IL136046A0 - Methods for classifying proteins - Google Patents

Methods for classifying proteins

Info

Publication number
IL136046A0
IL136046A0 IL13604698A IL13604698A IL136046A0 IL 136046 A0 IL136046 A0 IL 136046A0 IL 13604698 A IL13604698 A IL 13604698A IL 13604698 A IL13604698 A IL 13604698A IL 136046 A0 IL136046 A0 IL 136046A0
Authority
IL
Israel
Prior art keywords
protein
molecules
shift
multiplicity
unfolding curve
Prior art date
Application number
IL13604698A
Other languages
English (en)
Original Assignee
Dimensional Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dimensional Pharm Inc filed Critical Dimensional Pharm Inc
Publication of IL136046A0 publication Critical patent/IL136046A0/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845Methods of identifying protein-protein interactions in protein mixtures
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00Methods of screening libraries
    • C40B30/04Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5302Apparatus specially adapted for immunological test procedures
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90Enzymes; Proenzymes
    • G01N2333/914Hydrolases (3)
    • G01N2333/948Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96433Serine endopeptidases (3.4.21)
    • G01N2333/96441Serine endopeptidases (3.4.21) with definite EC number
    • G01N2333/96444Factor X (3.4.21.6)
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2400/00Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
    • G01N2400/10Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • G01N2400/38Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence, e.g. gluco- or galactomannans, Konjac gum, Locust bean gum or Guar gum
    • G01N2400/40Glycosaminoglycans, i.e. GAG or mucopolysaccharides, e.g. chondroitin sulfate, dermatan sulfate, hyaluronic acid, heparin, heparan sulfate, and related sulfated polysaccharides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analyzing Materials Using Thermal Means (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
IL13604698A 1997-11-12 1998-11-12 Methods for classifying proteins IL136046A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6512997P 1997-11-12 1997-11-12
PCT/US1998/024035 WO1999024050A1 (en) 1997-11-12 1998-11-12 High throughput method for functionally classifying proteins identified using a genomics approach

Publications (1)

Publication Number Publication Date
IL136046A0 true IL136046A0 (en) 2001-05-20

Family

ID=22060528

Family Applications (1)

Application Number Title Priority Date Filing Date
IL13604698A IL136046A0 (en) 1997-11-12 1998-11-12 Methods for classifying proteins

Country Status (15)

