IL142096A0 - Indeno-, naphtho-and benzocyclohepta dihydrothiazole derivatives, the production thereof and their use as anorectic medicaments - Google Patents
Indeno-, naphtho-and benzocyclohepta dihydrothiazole derivatives, the production thereof and their use as anorectic medicamentsInfo
- Publication number
- IL142096A0 IL142096A0 IL14209699A IL14209699A IL142096A0 IL 142096 A0 IL142096 A0 IL 142096A0 IL 14209699 A IL14209699 A IL 14209699A IL 14209699 A IL14209699 A IL 14209699A IL 142096 A0 IL142096 A0 IL 142096A0
- Authority
- IL
- Israel
- Prior art keywords
- benzocyclohepta
- indeno
- naphtho
- production
- anorectic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19844547A DE19844547C2 (de) | 1998-09-29 | 1998-09-29 | Polycyclische Dihydrothiazole, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| PCT/EP1999/006860 WO2000018749A1 (de) | 1998-09-29 | 1999-09-16 | Indeno-, naphtho- und benzocyclohepta-dihydrothiazol derivate, deren herstellung und deren verwendung als anorektische arzneimittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL142096A0 true IL142096A0 (en) | 2002-03-10 |
Family
ID=7882588
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL14209699A IL142096A0 (en) | 1998-09-29 | 1999-09-16 | Indeno-, naphtho-and benzocyclohepta dihydrothiazole derivatives, the production thereof and their use as anorectic medicaments |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US6090833A (xx) |
| EP (1) | EP1119557B1 (xx) |
| JP (1) | JP3542078B2 (xx) |
| KR (1) | KR20010079952A (xx) |
| CN (1) | CN1143852C (xx) |
| AR (1) | AR020662A1 (xx) |
| AT (1) | ATE255569T1 (xx) |
| AU (1) | AU755158B2 (xx) |
| BR (1) | BR9915014A (xx) |
| CA (1) | CA2345359A1 (xx) |
| DE (2) | DE19844547C2 (xx) |
| DK (1) | DK1119557T3 (xx) |
| ES (1) | ES2212673T3 (xx) |
| HK (1) | HK1040080B (xx) |
| HU (1) | HUP0103504A3 (xx) |
| ID (1) | ID29578A (xx) |
| IL (1) | IL142096A0 (xx) |
| NO (1) | NO318388B1 (xx) |
| NZ (1) | NZ510399A (xx) |
| PL (1) | PL347072A1 (xx) |
| PT (1) | PT1119557E (xx) |
| RU (1) | RU2217427C2 (xx) |
| TR (1) | TR200100868T2 (xx) |
| WO (1) | WO2000018749A1 (xx) |
| ZA (1) | ZA200102446B (xx) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19908539A1 (de) * | 1999-02-26 | 2000-08-31 | Aventis Pharma Gmbh | Polycyclische 2-Amino-Dihydrothiazolsysteme, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| SK6132002A3 (en) | 1999-11-05 | 2002-11-06 | Aventis Pharma Gmbh | Polycyclic dihydrothiazole derivatives, the production thereof and their use as medicaments |
| JP4898052B2 (ja) | 2000-02-23 | 2012-03-14 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | ８ａ位で置換された８，８ａ−ジヒドロ−インデノ［１，２−ｄ］チアゾール誘導体、その製造方法及び医薬、例えば食欲抑制薬としてのその使用 |
| DE10008274A1 (de) * | 2000-02-23 | 2001-08-30 | Aventis Pharma Gmbh | Substituierte 8,8a-Dihydro-3aH-indeno[1,2-d]thiazole, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| JP4950405B2 (ja) * | 2000-02-26 | 2012-06-13 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | ２位にスルホンアミド又はスルホノ置換基を有する８，８ａ−ジヒドロインデノ［１，２−ｄ］チアゾール誘導体、その製造方法及び医薬としてのその使用 |
