 15123801A IL 15123801 A IL15123801 A IL 15123801A IL 151238 A0 IL151238 A0 IL 151238A0
- Authority
- IL
- Israel
- Prior art keywords
- preparation
- phosphorothioate triesters
- phosphonate
- alcohol
- phosphorothioate
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- -1 phosphorothioate triesters Chemical class 0.000 title abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- 108091034117 Oligonucleotide Proteins 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 230000008878 coupling Effects 0.000 abstract 1
- 239000007822 coupling agent Substances 0.000 abstract 1
- 238000010168 coupling process Methods 0.000 abstract 1
- 238000005859 coupling reaction Methods 0.000 abstract 1
- 239000002777 nucleoside Substances 0.000 abstract 1
- 125000003835 nucleoside group Chemical group 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/16—Esters of thiophosphoric acids or thiophosphorous acids
- C07F9/165—Esters of thiophosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Luminescent Compositions (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0004889.2A GB0004889D0 (en) | 2000-03-01 | 2000-03-01 | Synthesis of oligonucleotides |
| PCT/GB2001/000764 WO2001064702A1 (en) | 2000-03-01 | 2001-02-23 | Process for the preparation of phosphorothioate triesters |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL151238A0 true IL151238A0 (en) | 2003-04-10 |
Family
ID=9886705
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL15123801A IL151238A0 (en) | 2000-03-01 | 2001-02-23 | Process for the preparation of phosphorothioate triesters |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US7022833B2 (no) |
| EP (1) | EP1272501B1 (no) |
| JP (1) | JP2003525305A (no) |
| KR (1) | KR20030032924A (no) |
| CN (1) | CN1262557C (no) |
| AT (1) | ATE266037T1 (no) |
| AU (2) | AU2001235766B2 (no) |
| BR (1) | BR0108771A (no) |
| CA (1) | CA2401083A1 (no) |
| CZ (1) | CZ20022930A3 (no) |
| DE (1) | DE60103145T2 (no) |
| DK (1) | DK1272501T3 (no) |
| ES (1) | ES2220721T3 (no) |
| GB (1) | GB0004889D0 (no) |
| HU (1) | HUP0204249A3 (no) |
| IL (1) | IL151238A0 (no) |
| MX (1) | MXPA02008530A (no) |
| NO (1) | NO20024155L (no) |
| NZ (1) | NZ520778A (no) |
| PL (1) | PL362067A1 (no) |
| WO (1) | WO2001064702A1 (no) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9717158D0 (en) * | 1997-08-13 | 1997-10-22 | King S College London | Solution synthesis of oligonucleotides and their phosphorothioate analogues |
| AU2002339175A1 (en) * | 2001-11-21 | 2003-06-10 | Avecia Biotechnology Inc. | Coupling reagent for h-phosphonate chemistry |
| EP1386925A1 (en) * | 2002-07-31 | 2004-02-04 | Girindus AG | Method for preparing oligonucleotides |
| GB0229423D0 (en) * | 2002-12-18 | 2003-01-22 | Avecia Ltd | Process |
| AU2009323766B2 (en) | 2008-12-02 | 2016-10-06 | Wave Life Sciences Ltd. | Method for the synthesis of phosphorus atom modified nucleic acids |
| SG177564A1 (en) | 2009-07-06 | 2012-02-28 | Ontorii Inc | Novel nucleic acid prodrugs and methods of use thereof |
| DK2620428T3 (da) | 2010-09-24 | 2019-07-01 | Wave Life Sciences Ltd | Asymmetrisk hjælpegruppe |
| BR112014001244A2 (pt) | 2011-07-19 | 2017-02-21 | Wave Life Sciences Pte Ltd | métodos para a síntese de ácidos nucléicos funcionalizados |
| KR102450907B1 (ko) | 2012-07-13 | 2022-10-04 | 웨이브 라이프 사이언시스 리미티드 | 키랄 제어 |
| EP3812370A1 (en) | 2012-07-13 | 2021-04-28 | Wave Life Sciences Ltd. | Asymmetric auxiliary group |
| SG11201500243WA (en) | 2012-07-13 | 2015-04-29 | Shin Nippon Biomedical Lab Ltd | Chiral nucleic acid adjuvant |
