IL137831A0 - Immunological methods to modulate myostatin in vertebrate subjects - Google Patents
Immunological methods to modulate myostatin in vertebrate subjectsInfo
- Publication number
- IL137831A0 IL137831A0 IL13783199A IL13783199A IL137831A0 IL 137831 A0 IL137831 A0 IL 137831A0 IL 13783199 A IL13783199 A IL 13783199A IL 13783199 A IL13783199 A IL 13783199A IL 137831 A0 IL137831 A0 IL 137831A0
- Authority
- IL
- Israel
- Prior art keywords
- immunological methods
- vertebrate subjects
- modulate myostatin
- myostatin
- modulate
- Prior art date
Links
- 102000004472 Myostatin Human genes 0.000 title 1
- 108010056852 Myostatin Proteins 0.000 title 1
- 241000251539 Vertebrata <Metazoa> Species 0.000 title 1
- 230000001900 immune effect Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurology (AREA)
- Endocrinology (AREA)
- Physical Education & Sports Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Transplantation (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7521398P | 1998-02-19 | 1998-02-19 | |
| PCT/CA1999/000128 WO1999042573A1 (en) | 1998-02-19 | 1999-02-19 | Immunological methods to modulate myostatin in vertebrate subjects |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL137831A0 true IL137831A0 (en) | 2001-10-31 |
Family
ID=22124285
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL13783199A IL137831A0 (en) | 1998-02-19 | 1999-02-19 | Immunological methods to modulate myostatin in vertebrate subjects |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US6369201B1 (ja) |
| EP (3) | EP2018871B1 (ja) |
| JP (1) | JP2002504326A (ja) |
| KR (1) | KR20010041111A (ja) |
| AR (1) | AR019818A1 (ja) |
| AT (2) | ATE352619T1 (ja) |
| AU (1) | AU765014B2 (ja) |
| BR (1) | BR9907995A (ja) |
| CA (2) | CA2687533C (ja) |
| CY (2) | CY1108074T1 (ja) |
| DE (2) | DE69940230D1 (ja) |
| DK (2) | DK1056845T3 (ja) |
| ES (3) | ES2527410T3 (ja) |
| IL (1) | IL137831A0 (ja) |
| NZ (1) | NZ506911A (ja) |
| PT (2) | PT1056845E (ja) |
| WO (1) | WO1999042573A1 (ja) |
| ZA (1) | ZA991369B (ja) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6465239B1 (en) * | 1993-03-19 | 2002-10-15 | The John Hopkins University School Of Medicine | Growth differentiation factor-8 nucleic acid and polypeptides from aquatic species and non-human transgenic aquatic species |
| US5994618A (en) | 1997-02-05 | 1999-11-30 | Johns Hopkins University School Of Medicine | Growth differentiation factor-8 transgenic mice |
| US7566768B1 (en) * | 1995-10-26 | 2009-07-28 | The Johns Hopkins University School Of Medicine | Promyostatin peptides and methods of using same |
| US7393682B1 (en) * | 1993-03-19 | 2008-07-01 | The Johns Hopkins University School Of Medicine | Polynucleotides encoding promyostatin polypeptides |
| CA2157577C (en) | 1993-03-19 | 2009-11-17 | Se-Jin Lee | Growth differentiation factor-8 |
| US7332575B2 (en) | 1994-03-18 | 2008-02-19 | The Johns Hopkins University School Of Medicine | Growth differentiation factor-8 nucleic acid and polypeptide from aquatic species, and transgenic aquatic species |
| CN100567322C (zh) * | 1999-01-21 | 2009-12-09 | 梅塔莫菲克斯公司 | 抑制生长分化因子活性的多肽及表达该多肽的细胞 |
| US7056512B1 (en) * | 1999-07-20 | 2006-06-06 | Pharmexa A/S | Method for down-regulating GDF-8 activity |
| ZA200003786B (en) | 1999-07-30 | 2002-01-21 | Pfizer Prod Inc | Myostatin regulatory region, nucleotide sequence determination and methods for its use. |
| US7368534B2 (en) | 2000-01-18 | 2008-05-06 | Orico Limited | Myostatin and mimetics thereof |
