HUP0103798A3 - Process for manufacture of l-dopa ethyl ester - Google Patents
Process for manufacture of l-dopa ethyl esterInfo
- Publication number
- HUP0103798A3 HUP0103798A3 HU0103798A HUP0103798A HUP0103798A3 HU P0103798 A3 HUP0103798 A3 HU P0103798A3 HU 0103798 A HU0103798 A HU 0103798A HU P0103798 A HUP0103798 A HU P0103798A HU P0103798 A3 HUP0103798 A3 HU P0103798A3
- Authority
- HU
- Hungary
- Prior art keywords
- manufacture
- ethyl ester
- dopa ethyl
- dopa
- ester
- Prior art date
Links
- NULMGOSOSZBEQL-QMMMGPOBSA-N etilevodopa Chemical compound CCOC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 NULMGOSOSZBEQL-QMMMGPOBSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/38—Separation; Purification; Stabilisation; Use of additives
- C07C227/40—Separation; Purification
- C07C227/42—Crystallisation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Crystallography & Structural Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10782098P | 1998-11-10 | 1998-11-10 | |
| PCT/US1999/026548 WO2000027801A1 (en) | 1998-11-10 | 1999-11-10 | Process for manufacture of l-dopa ethyl ester |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0103798A2 HUP0103798A2 (hu) | 2002-02-28 |
| HUP0103798A3 true HUP0103798A3 (en) | 2002-12-28 |
Family
ID=22318659
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0103798A HUP0103798A3 (en) | 1998-11-10 | 1999-11-10 | Process for manufacture of l-dopa ethyl ester |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US6218566B1 (hu) |
| EP (1) | EP1137626A4 (hu) |
| JP (1) | JP2002529443A (hu) |
| CN (1) | CN1325379A (hu) |
| AU (1) | AU764844B2 (hu) |
| CA (1) | CA2350303A1 (hu) |
| HK (1) | HK1041475A1 (hu) |
| HU (1) | HUP0103798A3 (hu) |
| IL (1) | IL143070A (hu) |
| NO (1) | NO20012266L (hu) |
| NZ (1) | NZ512030A (hu) |
| WO (1) | WO2000027801A1 (hu) |
| ZA (1) | ZA200103525B (hu) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6746688B1 (en) | 1996-10-13 | 2004-06-08 | Neuroderm Ltd. | Apparatus for the transdermal treatment of Parkinson's disease |
| IL159813A0 (en) * | 2001-07-12 | 2004-06-20 | Teva Pharma | Dual release formulation comprising levodopa ethyl ester and a decarboxylase inhibitor in immediate release layer with levodopa ethyl ester and a decarboxylase inhibitor in a controlled release core |
| WO2003041646A2 (en) * | 2001-11-13 | 2003-05-22 | Teva Pharmaceutical Industries, Ltd. | L-dopa ethyl ester salts and uses thereof |
| WO2003042136A2 (en) * | 2001-11-13 | 2003-05-22 | Teva Pharmaceutical Industries, Ltd. | Process for the production of l-dopa ethyl ester |
| EP3291872A4 (en) | 2015-05-06 | 2019-02-13 | SynAgile Corporation | PHARMACEUTICAL SUSPENSIONS WITH ACTIVE SUBSTANCES, DEVICES FOR THEIR ADMINISTRATION AND METHOD FOR THEIR USE |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA716958B (en) | 1970-10-30 | 1973-01-31 | Hoffmann La Roche | Phenylalanine amides |
| US3803120A (en) | 1971-09-28 | 1974-04-09 | Hoffmann La Roche | Di-and tripeptides of 3-(3,4-dihydroxyphenyl)-alanine |
| US3939253A (en) | 1973-11-02 | 1976-02-17 | Interx Research Corporation | Novel, transient pro-drug forms of l-dopa useful in the treatment of parkinson's disease |
| JPS5157813A (en) | 1974-11-14 | 1976-05-20 | Sankyo Co | Ll dooba mataha sonojudotaiseizaino seiho |
| US4035507A (en) | 1975-04-17 | 1977-07-12 | Interx Research Corporation | Novel, transient pro-drug forms of L-DOPA to treat Parkinson's disease |
| US4916151A (en) | 1985-12-05 | 1990-04-10 | Merrell Dow Pharmaceuticals Inc. | Method of treating parkinson's syndrome |
| US4663349A (en) | 1985-12-30 | 1987-05-05 | Merck & Co., Inc. | Rectally absorbable form of L-dopa |
| US4771073A (en) | 1985-12-30 | 1988-09-13 | Merck & Co., Inc. | Rectally absorbable form of L-dopa |
| ATE76747T1 (de) | 1986-06-10 | 1992-06-15 | Chiesi Farma Spa | Levodopa-methyl-ester enthaltende pharmazeutische zusammensetzungen, ihre herstellung und therapeutische verwendungen. |
| US5354885A (en) | 1992-12-24 | 1994-10-11 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Process for preparing ethyl ester of L-DOPA |
| US5607969A (en) | 1992-12-24 | 1997-03-04 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | L-DOPA ethyl ester to treat Parkinson's disease |
-
1999
- 1999-11-10 IL IL14307099A patent/IL143070A/en not_active IP Right Cessation
- 1999-11-10 CA CA002350303A patent/CA2350303A1/en not_active Abandoned
- 1999-11-10 WO PCT/US1999/026548 patent/WO2000027801A1/en not_active Application Discontinuation
- 1999-11-10 AU AU17170/00A patent/AU764844B2/en not_active Ceased
- 1999-11-10 CN CN99813032A patent/CN1325379A/zh active Pending
- 1999-11-10 NZ NZ512030A patent/NZ512030A/en unknown
- 1999-11-10 US US09/437,700 patent/US6218566B1/en not_active Expired - Fee Related
- 1999-11-10 HU HU0103798A patent/HUP0103798A3/hu unknown
- 1999-11-10 JP JP2000580981A patent/JP2002529443A/ja active Pending
- 1999-11-10 EP EP99960259A patent/EP1137626A4/en not_active Withdrawn
-
2001
- 2001-05-02 ZA ZA200103525A patent/ZA200103525B/en unknown
- 2001-05-08 NO NO20012266A patent/NO20012266L/no unknown
- 2001-05-09 US US09/851,818 patent/US20020026069A1/en not_active Abandoned
-
2002
- 2002-03-28 HK HK02102399.1A patent/HK1041475A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU1717000A (en) | 2000-05-29 |
| US6218566B1 (en) | 2001-04-17 |
| CA2350303A1 (en) | 2000-05-18 |
| IL143070A0 (en) | 2002-04-21 |
| ZA200103525B (en) | 2002-05-02 |
| NZ512030A (en) | 2003-10-31 |
| NO20012266L (no) | 2001-06-26 |
| EP1137626A1 (en) | 2001-10-04 |
| US20020026069A1 (en) | 2002-02-28 |
| EP1137626A4 (en) | 2002-07-17 |
| HK1041475A1 (zh) | 2002-07-12 |
| CN1325379A (zh) | 2001-12-05 |
| WO2000027801A1 (en) | 2000-05-18 |
| IL143070A (en) | 2004-03-28 |
| AU764844B2 (en) | 2003-09-04 |
| NO20012266D0 (no) | 2001-05-08 |
| HUP0103798A2 (hu) | 2002-02-28 |
| JP2002529443A (ja) | 2002-09-10 |
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