IL143578A0 - Lipidized conjugates containing an amino group-containing biologically active substance and pharmaceutical compositions containing the same - Google Patents
Lipidized conjugates containing an amino group-containing biologically active substance and pharmaceutical compositions containing the sameInfo
- Publication number
- IL143578A0 IL143578A0 IL14357899A IL14357899A IL143578A0 IL 143578 A0 IL143578 A0 IL 143578A0 IL 14357899 A IL14357899 A IL 14357899A IL 14357899 A IL14357899 A IL 14357899A IL 143578 A0 IL143578 A0 IL 143578A0
- Authority
- IL
- Israel
- Prior art keywords
- amino group
- pharmaceutical compositions
- active substance
- biologically active
- same
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/54—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and unsaturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
- C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
- C07C323/59—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton with acylated amino groups bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/16—Oxytocins; Vasopressins; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Biophysics (AREA)
- Diabetes (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Furan Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11178498P | 1998-12-10 | 1998-12-10 | |
PCT/US1999/029119 WO2000034236A1 (fr) | 1998-12-10 | 1999-12-09 | REACTIFS LIPIDIFIANTS, SENSIBLES AU pH, AQUEUX ET REVERSIBLES, ET COMPOSITIONS ET PROCEDES D'UTILISATION CORRESPONDANTS |
Publications (1)
Publication Number | Publication Date |
---|---|
IL143578A0 true IL143578A0 (en) | 2002-04-21 |
Family
ID=22340445
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL14357899A IL143578A0 (en) | 1998-12-10 | 1999-12-09 | Lipidized conjugates containing an amino group-containing biologically active substance and pharmaceutical compositions containing the same |
IL143578A IL143578A (en) | 1998-12-10 | 2001-06-05 | Fatty pairs containing a substance with biological activity containing an amino group and pharmaceutical preparations containing them |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL143578A IL143578A (en) | 1998-12-10 | 2001-06-05 | Fatty pairs containing a substance with biological activity containing an amino group and pharmaceutical preparations containing them |
Country Status (16)
Country | Link |
---|---|
US (1) | US6590071B1 (fr) |
EP (1) | EP1137631B1 (fr) |
JP (1) | JP4637362B2 (fr) |
KR (1) | KR100676419B1 (fr) |
CN (1) | CN1168711C (fr) |
AR (1) | AR021604A1 (fr) |
AT (1) | ATE265429T1 (fr) |
AU (1) | AU764035B2 (fr) |
CA (1) | CA2354142A1 (fr) |
DE (1) | DE69916885T2 (fr) |
EA (1) | EA200100652A1 (fr) |
ES (1) | ES2220141T3 (fr) |
HK (1) | HK1045681B (fr) |
IL (2) | IL143578A0 (fr) |
TW (1) | TWI242000B (fr) |
WO (1) | WO2000034236A1 (fr) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7019113B2 (en) * | 1999-06-07 | 2006-03-28 | Mirus Bio Corporation | Reversible modification of membrane interaction |
US20080281041A1 (en) | 1999-06-07 | 2008-11-13 | Rozema David B | Reversibly Masked Polymers |
US8541548B2 (en) * | 1999-06-07 | 2013-09-24 | Arrowhead Madison Inc. | Compounds and methods for reversible modification of biologically active molecules |
US7442764B2 (en) * | 1999-06-07 | 2008-10-28 | Mirns Bio Corporation | Reversible modification of amine-containing compounds |
AU2002332054B2 (en) | 2001-09-24 | 2007-11-08 | Imperial Innovations Limited | Modification of feeding behavior |
AU2003201998C1 (en) | 2002-01-10 | 2012-10-25 | Imperial Innovations Limited | Modification of feeding behavior |
US8008355B2 (en) * | 2002-03-11 | 2011-08-30 | Roche Madison Inc. | Endosomolytic poly(vinyl ether) polymers |
US8138383B2 (en) * | 2002-03-11 | 2012-03-20 | Arrowhead Madison Inc. | Membrane active heteropolymers |
WO2004048530A2 (fr) * | 2002-11-22 | 2004-06-10 | Carnegie Mellon University | Compositions et procedes de capture reversible de biomolecules |
US20040151766A1 (en) * | 2003-01-30 | 2004-08-05 | Monahan Sean D. | Protein and peptide delivery to mammalian cells in vitro |
US20090074885A1 (en) * | 2003-09-08 | 2009-03-19 | Roche Madison Inc. | Reversible Hydrophobic Modification of Drugs for Improved Delivery to Cells |
US20050054612A1 (en) * | 2003-09-08 | 2005-03-10 | Monahan Sean D. | Delivery by labile hydrophobic modification of drugs |
FR2880627B1 (fr) * | 2005-01-07 | 2007-05-18 | Silab Sa | Procede d'obtention d'un principe actif pour l'eclat du teint, principe actif obtenu et compositions associees |
KR100726281B1 (ko) * | 2006-07-31 | 2007-06-11 | (주)아모레퍼시픽 | 신규 지방산 에스테르 화합물 및 이를 유효성분으로함유하는 당뇨 및 비만치료용 조성물 |
WO2008022309A2 (fr) * | 2006-08-18 | 2008-02-21 | F. Hoffmann-La Roche Ag | Polyconjugués pour l'administration in vivo de polynucléotides |
WO2008057298A2 (fr) * | 2006-10-27 | 2008-05-15 | Wei-Chiang Shen | Interféron lipidisé et ses utilisations |
TWI428346B (zh) | 2006-12-13 | 2014-03-01 | Imp Innovations Ltd | 新穎化合物及其等對進食行為影響 |
WO2009059984A2 (fr) * | 2007-11-06 | 2009-05-14 | F. Hoffmann-La Roche Ag | Hydrophobisation réversible pour une administration de médicament de premier passage |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2962504A (en) * | 1960-11-29 | Production of maleic anhydride | ||
US5144011A (en) | 1981-06-26 | 1992-09-01 | Boston University | Acidity-sensitive spacer molecule to control the release of pharmaceuticals from molecular carriers |
US4631190A (en) | 1981-06-26 | 1986-12-23 | Shen Wei C | Acidity-sensitive spacer molecule to control the release of pharmaceuticals from molecular carriers |
US4480106A (en) * | 1981-10-28 | 1984-10-30 | Ciba-Geigy Corporation | Process for the preparation of asymmetrically substituted maleic anhydrides, and asymmetrically substituted maleic anhydrides |
US4764368A (en) | 1984-08-29 | 1988-08-16 | Dana-Farber Cancer Institute, Inc. | Acid-cleavable compound |
US4542225A (en) | 1984-08-29 | 1985-09-17 | Dana-Farber Cancer Institute, Inc. | Acid-cleavable compound |
GB8430252D0 (en) | 1984-11-30 | 1985-01-09 | Beecham Group Plc | Compounds |
US4751286A (en) | 1985-11-19 | 1988-06-14 | The Johns Hopkins University | Protein label and drug delivery system |
US4889916A (en) | 1985-11-19 | 1989-12-26 | The Johns Hopkins University | Protein label and drug delivery system |
GB2189698A (en) | 1986-04-30 | 1987-11-04 | Haessle Ab | Coated omeprazole tablets |
GB2189699A (en) | 1986-04-30 | 1987-11-04 | Haessle Ab | Coated acid-labile medicaments |
US4997913A (en) | 1986-06-30 | 1991-03-05 | Oncogen | pH-sensitive immunoconjugates and methods for their use in tumor therapy |
US5017693A (en) | 1987-12-02 | 1991-05-21 | Neorx Corporation | Methods for introducing a sulfhydryl amino or hydroxyl groups to a compound |
US5563250A (en) | 1987-12-02 | 1996-10-08 | Neorx Corporation | Cleavable conjugates for the delivery and release of agents in native form |
US5066490A (en) | 1988-06-01 | 1991-11-19 | The United States Of America As Represented By The Secretary Of The Department Of Health & Human Services | Protein crosslinking reagents cleavable within acidified intracellular vesicles |
US5140013A (en) * | 1989-11-28 | 1992-08-18 | Universite Laval | Maleic anhydride derivatives used as conjugation agents of anti-tumor agents on desired carriers |
JPH04334377A (ja) * | 1990-12-31 | 1992-11-20 | Akzo Nv | 酸−不安定性リンカー分子 |
US5505931A (en) | 1993-03-04 | 1996-04-09 | The Dow Chemical Company | Acid cleavable compounds, their preparation and use as bifunctional acid-labile crosslinking agents |
US5907030A (en) * | 1995-01-25 | 1999-05-25 | University Of Southern California | Method and compositions for lipidization of hydrophilic molecules |
PL183698B1 (pl) * | 1995-03-17 | 2002-06-28 | Novo Nordisk As | Pochodna insuliny, kompozycja farmaceutyczna i zastosowanie pochodnej insuliny |
US5869602A (en) * | 1995-03-17 | 1999-02-09 | Novo Nordisk A/S | Peptide derivatives |
US5907530A (en) | 1995-08-30 | 1999-05-25 | Samsung Electronics Co., Ltd. | Optical pickup device |
CA2267179A1 (fr) | 1996-09-26 | 1998-04-02 | The University Of Southern California | Procedes et compositions pour la lipidation de molecules hydrophile |
US6093692A (en) | 1997-09-25 | 2000-07-25 | The University Of Southern California | Method and compositions for lipidization of hydrophilic molecules |
-
1999
- 1999-12-06 TW TW088121325A patent/TWI242000B/zh active
- 1999-12-09 US US09/457,587 patent/US6590071B1/en not_active Expired - Fee Related
- 1999-12-09 EA EA200100652A patent/EA200100652A1/ru unknown
- 1999-12-09 KR KR1020017007259A patent/KR100676419B1/ko not_active IP Right Cessation
- 1999-12-09 AU AU23556/00A patent/AU764035B2/en not_active Ceased
- 1999-12-09 EP EP99967238A patent/EP1137631B1/fr not_active Expired - Lifetime
- 1999-12-09 JP JP2000586684A patent/JP4637362B2/ja not_active Expired - Fee Related
- 1999-12-09 ES ES99967238T patent/ES2220141T3/es not_active Expired - Lifetime
- 1999-12-09 IL IL14357899A patent/IL143578A0/xx active IP Right Grant
- 1999-12-09 CN CNB998142441A patent/CN1168711C/zh not_active Expired - Fee Related
- 1999-12-09 DE DE69916885T patent/DE69916885T2/de not_active Expired - Lifetime
- 1999-12-09 WO PCT/US1999/029119 patent/WO2000034236A1/fr active IP Right Grant
- 1999-12-09 CA CA002354142A patent/CA2354142A1/fr not_active Abandoned
- 1999-12-09 AR ARP990106275A patent/AR021604A1/es unknown
- 1999-12-09 AT AT99967238T patent/ATE265429T1/de not_active IP Right Cessation
-
2001
- 2001-06-05 IL IL143578A patent/IL143578A/en not_active IP Right Cessation
-
2002
- 2002-09-26 HK HK02107065.3A patent/HK1045681B/zh not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
AU764035B2 (en) | 2003-08-07 |
KR20010080749A (ko) | 2001-08-22 |
DE69916885D1 (de) | 2004-06-03 |
CN1350519A (zh) | 2002-05-22 |
AR021604A1 (es) | 2002-07-31 |
DE69916885T2 (de) | 2005-04-07 |
JP4637362B2 (ja) | 2011-02-23 |
EP1137631A1 (fr) | 2001-10-04 |
CA2354142A1 (fr) | 2000-06-15 |
HK1045681A1 (en) | 2002-12-06 |
WO2000034236A1 (fr) | 2000-06-15 |
ATE265429T1 (de) | 2004-05-15 |
EA200100652A1 (ru) | 2001-12-24 |
EP1137631B1 (fr) | 2004-04-28 |
CN1168711C (zh) | 2004-09-29 |
HK1045681B (zh) | 2005-05-20 |
US6590071B1 (en) | 2003-07-08 |
TWI242000B (en) | 2005-10-21 |
ES2220141T3 (es) | 2004-12-01 |
AU2355600A (en) | 2000-06-26 |
JP2002531543A (ja) | 2002-09-24 |
KR100676419B1 (ko) | 2007-02-05 |
IL143578A (en) | 2006-07-05 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL143578A0 (en) | Lipidized conjugates containing an amino group-containing biologically active substance and pharmaceutical compositions containing the same | |
EP0950665A4 (fr) | Proteines modifiees physiologiquement actives et compositions medicamenteuses les contenant | |
EP0981649A4 (fr) | Peptides favorisant le transport d'un agent actif dans les tissus, compositions les renfermant et leurs procedes d'utilisation | |
HUP0004310A3 (en) | Cyclic amino acids, and derivatives thereof and pharmaceutical compositions comprising the said compounds as active agents | |
HUP0100507A3 (en) | Polyethylene glycol-grf conjugates, site-specific preparation thereof, pharmaceutical compositions comprising thereof and their use | |
EP1254666A4 (fr) | Compositions d'anticorps stables et preparations pour injection | |
ZA9811593B (en) | Substantially pure histidine-linked protein polymer conjugates | |
IL138573A0 (en) | Amide derivatives and pharmaceutical compositions containing the same | |
IL150224A0 (en) | Lipopeptides and pharmaceutical compositions containing the same | |
IL150223A0 (en) | Lipopeptides and pharmaceutical compositions containing the same | |
HUP0103265A2 (hu) | Proszapozineredetű ciklikus peptidek, azokat tartalmazó gyógyszerkészítmények és alkalmazásuk | |
IL137904A0 (en) | Peptide analogues of insulin and pharmaceutical compositions containing the same | |
HUP0004398A3 (en) | Alpha-aryl-n-alkylnitrones and pharmaceutical compositions containing the same | |
HUP0102369A3 (en) | Amino acid derivatives and drugs containing the same as the active ingredient | |
IL145733A0 (en) | A polpyeptide containing an immunogenic portion of a breast protein and pharmaceutical compositions containing the same | |
IL125908A (en) | Peptides and pharmaceutical compositions comprising same | |
IL131707A0 (en) | Acetylcholinesterase-derived peptides and uses thereof | |
IL146795A0 (en) | Biologically active materials | |
HUP0003330A3 (en) | Pharmaceutical compositions containing tizoxanide and nitazoxanide | |
ZA983239B (en) | Stable active human ob protein compositions and methods | |
DE69833061D1 (de) | Aktivierte Peptide und deren Konjugate | |
IL131266A0 (en) | Peptides and pharmaceutical compositions comprising same | |
IL125262A0 (en) | Synthetic peptides and pharmaceutical compositions comprising them | |
IL123535A (en) | Benzoxazinedione derivatives their conjugates with antibiotics and pharmaceutical compositions containing them | |
AU1067200A (en) | Pharmaceutical conjugates comprising two active agents |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FF | Patent granted | ||
KB | Patent renewed | ||
KB | Patent renewed |