IL143150A0 - A process for the preparation of n,n'-bis[2,3-dihydroxypropyl]-5[hydroxyacetyl) methylamino]-2,4,5-triiodo-1,3-benzenedicarboxamide - Google Patents
A process for the preparation of n,n'-bis[2,3-dihydroxypropyl]-5[hydroxyacetyl) methylamino]-2,4,5-triiodo-1,3-benzenedicarboxamideInfo
- Publication number
- IL143150A0 IL143150A0 IL14315099A IL14315099A IL143150A0 IL 143150 A0 IL143150 A0 IL 143150A0 IL 14315099 A IL14315099 A IL 14315099A IL 14315099 A IL14315099 A IL 14315099A IL 143150 A0 IL143150 A0 IL 143150A0
- Authority
- IL
- Israel
- Prior art keywords
- triiodo
- hydroxyacetyl
- dihydroxypropyl
- methylamino
- bis
- Prior art date
Links
- 125000000350 glycoloyl group Chemical group O=C([*])C([H])([H])O[H] 0.000 title 1
- 125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 title 1
- COFWQRPEYJADHT-UHFFFAOYSA-N 1-n,3-n-bis(2,3-dihydroxypropyl)-5-[(3-hydroxy-2-oxopropyl)amino]-2,4,6-triiodobenzene-1,3-dicarboxamide Chemical compound OCC(O)CNC(=O)C1=C(I)C(NCC(=O)CO)=C(I)C(C(=O)NCC(O)CO)=C1I COFWQRPEYJADHT-UHFFFAOYSA-N 0.000 abstract 1
- 239000002872 contrast media Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/14—Preparation of carboxylic acid amides by formation of carboxamide groups together with reactions not involving the carboxamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Polyamides (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT1998MI002574A IT1303797B1 (it) | 1998-11-27 | 1998-11-27 | Processo per la preparazione di n,n'-bis(2,3-diidrossipropil)-5-((idrossiacetil)metilammino)-2,4,6-triiodo-1,3-benzendicarbossammide. |
| PCT/EP1999/009118 WO2000032561A1 (en) | 1998-11-27 | 1999-11-25 | A process for the preparation of n,n'-bis[2, 3-dihydroxypropyl] -5-[ (hydroxyacetyl) methylamino]-2, 4,6-triiodo-1, 3-benzenedi carboxamide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL143150A0 true IL143150A0 (en) | 2002-04-21 |
Family
ID=11381150
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL14315099A IL143150A0 (en) | 1998-11-27 | 1999-11-25 | A process for the preparation of n,n'-bis[2,3-dihydroxypropyl]-5[hydroxyacetyl) methylamino]-2,4,5-triiodo-1,3-benzenedicarboxamide |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US6420603B1 (cs) |
| EP (1) | EP1133466B1 (cs) |
| JP (1) | JP4439123B2 (cs) |
| KR (1) | KR100630400B1 (cs) |
| CN (1) | CN1163474C (cs) |
| AT (1) | ATE247630T1 (cs) |
| AU (1) | AU753601B2 (cs) |
| BR (1) | BR9915608B1 (cs) |
| CA (1) | CA2351717C (cs) |
| CZ (1) | CZ296096B6 (cs) |
| DE (1) | DE69910609T2 (cs) |
| EA (1) | EA003253B1 (cs) |
| ES (1) | ES2205949T3 (cs) |
| HK (1) | HK1040988B (cs) |
| HR (1) | HRP20010393B1 (cs) |
| HU (1) | HU229092B1 (cs) |
| IL (1) | IL143150A0 (cs) |
| IT (1) | IT1303797B1 (cs) |
| ME (2) | ME00606B (cs) |
| NO (1) | NO327037B1 (cs) |
| RS (1) | RS50038B (cs) |
| SK (1) | SK285050B6 (cs) |
| TR (1) | TR200101439T2 (cs) |
| WO (1) | WO2000032561A1 (cs) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2093206A1 (en) * | 2008-02-20 | 2009-08-26 | BRACCO IMAGING S.p.A. | Process for the iodination of aromatic compounds |
| EP2243767A1 (en) | 2009-04-21 | 2010-10-27 | Bracco Imaging S.p.A | Process for the iodination of aromatic compounds |
| JP5661762B2 (ja) * | 2009-07-07 | 2015-01-28 | ブラッコ・イメージング・ソシエタ・ペル・アチオニＢｒａｃｃｏ Ｉｍａｇｉｎｇ Ｓ．Ｐ．Ａ． | ヨウ素化剤の製造方法 |
| EP2277846A1 (en) * | 2009-07-21 | 2011-01-26 | GE Healthcare AS | Obtaining free iodine in preparation of aqueous iodine chloride by adding potassium iodide |
| EP2394984A1 (en) | 2010-06-10 | 2011-12-14 | Bracco Imaging S.p.A | Process for the iodination of phenolic derivatives |
| IT1403988B1 (it) * | 2010-07-15 | 2013-11-08 | Bracco Imaging Spa | Processo per la preparazione di agenti di contrasto. |
| WO2012136813A2 (en) | 2011-04-07 | 2012-10-11 | Universitetet I Oslo | Agents for medical radar diagnosis |
| KR101833334B1 (ko) * | 2016-04-29 | 2018-02-28 | (주)유케이케미팜 | 신규 중간체 화합물 및 이를 이용한 이오메프롤의 제조방법 |
| KR102128423B1 (ko) | 2018-09-17 | 2020-07-01 | (주)유케이케미팜 | 조영제 이오메프롤의 제조방법 |
| WO2023046815A1 (en) | 2021-09-24 | 2023-03-30 | Bracco Imaging Spa | Electrochemical iodination of n,n'-(2,3-dihydroxypropyl)-5-hydroxy-1,3-benzenedicarboxamide |
| JP2025514326A (ja) | 2022-04-29 | 2025-05-02 | ブラッコ・イメージング・ソシエタ・ペル・アチオニ | ２，４，６－トリヨードフェノール誘導体の製造方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1196363B (it) * | 1984-12-10 | 1988-11-16 | Bracco Ind Chimica Spa | Derivati dell'acido 5-alcossi-2,4,6-triiodo- o -tribromo-isoftalico,metodo per la loro preparazione e relativi mezzi di contrasto radiologici |
| WO1988009328A1 (en) * | 1987-05-22 | 1988-12-01 | Bracco Industria Chimica S.P.A. | Preparation of 5-acylamino-2,4,6-triiodo- or tribromo-benzoic acid derivatives |
-
1998
- 1998-11-27 IT IT1998MI002574A patent/IT1303797B1/it active
-
1999
- 1999-11-25 DE DE69910609T patent/DE69910609T2/de not_active Expired - Lifetime
- 1999-11-25 EP EP99973018A patent/EP1133466B1/en not_active Expired - Lifetime
- 1999-11-25 IL IL14315099A patent/IL143150A0/xx not_active IP Right Cessation
- 1999-11-25 US US09/856,554 patent/US6420603B1/en not_active Expired - Lifetime
- 1999-11-25 RS YUP-371/01A patent/RS50038B/sr unknown
- 1999-11-25 JP JP2000585203A patent/JP4439123B2/ja not_active Expired - Lifetime
- 1999-11-25 AU AU13862/00A patent/AU753601B2/en not_active Expired
- 1999-11-25 SK SK705-2001A patent/SK285050B6/sk not_active IP Right Cessation
- 1999-11-25 CZ CZ20011833A patent/CZ296096B6/cs not_active IP Right Cessation
- 1999-11-25 KR KR1020017006458A patent/KR100630400B1/ko not_active Expired - Lifetime
- 1999-11-25 TR TR2001/01439T patent/TR200101439T2/xx unknown
- 1999-11-25 ME MEP-2009-88A patent/ME00606B/me unknown
- 1999-11-25 ME MEP-88/09A patent/MEP8809A/xx unknown
- 1999-11-25 EA EA200100462A patent/EA003253B1/ru not_active IP Right Cessation
- 1999-11-25 WO PCT/EP1999/009118 patent/WO2000032561A1/en active IP Right Grant
- 1999-11-25 HR HR20010393A patent/HRP20010393B1/xx not_active IP Right Cessation
- 1999-11-25 AT AT99973018T patent/ATE247630T1/de active
- 1999-11-25 HK HK02102762.0A patent/HK1040988B/zh not_active IP Right Cessation
- 1999-11-25 HU HU0104507A patent/HU229092B1/hu unknown
- 1999-11-25 CN CNB998136514A patent/CN1163474C/zh not_active Expired - Lifetime
- 1999-11-25 CA CA2351717A patent/CA2351717C/en not_active Expired - Lifetime
- 1999-11-25 BR BRPI9915608-3A patent/BR9915608B1/pt not_active IP Right Cessation
- 1999-11-25 ES ES99973018T patent/ES2205949T3/es not_active Expired - Lifetime
-
2001
- 2001-05-23 NO NO20012547A patent/NO327037B1/no not_active IP Right Cessation
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| EXP | Patent expired |