DE60125048D1 - Polycyclische dianthrachinone als antikrebsmittel und antiangiogenesemittel - Google Patents

Polycyclische dianthrachinone als antikrebsmittel und antiangiogenesemittel

Info

Publication number
DE60125048D1
DE60125048D1 DE60125048T DE60125048T DE60125048D1 DE 60125048 D1 DE60125048 D1 DE 60125048D1 DE 60125048 T DE60125048 T DE 60125048T DE 60125048 T DE60125048 T DE 60125048T DE 60125048 D1 DE60125048 D1 DE 60125048D1
Authority
DE
Germany
Prior art keywords
hydroxy
alkyl
alkoxy
hydrogen
independently selected
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60125048T
Other languages
English (en)
Other versions
DE60125048T2 (de
Inventor
Yehuda Mazur
Gad Lavie
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yeda Research and Development Co Ltd
New York University NYU
Original Assignee
Yeda Research and Development Co Ltd
New York University NYU
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/494,296 external-priority patent/US6229048B1/en
Application filed by Yeda Research and Development Co Ltd, New York University NYU filed Critical Yeda Research and Development Co Ltd
Publication of DE60125048D1 publication Critical patent/DE60125048D1/de
Application granted granted Critical
Publication of DE60125048T2 publication Critical patent/DE60125048T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE60125048T 2000-01-31 2001-01-31 Polycyclische dianthrachinone als antikrebsmittel und antiangiogenesemittel Expired - Fee Related DE60125048T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/494,296 US6229048B1 (en) 1997-07-31 2000-01-31 Helianthrone derivatives as anti-cancer agents
US494296 2000-01-31
PCT/IL2001/000091 WO2001056558A1 (en) 2000-01-31 2001-01-31 Polycyclic dianthraquinones as anti-cancer and anti-angiogenic agents

Publications (2)

Publication Number Publication Date
DE60125048D1 true DE60125048D1 (de) 2007-01-18
DE60125048T2 DE60125048T2 (de) 2007-07-12

Family

ID=23963894

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60125048T Expired - Fee Related DE60125048T2 (de) 2000-01-31 2001-01-31 Polycyclische dianthrachinone als antikrebsmittel und antiangiogenesemittel

Country Status (9)

Country Link
US (2) US6867235B2 (de)
EP (1) EP1313459B1 (de)
AT (1) ATE347355T1 (de)
AU (1) AU3047001A (de)
CA (1) CA2396704A1 (de)
DE (1) DE60125048T2 (de)
ES (1) ES2275647T3 (de)
IL (1) IL150457A0 (de)
WO (1) WO2001056558A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2396704A1 (en) * 2000-01-31 2001-08-09 Yeda Research And Development Co. Ltd. Polycyclic dianthraquinones as anti-cancer and anti-angiogenic agents
DE10261825A1 (de) * 2002-12-20 2004-07-01 Charité - Universitätsmedizin Berlin (Charité) Verwendung von Hypericin und/oder dessen Derivaten zur Tumorprävention
US7553326B2 (en) * 2003-11-24 2009-06-30 Sweet Richard M Method and apparatus for preventing dialysis graft intimal hyperplasia
WO2011139558A1 (en) 2010-05-04 2011-11-10 Hy Biopharma, Inc. Formulations and methods of treatment of skin conditions
RU2719582C1 (ru) 2016-03-01 2020-04-21 Солидженикс, Инк. Системы и способы для получения синтетического гиперицина

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL93682A (en) * 1989-03-16 1996-06-18 Yeda Res & Dev Polycyclic compounds with antigypical activity are used in the manufacture of medicines and pharmaceutical preparations containing them
DE4239959A1 (de) * 1992-11-27 1994-06-01 Schwabe Willmar Gmbh & Co Johanniskraut-Trockenextrakt, Verfahren zu seiner Herstellung und seine Verwendung
US5824654A (en) * 1994-09-02 1998-10-20 New York University Method for delivery of nucleic acids to cells using hypericin polyamine complexes
WO1997004761A1 (en) * 1995-07-28 1997-02-13 Trustees Of Boston University Methods and compositions for treating cell proliferative disorders
IL121440A0 (en) * 1997-07-31 1998-01-04 Yeda Res & Dev The use of 1,3,4,6-tetrahydroxy-helianthrone and its derivatives in photodynamic therapy and certain such novel derivatives
CA2396704A1 (en) * 2000-01-31 2001-08-09 Yeda Research And Development Co. Ltd. Polycyclic dianthraquinones as anti-cancer and anti-angiogenic agents

Also Published As

Publication number Publication date
US20050038115A1 (en) 2005-02-17
EP1313459A1 (de) 2003-05-28
US20030105357A1 (en) 2003-06-05
US6867235B2 (en) 2005-03-15
EP1313459B1 (de) 2006-12-06
AU3047001A (en) 2001-08-14
IL150457A0 (en) 2002-12-01
DE60125048T2 (de) 2007-07-12
ATE347355T1 (de) 2006-12-15
CA2396704A1 (en) 2001-08-09
ES2275647T3 (es) 2007-06-16
WO2001056558A1 (en) 2001-08-09

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee