IL136732A0 - Camptothecin tetracyclic analogues, preparation, methods, applications as medicines and pharmaceutical compositions containing them - Google Patents
Camptothecin tetracyclic analogues, preparation, methods, applications as medicines and pharmaceutical compositions containing themInfo
- Publication number
- IL136732A0 IL136732A0 IL13673298A IL13673298A IL136732A0 IL 136732 A0 IL136732 A0 IL 136732A0 IL 13673298 A IL13673298 A IL 13673298A IL 13673298 A IL13673298 A IL 13673298A IL 136732 A0 IL136732 A0 IL 136732A0
- Authority
- IL
- Israel
- Prior art keywords
- camptothecin
- medicines
- applications
- preparation
- methods
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9716461A FR2772763B1 (fr) | 1997-12-24 | 1997-12-24 | Nouveaux analogues tetracycliques de camptothecines, leurs procedes de preparation, leur application comme medicaments et les compositions pharmaceutiques les contenant |
| PCT/FR1998/002751 WO1999033829A1 (fr) | 1997-12-24 | 1998-12-16 | Nouveaux analogues tetracycliques de camptothecines, leurs procedes de preparation, leur application comme medicaments et les compositions pharmaceutiques les contenant |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL136732A0 true IL136732A0 (en) | 2001-06-14 |
Family
ID=9515095
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL13673298A IL136732A0 (en) | 1997-12-24 | 1998-12-16 | Camptothecin tetracyclic analogues, preparation, methods, applications as medicines and pharmaceutical compositions containing them |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US6436951B1 (de) |
| EP (1) | EP1042323B1 (de) |
| JP (1) | JP2001527075A (de) |
| AR (1) | AR016440A1 (de) |
| AT (1) | ATE215951T1 (de) |
| AU (1) | AU749224B2 (de) |
| CA (1) | CA2315897C (de) |
| DE (1) | DE69804856T2 (de) |
| DK (1) | DK1042323T3 (de) |
| ES (1) | ES2175834T3 (de) |
| FR (1) | FR2772763B1 (de) |
| HU (1) | HUP0004628A3 (de) |
| IL (1) | IL136732A0 (de) |
| MY (1) | MY117585A (de) |
| NO (1) | NO316676B1 (de) |
| NZ (1) | NZ505339A (de) |
| PL (1) | PL193468B1 (de) |
| PT (1) | PT1042323E (de) |
| RU (1) | RU2220144C2 (de) |
| TW (1) | TW513429B (de) |
| WO (1) | WO1999033829A1 (de) |
| ZA (1) | ZA9811796B (de) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003225642A1 (en) * | 2002-03-01 | 2003-09-16 | Fluorous Techonologies Inc | Mappicine analogs, intermediates in the synthesis of mappicine analogs and methods of synthesis of mappicine analogs |
| WO2003080077A1 (fr) * | 2002-03-26 | 2003-10-02 | Banyu Pharmaceutical Co., Ltd. | Utilisation combinee de derives anticancereux de l'indolopyrrolocarbazole et d'un autre agent anticancereux |
| TW200623953A (en) * | 2004-12-08 | 2006-07-01 | Fuji Electric Holdings | Organic electro-luminescent element |
| AR059898A1 (es) | 2006-03-15 | 2008-05-07 | Janssen Pharmaceutica Nv | Derivados de 3-ciano-piridona 1,4-disustituida y su uso como moduladores alostericos de los receptores mglur2 |
| TW200845978A (en) | 2007-03-07 | 2008-12-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives |
| TW200900065A (en) | 2007-03-07 | 2009-01-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives |
| JP5126707B2 (ja) * | 2007-04-23 | 2013-01-23 | 有機合成薬品工業株式会社 | α−ヒドロキシアシルピリジンの製造方法 |
| BRPI0816767B8 (pt) | 2007-09-14 | 2021-05-25 | Addex Pharmaceuticals Sa | composto 4-fenil-3,4,5,6-tetra-hidro-2h,1'h-[1,4']bipiridi¬nil-2'-onas 1',3'-dissubstituídas, composição farmacêutica e uso dos mesmos |
| AU2009289784B2 (en) | 2008-09-02 | 2012-03-22 | Addex Pharma S.A. | 3-azabicyclo[3.1.0]hexyl derivatives as modulators of metabotropic glutamate receptors |
| WO2010060589A1 (en) | 2008-11-28 | 2010-06-03 | Ortho-Mcneil-Janssen Pharmaceuticals, Inc. | Indole and benzoxazine derivatives as modulators of metabotropic glutamate receptors |
| MY153913A (en) | 2009-05-12 | 2015-04-15 | Janssen Pharmaceuticals Inc | 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
| US8946205B2 (en) | 2009-05-12 | 2015-02-03 | Janssen Pharmaceuticals, Inc. | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors |
| MY161325A (en) | 2009-05-12 | 2017-04-14 | Janssen Pharmaceuticals Inc | 1, 2, 4-triazolo[4,3-a]pyridine derivatives and their use for the treatment or prevention of neurological and psychiatric disorders |
| CN103261195B (zh) | 2010-11-08 | 2015-09-02 | 杨森制药公司 | 1,2,4-三唑并[4,3-a]吡啶衍生物及其作为MGLUR2受体的正变构调节剂的用途 |
| AU2011328203B2 (en) | 2010-11-08 | 2015-03-19 | Janssen Pharmaceuticals, Inc. | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors |
| PL2649069T3 (pl) | 2010-11-08 | 2016-01-29 | Janssen Pharmaceuticals Inc | Pochodne 1,2,4-triazolo[4,3-a]pirydyny i ich zastosowanie jako dodatnich allosterycznych modulatorów receptorów mGluR2 |
| EP2956138B1 (de) | 2013-02-15 | 2022-06-22 | Kala Pharmaceuticals, Inc. | Therapeutische verbindungen und verwendungen davon |
| US9688688B2 (en) | 2013-02-20 | 2017-06-27 | Kala Pharmaceuticals, Inc. | Crystalline forms of 4-((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxyquinazolin-7-yl)oxy)-1-(2-oxa-7-azaspiro[3.5]nonan-7-yl)butan-1-one and uses thereof |
| ES2831625T3 (es) | 2013-02-20 | 2021-06-09 | Kala Pharmaceuticals Inc | Compuestos terapéuticos y sus usos |
| JO3368B1 (ar) | 2013-06-04 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2 |
| JO3367B1 (ar) | 2013-09-06 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2 |
| US9890173B2 (en) | 2013-11-01 | 2018-02-13 | Kala Pharmaceuticals, Inc. | Crystalline forms of therapeutic compounds and uses thereof |
| MX355330B (es) | 2013-11-01 | 2018-04-16 | Kala Pharmaceuticals Inc | Formas cristalinas de compuestos terapeuticos y sus usos. |
| CN103588660B (zh) * | 2013-11-18 | 2016-06-01 | 中国医学科学院生物医学工程研究所 | 一种新型的酰基苯胺化合物及用途 |
| CN105793252B (zh) | 2013-12-13 | 2018-01-30 | 豪夫迈·罗氏有限公司 | 布鲁顿氏酪氨酸激酶抑制剂 |
| UA121965C2 (uk) | 2014-01-21 | 2020-08-25 | Янссен Фармацевтика Нв | Комбінації, які містять позитивні алостеричні модулятори або ортостеричні агоністи метаботропного глутаматергічного рецептора 2 підтипу, та їх застосування |
| KR102461134B1 (ko) | 2014-01-21 | 2022-10-28 | 얀센 파마슈티카 엔.브이. | 대사 조절형 글루탐산 작동성 수용체 제2아형의 양성 알로스테릭 조절제 또는 오르토스테릭 작동제를 포함하는 조합 및 그 용도 |
| AU2017324713B2 (en) | 2016-09-08 | 2020-08-13 | KALA BIO, Inc. | Crystalline forms of therapeutic compounds and uses thereof |
| KR20190051010A (ko) | 2016-09-08 | 2019-05-14 | 칼라 파마슈티컬스, 인크. | 치료 화합물의 결정형 및 그의 용도 |
| CA3036340A1 (en) | 2016-09-08 | 2018-03-15 | Kala Pharmaceuticals, Inc. | Crystalline forms of therapeutic compounds and uses thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2164515C2 (ru) * | 1995-06-21 | 2001-03-27 | Сосьете де Консей де Решерш э Д'Аппликасьон Сьентифик (СКРАС) | Соединения камптотецина, способы их получения, промежуточные соединения и терапевтические композиции |
| GB9624482D0 (en) * | 1995-12-18 | 1997-01-15 | Zeneca Phaema S A | Chemical compounds |
-
1997
- 1997-12-24 FR FR9716461A patent/FR2772763B1/fr not_active Expired - Fee Related
-
1998
- 1998-12-14 TW TW087120746A patent/TW513429B/zh not_active IP Right Cessation
- 1998-12-15 MY MYPI98005659A patent/MY117585A/en unknown
- 1998-12-16 US US09/582,068 patent/US6436951B1/en not_active Expired - Fee Related
- 1998-12-16 PT PT98962480T patent/PT1042323E/pt unknown
- 1998-12-16 ES ES98962480T patent/ES2175834T3/es not_active Expired - Lifetime
- 1998-12-16 RU RU2000119731/04A patent/RU2220144C2/ru not_active IP Right Cessation
- 1998-12-16 DK DK98962480T patent/DK1042323T3/da active
- 1998-12-16 EP EP98962480A patent/EP1042323B1/de not_active Expired - Lifetime
- 1998-12-16 WO PCT/FR1998/002751 patent/WO1999033829A1/fr active IP Right Grant
- 1998-12-16 AT AT98962480T patent/ATE215951T1/de not_active IP Right Cessation
- 1998-12-16 CA CA002315897A patent/CA2315897C/fr not_active Expired - Fee Related
- 1998-12-16 JP JP2000526510A patent/JP2001527075A/ja not_active Ceased
- 1998-12-16 NZ NZ505339A patent/NZ505339A/xx active IP Right Revival
- 1998-12-16 AU AU17645/99A patent/AU749224B2/en not_active Ceased
- 1998-12-16 PL PL98341288A patent/PL193468B1/pl not_active IP Right Cessation
- 1998-12-16 IL IL13673298A patent/IL136732A0/xx not_active IP Right Cessation
- 1998-12-16 HU HU0004628A patent/HUP0004628A3/hu unknown
- 1998-12-16 DE DE69804856T patent/DE69804856T2/de not_active Expired - Lifetime
- 1998-12-21 AR ARP980106556A patent/AR016440A1/es unknown
- 1998-12-22 ZA ZA9811796A patent/ZA9811796B/xx unknown
-
2000
- 2000-06-23 NO NO20003314A patent/NO316676B1/no not_active IP Right Cessation
- 2000-12-12 US US09/734,167 patent/US6632946B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| PT1042323E (pt) | 2002-09-30 |
| DE69804856T2 (de) | 2002-11-07 |
| NO20003314L (no) | 2000-06-30 |
| PL193468B1 (pl) | 2007-02-28 |
| FR2772763A1 (fr) | 1999-06-25 |
| NZ505339A (en) | 2003-01-31 |
| DK1042323T3 (da) | 2002-08-05 |
| ES2175834T3 (es) | 2002-11-16 |
| FR2772763B1 (fr) | 2004-01-23 |
| ZA9811796B (en) | 1999-06-29 |
| AU749224B2 (en) | 2002-06-20 |
| WO1999033829A1 (fr) | 1999-07-08 |
| RU2220144C2 (ru) | 2003-12-27 |
| NO316676B1 (no) | 2004-03-29 |
| ATE215951T1 (de) | 2002-04-15 |
| HUP0004628A3 (en) | 2001-11-28 |
| TW513429B (en) | 2002-12-11 |
| MY117585A (en) | 2004-07-31 |
| US20010000521A1 (en) | 2001-04-26 |
| NO20003314D0 (no) | 2000-06-23 |
| US6632946B2 (en) | 2003-10-14 |
| HUP0004628A1 (hu) | 2001-05-28 |
| EP1042323A1 (de) | 2000-10-11 |
| AR016440A1 (es) | 2001-07-04 |
| PL341288A1 (en) | 2001-04-09 |
| US6436951B1 (en) | 2002-08-20 |
| DE69804856D1 (de) | 2002-05-16 |
| CA2315897A1 (fr) | 1999-07-08 |
| EP1042323B1 (de) | 2002-04-10 |
| JP2001527075A (ja) | 2001-12-25 |
| AU1764599A (en) | 1999-07-19 |
| CA2315897C (fr) | 2010-01-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL136732A0 (en) | Camptothecin tetracyclic analogues, preparation, methods, applications as medicines and pharmaceutical compositions containing them | |
| IL112384A0 (en) | Tetracyclic derivatives, their preparation and pharmaceutical compositions containing them | |
| HUP9602122A2 (en) | Camptothecin derivatives, process for the preparation thereof and pharmaceutical compositions containing them | |
| IL134961A0 (en) | Carboxamidothiazole derivatives, preparation, pharmaceutical compositions containing them | |
| HUP0103513A3 (en) | Novel amidine derivatives their preparation and application as medicines and pharmaceutical compositions containing same | |
| HUP0200210A3 (en) | Camptothecin derivatives having antitumor activity, process for their preparation and pharmaceutical compositions containing them | |
| IL119994A0 (en) | 2-oxo- and 2-thio-1,2-dihydroquinolinyl-oxazolidinones their preparation and pharmaceutical compositions containing them | |
| PL345354A1 (en) | 2-aminopyridine erivatives, their use as medicines and pharmaceutical compositions containing them | |
| PL349448A1 (en) | Benzopyrans and benzoxepines, pharmaceutical compositions comprising them and preparation process | |
| HUP0002272A3 (en) | Aroyl-piperazine derivatives, their preparation pharmaceutical compositions containing them and their use | |
| IL131915A0 (en) | Novel-2-(iminomethyl) amino-phenyl derivatives preparation application as medicines and pharmaceutical compositions containing same | |
| HUP0100488A3 (en) | Thienopyrimidines, process for their preparation and pharmaceutical compositions containing them | |
| IL114980A0 (en) | Cyclic urea derivatives, their preparation and pharmaceutical compositions containing them | |
| HUP0201649A3 (en) | Purine derivatives, preparation method and pharmaceutical compositions containing same | |
| HUP0003577A3 (en) | Tetrahydro gamma-carbolines, process for their preparation, their use and pharmaceutical compositions containing them | |
| HK1036985A1 (en) | Artemisinin derivatives, method for the preparation thereof and pharmaceutical compositions containing the same | |
| HUP9900987A3 (en) | Camptothecin derivatives process for their preparation, use thereof as antitumor agents and pharmaceutical compositions containing them | |
| HUP0003174A3 (en) | 20(s) camptothecin glycoconjugates, process for their preparation and pharmaceutical compositions containing them | |
| EG23760A (en) | Novel pentasaccharides, processes for their preparation and pharmaceutical compositions containing them | |
| HUP9904210A3 (en) | Analogues of camptothecin,their application as medicine and pharmaceutical compositions containing them | |
| HUP0104834A3 (en) | Sulphonyloxazolamines, their use, pharmaceutical compositions containing them and their preparation | |
| IL112998A0 (en) | Taxane derivatives, their preparation and pharmaceutical compositions containing them | |
| HUP9800395A3 (en) | Sulfonamide-substituted benzoxepine derivatives, their use as medicines and pharmaceutical compositions containing them | |
| SI1215213T1 (sl) | Biciklicni derivati amino-pirazonov, postopek za njihovo pripravo in farmacevtski sestavki, ki jih vsebujejo | |
| HUP0200529A3 (en) | Optically pure camptothecin analogues, pharmaceutical compositions containing them and their use |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |