IL141515A - Optically active pyridyl- 4h - 1, 2, 4 - oxadiazine derivative and its use in the treatment of vascular diseases and pharmaceutical composition comprising same - Google Patents
Optically active pyridyl- 4h - 1, 2, 4 - oxadiazine derivative and its use in the treatment of vascular diseases and pharmaceutical composition comprising sameInfo
- Publication number
- IL141515A IL141515A IL14151599A IL14151599A IL141515A IL 141515 A IL141515 A IL 141515A IL 14151599 A IL14151599 A IL 14151599A IL 14151599 A IL14151599 A IL 14151599A IL 141515 A IL141515 A IL 141515A
- Authority
- IL
- Israel
- Prior art keywords
- treatment
- pharmaceutical composition
- same
- optically active
- vascular diseases
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 208000019553 vascular disease Diseases 0.000 title 1
- CEVOFONPLDDUDU-UHFFFAOYSA-N 4-methyl-5-piperidin-1-yl-3-pyridin-3-yl-5,6-dihydro-1,2,4-oxadiazine Chemical compound CN1C(N2CCCCC2)CON=C1C1=CC=CN=C1 CEVOFONPLDDUDU-UHFFFAOYSA-N 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5355—Non-condensed oxazines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU9802897A HU226617B1 (en) | 1998-12-14 | 1998-12-14 | Optically active pyridyl-4h-1,2,4-oxadiazine derivatives, and pharmaceutical composition containing the compound as active ingredient |
| PCT/HU1999/000095 WO2000035914A1 (en) | 1998-12-14 | 1999-12-07 | Optically active pyridyl-4h-1,2,4-oxadiazine derivative and its use in the treatment of vascular diseases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL141515A0 IL141515A0 (en) | 2002-03-10 |
| IL141515A true IL141515A (en) | 2005-09-25 |
Family
ID=10991166
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL14151599A IL141515A (en) | 1998-12-14 | 1999-12-07 | Optically active pyridyl- 4h - 1, 2, 4 - oxadiazine derivative and its use in the treatment of vascular diseases and pharmaceutical composition comprising same |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US6384029B1 (cs) |
| EP (1) | EP1147105B1 (cs) |
| JP (2) | JP2002532498A (cs) |
| KR (1) | KR100661774B1 (cs) |
| AT (1) | ATE266027T1 (cs) |
| AU (1) | AU765336B2 (cs) |
| BG (1) | BG65179B1 (cs) |
| BR (1) | BR9913982A (cs) |
| CA (1) | CA2340734C (cs) |
| CZ (1) | CZ300764B6 (cs) |
| DE (1) | DE69917074T2 (cs) |
| DK (1) | DK1147105T3 (cs) |
| EE (1) | EE04551B1 (cs) |
| ES (1) | ES2219091T3 (cs) |
| HR (1) | HRP20010133B1 (cs) |
| HU (1) | HU226617B1 (cs) |
| IL (1) | IL141515A (cs) |
| NO (1) | NO317649B1 (cs) |
| PL (1) | PL196584B1 (cs) |
| PT (1) | PT1147105E (cs) |
| RS (1) | RS50129B (cs) |
| RU (1) | RU2222538C2 (cs) |
| SI (1) | SI1147105T1 (cs) |
| SK (1) | SK285582B6 (cs) |
| UA (1) | UA70340C2 (cs) |
| WO (1) | WO2000035914A1 (cs) |
| ZA (1) | ZA200101182B (cs) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL162941A0 (en) | 2002-01-11 | 2005-11-20 | Biorex Kutato Fejlesztoe Kft | Carboxamidine derivatives and their use in the treatment of vascular diseases |
| KR100678577B1 (ko) * | 2006-09-11 | 2007-02-06 | 조만규 | 가정용 분전함 |
| CN102123729B (zh) | 2008-06-26 | 2015-04-29 | 奥菲泽米有限公司 | Hsp70作为酶促活性调节物的应用 |
| WO2010058779A1 (ja) | 2008-11-18 | 2010-05-27 | 参天製薬株式会社 | ピリジン－３－カルバルデヒド ｏ－（ピペリジン－１－イル－プロピル）－オキシム誘導体を有効成分として含有する網脈絡膜変性疾患の治療剤 |
| AU2011335545A1 (en) | 2010-11-30 | 2013-06-13 | Orphazyme Aps | Methods for increasing intracellular activity of Hsp70 |
| HUP1100534A2 (en) | 2011-09-26 | 2013-04-29 | Balazs Dr Hazay | Pharmaceutical composition for the treatment of muscle atrophy |
| PL3193840T3 (pl) | 2014-09-15 | 2021-12-06 | Orphazyme A/S | Preparat arimoklomolu |
| EP3442530A1 (en) | 2016-04-13 | 2019-02-20 | Orphazyme A/S | Heat shock proteins and cholesterol homeostasis |
| EP3782624B1 (en) | 2016-04-29 | 2025-09-10 | Zevra Denmark A/S | Arimoclomol for treating glucocerebrosidase associated disorders |
| JP2020520947A (ja) | 2017-05-24 | 2020-07-16 | オーファザイム エー／エス | 熱ショックタンパク質誘導因子および前頭側頭障害 |
| CN112166326A (zh) | 2018-05-28 | 2021-01-01 | 奥菲泽米有限公司 | Pbmc样本中的hsp70蛋白水平作为疾病的生物标记物 |
| CA3202568A1 (en) | 2020-11-19 | 2022-05-27 | Zevra Denmark A/S | Processes for preparing arimoclomol citrate and intermediates thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT395853B (de) * | 1991-01-31 | 1993-03-25 | Chem Pharm Forsch Gmbh | Neue imidazolderivate, verfahren zu ihrer herstellung und ihre verwendung |
| HU222994B1 (hu) * | 1995-11-02 | 2004-01-28 | BIOREX Kutató és Fejlesztő Rt. | Hidroxilaminszármazékok és azok alkalmazása sejtek molekuláris chaperon-termelésének fokozására alkalmas gyógyszerkészítmények előállítására |
| DE69628320D1 (de) * | 1995-11-03 | 2003-06-26 | Summit Packaging Systems Ltd | Vorrichtung zum abgeben und füllen von beuteln an einem kassenplatz eines supermarkts |
| UA64716C2 (en) * | 1996-08-09 | 2004-03-15 | Pharmaceuticals for therapy or prevention of illnesses connected with dysfunction of vascular endothelial cells |
-
1998
- 1998-12-14 HU HU9802897A patent/HU226617B1/hu not_active IP Right Cessation
-
1999
- 1999-07-12 UA UA2001063850A patent/UA70340C2/uk unknown
- 1999-12-07 ES ES99961225T patent/ES2219091T3/es not_active Expired - Lifetime
- 1999-12-07 AT AT99961225T patent/ATE266027T1/de active
- 1999-12-07 US US09/762,949 patent/US6384029B1/en not_active Expired - Lifetime
- 1999-12-07 SK SK234-2001A patent/SK285582B6/sk not_active IP Right Cessation
- 1999-12-07 DK DK99961225T patent/DK1147105T3/da active
- 1999-12-07 CA CA002340734A patent/CA2340734C/en not_active Expired - Lifetime
- 1999-12-07 RS YUP-250/01A patent/RS50129B/sr unknown
- 1999-12-07 BR BR9913982-0A patent/BR9913982A/pt not_active Application Discontinuation
- 1999-12-07 EE EEP200100188A patent/EE04551B1/xx not_active IP Right Cessation
- 1999-12-07 PL PL346767A patent/PL196584B1/pl not_active IP Right Cessation
- 1999-12-07 HR HR20010133A patent/HRP20010133B1/xx not_active IP Right Cessation
- 1999-12-07 CZ CZ20011550A patent/CZ300764B6/cs not_active IP Right Cessation
- 1999-12-07 AU AU17906/00A patent/AU765336B2/en not_active Expired
- 1999-12-07 RU RU2001118854/04A patent/RU2222538C2/ru not_active IP Right Cessation
- 1999-12-07 IL IL14151599A patent/IL141515A/xx not_active IP Right Cessation
- 1999-12-07 JP JP2000588174A patent/JP2002532498A/ja not_active Withdrawn
- 1999-12-07 EP EP99961225A patent/EP1147105B1/en not_active Expired - Lifetime
- 1999-12-07 KR KR1020017002870A patent/KR100661774B1/ko not_active Expired - Fee Related
- 1999-12-07 PT PT99961225T patent/PT1147105E/pt unknown
- 1999-12-07 SI SI9930566T patent/SI1147105T1/xx unknown
- 1999-12-07 DE DE69917074T patent/DE69917074T2/de not_active Expired - Lifetime
- 1999-12-07 WO PCT/HU1999/000095 patent/WO2000035914A1/en active IP Right Grant
-
2001
- 2001-02-12 ZA ZA200101182A patent/ZA200101182B/en unknown
- 2001-03-14 BG BG105342A patent/BG65179B1/bg unknown
- 2001-05-10 NO NO20012310A patent/NO317649B1/no not_active IP Right Cessation
-
2011
- 2011-06-08 JP JP2011128516A patent/JP5620340B2/ja not_active Expired - Lifetime
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| TW262461B (cs) | ||
| CA2396561A1 (en) | Substituted oxazolidinones and their use in the field of blood coagulation | |
| IL125282A (en) | Substituted imidazole compounds, process for their preparation, pharmaceutical compositions containing them and use thereof in the preparation of medicaments for treating cytokine mediated diseases | |
| GEP20033025B (en) | 4,4-Biarylpiperidine Derivatives with Opioid Receptor Activity | |
| MY111260A (en) | Pharmaceutical composition for the treatment of nicotine dependence | |
| IL141515A (en) | Optically active pyridyl- 4h - 1, 2, 4 - oxadiazine derivative and its use in the treatment of vascular diseases and pharmaceutical composition comprising same | |
| BG106155A (en) | Novel derivatives and analogues of galanthamin | |
| IL109534A0 (en) | Pour-on formulations containing polymeric material, glycols and glycerides and a process for their preparation | |
| IL102032A0 (en) | 2-amino-5-cyano-1,4-dihydropyridines,their preparation and pharmaceutical compositions containing them | |
| TW374085B (en) | Novel piperidine derivatives, their preparation, pharmaceutical formulation and medical use | |
| LT96094A (en) | The active ingredient of pharmaceutical composition for treating constipation | |
| DK1492539T3 (da) | Statin-terapi til forögelse af kognitiv funktion | |
| ATE106732T1 (de) | Arzneimittelzubereitung, enthaltend stigmasta-4- en-3-on sowie deren verwendung. | |
| FR2673105B1 (fr) | Nouvelles compositions pharmaceutiques, notamment pour le traitement des colopathies fonctionnelles, et procedes de preparation de compositions et de medicaments, notamment pour le traitement de ces affections. | |
| HUP9802896A3 (en) | Optically active piperidinoalkyl-4h-1,2,4-oxadiazine derivative, the use thereof in the treatment of vascular diseases and pharmaceutical composition containing the compound as active ingredient | |
| UA41326C2 (uk) | Фармацевтична композиція для профілактики або лікування вірусних захворювань, засіб для профілактики або лікування вірусних захворювань | |
| DE69808287D1 (de) | Pharmazeutische zusammensetzungen von cinchonin dihydrochlorid | |
| GEP20002141B (en) | Use of 2-Phenyl-1, 2-Benzisoselenazol-3(2H)-One for Prevention and/or Treatment of Dementia, a Pharmaceutical Composition for Prevention and/or Treatment of the Alzheimer’s Disease | |
| JO1653B1 (en) | The current benzimidazole is a therapeutically active method for preparing it |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |