IL144147A0 - Regulators of the pct or smoothened pathway, compositions and uses related thereto - Google Patents
Regulators of the pct or smoothened pathway, compositions and uses related theretoInfo
- Publication number
- IL144147A0 IL144147A0 IL14414700A IL14414700A IL144147A0 IL 144147 A0 IL144147 A0 IL 144147A0 IL 14414700 A IL14414700 A IL 14414700A IL 14414700 A IL14414700 A IL 14414700A IL 144147 A0 IL144147 A0 IL 144147A0
- Authority
- IL
- Israel
- Prior art keywords
- regulators
- pct
- compositions
- uses related
- smoothened pathway
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
- A61K31/585—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin containing lactone rings, e.g. oxandrolone, bufalin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/16—Masculine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurology (AREA)
- Dermatology (AREA)
- Molecular Biology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Reproductive Health (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Cosmetics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11564299P | 1999-01-13 | 1999-01-13 | |
US11959499P | 1999-02-10 | 1999-02-10 | |
US14212499P | 1999-07-02 | 1999-07-02 | |
US09/417,564 US6291516B1 (en) | 1999-01-13 | 1999-10-14 | Regulators of the hedgehog pathway, compositions and uses related thereto |
PCT/US2000/000873 WO2000041545A2 (en) | 1999-01-13 | 2000-01-13 | Regulators of the pct or smoothened pathway, compositions and uses related thereto |
Publications (1)
Publication Number | Publication Date |
---|---|
IL144147A0 true IL144147A0 (en) | 2002-05-23 |
Family
ID=27494029
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL14414700A IL144147A0 (en) | 1999-01-13 | 2000-01-13 | Regulators of the pct or smoothened pathway, compositions and uses related thereto |
IL144147A IL144147A (en) | 1999-01-13 | 2001-07-04 | Uses of camp agonists for the preparation of preparations and compositions for inhibiting cell growth or delaying progression of basal cell carcinoma |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL144147A IL144147A (en) | 1999-01-13 | 2001-07-04 | Uses of camp agonists for the preparation of preparations and compositions for inhibiting cell growth or delaying progression of basal cell carcinoma |
Country Status (7)
Country | Link |
---|---|
US (4) | US6291516B1 (ja) |
EP (1) | EP1143961A2 (ja) |
JP (1) | JP2003517279A (ja) |
AU (1) | AU778866B2 (ja) |
CA (1) | CA2370042A1 (ja) |
IL (2) | IL144147A0 (ja) |
WO (1) | WO2000041545A2 (ja) |
Families Citing this family (83)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE449836T1 (de) | 1997-02-10 | 2009-12-15 | Harvard College | Verfahren zur modulation von hämatopoese und vaskulärem wachstum |
US7291626B1 (en) | 1998-04-09 | 2007-11-06 | John Hopkins University School Of Medicine | Inhibitors of hedgehog signaling pathways, compositions and uses related thereto |
US6291516B1 (en) * | 1999-01-13 | 2001-09-18 | Curis, Inc. | Regulators of the hedgehog pathway, compositions and uses related thereto |
DE60016402T2 (de) * | 1999-06-08 | 2005-10-27 | Lorantis Ltd. | Therapeutische verwendung eines inhibitors des hedgehog signalübertragungsweges |
US20070021493A1 (en) | 1999-09-16 | 2007-01-25 | Curis, Inc. | Mediators of hedgehog signaling pathways, compositions and uses related thereto |
IL149069A0 (en) | 1999-10-13 | 2002-11-10 | Univ Johns Hopkins Med | Regulators of the hedgehog pathway, compositions and uses related thereto |
US8168178B2 (en) * | 1999-11-30 | 2012-05-01 | Curis, Inc. | Methods and compositions for regulating lymphocyte activity |
IL133809A0 (en) * | 1999-12-30 | 2001-04-30 | Yeda Res & Dev | Steroidal alkaloids and pharmaceutical compositions comprising them |
US6683192B2 (en) * | 2000-03-30 | 2004-01-27 | Curis, Inc. | Small organic molecule regulators of cell proliferation |
ES2250377T5 (es) * | 2000-03-30 | 2010-04-06 | Curis, Inc. | Moleculas organicas pequeñas reguladoras de la proliferacion celular. |
US7498304B2 (en) | 2000-06-16 | 2009-03-03 | Curis, Inc. | Angiogenesis-modulating compositions and uses |
JP4954426B2 (ja) * | 2000-06-16 | 2012-06-13 | キュリス,インコーポレイテッド | 血管形成調節組成物及び利用 |
US8044259B2 (en) | 2000-08-03 | 2011-10-25 | The Regents Of The University Of Michigan | Determining the capability of a test compound to affect solid tumor stem cells |
US6984522B2 (en) | 2000-08-03 | 2006-01-10 | Regents Of The University Of Michigan | Isolation and use of solid tumor stem cells |
AU2001276722A1 (en) * | 2000-08-04 | 2002-02-18 | Takeda Chemical Industries Ltd. | Use of gli1 gene |
US7708998B2 (en) | 2000-10-13 | 2010-05-04 | Curis, Inc. | Methods of inhibiting unwanted cell proliferation using hedgehog antagonists |
DK1387674T3 (en) * | 2000-10-13 | 2017-04-10 | Curis Inc | Hedgehog antagonists, methods and uses related thereto |
US7682607B2 (en) * | 2001-05-01 | 2010-03-23 | The Regents Of The University Of California | Wnt and frizzled receptors as targets for immunotherapy in head and neck squamous cell carcinomas |
US20030044409A1 (en) * | 2001-05-01 | 2003-03-06 | Carson Dennis A. | Immunologic compositions and methods for studying and treating cancers expressing frizzled antigens |
ES2250434T3 (es) * | 2001-07-02 | 2006-04-16 | Tas, Sinan | Utilizacion de ciclopamina en el tratamiento del carcinoma de celulas basales y de otros tumores. |
CA2452152A1 (en) * | 2001-07-02 | 2002-10-10 | Sinan Tas | Use of cyclopamine in the treatment of psoriasis |
NZ530580A (en) * | 2001-07-27 | 2007-02-23 | Curis Inc | Mediators of hedgehog signaling pathways, compositions and uses related thereto |
GB0221539D0 (en) * | 2002-09-17 | 2002-10-23 | Medical Res Council | Methods of treatment |
US20070231828A1 (en) * | 2003-10-01 | 2007-10-04 | Johns Hopkins University | Methods of predicting behavior of cancers |
US20080095761A1 (en) * | 2003-10-01 | 2008-04-24 | The Johns Hopkins University | Hedgehog Signaling in Prostate Regeneration Neoplasia and Metastasis |
JP2005305107A (ja) * | 2004-03-25 | 2005-11-04 | Sei Matsuoka | 価値的情報値の測定装置およびこれを使用した測定方法 |
ES2707393T3 (es) | 2004-03-26 | 2019-04-03 | Curis Inc | Moduladores de interferencia de ARN de señalización de hedgehog y usos de los mismos |
BRPI0514444A (pt) * | 2004-08-27 | 2008-06-10 | Infinity Pharmaceuticals Inc | análogos de ciclopamina e métodos de uso destes |
WO2006039569A1 (en) * | 2004-09-30 | 2006-04-13 | The University Of Chicago | Combination therapy of hedgehog inhibitors, radiation and chemotherapeutic agents |
US20060165739A1 (en) * | 2005-01-06 | 2006-07-27 | Mary Kay Inc. | Alcohol-free microemulsion composition |
US8309057B2 (en) * | 2005-06-10 | 2012-11-13 | The Invention Science Fund I, Llc | Methods for elevating neurotrophic agents |
WO2007027421A2 (en) * | 2005-08-16 | 2007-03-08 | Trustees Of Dartmouth College | Method for diagnosing non-small cell lung carcinoma |
WO2007053577A2 (en) | 2005-10-31 | 2007-05-10 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for diagnosing and treating cancer |
US7723477B2 (en) | 2005-10-31 | 2010-05-25 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth |
US7723112B2 (en) | 2005-10-31 | 2010-05-25 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing cancer |
US20090156611A1 (en) * | 2005-11-11 | 2009-06-18 | Licentia Ltd. | Mammalian hedgehog signaling modulators |
