IL141639A - Multicomponent vaccines - Google Patents

Multicomponent vaccines

Info

Publication number
IL141639A
IL141639A IL14163999A IL14163999A IL141639A IL 141639 A IL141639 A IL 141639A IL 14163999 A IL14163999 A IL 14163999A IL 14163999 A IL14163999 A IL 14163999A IL 141639 A IL141639 A IL 141639A
Authority
IL
Israel
Prior art keywords
proteins
fragments
fragment
protein
bacterial
Prior art date
Application number
IL14163999A
Other languages
English (en)
Other versions
IL141639A0 (en
Original Assignee
Inhibitex Inc
Texas A & M Univ Sys
Trinity College Dublin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inhibitex Inc, Texas A & M Univ Sys, Trinity College Dublin filed Critical Inhibitex Inc
Publication of IL141639A0 publication Critical patent/IL141639A0/xx
Publication of IL141639A publication Critical patent/IL141639A/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
    • C07K16/1275—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Streptococcus (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/085—Staphylococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
    • C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
    • C07K16/1271—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Micrococcaceae (F), e.g. Staphylococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL14163999A 1998-08-31 1999-08-31 Multicomponent vaccines IL141639A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9843998P 1998-08-31 1998-08-31
PCT/US1999/019727 WO2000012131A1 (fr) 1998-08-31 1999-08-31 Vaccins a plusieurs constituants

Publications (2)

Publication Number Publication Date
IL141639A0 IL141639A0 (en) 2002-03-10
IL141639A true IL141639A (en) 2005-12-18

Family

ID=22269290

Family Applications (1)

Application Number Title Priority Date Filing Date
IL14163999A IL141639A (en) 1998-08-31 1999-08-31 Multicomponent vaccines

Country Status (13)

Country Link
EP (1) EP1109577B1 (fr)
JP (2) JP2002523473A (fr)
KR (1) KR100644953B1 (fr)
CN (1) CN1314450C (fr)
AT (1) ATE422368T1 (fr)
AU (1) AU771426B2 (fr)
BR (1) BR9913340A (fr)
CA (2) CA2777661C (fr)
DE (1) DE69940404D1 (fr)
ES (1) ES2322409T3 (fr)
IL (1) IL141639A (fr)
MX (1) MXPA01002119A (fr)
WO (1) WO2000012131A1 (fr)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA01002120A (es) * 1998-08-31 2003-03-27 Trinity College Dublin Polipeptidos y polinucleotidos de estafilococo negativo a coagulasa.
US6692739B1 (en) 1998-08-31 2004-02-17 Inhibitex, Inc. Staphylococcal immunotherapeutics via donor selection and donor stimulation
JP2002523474A (ja) * 1998-08-31 2002-07-30 インヒビテツクス，インコーポレイテツド ドナーの選択およびドナーの刺激によるブドウ球菌の免疫療法
GB0014907D0 (en) * 2000-06-20 2000-08-09 Univ Sheffield Antigenic polypeptides
JP2004512040A (ja) * 2000-10-20 2004-04-22 インヒビテックス　インコーポレーテッド Ｍａｐタンパク質に対するモノクローナル抗体、および感染を処置または予防することにおける使用方法
EP1481011A4 (fr) * 2002-03-05 2007-05-30 Inhibitex Inc Anticorps monoclonaux et polyclonaux reconnaissant des proteines staphylocoques a coagulase negative
WO2004080490A2 (fr) * 2003-03-07 2004-09-23 Wyeth Holdings Corporation Conjugues de proteine-polysaccharide porteuse d'adhesine superficielle staphylococcique pour immunisation contre des infections nosocomiales
WO2004094600A2 (fr) * 2003-04-16 2004-11-04 The Texas A & M University System Proteine efb issue de staphylococcus aureus et region de liaison a c3 inhibant l'activation du complement
WO2004110367A2 (fr) * 2003-05-29 2004-12-23 Inhibitex, Inc. Proteines sdr du staphylocoque capitis et utilisation associee dans la prevention et le traitement d'infections
BR122016029840B1 (pt) * 2004-09-22 2021-10-13 Glaxosmithkline Biologicals S.A. Composição imunogênica, método de fabricar uma composição imunogênica, e, uso da composição imunogênica
US7829294B2 (en) * 2004-12-28 2010-11-09 Daiichi Pure Chemicals Co., Ltd. Anti-human soluble fibrin monoclonal antibody and immunological assay method using the antibody
GB0526038D0 (en) 2005-12-21 2006-02-01 Glaxosmithkline Biolog Sa Immunogenic composition
EP1998800A2 (fr) * 2006-01-18 2008-12-10 University Of Chicago Compositions et procédés se rapportant à des protéines de bactéries staphylococciques
CA2647441C (fr) * 2006-03-30 2021-02-23 Glaxosmithkline Biologicals S.A. Composition immunogene comprenant des saccharides staphylococcus aureus
CA2693239A1 (fr) 2007-07-23 2009-01-29 Vaccine Research International Plc Vaccin a cellules entieres staphylococciques inactivees
US8840906B2 (en) 2007-08-31 2014-09-23 The University Of Chicago Methods and compositions related to immunizing against Staphylococcal lung disease and conditions
US9181329B2 (en) 2007-08-31 2015-11-10 The University Of Chicago Methods and compositions related to immunizing against Staphylococcal lung diseases and conditions
EA018068B1 (ru) 2008-03-03 2013-05-30 Айрм Ллк Соединения и композиции в качестве модуляторов активности tlr
WO2010014304A1 (fr) 2008-07-29 2010-02-04 University Of Chicago Compositions et procédés apparentés à des protéines de bactérie staphylococcique
PT3281947T (pt) 2009-04-03 2020-05-07 Univ Chicago Composições e métodos relacionados com variantes da proteína a (spa)
JP5867952B2 (ja) 2009-06-10 2016-02-24 ノバルティス アーゲー ベンゾナフチリジン含有ワクチン
US8568735B2 (en) 2009-06-22 2013-10-29 Wyeth Llc Immunogenic compositions of Staphylococcus aureus antigens
BRPI1011753B8 (pt) 2009-06-22 2021-05-25 Wyeth Llc conjugados imunogênicos de polissacarídeo capsular de staphylococcus aureus de sorotipos 5 e 8, seu uso e composições que os compreendem
US20110020323A1 (en) 2009-07-15 2011-01-27 Tim Beaumont Gram-positive bacteria specific binding compounds
TWI445708B (zh) 2009-09-02 2014-07-21 Irm Llc 作為ｔｌｒ活性調節劑之化合物及組合物
AU2010290896B2 (en) 2009-09-02 2014-07-03 Glaxosmithkline Biologicals S.A. Immunogenic compositions including TLR activity modulators
WO2011057148A1 (fr) 2009-11-05 2011-05-12 Irm Llc Composés et compositions permettant de moduler l'activité des tlr-7
SG181712A1 (en) 2009-12-15 2012-07-30 Novartis Ag Homogeneous suspension of immunopotentiating compounds and uses thereof
KR101853513B1 (ko) 2010-03-23 2018-04-30 노파르티스 아게 감염, 염증, 호흡기 질환 등의 치료를 위해 사용되는 ｔｌｒ2 효능제로서의 화합물 (시스테인 기재 리포펩티드) 및 조성물
US8821894B2 (en) 2010-07-02 2014-09-02 The University Of Chicago Compositions and methods related to protein A (SpA) variants
US9192661B2 (en) 2010-07-06 2015-11-24 Novartis Ag Delivery of self-replicating RNA using biodegradable polymer particles
ES2769425T3 (es) * 2010-12-22 2020-06-25 Wyeth Llc Composiciones inmunogénicas estables de antígenos de Staphylococcus aureus
US8945588B2 (en) 2011-05-06 2015-02-03 The University Of Chicago Methods and compositions involving protective staphylococcal antigens, such as EBH polypeptides
KR20150024315A (ko) * 2012-05-07 2015-03-06 재단법인 목암생명공학연구소 포도상구균 감염 예방용 백신 조성물
WO2014118305A1 (fr) 2013-02-01 2014-08-07 Novartis Ag Administration intradermique de compositions immunologiques comprenant des agonistes des récepteurs de type toll
US20170281744A1 (en) * 2014-12-10 2017-10-05 Glaxosmithkline Biologicals Sa Method of treatment
CN107007832A (zh) * 2016-01-28 2017-08-04 中创云牧科技咨询(北京)股份有限公司 一种ClfA-A靶位的金黄色葡萄球菌奶牛乳房炎疫苗的制备方法
CA3090271A1 (fr) 2018-02-12 2019-08-15 Inimmune Corporation Ligands du recepteur de type toll
KR102528412B1 (ko) * 2020-09-08 2023-05-04 클립스비엔씨 주식회사 신규한 포도상구균 감염 질환의 예방 또는 치료용 조성물
IL302448A (en) 2020-11-04 2023-06-01 Eligo Bioscience Phage-derived particles for in situ delivery of DNA cargo into the C. acnes population

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE454403B (sv) * 1984-05-30 1988-05-02 Alfa Laval Agri Int Anvendning av ett cellyteprotein med fibronektin-, fibrinogen-, kollagen-, och/eller lamininbindande egenskaper vid framstellning av sarbehandlingsmedel
US5189015A (en) * 1984-05-30 1993-02-23 Alfa-Laval Agri International Ab Method for prophylactic treatment of the colonization of a Staphylococcus aureus bacterial strain by bacterial cell surface protein with fibronectin and fibrinogen binding ability
US5730978A (en) * 1989-09-01 1998-03-24 Fred Hutchinson Cancer Research Center Inhibition of lymphocyte adherence with α4β1-specific antibodies
US5440014A (en) * 1990-08-10 1995-08-08 H+E,Uml/Oo/ K; Magnus Fibronectin binding peptide
US5851794A (en) * 1990-10-22 1998-12-22 Alfa Laval Ab Collagen binding protein as well as its preparation
US5648240A (en) * 1994-05-24 1997-07-15 Texas A&M University MHC II analog from Staphylococcus aureus
US6288214B1 (en) * 1996-05-16 2001-09-11 Texas A&M University Systems Collagen binding protein compositions and methods of use
SE9602496D0 (sv) * 1996-06-20 1996-06-20 Bengt Guss Method and means for producing a fibrinogen binding protein and its use in biotechnology
EP0971740B1 (fr) * 1997-01-21 2009-08-19 THE TEXAS A&M UNIVERSITY SYSTEM Peptides derives de proteines liant la fibronectine qui ne lient pas cette derniere, leurs anticorps et usages therapeutiques
EP1034277B1 (fr) * 1997-11-26 2012-06-27 Inhibitex, Inc. Proteines liant la matrice extracellulaire issues du Staphylococcus aureus

Also Published As

Publication number Publication date
DE69940404D1 (de) 2009-03-26
MXPA01002119A (es) 2003-03-27
CN1314450C (zh) 2007-05-09
WO2000012131A1 (fr) 2000-03-09
BR9913340A (pt) 2001-11-06
CA2340304A1 (fr) 2000-03-09
IL141639A0 (en) 2002-03-10
AU5588999A (en) 2000-03-21
ES2322409T3 (es) 2009-06-19
CA2777661C (fr) 2014-10-21
JP2002523473A (ja) 2002-07-30
EP1109577B1 (fr) 2009-02-11
AU771426B2 (en) 2004-03-18
ATE422368T1 (de) 2009-02-15
KR20010085745A (ko) 2001-09-07
KR100644953B1 (ko) 2006-11-10
EP1109577A1 (fr) 2001-06-27
CA2340304C (fr) 2012-12-04
JP2011168607A (ja) 2011-09-01
EP1109577A4 (fr) 2002-03-13
CN1317976A (zh) 2001-10-17
CA2777661A1 (fr) 2000-03-09
JP5460642B2 (ja) 2014-04-02

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