IL143070A - Process for the manufacture of l-dopa ethyl ester - Google Patents

Process for the manufacture of l-dopa ethyl ester

Info

Publication number
IL143070A
IL143070A IL14307099A IL14307099A IL143070A IL 143070 A IL143070 A IL 143070A IL 14307099 A IL14307099 A IL 14307099A IL 14307099 A IL14307099 A IL 14307099A IL 143070 A IL143070 A IL 143070A
Authority
IL
Israel
Prior art keywords
ethyl ester
dopa
solution
dopa ethyl
crude
Prior art date
Application number
IL14307099A
Other languages
English (en)
Other versions
IL143070A0 (en
Original Assignee
Teva Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Pharma filed Critical Teva Pharma
Publication of IL143070A0 publication Critical patent/IL143070A0/xx
Publication of IL143070A publication Critical patent/IL143070A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/38—Separation; Purification; Stabilisation; Use of additives
    • C07C227/40—Separation; Purification
    • C07C227/42—Crystallisation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
IL14307099A 1998-11-10 1999-11-10 Process for the manufacture of l-dopa ethyl ester IL143070A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10782098P 1998-11-10 1998-11-10
PCT/US1999/026548 WO2000027801A1 (en) 1998-11-10 1999-11-10 Process for manufacture of l-dopa ethyl ester

Publications (2)

Publication Number Publication Date
IL143070A0 IL143070A0 (en) 2002-04-21
IL143070A true IL143070A (en) 2004-03-28

Family

ID=22318659

Family Applications (1)

Application Number Title Priority Date Filing Date
IL14307099A IL143070A (en) 1998-11-10 1999-11-10 Process for the manufacture of l-dopa ethyl ester

Country Status (13)

Country Link
US (2) US6218566B1 (no)
EP (1) EP1137626A4 (no)
JP (1) JP2002529443A (no)
CN (1) CN1325379A (no)
AU (1) AU764844B2 (no)
CA (1) CA2350303A1 (no)
HK (1) HK1041475A1 (no)
HU (1) HUP0103798A3 (no)
IL (1) IL143070A (no)
NO (1) NO20012266L (no)
NZ (1) NZ512030A (no)
WO (1) WO2000027801A1 (no)
ZA (1) ZA200103525B (no)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6746688B1 (en) 1996-10-13 2004-06-08 Neuroderm Ltd. Apparatus for the transdermal treatment of Parkinson's disease
IL159813A0 (en) * 2001-07-12 2004-06-20 Teva Pharma Dual release formulation comprising levodopa ethyl ester and a decarboxylase inhibitor in immediate release layer with levodopa ethyl ester and a decarboxylase inhibitor in a controlled release core
WO2003041646A2 (en) * 2001-11-13 2003-05-22 Teva Pharmaceutical Industries, Ltd. L-dopa ethyl ester salts and uses thereof
WO2003042136A2 (en) * 2001-11-13 2003-05-22 Teva Pharmaceutical Industries, Ltd. Process for the production of l-dopa ethyl ester
EP3291872A4 (en) 2015-05-06 2019-02-13 SynAgile Corporation PHARMACEUTICAL SUSPENSIONS WITH ACTIVE SUBSTANCES, DEVICES FOR THEIR ADMINISTRATION AND METHOD FOR THEIR USE

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA716958B (en) 1970-10-30 1973-01-31 Hoffmann La Roche Phenylalanine amides
US3803120A (en) 1971-09-28 1974-04-09 Hoffmann La Roche Di-and tripeptides of 3-(3,4-dihydroxyphenyl)-alanine
US3939253A (en) 1973-11-02 1976-02-17 Interx Research Corporation Novel, transient pro-drug forms of l-dopa useful in the treatment of parkinson's disease
JPS5157813A (en) 1974-11-14 1976-05-20 Sankyo Co Ll dooba mataha sonojudotaiseizaino seiho
US4035507A (en) 1975-04-17 1977-07-12 Interx Research Corporation Novel, transient pro-drug forms of L-DOPA to treat Parkinson's disease
US4916151A (en) 1985-12-05 1990-04-10 Merrell Dow Pharmaceuticals Inc. Method of treating parkinson's syndrome
US4663349A (en) 1985-12-30 1987-05-05 Merck & Co., Inc. Rectally absorbable form of L-dopa
US4771073A (en) 1985-12-30 1988-09-13 Merck & Co., Inc. Rectally absorbable form of L-dopa
ATE76747T1 (de) 1986-06-10 1992-06-15 Chiesi Farma Spa Levodopa-methyl-ester enthaltende pharmazeutische zusammensetzungen, ihre herstellung und therapeutische verwendungen.
US5354885A (en) 1992-12-24 1994-10-11 Yissum Research Development Company Of The Hebrew University Of Jerusalem Process for preparing ethyl ester of L-DOPA
US5607969A (en) 1992-12-24 1997-03-04 Yissum Research Development Company Of The Hebrew University Of Jerusalem L-DOPA ethyl ester to treat Parkinson's disease

Also Published As

Publication number Publication date
AU1717000A (en) 2000-05-29
US6218566B1 (en) 2001-04-17
CA2350303A1 (en) 2000-05-18
IL143070A0 (en) 2002-04-21
ZA200103525B (en) 2002-05-02
NZ512030A (en) 2003-10-31
NO20012266L (no) 2001-06-26
EP1137626A1 (en) 2001-10-04
US20020026069A1 (en) 2002-02-28
EP1137626A4 (en) 2002-07-17
HK1041475A1 (zh) 2002-07-12
CN1325379A (zh) 2001-12-05
HUP0103798A3 (en) 2002-12-28
WO2000027801A1 (en) 2000-05-18
AU764844B2 (en) 2003-09-04
NO20012266D0 (no) 2001-05-08
HUP0103798A2 (hu) 2002-02-28
JP2002529443A (ja) 2002-09-10

Similar Documents

Publication Publication Date Title
JP6594917B2 (ja) 所定の粒子径を有する純粋な非多形結晶性胆汁酸の最適合成
IL185576A (en) Formation and purification of glycopyrronium bromide
CN108948020A (zh) 一种枸橼酸托法替布的精制方法
EP3100735B1 (en) Crystalline fosaprepitant dicyclohexylamine salt and its preparation
US6218566B1 (en) Process for manufacturing of L-DOPA ethyl ester
CA2615691C (en) Process for the preparation of crystalline perindopril
JP4257573B2 (ja) Ｒ（＋）α−リポ酸の製造方法
US20200407355A1 (en) Crystalline forms of venetoclax
EP0385848A1 (fr) Nouveaux dérivés benzoxazolinoniques, leurs procédés de préparation et les compositions pharmaceutiques qui les contiennent
US20030135065A1 (en) Process for the production of L-DOPA ethyl ester
WO2008138874A1 (en) Process for preparing (s)-pregabalin by optical resolution of racemic pregabalin
WO2009045410A1 (en) Process for preparing r-gossypol l-phenylalaninol dienamine
WO1985003932A1 (en) Novel diastereomer salts of phenylalanine and n-acyl derivatives thereof and process for the separation of optically active phenylalanine and n-acyl derivatives thereof
CH637967A5 (fr) Produit d'addition du n,n-dimethylacetamide et d'un derive d'un acide cephem-4-carboxylique et procede de sa preparation.
JPS61122261A (ja) Ｎ−カルバモイル−フエニルアラニンの光学分割法
HU193202B (en) Process for preparing alpha-/acetyl-amino/-beta-phenyl-propionic acid enantiomers

Legal Events

Date Code Title Description
MM9K Patent not in force due to non-payment of renewal fees