| US7037501B2 (en) * | 2001-01-04 | 2006-05-02 | Regents Of The University Of Minnesota | Myostatin immnoconjugate |
| TW200526779A (en) | 2001-02-08 | 2005-08-16 | Wyeth Corp | Modified and stabilized GDF propeptides and uses thereof |
| US7320789B2 (en) | 2001-09-26 | 2008-01-22 | Wyeth | Antibody inhibitors of GDF-8 and uses thereof |
| AU2003217612A1 (en) * | 2002-02-21 | 2003-09-09 | Wyeth | GASP1: a follistatin domain containing protein |
| JP4429728B2 (ja) * | 2002-02-21 | 2010-03-10 | ワイス エルエルシー | フォリスタチン（ｆｏｌｌｉｓｔａｔｉｎ）ドメイン含有タンパク質 |
| MXPA05002968A (es) * | 2002-09-16 | 2005-09-08 | Univ Johns Hopkins | Activacion de miostatina por metaloproteasa, y metodos de modular la actividad de miostatina. |
| US7261893B2 (en) | 2002-10-22 | 2007-08-28 | Wyeth | Neutralizing antibodies against GDF-8 and uses therefor |
| US20040223966A1 (en) * | 2002-10-25 | 2004-11-11 | Wolfman Neil M. | ActRIIB fusion polypeptides and uses therefor |
| DE60335915D1 (de) * | 2002-12-20 | 2011-03-10 | Amgen Inc | Myostatin hemmende bindungsstoffe |
| RU2322261C2 (ru) | 2003-06-02 | 2008-04-20 | Уайт | Применение ингибиторов миостатика (gdf8) в сочетании с кортикостероидами для лечения нервно-мышечных заболеваний |
| BRPI0418317A (pt) * | 2003-12-31 | 2007-05-02 | Schering Plough Ltd | vacina de aumento de crescimento à base de epitopo de neutralização |
| JP4688483B2 (ja) | 2004-04-15 | 2011-05-25 | 株式会社テクノネットワーク四国 | フォリスタチン変異体ポリペプチド |
| EP1778275A2 (en) * | 2004-08-12 | 2007-05-02 | Wyeth | Combination therapy for diabetes, obesity, and cardiovascular diseases using gdf-8 inhibitors |
| US20080118487A1 (en) | 2004-09-30 | 2008-05-22 | Orico Limited | Myostatin Isoform |
| WO2006073827A2 (en) * | 2004-12-30 | 2006-07-13 | Schering-Plough Ltd. | Neutralizing epitope-based growth enhancing vaccine |
| NZ538097A (en) * | 2005-02-07 | 2006-07-28 | Ovita Ltd | Method and compositions for improving wound healing |
| CN101137906A (zh) * | 2005-03-23 | 2008-03-05 | 惠氏公司 | 对gdf-8调节剂的免疫应答的检测 |
| CA2632544C (en) * | 2005-12-06 | 2014-09-23 | Amgen Inc. | Use of myostatin antagonist for treating the effects of hypogonadism |
| BRPI0715072A2 (pt) * | 2006-08-03 | 2013-06-25 | Orico Ltd | antagonistas de miostatina |
| AU2013231037B2 (en) * | 2006-08-03 | 2016-05-12 | Myostin Therapeutics Pty Ltd | Myostatin antagonists |
| JP5058261B2 (ja) | 2006-09-05 | 2012-10-24 | イーライ リリー アンド カンパニー | 抗ミオスタチン抗体 |
| GB0715087D0 (en) | 2007-08-03 | 2007-09-12 | Summit Corp Plc | Drug combinations for the treatment of duchenne muscular dystrophy |
| JP2010535708A (ja) | 2007-08-03 | 2010-11-25 | ビオマリン アイジーエー リミテッド | デュシェンヌ型筋ジストロフィーの治療のための薬物併用 |
| KR100857861B1 (ko) * | 2007-10-15 | 2008-09-11 | 주식회사 바이오리더스 | Ｍｙｏ－２ 펩타이드 중합체와 마이오스타틴의 융합단백질표면발현용 벡터 및 상기 벡터로 형질전환된 미생물 |
| CA2880649C (en) | 2012-08-01 | 2023-03-14 | Elizabeth MCNALLY | Mitigating tissue damage and fibrosis via latent transforming growth factor beta binding protein (ltbp4) |
| CN104391628B (zh) * | 2014-04-02 | 2018-02-23 | 贵阳朗玛信息技术股份有限公司 | 进程切换方法及装置 |
| EP2960653A1 (en) * | 2014-06-24 | 2015-12-30 | Stichting Kwaliteitsgarantie Vleeskalversector | Diagnostic kit and method for the identification of the manipulation of muscle mass in a domestic animal |
| US20220143136A1 (en) | 2018-12-21 | 2022-05-12 | Northwestern University | Use of annexins in preventing and treating muscle membrane injury |
| US20220062299A1 (en) | 2018-12-26 | 2022-03-03 | Northwestern University | Use of glucocorticoid steroids in preventing and treating conditions of muscle wasting, aging and metabolic disorder |
| JP7445640B2 (ja) | 2019-03-01 | 2024-03-07 | 神戸天然物化学株式会社 | ミオスタチンスプライスバリアント由来タンパク質によるミオスタチンシグナル阻害とその利用 |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1605763A (en) | 1926-11-02 | Garment retainer | ||
| US2754818A (en) | 1950-06-24 | 1956-07-17 | Scherer Corp R P | Hypo jet injector |
| US3330276A (en) | 1963-10-07 | 1967-07-11 | Scherer Corp R P | Hypodermic jet injector |
| US3788315A (en) | 1971-04-20 | 1974-01-29 | S Laurens | Disposable cutaneous transjector |
| US3853125A (en) | 1971-10-05 | 1974-12-10 | W Clark | Disposable needleless injector |
| US4491632A (en) | 1979-10-22 | 1985-01-01 | The Massachusetts General Hospital | Process for producing antibodies to hepatitis virus and cell lines therefor |
| US4310550A (en) | 1979-10-26 | 1982-01-12 | Pfizer Inc. | Lipid amines formulated with fat or lipid emulsions as vaccine adjuvants |
| US4431739A (en) | 1979-11-05 | 1984-02-14 | Genentech, Inc. | Transformant bacterial culture capable of expressing heterologous protein |
| US4425437A (en) | 1979-11-05 | 1984-01-10 | Genentech, Inc. | Microbial polypeptide expression vehicle |
| US4444887A (en) | 1979-12-10 | 1984-04-24 | Sloan-Kettering Institute | Process for making human antibody producing B-lymphocytes |
| US4338397A (en) | 1980-04-11 | 1982-07-06 | President And Fellows Of Harvard College | Mature protein synthesis |
| EP0043718B1 (en) | 1980-07-07 | 1984-11-28 | National Research Development Corporation | Improvements in or relating to cell lines |
| US4341761A (en) | 1980-07-25 | 1982-07-27 | E. I. Du Pont De Nemours And Company | Antibodies to immunogenic peptides and their use to purify human fibroblast interferon |
| US4466917A (en) | 1981-02-12 | 1984-08-21 | New York University | Malaria vaccine |
| US4493890A (en) | 1981-03-23 | 1985-01-15 | Miles Laboratories, Inc. | Activated apoglucose oxidase and its use in specific binding assays |
| JPS5873993U (ja) | 1981-11-12 | 1983-05-19 | 三菱電機株式会社 | ２気筒回転式圧縮機 |
| US4399121A (en) | 1981-11-04 | 1983-08-16 | Miles Laboratories, Inc. | Iodothyronine immunogens and antibodies |
| US4427783A (en) | 1981-12-14 | 1984-01-24 | Hoffmann-La Roche Inc. | Immunoassay of thymosin α1 |
| JPS60500673A (ja) | 1983-03-08 | 1985-05-09 | コモンウエルス セラム ラボラトリ−ズ コミツシヨン | 抗原活性を有するアミノ酸配列 |
| US4518385A (en) | 1983-06-13 | 1985-05-21 | Preci-Tech Ltd. | Disposable syringe for needleless injector |
| US4722840A (en) | 1984-09-12 | 1988-02-02 | Chiron Corporation | Hybrid particle immunogens |
| US4596556A (en) | 1985-03-25 | 1986-06-24 | Bioject, Inc. | Hypodermic injection apparatus |
| US5374426A (en) | 1986-09-03 | 1994-12-20 | University Of Saskatchewan | Rotavirus nucleocapsid protein VP6 in vaccine compositions |
| US5055400A (en) | 1986-11-26 | 1991-10-08 | University Of Guelph | Leukotoxin gene of pasteurella haemolytica |
| US4957739A (en) | 1987-08-13 | 1990-09-18 | Board Of Regents, The University Of Texas System | Pharmaceutical compositions of a 105 kD P. Haemolytica derived antigen useful for treatment of Shipping Fever |
| US5151267A (en) | 1988-07-15 | 1992-09-29 | University Of Saskatchewan | Bovine herpesvirus type 1 polypeptides and vaccines |
| US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| CA2014033C (en) | 1989-04-07 | 1993-02-09 | Stephen D. Acres | Compositions and treatments for pneumonia in animals |
| US5062830A (en) | 1990-04-04 | 1991-11-05 | Derata Corporation | Dry disposable nozzle assembly for medical jet injector |
| US5204253A (en) | 1990-05-29 | 1993-04-20 | E. I. Du Pont De Nemours And Company | Method and apparatus for introducing biological substances into living cells |
| US5149655A (en) | 1990-06-21 | 1992-09-22 | Agracetus, Inc. | Apparatus for genetic transformation |
| US5837268A (en) | 1991-10-16 | 1998-11-17 | University Of Saskatchewan | GnRH-leukotoxin chimeras |
| US5994618A (en) | 1997-02-05 | 1999-11-30 | Johns Hopkins University School Of Medicine | Growth differentiation factor-8 transgenic mice |
| CA2157577C (en) | 1993-03-19 | 2009-11-17 | Se-Jin Lee | Growth differentiation factor-8 |
| WO1996001845A1 (en) | 1994-07-08 | 1996-01-25 | The Johns Hopkins University School Of Medicine | Growth differentiation factor-11 |
| AU6274298A (en) | 1997-02-05 | 1998-08-25 | Johns Hopkins University School Of Medicine, The | Growth differentiation factor-8 |
| EP2045322B1 (en) | 1997-07-14 | 2015-07-01 | Université de Liège | Double-muscling in mammals |
| WO1999006559A1 (en) | 1997-08-01 | 1999-02-11 | The Johns Hopkins University School Of Medicine | Methods to identify growth differentiation factor (gdf) receptors |
| WO1999024618A1 (en) | 1997-11-10 | 1999-05-20 | The Johns Hopkins University School Of Medicine | Methods for detection of mutations in myostatin variants |
| WO1999040181A1 (en) | 1998-02-05 | 1999-08-12 | The Johns Hopkins University School Of Medicine | Growth differentiation factor-8 |
| US7056512B1 (en) | 1999-07-20 | 2006-06-06 | Pharmexa A/S | Method for down-regulating GDF-8 activity |
-
1999
- 1999-02-18 US US09/252,149 patent/US6369201B1/en not_active Expired - Lifetime
- 1999-02-19 AT AT99904660T patent/ATE352619T1/de active
- 1999-02-19 ES ES08018446.8T patent/ES2527410T3/es not_active Expired - Lifetime
- 1999-02-19 BR BR9907995-0A patent/BR9907995A/pt active Search and Examination
- 1999-02-19 NZ NZ506911A patent/NZ506911A/en not_active IP Right Cessation
- 1999-02-19 DE DE69940230T patent/DE69940230D1/de not_active Expired - Lifetime
- 1999-02-19 CA CA2687533A patent/CA2687533C/en not_active Expired - Lifetime
- 1999-02-19 ZA ZA9901369A patent/ZA991369B/xx unknown
- 1999-02-19 IL IL13783199A patent/IL137831A0/xx unknown
- 1999-02-19 DK DK99904660T patent/DK1056845T3/da active
- 1999-02-19 CA CA002323607A patent/CA2323607C/en not_active Expired - Fee Related
- 1999-02-19 EP EP08018446.8A patent/EP2018871B1/en not_active Expired - Lifetime
- 1999-02-19 DK DK06026306T patent/DK1770162T3/da active
- 1999-02-19 ES ES99904660T patent/ES2280115T3/es not_active Expired - Lifetime
- 1999-02-19 KR KR1020007009152A patent/KR20010041111A/ko not_active Application Discontinuation
- 1999-02-19 WO PCT/CA1999/000128 patent/WO1999042573A1/en active IP Right Grant
- 1999-02-19 PT PT99904660T patent/PT1056845E/pt unknown
- 1999-02-19 DE DE69934970T patent/DE69934970T2/de not_active Expired - Lifetime
- 1999-02-19 AU AU25073/99A patent/AU765014B2/en not_active Ceased
- 1999-02-19 EP EP99904660A patent/EP1056845B1/en not_active Expired - Lifetime
- 1999-02-19 AT AT06026306T patent/ATE419353T1/de active
- 1999-02-19 EP EP06026306A patent/EP1770162B1/en not_active Expired - Lifetime
- 1999-02-19 PT PT06026306T patent/PT1770162E/pt unknown
- 1999-02-19 JP JP2000532513A patent/JP2002504326A/ja active Pending
- 1999-02-19 ES ES06026306T patent/ES2318654T3/es not_active Expired - Lifetime
- 1999-02-23 AR ARP990100671A patent/AR019818A1/es active IP Right Grant
-
2002
- 2002-02-11 US US10/074,152 patent/US20030065137A1/en not_active Abandoned
-
2007
- 2007-04-23 CY CY20071100550T patent/CY1108074T1/el unknown
-
2009
- 2009-03-18 CY CY20091100304T patent/CY1108889T1/el unknown
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