IL148573A0 - New pyrimidine -2,4,6-trione derivatives, processes for their production and pharmaceutical agents containing these compounds - Google Patents
New pyrimidine -2,4,6-trione derivatives, processes for their production and pharmaceutical agents containing these compoundsInfo
- Publication number
- IL148573A0 IL148573A0 IL14857300A IL14857300A IL148573A0 IL 148573 A0 IL148573 A0 IL 148573A0 IL 14857300 A IL14857300 A IL 14857300A IL 14857300 A IL14857300 A IL 14857300A IL 148573 A0 IL148573 A0 IL 148573A0
- Authority
- IL
- Israel
- Prior art keywords
- compounds
- processes
- production
- pharmaceutical agents
- agents containing
- Prior art date
Links
- HNYOPLTXPVRDBG-UHFFFAOYSA-N barbituric acid Chemical class O=C1CC(=O)NC(=O)N1 HNYOPLTXPVRDBG-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 239000008177 pharmaceutical agent Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
- A61K31/515—Barbituric acids; Derivatives thereof, e.g. sodium pentobarbital
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP99119506 | 1999-10-01 | ||
| PCT/EP2000/009535 WO2001025217A1 (en) | 1999-10-01 | 2000-09-29 | New pyrimidine-2,4,6-trione derivatives, processes for their production and pharmaceutical agents containing these compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL148573A0 true IL148573A0 (en) | 2002-09-12 |
Family
ID=8239103
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL14857300A IL148573A0 (en) | 1999-10-01 | 2000-09-29 | New pyrimidine -2,4,6-trione derivatives, processes for their production and pharmaceutical agents containing these compounds |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US6498252B1 (de) |
| EP (1) | EP1226128B1 (de) |
| JP (1) | JP3848160B2 (de) |
| KR (1) | KR100459975B1 (de) |
| CN (1) | CN1157382C (de) |
| AR (1) | AR033651A1 (de) |
| AT (1) | ATE289595T1 (de) |
| AU (1) | AU768309B2 (de) |
| BR (1) | BR0014678A (de) |
| CA (1) | CA2385863C (de) |
| CO (1) | CO5210860A1 (de) |
| CZ (1) | CZ20021535A3 (de) |
| DE (1) | DE60018301T2 (de) |
| ES (1) | ES2235955T3 (de) |
| HU (1) | HUP0202832A3 (de) |
| IL (1) | IL148573A0 (de) |
| MA (1) | MA26823A1 (de) |
| MX (1) | MXPA02003192A (de) |
| NO (1) | NO20021380D0 (de) |
| NZ (1) | NZ517635A (de) |
| PE (1) | PE20010659A1 (de) |
| PL (1) | PL202680B1 (de) |
| RU (1) | RU2248971C2 (de) |
| TR (1) | TR200200858T2 (de) |
| UY (1) | UY26362A1 (de) |
| WO (1) | WO2001025217A1 (de) |
| YU (1) | YU22102A (de) |
| ZA (1) | ZA200201754B (de) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6716845B2 (en) * | 2001-03-30 | 2004-04-06 | Hoffmann-La Roche Inc. | Barbituric acid derivatives |
| WO2003053940A1 (en) | 2001-12-20 | 2003-07-03 | Bristol-Myers Squibb Company | Barbituric acid derivatives as inhibitors of tnf-$g(a) converting enzyme (tace) and/or matrix metalloproteinases |
| WO2004084903A1 (en) * | 2003-03-27 | 2004-10-07 | F. Hoffmann-La Roche Ag | Use of a trioxopyrimidine for the treatment and prevention of ocular pathologic angiogenesis |
| WO2004084902A1 (en) * | 2003-03-28 | 2004-10-07 | F. Hoffmann-La Roche Ag | Use of a trioxopyrimidine for the treatment of chronic wounds |
| CN100558362C (zh) * | 2004-04-01 | 2009-11-11 | 霍夫曼-拉罗奇有限公司 | 三氧嘧啶治疗和预防支气管炎症疾病的应用 |
| KR100771411B1 (ko) | 2004-04-01 | 2007-10-30 | 에프. 호프만-라 로슈 아게 | 피리미딘-2,4,6-트리온의 시클로덱스트린 포접 복합체 |
| EP1632489A1 (de) * | 2004-08-24 | 2006-03-08 | University of Liege | 5-(1,1'-Biphenyl)-4-yl-5-(4-(4-aminoacylphenyl)-piperazin)-1-yl-pyrimidine-2,4,6-trione Derivate als Inhibitoren von Zink Metalloendopeptidasen, ihre Herstellung und Verwendung. |
| RU2449994C1 (ru) * | 2011-03-10 | 2012-05-10 | Светлана Алексеевна Мещерякова | 6-(4-бензилпиперазино)-1,3-диметилурацила дигидрохлорид, проявляющий биологическую активность |
| RU2598607C1 (ru) * | 2015-07-16 | 2016-09-27 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Астраханский государственный университет" (Астраханский государственный университет) | Способ получения 5-гетарилметиленпиримидин-2,4,6-трионов |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1246743B (de) * | 1965-01-12 | 1967-08-10 | Dresden Arzneimittel | Verfahren zur Herstellung von 5-Phenyl-5-piperidinobarbitursaeuren |
| US4595700A (en) | 1984-12-21 | 1986-06-17 | G. D. Searle & Co. | Thiol based collagenase inhibitors |
| GB8726714D0 (en) | 1987-11-14 | 1987-12-16 | Beecham Group Plc | Compounds |
| GB8827305D0 (en) | 1988-11-23 | 1988-12-29 | British Bio Technology | Compounds |
| US5239078A (en) | 1990-11-21 | 1993-08-24 | Glycomed Incorporated | Matrix metalloprotease inhibitors |
| CA2073510A1 (en) | 1990-12-03 | 1992-06-04 | Celltech Therapeutics Limited | Peptidyl derivatives |
| CA2058797A1 (en) | 1991-02-01 | 1992-08-02 | Michael John Broadhurst | Amino acid derivatives |
| US5789434A (en) | 1994-11-15 | 1998-08-04 | Bayer Corporation | Derivatives of substituted 4-biarylbutyric acid as matrix metalloprotease inhibitors |
| DE69633947T2 (de) | 1995-12-08 | 2005-12-01 | Agouron Pharmaceuticals, Inc., San Diego | Zwischenprodukte zur Herstellung von Metallproteinasehemmern |
| DE19548624A1 (de) | 1995-12-23 | 1997-06-26 | Boehringer Mannheim Gmbh | Neue Barbitursäure-Derivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel |
| US6350786B1 (en) * | 1998-09-22 | 2002-02-26 | Hoffmann-La Roche Inc. | Stable complexes of poorly soluble compounds in ionic polymers |
-
2000
- 2000-09-27 AR ARP000105063A patent/AR033651A1/es not_active Application Discontinuation
- 2000-09-27 CO CO00073355A patent/CO5210860A1/es not_active Application Discontinuation
- 2000-09-27 PE PE2000001013A patent/PE20010659A1/es not_active Application Discontinuation
- 2000-09-29 ES ES00967823T patent/ES2235955T3/es not_active Expired - Lifetime
- 2000-09-29 DE DE60018301T patent/DE60018301T2/de not_active Expired - Lifetime
- 2000-09-29 TR TR2002/00858T patent/TR200200858T2/xx unknown
- 2000-09-29 YU YU22102A patent/YU22102A/sh unknown
- 2000-09-29 RU RU2002110106/04A patent/RU2248971C2/ru not_active IP Right Cessation
- 2000-09-29 PL PL357385A patent/PL202680B1/pl not_active IP Right Cessation
- 2000-09-29 CZ CZ20021535A patent/CZ20021535A3/cs unknown
- 2000-09-29 BR BR0014678-1A patent/BR0014678A/pt not_active Application Discontinuation
- 2000-09-29 IL IL14857300A patent/IL148573A0/xx unknown
- 2000-09-29 JP JP2001528163A patent/JP3848160B2/ja not_active Expired - Fee Related
- 2000-09-29 HU HU0202832A patent/HUP0202832A3/hu unknown
- 2000-09-29 MX MXPA02003192A patent/MXPA02003192A/es active IP Right Grant
- 2000-09-29 AU AU77849/00A patent/AU768309B2/en not_active Ceased
- 2000-09-29 EP EP00967823A patent/EP1226128B1/de not_active Expired - Lifetime
- 2000-09-29 NZ NZ517635A patent/NZ517635A/en unknown
- 2000-09-29 UY UY26362A patent/UY26362A1/es not_active Application Discontinuation
- 2000-09-29 US US09/675,935 patent/US6498252B1/en not_active Expired - Fee Related
- 2000-09-29 CA CA002385863A patent/CA2385863C/en not_active Expired - Fee Related
- 2000-09-29 KR KR10-2002-7003979A patent/KR100459975B1/ko not_active Expired - Fee Related
- 2000-09-29 WO PCT/EP2000/009535 patent/WO2001025217A1/en not_active Ceased
- 2000-09-29 AT AT00967823T patent/ATE289595T1/de not_active IP Right Cessation
- 2000-09-29 CN CNB00813006XA patent/CN1157382C/zh not_active Expired - Fee Related
-
2002
- 2002-03-01 ZA ZA200201754A patent/ZA200201754B/en unknown
- 2002-03-20 NO NO20021380A patent/NO20021380D0/no not_active Application Discontinuation
- 2002-04-01 MA MA26578A patent/MA26823A1/fr unknown
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