US20080019961A1 (en) * | 2006-02-21 | 2008-01-24 | Regents Of The University Of Michigan | Hedgehog signaling pathway antagonist cancer treatment |
US20110034498A1 (en) * | 2006-03-24 | 2011-02-10 | Mcgovern Karen J | Dosing regimens for the treatment of cancer |
WO2008057468A1 (en) | 2006-11-02 | 2008-05-15 | Curis, Inc. | Small organic molecule regulators of cell proliferation |
TWI433674B (zh) | 2006-12-28 | 2014-04-11 | Infinity Discovery Inc | 環杷明(cyclopamine)類似物類 |
WO2008089123A2 (en) * | 2007-01-12 | 2008-07-24 | Infinity Discovery, Inc. | Methods for analysis of hedgehog pathway inhibitors |
WO2008092002A2 (en) | 2007-01-24 | 2008-07-31 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing pancreatic cancer |
WO2008090517A2 (en) * | 2007-01-26 | 2008-07-31 | Piramal Life Sciences Limited | Enriched plant extract, compound, and methods for the treatment of proliferative disorders |
EP2134719B1 (en) | 2007-03-07 | 2013-07-17 | Infinity Discovery, Inc. | Cyclopamine lactam analogs and methods of use thereof |
CN101687877B (zh) * | 2007-03-07 | 2014-07-23 | 无限发现股份有限公司 | 杂环环杷明类似物及其使用方法 |
AU2008289255B2 (en) | 2007-08-16 | 2012-02-02 | Irm Llc | Methods and compositions for treating cancers |
US20090098220A1 (en) * | 2007-10-12 | 2009-04-16 | Lance Ashworth | Liquid pharmaceutical preparation comprising forskolin for promoting lean body mass |
US8669243B2 (en) | 2007-10-30 | 2014-03-11 | The Wistar Institute | Steroid-derived cyclopamine analogs and methods for using the same in the prevention or treatment of cancer |
US8575141B2 (en) | 2007-10-30 | 2013-11-05 | The Wistar Institute | Steroid-derived cyclopamine analogs and methods for using the same in the prevention or treatment of cancer |
JP2011522773A (ja) * | 2007-12-27 | 2011-08-04 | インフィニティ ファーマスーティカルズ、インク. | 治療剤での癌の処置方法 |
EP3190121B1 (en) | 2007-12-27 | 2019-02-20 | Infinity Pharmaceuticals, Inc. | Methods for stereoselective reduction of cyclopamine 4-en-3-one derivative |
US20100297118A1 (en) * | 2007-12-27 | 2010-11-25 | Macdougall John | Therapeutic Cancer Treatments |
WO2009112266A1 (en) * | 2008-03-12 | 2009-09-17 | Ludwig-Maximilians-Universität | Active substance combination with gemcitabine for the treatment of epithelial cancer |
WO2010019450A2 (en) * | 2008-08-09 | 2010-02-18 | Nyles Bauer | Synergizing active compounds for treating inflammation and other conditions |
WO2010024930A2 (en) | 2008-08-28 | 2010-03-04 | President And Fellows Of Harvard College | Cortistatin analogues and syntheses therof |
RU2579897C2 (ru) | 2008-09-26 | 2016-04-10 | Онкомед Фармасьютикалс, Инк. | Агенты, связывающие рецептор "frizzled", и их применение |
JP2009143963A (ja) * | 2009-03-25 | 2009-07-02 | Sinan Tas | 腫瘍細胞のアポトーシスを阻害するためにヘッジホッグ/スムーズンド信号を使用する腫瘍を治療するための製薬組成物 |
FR2948367A1 (fr) | 2009-07-24 | 2011-01-28 | Centre Nat Rech Scient | Derives d'acyl-guanidines modulateurs de la voie de signalisation des proteines hedgehog |
CN102574791A (zh) | 2009-08-05 | 2012-07-11 | 无限药品股份有限公司 | 环杷明类似物的酶促转氨基反应 |
IN2012DN02018A (ja) | 2009-08-25 | 2015-07-31 | Abraxis Bioscience Llc | |
WO2011057222A1 (en) * | 2009-11-06 | 2011-05-12 | Infinity Pharmaceuticals, Inc. | Oral formulations of a hedgehog pathway inhibitor |
TWI535445B (zh) | 2010-01-12 | 2016-06-01 | 安可美德藥物股份有限公司 | Wnt拮抗劑及治療和篩選方法 |
WO2011088404A1 (en) * | 2010-01-15 | 2011-07-21 | Infinity Pharmaceuticals , Inc | Treatment of fibrotic conditions using hedgehog inhibitors |
KR20130043102A (ko) | 2010-04-01 | 2013-04-29 | 온코메드 파마슈티칼스, 인크. | 프리즐드-결합 작용제 및 그의 용도 |
WO2012037217A1 (en) | 2010-09-14 | 2012-03-22 | Infinity Pharmaceuticals, Inc. | Transfer hydrogenation of cyclopamine analogs |
FR2967498B1 (fr) | 2010-11-16 | 2015-01-02 | Centre Nat Rech Scient | Utilisation de derives de quinolinone comme outil de recherche |
FR2980477B1 (fr) | 2011-09-23 | 2013-10-18 | Centre Nat Rech Scient | Nouveaux composes modulateurs de la voie de signalisation des proteines hedgehog, leurs formes marquees, et applications |
GB201201298D0 (en) | 2012-01-26 | 2012-03-07 | Universitat Leipzig | Therapeutic use of activators of zinc finger protein gli3 |
US8741247B2 (en) | 2012-03-27 | 2014-06-03 | Alstom Technology Ltd | Method and system for low energy carbon dioxide removal |
AU2013334790A1 (en) | 2012-10-23 | 2015-04-30 | Oncomed Pharmaceuticals, Inc. | Methods of treating neuroendocrine tumors using Wnt pathway-binding agents |
CN105073195A (zh) | 2013-02-04 | 2015-11-18 | 昂科梅德制药有限公司 | 使用Wnt途径抑制剂进行治疗的方法及对该治疗的监测 |
US9168300B2 (en) | 2013-03-14 | 2015-10-27 | Oncomed Pharmaceuticals, Inc. | MET-binding agents and uses thereof |
WO2014149895A1 (en) * | 2013-03-15 | 2014-09-25 | Boston Scientific Neuromodulation Corporation | Neuromodulation system for providing multiple modulation patterns in a single channel |
WO2015036405A1 (en) | 2013-09-10 | 2015-03-19 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for diagnosing and treating basal cell carcinoma |
JP2014028835A (ja) * | 2013-09-18 | 2014-02-13 | Sinan Tas | 基底細胞癌及び他の腫瘍の治療におけるシクロパミンの使用方法 |
EA201891279A1 (ru) | 2013-12-24 | 2019-01-31 | Президент Энд Феллоус Оф Гарвард Колледж | Аналоги кортистатина, их синтез и применения |
EP3294298A4 (en) | 2015-05-08 | 2018-10-17 | President and Fellows of Harvard College | Cortistatin analogues, syntheses, and uses thereof |
BR112017026103B1 (pt) | 2015-06-04 | 2023-10-03 | Sol-Gel Technologies Ltd | Composições tópicas com composto inibidor de hedgehog, sistema de entrega tópica e seus usos |
WO2017004411A1 (en) | 2015-07-01 | 2017-01-05 | President And Fellows Of Harvard College | Cortistatin analogues and syntheses and uses thereof |
US10772813B2 (en) | 2016-06-03 | 2020-09-15 | Colradel, LLC | Compositions and methods of administering a colchicine based topical composition for the prevention of radiation fibrosis |
US10548908B2 (en) * | 2016-09-15 | 2020-02-04 | Nostopharma, LLC | Compositions and methods for preventing and treating heterotopic ossification and pathologic calcification |
AU2017386417B2 (en) | 2016-12-30 | 2022-07-14 | Frequency Therapeutics, Inc. | 1H-pyrrole-2,5-dione compounds and methods of using them to induce self-renewal of stem/progenitor supporting cells |
WO2024173529A1 (en) * | 2023-02-15 | 2024-08-22 | The Board Of Trustees Of The Leland Stanford Junior University | Enhancing nerve regeneration and repair with a smoothened agonist applied to sites of nerve repair or surgery |
Family Cites Families (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4007268A (en) * | 1973-01-16 | 1977-02-08 | The Regents Of The University Of Michigan | Process for alleviating proliferative skin diseases |
NZ193564A (en) | 1979-05-02 | 1985-01-31 | Aruba Pty Ltd | Steroid alkaloids from solanum sodomeum and pharmaceutical compositions |
US4353888A (en) | 1980-12-23 | 1982-10-12 | Sefton Michael V | Encapsulation of live animal cells |
US4751224A (en) | 1983-07-21 | 1988-06-14 | Brown University Research Foundation | Treatment of metastasis |
JPS6094992A (ja) | 1983-10-28 | 1985-05-28 | Sankyo Co Ltd | グリゼオ−ル酸誘導体 |
US5041138A (en) | 1986-11-20 | 1991-08-20 | Massachusetts Institute Of Technology | Neomorphogenesis of cartilage in vivo from cell culture |
US5092871A (en) | 1987-03-13 | 1992-03-03 | Brown University Research Foundation | Electrically-charged nerve guidance channels |
US4892538A (en) | 1987-11-17 | 1990-01-09 | Brown University Research Foundation | In vivo delivery of neurotransmitters by implanted, encapsulated cells |
WO1989011487A1 (en) | 1988-05-23 | 1989-11-30 | United States Of America, Represented By The Secre | Derivatives of cyclic amp as treatment for cancer |
US4955892A (en) | 1988-10-24 | 1990-09-11 | Louisiana State University | Neural cell adhesion protein nerve prosthesis |
JPH05501611A (ja) | 1989-11-13 | 1993-03-25 | アフィマックス テクノロジーズ ナームロゼ ベノートスハップ | 表面上への抗リガンドの空間的アドレス可能な固定化 |
AU654474B2 (en) | 1990-01-18 | 1994-11-10 | Cura Nominees Pty Ltd | Glycoalkaloids |
DE69115528T2 (de) * | 1990-03-23 | 1996-05-15 | Nippon Kayaku Kk | Neue pharmazeutische Verwendungen von Forskolin-Derivaten |
JPH06504997A (ja) | 1990-12-06 | 1994-06-09 | アフィメトリックス, インコーポレイテッド | 非常に大きい規模の固定化されたポリマーの合成 |
EP0594669B9 (en) | 1991-07-08 | 2008-03-19 | NeuroSpheres Holdings Ltd. | Growth factor-responsive neural progenitor cells which can be proliferated in vitro. |
IL99368A (en) * | 1991-09-02 | 1996-01-19 | Teva Pharma | Preparations for the treatment of psoriasis and atopic dermatitis, which contain the result of xanthine |
ATE293011T1 (de) | 1991-11-22 | 2005-04-15 | Affymetrix Inc A Delaware Corp | Kombinatorische strategien für die polymersynthese |
US5359115A (en) | 1992-03-26 | 1994-10-25 | Affymax Technologies, N.V. | Methods for the synthesis of phosphonate esters |
US5573905A (en) | 1992-03-30 | 1996-11-12 | The Scripps Research Institute | Encoded combinatorial chemical libraries |
WO1993021929A1 (en) | 1992-05-01 | 1993-11-11 | The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Phosphorothioate derivatives of cyclic amp analogues |
US5288514A (en) | 1992-09-14 | 1994-02-22 | The Regents Of The University Of California | Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support |
PT665897E (pt) | 1992-10-01 | 2003-11-28 | Trustees Of Columbia U In The | Bibliotecas quimicas combinatorias complexas codificadas com etiquetas |
WO1994009229A1 (en) | 1992-10-12 | 1994-04-28 | Jack Uhlmann | A method in arrangement for holding objects and an arrangement for carrying out the method |
AU5367694A (en) | 1992-10-28 | 1994-05-24 | Neurospheres Holdings Ltd | Biological factors and neural stem cells |
ES2218524T3 (es) | 1993-01-29 | 2004-11-16 | Neurospheres Holdings Ltd. | Modificacion genetica de celulas primordiales neurales. |
US5519035A (en) * | 1993-07-02 | 1996-05-21 | Cornell Research Foundation, Inc. | Treatment of stroke or in anticipation of the occurrence of brain ischemia |
US5362899A (en) | 1993-09-09 | 1994-11-08 | Affymax Technologies, N.V. | Chiral synthesis of alpha-aminophosponic acids |
US5712171A (en) | 1995-01-20 | 1998-01-27 | Arqule, Inc. | Method of generating a plurality of chemical compounds in a spatially arranged array |
US5891875A (en) * | 1996-05-20 | 1999-04-06 | Eli Lilly And Company | Morpholinyl tachykinin receptor antagonists |
WO1998058543A1 (en) | 1997-06-20 | 1998-12-30 | Gubarev Michael J | Method to enhance innate immunity defense mechanisms by treatment with plant-derived alkaloids |
EP1067939B1 (en) | 1998-04-09 | 2015-09-16 | The Johns Hopkins University | Use of steroidal alkaloid derivatives as inhibitors of hedgehog protein signaling pathways |
US6291516B1 (en) * | 1999-01-13 | 2001-09-18 | Curis, Inc. | Regulators of the hedgehog pathway, compositions and uses related thereto |
-
1999
- 1999-10-14 US US09/417,564 patent/US6291516B1/en not_active Expired - Lifetime
-
2000
- 2000-01-13 AU AU28491/00A patent/AU778866B2/en not_active Ceased
- 2000-01-13 IL IL14414700A patent/IL144147A0/xx active IP Right Grant
- 2000-01-13 WO PCT/US2000/000873 patent/WO2000041545A2/en active IP Right Grant
- 2000-01-13 CA CA002370042A patent/CA2370042A1/en not_active Abandoned
- 2000-01-13 JP JP2000593166A patent/JP2003517279A/ja active Pending
- 2000-01-13 EP EP00906910A patent/EP1143961A2/en not_active Withdrawn
-
2001
- 2001-05-29 US US09/867,311 patent/US6686388B2/en not_active Expired - Lifetime
- 2001-07-04 IL IL144147A patent/IL144147A/en not_active IP Right Cessation
-
2003
- 2003-12-12 US US10/735,116 patent/US20040127474A1/en not_active Abandoned
-
2005
- 2005-09-19 US US11/230,063 patent/US20060020020A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
JP2003517279A (ja) | 2003-05-27 |
WO2000041545A2 (en) | 2000-07-20 |
AU2849100A (en) | 2000-08-01 |
US6291516B1 (en) | 2001-09-18 |
US20060020020A1 (en) | 2006-01-26 |
US20040127474A1 (en) | 2004-07-01 |
US6686388B2 (en) | 2004-02-03 |
CA2370042A1 (en) | 2000-07-20 |
IL144147A (en) | 2015-03-31 |
WO2000041545A3 (en) | 2000-09-28 |
US20010034337A1 (en) | 2001-10-25 |
AU778866B2 (en) | 2004-12-23 |
EP1143961A2 (en) | 2001-10-17 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL144147A0 (en) | Regulators of the pct or smoothened pathway, compositions and uses related thereto | |
HK1078266A1 (en) | Substituted 2-thio-3,5-dicyano-4-phenyl-6-aminopyridines and the use of the same | |
HUP0300268A3 (en) | Herbicidal benzoylpyrazole derivatives, compositions containing the same and their use | |
HRP20020375A2 (en) | Substituted 2-thio-3,5-dicyano-4-aryl-6-aminopyridines and the use thereof | |
IL155071A0 (en) | Glucopyranosyloxybenzylbenzene derivatives and medical compositions containing the same | |
ZA200204020B (en) | Use of anti-CTLA-4-antibodies. | |
EP1426027A4 (en) | COMPOSITION AND COSMETIC PREPARATION CONTAINING THE SAID COMPOSITION | |
PL359064A1 (en) | Novel compounds of the n-acylamino-amide family, compositions comprising same, and uses | |
AUPQ798800A0 (en) | Support of loads from garments, carry-packs or the like | |
HK1042845A1 (en) | Cosmetic composition. | |
ZA200404306B (en) | 3'-prodrugs of 2'-deoxy-beta-L-nucleosides. | |
HUP0402489A3 (en) | 5-sulphanyl-4h-1,2,4-triazole derivatives and their use as medicine | |
MXPA03004932A (es) | 2-anilino-bencimidazoles sustituidos y su uso como inhibidores de nhe. | |
IL157908A0 (en) | Phthalazinone derivatives and pharmaceutical compositions containing the same | |
HUP0303155A3 (en) | 2-thio-substituted imidazole derivatives, the use thereof and pharmaceutical compositions containing them | |
MXPA03007314A (es) | Composicion para la piel para reducir aceites y grasa de la piel. | |
HK1048318A1 (en) | Substituted 3-phenyl-5-alkoxi-1,3,4-oxdiazol-2-ones and their use as lipase inhibitors. | |
SI1532141T1 (sl) | 2-pirolidin-2-il-(1,3,4)-oksadiazolni derivati in njihova uporaba kot antidepresivi | |
HK1066022A1 (en) | Use of 1,1,1,3,3-pentafluorobutan | |
AU2001233588A1 (en) | New toralactone and its derivation and the use of decreasing blood-fat and losing weight | |
HK1049485A1 (en) | DithiepinoÄ6,5-BÜpyridines, and related compositions, methods of producing and uses. | |
IL162223A0 (en) | 1,3-Diarylprop-2-en-1-ones, compositions containing same and use thereof | |
AU7422100A (en) | Alkyl-amino-1,3,5-triazines and their use as herbicides | |
AU2001284480A1 (en) | Benzothiophene derivatives and herbicidal compositions containing the same | |
AU2002365643A1 (en) | Substituted aryl-cycloalkanes, and use thereof as anticancer agents |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FF | Patent granted | ||
KB | Patent renewed |