| JPWO2015108047A1 (ja) | 2014-01-15 | 2017-03-23 | 株式会社新日本科学 | 免疫誘導活性を有するキラル核酸アジュバンド及び免疫誘導活性剤 |
| JPWO2015108046A1 (ja) | 2014-01-15 | 2017-03-23 | 株式会社新日本科学 | 抗アレルギー作用を有するキラル核酸アジュバンド及び抗アレルギー剤 |
| EP3095459A4 (en) | 2014-01-15 | 2017-08-23 | Shin Nippon Biomedical Laboratories, Ltd. | Chiral nucleic acid adjuvant having antitumor effect and antitumor agent |
| EP4137572A1 (en) | 2014-01-16 | 2023-02-22 | Wave Life Sciences Ltd. | Chiral design |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9501465D0 (en) * | 1995-01-25 | 1995-03-15 | King S College London | Nucleoside phosphorothioate derivatives,synthesis and use thereof |
| US6096881A (en) * | 1997-05-30 | 2000-08-01 | Hybridon, Inc. | Sulfur transfer reagents for oligonucleotide synthesis |
| GB9717158D0 (en) * | 1997-08-13 | 1997-10-22 | King S College London | Solution synthesis of oligonucleotides and their phosphorothioate analogues |
| GB9924285D0 (en) | 1999-10-14 | 1999-12-15 | Avecia Ltd | Process |
-
2000
- 2000-03-01 GB GBGB0004889.2A patent/GB0004889D0/en not_active Ceased
-
2001
- 2001-02-23 KR KR1020027011442A patent/KR20030032924A/ko not_active Application Discontinuation
- 2001-02-23 NZ NZ520778A patent/NZ520778A/en unknown
- 2001-02-23 AT AT01907898T patent/ATE266037T1/de not_active IP Right Cessation
- 2001-02-23 WO PCT/GB2001/000764 patent/WO2001064702A1/en not_active Application Discontinuation
- 2001-02-23 CA CA002401083A patent/CA2401083A1/en not_active Abandoned
- 2001-02-23 CN CNB018058906A patent/CN1262557C/zh not_active Expired - Fee Related
- 2001-02-23 EP EP01907898A patent/EP1272501B1/en not_active Expired - Lifetime
- 2001-02-23 JP JP2001564195A patent/JP2003525305A/ja active Pending
- 2001-02-23 DE DE60103145T patent/DE60103145T2/de not_active Expired - Fee Related
- 2001-02-23 MX MXPA02008530A patent/MXPA02008530A/es not_active Application Discontinuation
- 2001-02-23 HU HU0204249A patent/HUP0204249A3/hu unknown
- 2001-02-23 CZ CZ20022930A patent/CZ20022930A3/cs unknown
- 2001-02-23 AU AU2001235766A patent/AU2001235766B2/en not_active Ceased
- 2001-02-23 IL IL15123801A patent/IL151238A0/xx unknown
- 2001-02-23 ES ES01907898T patent/ES2220721T3/es not_active Expired - Lifetime
- 2001-02-23 PL PL36206701A patent/PL362067A1/xx unknown
- 2001-02-23 DK DK01907898T patent/DK1272501T3/da active
- 2001-02-23 BR BR0108771-1A patent/BR0108771A/pt not_active IP Right Cessation
- 2001-02-23 AU AU3576601A patent/AU3576601A/xx active Pending
- 2001-02-23 US US10/220,353 patent/US7022833B2/en not_active Expired - Lifetime
-
2002
- 2002-08-30 NO NO20024155A patent/NO20024155L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA02008530A (es) | 2003-02-12 |
| WO2001064702A1 (en) | 2001-09-07 |
| NO20024155D0 (no) | 2002-08-30 |
| CA2401083A1 (en) | 2001-09-07 |
| CN1262557C (zh) | 2006-07-05 |
| DE60103145T2 (de) | 2005-05-04 |
| US7022833B2 (en) | 2006-04-04 |
| DE60103145D1 (de) | 2004-06-09 |
| KR20030032924A (ko) | 2003-04-26 |
| AU2001235766B2 (en) | 2005-01-27 |
| NO20024155L (no) | 2002-10-24 |
| AU3576601A (en) | 2001-09-12 |
| NZ520778A (en) | 2004-05-28 |
| CZ20022930A3 (cs) | 2002-11-13 |
| HUP0204249A3 (en) | 2004-08-30 |
| DK1272501T3 (da) | 2004-08-16 |
| CN1406242A (zh) | 2003-03-26 |
| GB0004889D0 (en) | 2000-04-19 |
| EP1272501A1 (en) | 2003-01-08 |
| HUP0204249A2 (hu) | 2003-04-28 |
| EP1272501B1 (en) | 2004-05-06 |
| PL362067A1 (en) | 2004-10-18 |
| ATE266037T1 (de) | 2004-05-15 |
| ES2220721T3 (es) | 2004-12-16 |
| JP2003525305A (ja) | 2003-08-26 |
| US20030099981A1 (en) | 2003-05-29 |
| BR0108771A (pt) | 2002-11-26 |
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