IL137766A0 - Strategically modified hepatitis b core proteins and their derivatives - Google Patents

Strategically modified hepatitis b core proteins and their derivatives

Info

Publication number
IL137766A0
IL137766A0 IL13776699A IL13776699A IL137766A0 IL 137766 A0 IL137766 A0 IL 137766A0 IL 13776699 A IL13776699 A IL 13776699A IL 13776699 A IL13776699 A IL 13776699A IL 137766 A0 IL137766 A0 IL 137766A0
Authority
IL
Israel
Prior art keywords
modified
modified hepatitis
derivatives
hepatitis
core proteins
Prior art date
Application number
IL13776699A
Other languages
English (en)
Original Assignee
Immune Complex Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immune Complex Corp filed Critical Immune Complex Corp
Publication of IL137766A0 publication Critical patent/IL137766A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/01—DNA viruses
    • C07K14/02—Hepadnaviridae, e.g. hepatitis B virus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C12N9/0077—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14) with a reduced iron-sulfur protein as one donor (1.14.15)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2730/00—Reverse transcribing DNA viruses
    • C12N2730/00011—Details
    • C12N2730/10011—Hepadnaviridae
    • C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
    • C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/788—Of specified organic or carbon-based composition
    • Y10S977/795—Composed of biological material
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/84—Manufacture, treatment, or detection of nanostructure
    • Y10S977/894—Manufacture, treatment, or detection of nanostructure having step or means utilizing biological growth
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/915—Therapeutic or pharmaceutical composition
    • Y10S977/917—Vaccine

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Communicable Diseases (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pyrrole Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
IL13776699A 1998-02-12 1999-02-11 Strategically modified hepatitis b core proteins and their derivatives IL137766A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7453798P 1998-02-12 1998-02-12
PCT/US1999/003055 WO1999040934A1 (fr) 1998-02-12 1999-02-11 Proteines noyaux de l'hepatite b strategiquement modifiees et leurs derives

Publications (1)

Publication Number Publication Date
IL137766A0 true IL137766A0 (en) 2001-10-31

Family

ID=22120092

Family Applications (2)

Application Number Title Priority Date Filing Date
IL13776699A IL137766A0 (en) 1998-02-12 1999-02-11 Strategically modified hepatitis b core proteins and their derivatives
IL137766A IL137766A (en) 1998-02-12 2000-08-08 Core proteins that have been modified from the hepatitis B virus and their derivatives

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL137766A IL137766A (en) 1998-02-12 2000-08-08 Core proteins that have been modified from the hepatitis B virus and their derivatives

Country Status (20)

Country Link
US (1) US6231864B1 (fr)
EP (1) EP1054689B1 (fr)
JP (1) JP4480268B2 (fr)
KR (1) KR100581991B1 (fr)
CN (1) CN100387622C (fr)
AT (1) ATE249240T1 (fr)
AU (1) AU767144B2 (fr)
BR (1) BR9907855A (fr)
CA (1) CA2320488C (fr)
CZ (1) CZ302092B6 (fr)
DE (1) DE69911175T2 (fr)
DK (1) DK1054689T3 (fr)
ES (1) ES2207177T3 (fr)
HK (1) HK1038306A1 (fr)
ID (1) ID26669A (fr)
IL (2) IL137766A0 (fr)
NZ (1) NZ506245A (fr)
PT (1) PT1054689E (fr)
TR (1) TR200002338T2 (fr)
WO (1) WO1999040934A1 (fr)

Families Citing this family (90)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020147143A1 (en) 1998-03-18 2002-10-10 Corixa Corporation Compositions and methods for the therapy and diagnosis of lung cancer
US20030235557A1 (en) 1998-09-30 2003-12-25 Corixa Corporation Compositions and methods for WT1 specific immunotherapy
US20040009535A1 (en) 1998-11-27 2004-01-15 Celltech R&D, Inc. Compositions and methods for increasing bone mineralization
CN1193791C (zh) 1998-11-30 2005-03-23 希托斯生物技术股份公司 抗原的有序分子呈递,制备及使用的方法
US6887464B1 (en) 1999-02-02 2005-05-03 Biocache Pharmaceuticals, Inc. Advanced antigen presentation platform
AU2977500A (en) * 1999-02-02 2000-08-25 Biocache Pharmaceuticals, Llc Advanced antigen presentation platform
WO2001016174A2 (fr) * 1999-08-30 2001-03-08 Rolf Kiessling Induction d'une reponse de lymphocytes t cytotoxiques par des determinants antigeniques restreints par hla de categorie 1a de proteines de choc thermique mycobacteriennes 65
ES2389445T3 (es) 2000-02-23 2012-10-26 Glaxosmithkline Biologicals Sa Compuestos novedosos
CA2407897A1 (fr) 2000-05-05 2001-11-15 Cytos Biotechnology Ag Jeu ordonne d'antigenes moleculaires
AU2001273149A1 (en) 2000-06-28 2002-01-08 Corixa Corporation Compositions and methods for the therapy and diagnosis of lung cancer
US6942866B2 (en) * 2000-08-16 2005-09-13 Apovia, Inc. Malaria immunogen and vaccine
US20030138769A1 (en) * 2000-08-16 2003-07-24 Birkett Ashley J. Immunogenic HBc chimer particles having enhanced stability
US7022830B2 (en) * 2000-08-17 2006-04-04 Tripep Ab Hepatitis C virus codon optimized non-structural NS3/4A fusion gene
US7320793B2 (en) * 2001-01-19 2008-01-22 Cytos Biotechnology Ag Molecular antigen array
US7094409B2 (en) 2001-01-19 2006-08-22 Cytos Biotechnology Ag Antigen arrays for treatment of allergic eosinophilic diseases
US7128911B2 (en) * 2001-01-19 2006-10-31 Cytos Biotechnology Ag Antigen arrays for treatment of bone disease
JP2005505238A (ja) * 2001-02-05 2005-02-24 ストレスゲン バイオテクノロジーズ コーポレイション Ｂ型肝炎ウイルスの治療法
CA2446788A1 (fr) 2001-05-09 2002-11-14 Corixa Corporation Compositions et procedes pour la therapie et le diagnostic du cancer de la prostate
US20040146524A1 (en) * 2002-02-21 2004-07-29 Katelynne Lyons Stabilized immunogenic HBc chimer particles
US7361352B2 (en) * 2001-08-15 2008-04-22 Acambis, Inc. Influenza immunogen and vaccine
US20030037327A1 (en) * 2001-08-15 2003-02-20 International Business Machines Corporation Run-time rule-based topological installation suite
US20030185858A1 (en) * 2001-08-15 2003-10-02 Birkett Ashley J. Immunogenic HBc chimer particles stabilized with an N-terminal cysteine
