IL140650A0 - Delivery system - Google Patents

Delivery system

Info

Publication number
IL140650A0
IL140650A0 IL14065099A IL14065099A IL140650A0 IL 140650 A0 IL140650 A0 IL 140650A0 IL 14065099 A IL14065099 A IL 14065099A IL 14065099 A IL14065099 A IL 14065099A IL 140650 A0 IL140650 A0 IL 140650A0
Authority
IL
Israel
Prior art keywords
delivery system
drug
moiety
carrier moiety
fragment
Prior art date
Application number
IL14065099A
Other languages
English (en)
Original Assignee
Cyclacel Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cyclacel Ltd filed Critical Cyclacel Ltd
Publication of IL140650A0 publication Critical patent/IL140650A0/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Threshing Machine Elements (AREA)
  • Refuse Collection And Transfer (AREA)
IL14065099A 1998-07-03 1999-06-22 Delivery system IL140650A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9814527.9A GB9814527D0 (en) 1998-07-03 1998-07-03 Delivery system
PCT/GB1999/001957 WO2000001417A1 (en) 1998-07-03 1999-06-22 Delivery system

Publications (1)

Publication Number Publication Date
IL140650A0 true IL140650A0 (en) 2002-02-10

Family

ID=10834959

Family Applications (1)

Application Number Title Priority Date Filing Date
IL14065099A IL140650A0 (en) 1998-07-03 1999-06-22 Delivery system

Country Status (13)

Country Link
US (2) US6472507B1 (de)
EP (1) EP1093383B1 (de)
JP (1) JP2002519392A (de)
AT (1) ATE279210T1 (de)
AU (1) AU756014B2 (de)
CA (1) CA2333145C (de)
DE (1) DE69921138T2 (de)
DK (1) DK1093383T3 (de)
ES (1) ES2230860T3 (de)
GB (2) GB9814527D0 (de)
HU (1) HUP0300246A3 (de)
IL (1) IL140650A0 (de)
WO (1) WO2000001417A1 (de)

Families Citing this family (64)

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GB9814527D0 (en) 1998-07-03 1998-09-02 Cyclacel Ltd Delivery system
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ATE497603T1 (de) * 2001-03-02 2011-02-15 Gpc Biotech Ag Drei-hybrid-assaysystem
EP1476176A4 (de) * 2002-01-30 2006-02-22 Univ Yale Transport-peptide und ihre verwendung
JP4903036B2 (ja) 2003-01-06 2012-03-21 アンジオケム・インコーポレーテッド 血液脳関門を通過する担体としてのアプロチニンおよび類似体
FR2849603B1 (fr) * 2003-01-07 2006-09-08 Centre Nat Rech Scient Composition pour le transport intracellulaire de macromolecules ou particules biologiques
US20060178297A1 (en) * 2003-01-28 2006-08-10 Troy Carol M Systems and methods for silencing expression of a gene in a cell and uses thereof
EP2161037A3 (de) * 2003-04-22 2010-05-26 Ipsen Pharma Camptothecin-Somatostatin Konjugaten
US20060229433A1 (en) * 2003-05-20 2006-10-12 Cellpep Sa Modified antiviral peptides with increased activity and cell membrane affinity
US7458683B2 (en) 2003-06-16 2008-12-02 Amo Manufacturing Usa, Llc Methods and devices for registering optical measurement datasets of an optical system
US7342114B2 (en) 2003-07-01 2008-03-11 California Pacific Medical Center Podophyllotoxin derivatives
ES2365918T3 (es) 2003-09-05 2011-10-13 The General Hospital Corporation Conjugados de poliacetal-fármaco como sistema de liberación.
US20050148534A1 (en) * 2003-09-22 2005-07-07 Castellino Angelo J. Small molecule compositions and methods for increasing drug efficiency using compositions thereof
WO2005040193A2 (en) * 2003-10-20 2005-05-06 The Regent Of The University Of California Synthetic peptides that cause f-actin bundling and block actin depolymerization
US20050209147A1 (en) * 2004-01-16 2005-09-22 The Board Of Trustees Of The Leland Stanford Junior University Peptide inhibitors of RhoA signaling
CN101084002B (zh) 2004-09-02 2015-01-21 克格诺西有限公司 改进的apo e类似物及其使用方法
US8034762B2 (en) 2004-09-02 2011-10-11 Cognosci, Inc. Treatment of subarachnoid hemorrhage with Apo E analogs
ES2784554T3 (es) 2004-12-22 2020-09-28 Nitto Denko Corp Portador de fármacos y kit de portador de fármacos para inhibir la fibrosis
US20120269886A1 (en) 2004-12-22 2012-10-25 Nitto Denko Corporation Therapeutic agent for pulmonary fibrosis
PL2360258T3 (pl) 2005-02-18 2015-03-31 Angiochem Inc Polipeptydy aprotyniny do transportowania związków przez barierę krew-mózg
EP2433653B1 (de) 2005-07-15 2019-06-05 Angiochem Inc. Verwendung von Aprotinin-Polypeptiden als Träger in pharmazeutischen Konjugaten
US9572886B2 (en) 2005-12-22 2017-02-21 Nitto Denko Corporation Agent for treating myelofibrosis
US8410045B2 (en) 2006-03-30 2013-04-02 Drais Pharmaceuticals, Inc. Camptothecin-peptide conjugates and pharmaceutical compositions containing the same
CN101516404B (zh) * 2006-03-30 2013-04-10 德莱斯医药公司 喜树碱-细胞渗透肽缀合物和含有其的药物组合物
TWI407971B (zh) 2007-03-30 2013-09-11 Nitto Denko Corp Cancer cells and tumor-related fibroblasts
US9365634B2 (en) 2007-05-29 2016-06-14 Angiochem Inc. Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues
US8003621B2 (en) 2007-09-14 2011-08-23 Nitto Denko Corporation Drug carriers
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WO2009108340A2 (en) 2008-02-27 2009-09-03 Temple University - Of The Commonwealth System Of Higher Education Leptin agonist and methods of use
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CN104622809B (zh) 2008-05-23 2019-04-19 英属哥伦比亚大学 用于脂质体纳米颗粒的修饰的药物
EP2350118B1 (de) 2008-09-19 2016-03-30 Nektar Therapeutics Kohlenhydratbasisierte polymere zur wirkstoffabgabe und konjugate davon
WO2010043047A1 (en) 2008-10-15 2010-04-22 Angiochem Inc. Conjugates of glp-1 agonists and uses thereof
MX2011005963A (es) 2008-12-05 2011-09-01 Angiochem Inc Conjugados de neurotensina o analogos de neurotensina y sus usos.
MX2011006685A (es) 2008-12-17 2011-09-27 Angiochem Inc Inhibidores de metaloproteinas de matriz de membrana tipo-1 y sus usos.
FR2941230B1 (fr) 2009-01-19 2011-03-18 Centre Nat Rech Scient Polypeptides d'adressage specifique a des cellules-cibles d'otx2
JP2012524030A (ja) 2009-04-20 2012-10-11 アンジオケム インコーポレーテッド Ａｎｇｉｏｐｅｐ−２アナログにコンジュゲート化した抗癌剤を用いた卵巣癌の治療
US8501242B2 (en) 2009-05-29 2013-08-06 University Of Florida Research Foundation Methods and compositions for treating neoplasia
US9161988B2 (en) 2009-07-02 2015-10-20 Angiochem Inc. Multimeric peptide conjugates and uses thereof
GB201001602D0 (en) 2010-02-01 2010-03-17 Cytovation As Oligopeptidic compounds and uses therof
JP5757497B2 (ja) * 2010-10-06 2015-07-29 公立大学法人大阪府立大学 シガトキシン類ｃｔｘ１ｂおよび５４−デオキシ−ｃｔｘ１ｂを認識するモノクローナル抗体およびそれを用いるシガトキシン類検出キット
CN103781471B (zh) * 2011-09-08 2019-02-12 健康科学西部大学 癌症治疗中的靶向脂质体
CN103083239B (zh) * 2012-12-26 2015-11-25 中国人民解放军第四军医大学 一种蟾毒灵脂质体及其制备方法和应用
GB201318954D0 (en) * 2013-10-28 2013-12-11 Cupid Peptide Company Ltd Cell transport
CN107530396B (zh) 2015-05-01 2022-08-26 雅利斯塔制药公司 用于治疗眼科疾病的脂联素拟肽
GB201507722D0 (en) 2015-05-06 2015-06-17 Norwegian Univ Sci & Tech Ntnu Anti-bacterial agents and their use in therapy
DK3307326T3 (da) 2015-06-15 2020-10-19 Angiochem Inc Fremgangsmåder til behandling af leptomeningeal karcinomatose
US10087194B2 (en) 2015-10-27 2018-10-02 California Pacific Medical Center Podophyllotoxin derivatives and their use
JP6550538B2 (ja) 2015-10-27 2019-07-24 カリフォルニア パシフィック メディカル センター ポドフィロトキシン誘導体およびそれらの使用
WO2018085836A1 (en) 2016-11-07 2018-05-11 Colorado State University Research Foundation Anti-hiv peptides
CN110563739A (zh) * 2018-06-05 2019-12-13 薪火炙药(北京)科技有限公司 具有选择性抗肺癌作用的鬼臼毒素类化合物p-x及其制备方法和应用
GB201915454D0 (en) 2019-10-24 2019-12-11 Norwegian Univ Sci & Tech Ntnu Antibacterial bone cement and uses thereof
KR102397922B1 (ko) * 2020-02-19 2022-05-13 서울대학교 산학협력단 신규한 종양-관련 항원 단백질 olfm4 및 이의 용도
GB202006699D0 (en) 2020-05-06 2020-06-17 Therapim Pty Ltd Dosage regimen
GB202008888D0 (en) 2020-06-11 2020-07-29 Norwegian Univ Of Science And Technology (Ntnu) Peptides for sepsis treatment
EP4281034A1 (de) 2021-01-24 2023-11-29 Forrest, Michael, David Inhibitoren der atp-synthase kosmetische und therapeutische verwendungen

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US4847240A (en) * 1978-01-16 1989-07-11 The Trustees Of Boston University Method of effecting cellular uptake of molecules
US5043329A (en) * 1987-02-17 1991-08-27 Board Of Regents, University Of Texas System Methods and compositions employing unique mixtures of polar and neutral lipids for protecting the gastrointestinal tract
DE3836971C1 (de) * 1988-10-31 1990-05-17 Weck, Wolfgang, Dr.Med., 6990 Bad Mergentheim, De
US5888762A (en) * 1990-06-05 1999-03-30 Centre National De La Recherche Scientifique (Cnrs) Neurotropic growth factors comprising a homeobox peptide
FR2662698A1 (fr) * 1990-06-05 1991-12-06 Centre Nat Rech Scient Nouveaux facteurs de croissance neurotropes comprenant un peptide homeoboite.
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GB9814527D0 (en) 1998-07-03 1998-09-02 Cyclacel Ltd Delivery system

Also Published As

Publication number Publication date
GB9914577D0 (en) 1999-08-25
HUP0300246A2 (en) 2003-05-28
WO2000001417A1 (en) 2000-01-13
CA2333145A1 (en) 2000-01-13
AU756014B2 (en) 2003-01-02
US6472507B1 (en) 2002-10-29
DK1093383T3 (da) 2005-02-14
HUP0300246A3 (en) 2005-09-28
US20030119735A1 (en) 2003-06-26
ES2230860T3 (es) 2005-05-01
AU4519899A (en) 2000-01-24
EP1093383A1 (de) 2001-04-25
US6992169B2 (en) 2006-01-31
EP1093383B1 (de) 2004-10-13
ATE279210T1 (de) 2004-10-15
DE69921138T2 (de) 2005-11-24
GB9814527D0 (en) 1998-09-02
CA2333145C (en) 2008-03-25
DE69921138D1 (de) 2004-11-18
GB2340121B (en) 2000-09-06
JP2002519392A (ja) 2002-07-02
GB2340121A (en) 2000-02-16

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Legal Events

Date Code Title Description
FF Patent granted
MM9K Patent not in force due to non-payment of renewal fees