IL142398A0 - Serine protease inhibitor - Google Patents
Serine protease inhibitorInfo
- Publication number
- IL142398A0 IL142398A0 IL14239899A IL14239899A IL142398A0 IL 142398 A0 IL142398 A0 IL 142398A0 IL 14239899 A IL14239899 A IL 14239899A IL 14239899 A IL14239899 A IL 14239899A IL 142398 A0 IL142398 A0 IL 142398A0
- Authority
- IL
- Israel
- Prior art keywords
- protease inhibitor
- serine protease
- serine
- inhibitor
- protease
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/30—Phthalazines
- C07D237/34—Phthalazines with nitrogen atoms directly attached to carbon atoms of the nitrogen-containing ring, e.g. hydrazine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98203559 | 1998-10-23 | ||
| PCT/EP1999/007928 WO2000024718A1 (en) | 1998-10-23 | 1999-10-19 | Serine protease inhibitor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL142398A0 true IL142398A0 (en) | 2002-03-10 |
Family
ID=8234249
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL14239899A IL142398A0 (en) | 1998-10-23 | 1999-10-19 | Serine protease inhibitor |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US6903107B1 (zh) |
| EP (1) | EP1123280A1 (zh) |
| JP (1) | JP2002528438A (zh) |
| KR (1) | KR20010075648A (zh) |
| CN (1) | CN1146543C (zh) |
| AR (1) | AR020922A1 (zh) |
| AU (1) | AU763667B2 (zh) |
| BR (1) | BR9914694A (zh) |
| CA (1) | CA2346990A1 (zh) |
| CO (1) | CO5140114A1 (zh) |
| CZ (1) | CZ20011440A3 (zh) |
| HU (1) | HUP0103806A3 (zh) |
| ID (1) | ID29885A (zh) |
| IL (1) | IL142398A0 (zh) |
| NO (1) | NO20011966L (zh) |
| NZ (1) | NZ511067A (zh) |
| PE (1) | PE20001283A1 (zh) |
| PL (1) | PL347948A1 (zh) |
| RU (1) | RU2232760C2 (zh) |
| SK (1) | SK5372001A3 (zh) |
| TR (1) | TR200101120T2 (zh) |
| TW (1) | TW575567B (zh) |
| WO (1) | WO2000024718A1 (zh) |
| ZA (1) | ZA200102970B (zh) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10046272A1 (de) * | 2000-09-19 | 2002-03-28 | Merck Patent Gmbh | Aminoheterocyclen (Faktor Xa Inhibitoren 14) |
| US6924285B2 (en) | 2002-03-30 | 2005-08-02 | Boehringer Ingelheim Pharma Gmbh & Co. | Bicyclic heterocyclic compounds, pharmaceutical compositions containing these compounds, their use and process for preparing them |
| DK1569912T3 (en) | 2002-12-03 | 2015-06-29 | Pharmacyclics Inc | 2- (2-hydroxybiphenyl-3-yl) -1h-benzoimidazole-5-carboxamidine derivatives as factor VIIa inhibitors. |
| GB0309850D0 (en) | 2003-04-30 | 2003-06-04 | Astrazeneca Ab | Quinazoline derivatives |
| GB0322409D0 (en) | 2003-09-25 | 2003-10-29 | Astrazeneca Ab | Quinazoline derivatives |
| GB0326459D0 (en) | 2003-11-13 | 2003-12-17 | Astrazeneca Ab | Quinazoline derivatives |
| EP1713781B1 (en) | 2004-02-03 | 2008-11-05 | AstraZeneca AB | Quinazoline derivatives |
| AU2006264043B2 (en) | 2005-06-28 | 2012-04-26 | Sanofi-Aventis | Isoquinoline derivatives as inhibitors of Rho-kinase |
| CN101228132B (zh) | 2005-07-26 | 2012-10-10 | 塞诺菲-安万特股份有限公司 | 作为Rho-激酶抑制剂的环己基胺异喹啉酮衍生物 |
| UA93882C2 (ru) | 2005-07-26 | 2011-03-25 | Санофи-Авентис | Пиперидинил-замещенные производные изохинолона kak ингибиторы rho-киназы |
| TWI389899B (zh) | 2006-08-08 | 2013-03-21 | Msd Oss Bv | 具口服活性之凝血酶抑制劑 |
| EP1921070A1 (de) | 2006-11-10 | 2008-05-14 | Boehringer Ingelheim Pharma GmbH & Co. KG | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstelllung |
| WO2008077555A2 (en) | 2006-12-27 | 2008-07-03 | Sanofi-Aventis | Substituted isoquinolines and their use as rho-kinase inhibitors |
| BRPI0720862A2 (pt) * | 2006-12-27 | 2014-02-25 | Sanofi Aventis | Derivados de isoquinolina e isoquinolinona substituídos como inibidores de rho-cinase |
| MY155009A (en) | 2006-12-27 | 2015-08-28 | Sanofi Aventis | Cycloalkylamine substituted isoquinolone derivatives |
| KR20090094338A (ko) * | 2006-12-27 | 2009-09-04 | 사노피-아벤티스 | 치환된 이소퀴놀린 및 이소퀴놀리논 유도체 |
| KR101494452B1 (ko) * | 2006-12-27 | 2015-02-16 | 사노피 | 사이클로알킬아민 치환된 이소퀴놀린 및 이소퀴놀리논 유도체 |
| CN101611012B (zh) | 2006-12-27 | 2012-11-14 | 塞诺菲-安万特股份有限公司 | 环烷基胺取代的异喹啉衍生物 |
| ES2364511T3 (es) * | 2006-12-27 | 2011-09-05 | Sanofi | Derivados de isoquinolona e isoquinolinona sustituidos con cicloalquilamina. |
| MX2009007610A (es) | 2007-02-06 | 2009-07-24 | Boehringer Ingelheim Int | Heterociclicos biciclicos, medicamentos que contienen estos compuestos, su utilizacion y procedimientos para su preparacion. |
| WO2009098061A1 (de) | 2008-02-07 | 2009-08-13 | Boehringer Ingelheim International Gmbh | Spirocyclische heterocyclen, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung |
| NZ589883A (en) | 2008-05-13 | 2012-06-29 | Astrazeneca Ab | Fumarate salt of 4- (3-chloro-2-fluoroanilino) -7-methoxy-6- { [1- (n-methylcarbamoylmethyl) piperidin- 4-yl] oxy} quinazoline |
| KR101638326B1 (ko) * | 2008-06-24 | 2016-07-12 | 사노피 | Ｒｈｏ 키나제 억제제로서의 치환된 이소퀴놀린 및 이소퀴놀리논 |
| PL2313374T3 (pl) | 2008-06-24 | 2014-03-31 | Sanofi Sa | 6-podstawione izochinoliny i izochinolinony |
| RU2532481C2 (ru) | 2008-06-24 | 2014-11-10 | Санофи-Авентис | Би- и полициклические замещенные производные изохинолина и изохинолинона, полезные в качестве ингибиторов rho-киназы |
| JP5539351B2 (ja) | 2008-08-08 | 2014-07-02 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | シクロヘキシルオキシ置換ヘテロ環、これらの化合物を含有する医薬、およびそれらを生成するための方法 |
| MX356433B (es) * | 2011-06-28 | 2018-05-29 | Inhibrx Lp | Polipéptidos de fusión con domino de proteína ácida del suero, y métodos de uso de los mismos. |
| IL312872A (en) * | 2011-06-28 | 2024-07-01 | Inhibrx Inc | Methods for purifying fusion proteins containing serphin |
| US10400029B2 (en) | 2011-06-28 | 2019-09-03 | Inhibrx, Lp | Serpin fusion polypeptides and methods of use thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4473501A (en) | 1981-05-04 | 1984-09-25 | G. D. Searle & Co. | Dihydro azino isoquinolines |
| GB8908229D0 (en) * | 1989-04-12 | 1989-05-24 | Smithkline Beckman Intercredit | Compounds |
| JP2000509028A (ja) | 1996-04-13 | 2000-07-18 | アストラ・フアーマシユウテイカルズ・リミテツド | アミノイソキノリンおよびアミノチエノピリジン誘導体ならびに抗炎症剤としてのそれらの使用 |
| IL123986A (en) * | 1997-04-24 | 2011-10-31 | Organon Nv | Medicinal compounds |
| KR20010042042A (ko) * | 1998-03-19 | 2001-05-25 | 에가시라 구니오 | 아미노이소퀴놀린 유도체 |
-
1999
- 1999-10-04 TW TW88117079A patent/TW575567B/zh not_active IP Right Cessation
- 1999-10-19 NZ NZ511067A patent/NZ511067A/xx unknown
- 1999-10-19 EP EP99950761A patent/EP1123280A1/en not_active Withdrawn
- 1999-10-19 ID IDW20010914A patent/ID29885A/id unknown
- 1999-10-19 RU RU2001113734/04A patent/RU2232760C2/ru not_active IP Right Cessation
- 1999-10-19 IL IL14239899A patent/IL142398A0/xx unknown
- 1999-10-19 WO PCT/EP1999/007928 patent/WO2000024718A1/en not_active Application Discontinuation
- 1999-10-19 PL PL99347948A patent/PL347948A1/xx unknown
- 1999-10-19 SK SK537-2001A patent/SK5372001A3/sk unknown
- 1999-10-19 HU HU0103806A patent/HUP0103806A3/hu unknown
- 1999-10-19 JP JP2000578288A patent/JP2002528438A/ja not_active Withdrawn
- 1999-10-19 CN CNB998124966A patent/CN1146543C/zh not_active Expired - Fee Related
- 1999-10-19 TR TR2001/01120T patent/TR200101120T2/xx unknown
- 1999-10-19 US US09/830,227 patent/US6903107B1/en not_active Expired - Fee Related
- 1999-10-19 CZ CZ20011440A patent/CZ20011440A3/cs unknown
- 1999-10-19 KR KR1020017004938A patent/KR20010075648A/ko not_active Application Discontinuation
- 1999-10-19 CA CA002346990A patent/CA2346990A1/en not_active Abandoned
- 1999-10-19 BR BR9914694-0A patent/BR9914694A/pt not_active IP Right Cessation
- 1999-10-19 AU AU63413/99A patent/AU763667B2/en not_active Ceased
- 1999-10-21 AR ARP990105310A patent/AR020922A1/es unknown
- 1999-10-21 PE PE1999001065A patent/PE20001283A1/es not_active Application Discontinuation
- 1999-10-22 CO CO99067058A patent/CO5140114A1/es unknown
-
2001
- 2001-04-10 ZA ZA200102970A patent/ZA200102970B/en unknown
- 2001-04-20 NO NO20011966A patent/NO20011966L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AR020922A1 (es) | 2002-06-05 |
| PE20001283A1 (es) | 2000-11-20 |
| CA2346990A1 (en) | 2000-05-04 |
| CN1146543C (zh) | 2004-04-21 |
| JP2002528438A (ja) | 2002-09-03 |
| EP1123280A1 (en) | 2001-08-16 |
| RU2232760C2 (ru) | 2004-07-20 |
| AU763667B2 (en) | 2003-07-31 |
| CZ20011440A3 (cs) | 2001-09-12 |
| BR9914694A (pt) | 2001-07-10 |
| WO2000024718A1 (en) | 2000-05-04 |
| SK5372001A3 (en) | 2001-11-06 |
| TR200101120T2 (tr) | 2001-08-21 |
| HUP0103806A3 (en) | 2002-03-28 |
| ID29885A (id) | 2001-10-18 |
| HUP0103806A2 (hu) | 2002-02-28 |
| CN1348444A (zh) | 2002-05-08 |
| PL347948A1 (en) | 2002-04-22 |
| NO20011966L (no) | 2001-04-23 |
| NO20011966D0 (no) | 2001-04-20 |
| CO5140114A1 (es) | 2002-03-22 |
| AU6341399A (en) | 2000-05-15 |
| US6903107B1 (en) | 2005-06-07 |
| ZA200102970B (en) | 2002-07-10 |
| TW575567B (en) | 2004-02-11 |
| NZ511067A (en) | 2003-03-28 |
| KR20010075648A (ko) | 2001-08-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL142398A0 (en) | Serine protease inhibitor | |
| ZA983629B (en) | Serine protease inhibitors | |
| PL349192A1 (en) | Protease inhibitors | |
| ZA992447B (en) | Quinoxalinones as serine protease inhibitors. | |
| AU7127298A (en) | Serine protease inhibitors | |
| IL131661A0 (en) | Protease inhibitors | |
| HUP9901187A3 (en) | Serine protease inhibitors | |
| ZA992448B (en) | Quinoxalinones as serine protease inhibitors. | |
| PL343317A1 (en) | Benzoxazinones/benzothiazinones as serine protease inhibitors | |
| NZ331486A (en) | Serine protease inhibitors | |
| EP1093367A4 (en) | PROTEASE INHIBITORS | |
| HUP0002247A3 (en) | Protease inhibitors | |
| HK1021541A1 (en) | Serine protease inhibitors | |
| IL132630A0 (en) | Protease inhibitors | |
| IL132629A0 (en) | Protease inhibitors | |
| EP1067894A4 (en) | PROTHEASEINHIBITOREN | |
| GB9800817D0 (en) | Serine protease inhibitors | |
| EP1079821A4 (en) | PROTEASE INHIBITORS | |
| EP1179052A4 (en) | SERINE PROTEASES | |
| HK1041690A1 (zh) | 蛋白酶抑制劑 | |
| EP1086083A4 (en) | PROTEASE INHIBITORS | |
| GB9603217D0 (en) | Serine protease inhibitors | |
| EP1015438A4 (en) | PROTEASE INHIBITORS | |
| EP1132473A4 (en) | NEW SERINE PROTEASE BSSP6 | |
| EP0975612A4 (en) | PROTEASE INHIBITORS |