| DE10142665B4 (de) * | 2001-08-31 | 2004-05-06 | Aventis Pharma Deutschland Gmbh | C2-Disubstituierte Indan-1-one und ihre Derivate |
| DE10142663B4 (de) * | 2001-08-31 | 2004-08-19 | Aventis Pharma Deutschland Gmbh | C2-Disubstituierte Indan-1-ol-Systeme |
| DE10142722A1 (de) * | 2001-08-31 | 2003-03-27 | Aventis Pharma Deutschland GmbH, 65929 Frankfurt | C2-substituierte Indan-1-one und ihre Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| WO2005097127A2 (en) | 2004-04-02 | 2005-10-20 | Merck & Co., Inc. | Method of treating men with metabolic and anthropometric disorders |
| AU2007293885A1 (en) | 2006-09-07 | 2008-03-13 | Takeda Gmbh | Combination treatment for diabetes mellitus |
| AU2008259342B2 (en) | 2007-06-04 | 2014-07-10 | Ben-Gurion University Of The Negev Research And Development Authority | Tri-aryl compounds and compositions comprising the same |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| AU2008261102B2 (en) | 2007-06-04 | 2013-11-28 | Bausch Health Ireland Limited | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| EP2328910B1 (en) | 2008-06-04 | 2014-08-06 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| EP3241839B1 (en) | 2008-07-16 | 2019-09-04 | Bausch Health Ireland Limited | Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders |
| MX2011004258A (es) | 2008-10-22 | 2011-06-01 | Merck Sharp & Dohme | Derivados de bencimidazol ciclicos novedosos utiles como agentes anti-diabeticos. |
| EP2362731B1 (en) | 2008-10-31 | 2016-04-06 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
| WO2011106273A1 (en) | 2010-02-25 | 2011-09-01 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
| US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
| WO2012116145A1 (en) | 2011-02-25 | 2012-08-30 | Merck Sharp & Dohme Corp. | Novel cyclic azabenzimidazole derivatives useful as anti-diabetic agents |
| MX357121B (es) | 2011-03-01 | 2018-06-27 | Synergy Pharmaceuticals Inc Star | Proceso de preparacion de agonistas c de guanilato ciclasa. |
| JP2015525782A (ja) | 2012-08-02 | 2015-09-07 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | 抗糖尿病性三環式化合物 |
| CN104994848A (zh) | 2013-02-22 | 2015-10-21 | 默沙东公司 | 抗糖尿病二环化合物 |
| US9650375B2 (en) | 2013-03-14 | 2017-05-16 | Merck Sharp & Dohme Corp. | Indole derivatives useful as anti-diabetic agents |
| WO2014151206A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
| AU2014235209B2 (en) | 2013-03-15 | 2018-06-14 | Bausch Health Ireland Limited | Guanylate cyclase receptor agonists combined with other drugs |
| BR112015030326A2 (pt) | 2013-06-05 | 2017-08-29 | Synergy Pharmaceuticals Inc | Agonistas ultrapuros de guanilato ciclase c, método de fabricar e usar os mesmos |
| WO2015051496A1 (en) | 2013-10-08 | 2015-04-16 | Merck Sharp & Dohme Corp. | Antidiabetic tricyclic compounds |
| CA2928725A1 (en) | 2013-11-05 | 2015-05-14 | Esther Priel | Compounds for the treatment of diabetes and disease complications arising from same |
| US11072602B2 (en) | 2016-12-06 | 2021-07-27 | Merck Sharp & Dohme Corp. | Antidiabetic heterocyclic compounds |
| US10968232B2 (en) | 2016-12-20 | 2021-04-06 | Merck Sharp & Dohme Corp. | Antidiabetic spirochroman compounds |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2942003A (en) * | 1957-06-06 | 1960-06-21 | Gen Aniline & Film Corp | Process for preparing naphtho [1, 2-d]-thiazoles |
| DE2640358A1 (de) * | 1976-09-08 | 1978-03-16 | Hoechst Ag | Thiazolidinderivate und verfahren zu ihrer herstellung |
| JPH0514068A (ja) * | 1991-07-03 | 1993-01-22 | Shimada Phys & Chem Ind Co Ltd | 並列増幅部切換型高周波低雑音増幅装置 |
| JP3197602B2 (ja) * | 1992-02-17 | 2001-08-13 | 久光製薬株式会社 | チアゾール類縁化合物及び皮膚外用剤 |
| CA2184685A1 (en) * | 1994-03-11 | 1995-09-14 | Kiyoshi Iwaoka | 5-ht3 receptor agonist, novel thiazole derivative and intermediate thereof |
| GB9517381D0 (en) * | 1995-08-24 | 1995-10-25 | Pharmacia Spa | Aryl and heteroaryl piperazine derivatives |
| TW416953B (en) * | 1996-09-25 | 2001-01-01 | Takeda Chemical Industries Ltd | Tricyclic compounds for eliciting a prostaglandin I2 receptor agonistic effect, their production and use |
-
1998
- 1998-09-29 DE DE19844547A patent/DE19844547C2/de not_active Expired - Fee Related
-
1999
- 1999-09-16 PL PL99347072A patent/PL347072A1/xx not_active Application Discontinuation
- 1999-09-16 CA CA002345359A patent/CA2345359A1/en not_active Abandoned
- 1999-09-16 NZ NZ510399A patent/NZ510399A/en unknown
- 1999-09-16 WO PCT/EP1999/006860 patent/WO2000018749A1/de not_active Application Discontinuation
- 1999-09-16 CN CNB998114820A patent/CN1143852C/zh not_active Expired - Fee Related
- 1999-09-16 KR KR1020017004010A patent/KR20010079952A/ko active IP Right Grant
- 1999-09-16 ID IDW20010719A patent/ID29578A/id unknown
- 1999-09-16 DE DE59907961T patent/DE59907961D1/de not_active Expired - Lifetime
- 1999-09-16 HU HU0103504A patent/HUP0103504A3/hu unknown
- 1999-09-16 EP EP99969717A patent/EP1119557B1/de not_active Expired - Lifetime
- 1999-09-16 PT PT99969717T patent/PT1119557E/pt unknown
- 1999-09-16 ES ES99969717T patent/ES2212673T3/es not_active Expired - Lifetime
- 1999-09-16 AT AT99969717T patent/ATE255569T1/de not_active IP Right Cessation
- 1999-09-16 TR TR2001/00868T patent/TR200100868T2/xx unknown
- 1999-09-16 RU RU2001111750/04A patent/RU2217427C2/ru not_active IP Right Cessation
- 1999-09-16 DK DK99969717T patent/DK1119557T3/da active
- 1999-09-16 BR BR9915014-0A patent/BR9915014A/pt not_active IP Right Cessation
- 1999-09-16 JP JP2000572209A patent/JP3542078B2/ja not_active Expired - Fee Related
- 1999-09-16 AU AU59787/99A patent/AU755158B2/en not_active Ceased
- 1999-09-16 IL IL14209699A patent/IL142096A0/xx not_active IP Right Cessation
- 1999-09-27 AR ARP990104867A patent/AR020662A1/es unknown
- 1999-09-29 US US09/406,855 patent/US6090833A/en not_active Expired - Lifetime
-
2000
- 2000-06-27 US US09/604,666 patent/US6291486B1/en not_active Expired - Lifetime
-
2001
- 2001-03-23 NO NO20011503A patent/NO318388B1/no unknown
- 2001-03-26 ZA ZA200102446A patent/ZA200102446B/en unknown
-
2002
- 2002-03-01 HK HK02101580.2A patent/HK1040080B/zh not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM9K | Patent not in force due to non-payment of renewal fees |