WO2003102165A2 (fr) * 2002-02-21 2003-12-11 Apovia, Inc. Particules chimeriques hbc immunogenes stabilisees avec une cysteine d'extremite n-termnale
US20030175863A1 (en) * 2001-08-15 2003-09-18 Birkett Ashley J. Influenza immunogen and vaccine
AU2002347404A1 (en) * 2001-09-14 2003-04-01 Cytos Biotechnology Ag In vivo activation of antigen presenting cells for enhancement of immune responses induced by virus like particles
DE60234375D1 (de) 2001-09-14 2009-12-24 Cytos Biotechnology Ag VERPACKUNG VON IMMUNSTIMULIERENDEM CpG IN VIRUSÄHNLICHEN PARTIKELN: HERSTELLUNGSVERFAHREN UND VERWENDUNG
US7115266B2 (en) * 2001-10-05 2006-10-03 Cytos Biotechnology Ag Angiotensin peptide-carrier conjugates and uses thereof
BR0213117A (pt) 2001-10-05 2004-09-21 Cytos Biotechnology Ag Conjugados peptìdeo angiotensina-veìculo e seus usos
EP2224012B1 (fr) 2001-12-17 2013-01-30 Corixa Corporation Compositions et procédés pour la thérapie et le diagnostic de maladies intestines inflammatoires
US20030219459A1 (en) * 2002-01-18 2003-11-27 Cytos Biotechnology Ag Prion protein carrier-conjugates
WO2003066833A2 (fr) * 2002-02-08 2003-08-14 New York University Utilisation de particules capsidiques recombinantes de l'hepatite b pour le developpement de vaccins diriges contre des pathogenes infectieux et des cancers
AU2003213194A1 (en) * 2002-02-21 2003-09-09 Apovia, Inc. IMMUNOGENIC AVIAN HBc CHIMER PARTICLES HAVING ENHANCED STABILITY
AU2003215395A1 (en) * 2002-02-21 2003-09-09 Apovia, Inc. STABILIZED HBc CHIMER PARTICLES HAVING MENINGOCCOCAL IMMUNOGENS
RU2322257C2 (ru) * 2002-06-20 2008-04-20 Цитос Байотекнолоджи Аг КОМПОЗИЦИИ, СОДЕРЖАЩИЕ CpG-ОЛИГОНУКЛЕОТИДЫ И ВИРУСОПОДОБНЫЕ ЧАСТИЦЫ, ДЛЯ ПРИМЕНЕНИЯ В КАЧЕСТВЕ АДЪЮВАНТОВ
AU2003246690B2 (en) 2002-07-17 2010-03-11 Cytos Biotechnology Ag Molecular antigen arrays using a virus like particle derived from the AP205 coat protein
NZ537003A (en) * 2002-07-18 2008-03-28 Cytos Biotechnology Ag Hapten-carrier conjugates comprising virus like particles and uses thereof
BR0312792A (pt) * 2002-07-19 2005-05-03 Cytos Biotechnology Ag Composições de vacinas contendo séries antigênicas de amilóide beta1-6
US20060210588A1 (en) * 2003-03-26 2006-09-21 Cytos Biotechnology Ag Hiv-peptide-carrier-conjugates
US7517520B2 (en) * 2003-03-26 2009-04-14 Cytos Biotechnology Ag Packaging of immunostimulatory oligonucleotides into virus-like particles: method of preparation and use
US7537767B2 (en) 2003-03-26 2009-05-26 Cytis Biotechnology Ag Melan-A- carrier conjugates
EP1623229A2 (fr) * 2003-05-15 2006-02-08 Cytos Biotechnology AG Selection des lymphocytes b avec specificite d'interet : procede de preparation et utilisation
US8080642B2 (en) 2003-05-16 2011-12-20 Vical Incorporated Severe acute respiratory syndrome DNA compositions and methods of use
US7381409B2 (en) 2003-06-16 2008-06-03 Celltech R&D, Inc. Antibodies specific for sclerostin and methods of screening and use therefor
US7883843B2 (en) 2003-07-30 2011-02-08 Vaccine Research Institute Of San Diego Hepatitis virus core proteins as vaccine platforms and methods of use thereof
US7144712B2 (en) * 2003-07-30 2006-12-05 Vaccine Research Institute Of San Diego Human hepatitis B virus core proteins as vaccine platforms and methods of use thereof
US7320795B2 (en) 2003-07-30 2008-01-22 Vaccine Research Institute Of San Diego Rodent hepatitis B virus core proteins as vaccine platforms and methods of use thereof
CN1305527C (zh) * 2003-11-21 2007-03-21 薛平 乙型肝炎治疗疫苗及其制备方法
BRPI0507002A (pt) * 2004-01-20 2007-06-05 Cytos Biotechnology Ag conjugados veìculos de grelina
US20060024670A1 (en) 2004-05-18 2006-02-02 Luke Catherine J Influenza virus vaccine composition and methods of use
WO2006031264A2 (fr) 2004-05-25 2006-03-23 Oregon Health And Science University Vaccination du virus de l'immunodeficience simienne (siv) et du virus de l'immunodeficience humaine (vih) utilisant des vecteurs de vaccin a base de rhcmv et hcmv
CA2567741A1 (fr) * 2004-05-25 2006-03-30 Chimeracore, Inc. Systeme d'administration de medicaments a base de nanoparticules a autoassemblage
GB0424563D0 (en) 2004-11-05 2004-12-08 Novartis Ag Organic compounds
US20070160628A1 (en) * 2005-08-31 2007-07-12 Birkett Ashley J Stabilized virus-like particles and epitope display systems
CA2648718A1 (fr) 2006-04-07 2007-10-18 The Research Foundation Of State University Of New York Polypeptides du recepteur de la transcobalamine, acides nucleiques et modulateurs associes, procedes d'utilisation associes destines a moduler la croissance cellulaire et a traiter le cancer et la deficience en cobalamine
ATE460922T1 (de) * 2006-04-07 2010-04-15 Chimeros Inc Zusammensetzungen und verfahren zur behandlung von b-zellen-malignomen
US20090226525A1 (en) * 2007-04-09 2009-09-10 Chimeros Inc. Self-assembling nanoparticle drug delivery system
GB0713880D0 (en) * 2007-07-17 2007-08-29 Novartis Ag Conjugate purification
EP2185195A2 (fr) 2007-08-16 2010-05-19 Tripep Ab Plate-forme immunogène
WO2009029272A2 (fr) * 2007-08-27 2009-03-05 Agadjanyan Michael G Vaccin épitopique pour la prévention et l'atténuation de la maladie d'alzheimer
EP2240199A4 (fr) 2008-02-09 2012-10-03 Sanofi Pasteur Biologics Llc Vaccins contre la grippe b
CN101423555B (zh) * 2008-11-14 2011-04-20 四川大学华西医院 特异性阻断乙肝病毒组装和复制的膜穿透性多肽
KR101644221B1 (ko) 2008-12-09 2016-07-29 화이자 백신스 엘엘씨 ＩｇＥ ＣＨ３ 펩티드 백신
US8445663B2 (en) 2009-02-02 2013-05-21 Chrontech Pharma Ab Compositions and methods that enhance an immune response
WO2010120874A2 (fr) 2009-04-14 2010-10-21 Chimeros, Inc. Agents thérapeutiques chimériques, compositions, et leurs procédés d'utilisation
RU2518291C2 (ru) 2009-07-30 2014-06-10 Пфайзер Вэксинс ЭлЭлСи Антигенные tau-пептиды и их применения
MY163512A (en) 2009-09-03 2017-09-15 Pfizer Vaccines Llc Pcsk9 vaccine
WO2011154878A1 (fr) 2010-06-07 2011-12-15 Pfizer Vaccines Llc Vaccin peptidique ige ch3
CA2827150C (fr) * 2011-02-12 2018-09-11 Globeimmune, Inc. Therapeutique a base de levure pour infection chronique par l'hepatite b
US20140004142A1 (en) 2011-03-02 2014-01-02 Pfizer Inc. Pcsk9 vaccine
CN103608030A (zh) 2011-06-21 2014-02-26 昂科发克特公司 用于治疗和诊断癌症的组合物和方法
CA2847888A1 (fr) 2011-09-09 2013-03-14 Biomed Realty, L.P. Procedes et compositions de regulation d'un assemblage de proteines virales
CA2882563C (fr) * 2012-08-21 2022-11-29 Eric Hryhorenko Anticorps diriges contre des haptenes de risperidone et leur utilisation
CA2936092A1 (fr) 2013-01-23 2014-07-31 The Board Of Trustees Of The Leland Stanford Junior University Polypeptide cƒur d'hepatite b stabilise
EP2968158A4 (fr) 2013-03-15 2017-01-11 VLP Biotech, Inc. Noyaux d'hépadnavirus rongeurs avec antigénicité spécifique à un support réduite
CA2906770A1 (fr) * 2013-03-15 2014-09-18 Vlp Biotech, Inc. Particules de type viral a base d'epitope palivizumab
GB201402890D0 (en) 2014-02-18 2014-04-02 Iqur Ltd Vaccines based on hepatitis B Core antigens
CN104208670B (zh) * 2014-09-09 2017-07-28 韩自勤 一种治疗乙肝的药物组合物
GB201505041D0 (en) * 2015-03-25 2015-05-06 Iqur Ltd Vaccines based on hepatitis B core antigens
CN107383176A (zh) * 2017-05-10 2017-11-24 于学杰 用于对汉滩病毒和汉城病毒引起的肾综合征出血热分型的多肽
MX2019015925A (es) * 2017-06-23 2020-08-06 American Type Culture Collection Atcc Partículas similares a virus que comprenden el antígeno del zika.
GB201710973D0 (en) 2017-07-07 2017-08-23 Avacta Life Sciences Ltd Scaffold proteins
JP7320601B2 (ja) 2018-09-11 2023-08-03 上▲海▼市公共▲衛▼生▲臨▼床中心 広域スペクトルな抗インフルエンザワクチン免疫原及びその使用
TW202120551A (zh) 2019-08-12 2021-06-01 美商普瑞諾生物科技公司 藉由adcc靶向cd39表現細胞促進及增強t細胞介導免疫反應之方法及組合物
TW202128775A (zh) 2019-10-16 2021-08-01 英商阿法克塔生命科學有限公司 PD-L1抑制劑-TGFβ抑制劑雙特異性藥物部分
CN110804097B (zh) * 2019-10-30 2021-02-26 云南沃森生物技术股份有限公司 一种同时制备两种单克隆抗体的方法
US11938182B2 (en) 2020-03-26 2024-03-26 Provectus Pharmatech, Inc. Halogenated xanthenes as vaccine adjuvants
WO2022234003A1 (fr) 2021-05-07 2022-11-10 Avacta Life Sciences Limited Polypeptides se liant à cd33 avec protéine stefin a
TW202332694A (zh) 2021-10-07 2023-08-16 英商阿凡克塔生命科學公司 血清半衰期延長之ｐｄ－ｌ１結合多肽
EP4413038A1 (fr) 2021-10-07 2024-08-14 Avacta Life Sciences Limited Affimers de liaison à pd-l1
WO2023218243A1 (fr) 2022-05-12 2023-11-16 Avacta Life Sciences Limited Protéines de fusion de liaison lag-3/pd-l1

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD147855A5 (de) 1978-12-22 1981-04-22 Biogen Nv Verfahren zur erzeugung mindestens eines hbv-antigenwirkung aufweisenden polypeptids
US5143726A (en) * 1986-12-09 1992-09-01 The Scripps Research Institute T cell epitopes of the hepatitis B virus nucleocapsid protein
US4818527A (en) * 1986-12-09 1989-04-04 Scripps Clinic And Research Foundation T cell epitopes of the hepatitis B virus nucleocapsid protein
US4882145A (en) 1986-12-09 1989-11-21 Scripps Clinic And Research Foundation T cell epitopes of the hepatitis B virus nucleocapsid protein
GB8903313D0 (en) * 1989-02-14 1989-04-05 Wellcome Found Conjugates
NZ235315A (en) 1989-09-19 1991-09-25 Wellcome Found Chimaeric hepadnavirus core antigen proteins and their construction
US5840303A (en) * 1991-08-26 1998-11-24 The Scripps Research Foundation Peptides for inducing cytotoxic T lymphocyte responses to hepatitis B virus
AU4248297A (en) * 1996-09-03 1998-03-26 General Hospital Corporation, The Inhibition of viral replication

Also Published As

Publication number Publication date
TR200002338T2 (tr) 2002-06-21
CZ302092B6 (cs) 2010-10-06
EP1054689A4 (fr) 2002-02-13
AU2675399A (en) 1999-08-30
EP1054689A1 (fr) 2000-11-29
US6231864B1 (en) 2001-05-15
KR100581991B1 (ko) 2006-05-23
ES2207177T3 (es) 2004-05-16
ATE249240T1 (de) 2003-09-15
DE69911175T2 (de) 2004-07-29
ID26669A (id) 2001-01-25
DE69911175D1 (de) 2003-10-16
PT1054689E (pt) 2003-11-28
CA2320488A1 (fr) 1999-08-19
NZ506245A (en) 2003-08-29
AU767144B2 (en) 2003-10-30
CN1300222A (zh) 2001-06-20
CA2320488C (fr) 2007-03-06
HK1038306A1 (en) 2002-03-15
DK1054689T3 (da) 2004-01-26
WO1999040934A1 (fr) 1999-08-19
JP4480268B2 (ja) 2010-06-16
CZ20002819A3 (en) 2001-06-13
BR9907855A (pt) 2001-04-24
IL137766A (en) 2007-12-03
EP1054689B1 (fr) 2003-09-10
KR20010052165A (ko) 2001-06-25
JP2002509700A (ja) 2002-04-02
CN100387622C (zh) 2008-05-14

Similar Documents

Publication Publication Date Title
HK1038306A1 (en) Strategically modified hepatitis b core proteins and their derivatives
NO932644L (no) Antigen-presenterende kapsid med fusert ms2-kappeprotein
WO1993001210A3 (fr) Antigenes peptidiques du virus de l'hepatite c et procede pour la determination du virus de l'hepatite c
GB2191690A (en) Air support for chairs, chair utilizing the same and method of manufacturing the same
CA2078694A1 (fr) Vaccin contre l'hepatite b
IE822084L (en) Preparation of polypeptides in vertebrate cell culture
MXPA02007733A (es) Mejoramiento de la vida media circulante de proteinas de fusion basadas en anticuerpos.
AU8223187A (en) T cell epitopes of the hepatitis b virus nucleocapsid protein
ZA853025B (en) Isolation of proteins of htlv-iii,serological detection of antibodies to htlv-iii in sera of patients with aids and pre-aids conditions,and detection of htlv-iii infection by immuno-assays using htlv-iii and its proteins
IE900502L (en) Conjugates
MY141641A (en) Compositions comprising viruses and methods for concentrating virus preparations
HK166495A (en) HIV-1 envelope muteins lacking hypervariable domains
NO884741L (no) Amfotericin b/kolesterolsulfatpreparat og fremgangsmaate for fremstilling derav.
MX9603182A (es) Vacuna de hepatitis b.
EP0540645A4 (en) Methods of use of bovine respiratory syncytial virus recombinant dna, proteins vaccines, antibodies, and transformed cells
CA2019218A1 (fr) Conjugats de proteine magnetiques, procede de preparation et utilisation
JPS6463392A (en) Monoclonal antibody against specific antigen for human immunodeficiency virus
DE3888887D1 (de) Monoklonale Antikörper gegen E7-Protein des Humanen Papillomvirus Typ 16, Verfahren zu ihrer Herstellung sowie ihre Verwendung.
WO2002012535B1 (fr) Utilisation d'anticorps anti-ceacam pour la stimulation de cellules b dans la production d'anticorps monoclonaux ou en immunotherapie
EP0836484A4 (fr) Encapsidation in vitro d'adn de virus adeno-associe
JPS5328164A (en) Maleimide derivatives
AU2910589A (en) Diagnostic method for primary biliary cirrhosis and antibodies suitable to be used in the method
EP0503252A3 (en) Recombinant proteins having the immunoreactivity of hepatitis b virus e antigens (hbeag), method for their production and their application in immunoassays and as vaccines
JPS5616415A (en) Preparation of antibody
Kim et al. A Clinical study of HBsAg and Anti-HBs in the serum of patients with various liver diseases

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed