IL150457A0 - Polycyclic dianthraquinones as anti-cancer and anti-angiogenic agents - Google Patents

Polycyclic dianthraquinones as anti-cancer and anti-angiogenic agents

Info

Publication number
IL150457A0
IL150457A0 IL15045701A IL15045701A IL150457A0 IL 150457 A0 IL150457 A0 IL 150457A0 IL 15045701 A IL15045701 A IL 15045701A IL 15045701 A IL15045701 A IL 15045701A IL 150457 A0 IL150457 A0 IL 150457A0
Authority
IL
Israel
Prior art keywords
hydroxy
alkyl
alkoxy
hydrogen
independently selected
Prior art date
Application number
IL15045701A
Other languages
English (en)
Original Assignee
Yeda Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/494,296 external-priority patent/US6229048B1/en
Application filed by Yeda Res & Dev filed Critical Yeda Res & Dev
Publication of IL150457A0 publication Critical patent/IL150457A0/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
IL15045701A 2000-01-31 2001-01-31 Polycyclic dianthraquinones as anti-cancer and anti-angiogenic agents IL150457A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/494,296 US6229048B1 (en) 1997-07-31 2000-01-31 Helianthrone derivatives as anti-cancer agents
PCT/IL2001/000091 WO2001056558A1 (en) 2000-01-31 2001-01-31 Polycyclic dianthraquinones as anti-cancer and anti-angiogenic agents

Publications (1)

Publication Number Publication Date
IL150457A0 true IL150457A0 (en) 2002-12-01

Family

ID=23963894

Family Applications (1)

Application Number Title Priority Date Filing Date
IL15045701A IL150457A0 (en) 2000-01-31 2001-01-31 Polycyclic dianthraquinones as anti-cancer and anti-angiogenic agents

Country Status (9)

Country Link
US (2) US6867235B2 (es)
EP (1) EP1313459B1 (es)
AT (1) ATE347355T1 (es)
AU (1) AU3047001A (es)
CA (1) CA2396704A1 (es)
DE (1) DE60125048T2 (es)
ES (1) ES2275647T3 (es)
IL (1) IL150457A0 (es)
WO (1) WO2001056558A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2396704A1 (en) * 2000-01-31 2001-08-09 Yeda Research And Development Co. Ltd. Polycyclic dianthraquinones as anti-cancer and anti-angiogenic agents
DE10261825A1 (de) * 2002-12-20 2004-07-01 Charité - Universitätsmedizin Berlin (Charité) Verwendung von Hypericin und/oder dessen Derivaten zur Tumorprävention
US7553326B2 (en) 2003-11-24 2009-06-30 Sweet Richard M Method and apparatus for preventing dialysis graft intimal hyperplasia
ES2619612T3 (es) 2010-05-04 2017-06-26 Soligenix, Inc. Formulaciones y métodos de tratamiento de afecciones de la piel
KR102592878B1 (ko) 2016-03-01 2023-10-20 솔리제닉스, 인크. 합성 하이페리신을 생산하기 위한 시스템 및 방법

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL93682A (en) * 1989-03-16 1996-06-18 Yeda Res & Dev Polycyclic compounds with antigypical activity are used in the manufacture of medicines and pharmaceutical preparations containing them
DE4239959A1 (de) * 1992-11-27 1994-06-01 Schwabe Willmar Gmbh & Co Johanniskraut-Trockenextrakt, Verfahren zu seiner Herstellung und seine Verwendung
US5824654A (en) * 1994-09-02 1998-10-20 New York University Method for delivery of nucleic acids to cells using hypericin polyamine complexes
WO1997004761A1 (en) * 1995-07-28 1997-02-13 Trustees Of Boston University Methods and compositions for treating cell proliferative disorders
IL121440A0 (en) * 1997-07-31 1998-01-04 Yeda Res & Dev The use of 1,3,4,6-tetrahydroxy-helianthrone and its derivatives in photodynamic therapy and certain such novel derivatives
CA2396704A1 (en) * 2000-01-31 2001-08-09 Yeda Research And Development Co. Ltd. Polycyclic dianthraquinones as anti-cancer and anti-angiogenic agents

Also Published As

Publication number Publication date
US20030105357A1 (en) 2003-06-05
WO2001056558A1 (en) 2001-08-09
US6867235B2 (en) 2005-03-15
EP1313459B1 (en) 2006-12-06
ATE347355T1 (de) 2006-12-15
CA2396704A1 (en) 2001-08-09
DE60125048T2 (de) 2007-07-12
US20050038115A1 (en) 2005-02-17
AU3047001A (en) 2001-08-14
DE60125048D1 (de) 2007-01-18
EP1313459A1 (en) 2003-05-28
ES2275647T3 (es) 2007-06-16

Similar Documents

Publication Publication Date Title
NL300338I2 (nl) Triazolytropaanderivaten als ccr5-modulatoren
AR016314A1 (es) Derivados de piridina, su uso como medicamentos y composiciones farmaceuticas que los contienen
GEP20094736B (en) Prodrugs of piperazine and substituted piperidine antiviral agents
DK1074542T3 (da) Sulfonamidholdige indolforbindelser
AR100696A2 (es) Uso de un compuesto de 15-ceto-prostaglandina para fabricar una composición para tratar estreñimiento inducido por drogas
AR047076A1 (es) Compuestos de pirrolotriazina como inhibidores de tirosina quinasas, composiciones farmaceuticas
AR067528A1 (es) Eteres heterociclicos sustituidos y su uso en trastornos del snc
WO2001064200A3 (en) Use of pdgf receptor tyrosine kinase inhibitors for the treatment of diabetic nephropathy
DE60324544D1 (de) Muskarin antagonisten
MXPA05007115A (es) Nuevos agonistas inversos del receptor cb 1.
DE60233656D1 (de) Pyridylcyanoguanidin verbindungen
AU1182702A (en) Amino-substituted tetracyclic compounds useful as anti-inflammatory agents and pharmaceutical compositions comprising same
DE60023025D1 (de) 3,4-dihydro-(1h)chinazolin-2-on-verbindungen als csbp/p39-kinase-inhibitoren
BR0109512A (pt) Imidazopiridinas tricìclicas
IL150457A0 (en) Polycyclic dianthraquinones as anti-cancer and anti-angiogenic agents
CY1106713T1 (el) Συνδυασμενη θεραπεια εναντιον καρκινωματων η οποια περιλαμβανει παραγωγα υποκαταστημενης ακρυλοϋλ δισταμυσινης και αλκυλιωτικους παραγοντες
ATE342261T1 (de) Pyranderivate als inhibitoren von ace und nep
TR200102514T2 (tr) COPD tedavisi için metod
PT1292290E (pt) Composicoes farmaceuticas que compreendem derivados de acriloil-distamicina e inibidores de topoisomerase 1 e ii
UY27544A1 (es) Derivados de piperazina desestabilizantes del receptor de andrógenos
DE60330373D1 (de) Piperidinderivate als ccr5-inhibitoren
EA200300059A1 (ru) Комбинированная противоопухолевая терапия, включающая применение производных замещенного акрилоилдистамицина, таксанов и/или антиметаболитов
DE60220678D1 (de) Hemmer der aggregation von polyq
DE60227113D1 (de) Kondensierte camptothecine als antitumormittel
DE602004010186D1 (de) Diazaspiropiperidinderivate als inhibitoren von glycintransporter 1 und glycintransporter 2