Country Link
US (2) US20010003648A1 (xx)
EP (1) EP1030678B1 (xx)
JP (1) JP2002514571A (xx)
KR (2) KR20030040425A (xx)
AT (1) ATE335498T1 (xx)
AU (1) AU750501B2 (xx)
CA (1) CA2309345C (xx)
DE (1) DE69835531T2 (xx)
DK (1) DK1030678T3 (xx)
ES (1) ES2273442T3 (xx)
HU (1) HU225767B1 (xx)
IL (1) IL136046A0 (xx)
NZ (1) NZ504483A (xx)
PL (1) PL194483B1 (xx)
WO (1) WO1999024050A1 (xx)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2203832A1 (en) * 1995-09-08 1997-03-13 Jaime E. Arenas Screen for compounds with affinity for rna
HU225767B1 (en) 1997-11-12 2007-08-28 Dimensional Pharmaceuticals 3 High throughput method for functionally classifying proteins identified using a genomics approach
US6569631B1 (en) * 1998-11-12 2003-05-27 3-Dimensional Pharmaceuticals, Inc. Microplate thermal shift assay for ligand development using 5-(4″dimethylaminophenyl)-2-(4′-phenyl)oxazole derivative fluorescent dyes
US20030059811A1 (en) * 2001-06-14 2003-03-27 Hakim Djaballah Methods of screening for ligands of target molecules
AU2002325755A1 (en) * 2001-09-18 2003-04-01 Affinium Pharmaceuticals, Inc. Methods and apparatuses for purification
AU2002325030A1 (en) * 2001-09-18 2003-04-01 Energetic Geonomics Corporation A high throughput energy array
GB0125436D0 (en) 2001-10-23 2001-12-12 Deltadot Ltd Analysis of temperature-dependent molecular configurations
US20040009530A1 (en) * 2002-01-16 2004-01-15 Wilson David S. Engineered binding proteins
CA2414570A1 (en) * 2002-01-24 2003-04-03 Ecopia Biosciences Inc. Method, system, and knowledge repository for identifying a secondary metabolite from a microorganism
CA2477021A1 (en) * 2002-02-20 2003-08-28 Affinium Pharmaceuticals, Inc. Methods and apparatuses for characterizing stability of biological molecules
US20050079526A1 (en) * 2002-02-20 2005-04-14 Affinium Pharmaceuticals, Inc. Methods and apparatuses for characterizing refolding and aggregation of biological molecules
WO2003087834A2 (en) * 2002-04-08 2003-10-23 Affinium Pharmaceuticals, Inc. High throughput analysis of recombinant proteins in multi-well plates
US20040121445A1 (en) * 2002-07-31 2004-06-24 Fabien Marino Cell cultures
DE102004017039A1 (de) * 2004-04-02 2005-11-03 Rwth Aachen Verfahren und Vorrichtung zur Erfassung von Prozessparametern von Reaktionsflüssigkeiten in mehreren geschüttelten Mikroreaktoren
WO2009055050A1 (en) * 2007-10-25 2009-04-30 Canon U.S. Life Sciences, Inc High-resolution melting analysis
US8993714B2 (en) * 2007-10-26 2015-03-31 Imiplex Llc Streptavidin macromolecular adaptor and complexes thereof
US9102526B2 (en) 2008-08-12 2015-08-11 Imiplex Llc Node polypeptides for nanostructure assembly
WO2010109204A1 (en) * 2009-03-26 2010-09-30 Ucb Pharma S.A. Thermofluor method
WO2010132363A1 (en) 2009-05-11 2010-11-18 Imiplex Llc Method of protein nanostructure fabrication
GB201106548D0 (en) * 2011-04-18 2011-06-01 Evitraproteoma Ab A method for determining ligand binding to a target protein using a thermal shift assahy
US9523693B2 (en) 2011-04-18 2016-12-20 Biotarget Engagement Interest Group Ab Methods for determining ligand binding to a target protein using a thermal shift assay
CN103797367B (zh) * 2011-09-06 2016-05-25 马克斯.普朗克促进科学协会 用于分析生物大分子复合物的方法及其用途
US9568478B2 (en) 2012-01-27 2017-02-14 Life Technologies Corporation Protein melt analysis using dipyrrometheneboron difluoride compounds
EP3495428A1 (en) 2013-03-15 2019-06-12 Life Technologies Corporation Methods for dye selection for protein melt temperature determinations
GB2524519B (en) * 2014-03-25 2019-11-06 Pelago Bioscience AB Methods for identifying a biomarker indicative of a reduced drug response using a thermal shift assay
WO2016140990A1 (en) * 2015-03-01 2016-09-09 Board Of Regents, The University Of Texas System Apparatuses and methods for pathogen detection using microfluidic biochips
US11001872B2 (en) * 2015-09-22 2021-05-11 Shawn Clark Designing customized protein-specific buffer system
US11466309B2 (en) 2018-10-12 2022-10-11 The Board Of Trustees Of The University Of Arkansas Mechanically-strained oligonucleotide constructs and methods of using the same
US12117410B1 (en) * 2023-04-13 2024-10-15 ThermoCap Laboratories Inc. Concurrent thermal measurements of a plurality of samples

Family Cites Families (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4626684A (en) 1983-07-13 1986-12-02 Landa Isaac J Rapid and automatic fluorescence immunoassay analyzer for multiple micro-samples
US4580895A (en) 1983-10-28 1986-04-08 Dynatech Laboratories, Incorporated Sample-scanning photometer
US4628026A (en) 1983-11-15 1986-12-09 Dietlind Gardell Method and apparatus for automated double fluorochromization analysis in lymphocytotoxicity testing
US5096807A (en) 1985-03-06 1992-03-17 Murex Corporation Imaging immunoassay detection system with background compensation and its use
JPS61241639A (ja) 1985-04-19 1986-10-27 Hitachi Ltd 反応試料分析装置
EP0216026B1 (en) 1985-06-26 1992-01-22 Japan Tectron Instruments Corporation Automatic analysis apparatus
US4859609A (en) 1986-04-30 1989-08-22 Genentech, Inc. Novel receptors for efficient determination of ligands and their antagonists or agonists
US5260207A (en) * 1987-04-06 1993-11-09 Enzon Labs Inc. Engineering of electrostatic interactions at metal ion binding sites for the stabilization of proteins
US4880750A (en) * 1987-07-09 1989-11-14 Miragen, Inc. Individual-specific antibody identification methods
US5217869A (en) 1987-10-13 1993-06-08 Terrapin Technologies, Inc. Method to produce immunodiagnostic reagents
US4963263A (en) 1988-03-24 1990-10-16 Terrapin Technologies, Inc. Method of identity analyte-binding peptides
US5338659A (en) 1991-04-02 1994-08-16 Terrapin Technologies, Inc. Method for determining analyte concentration by cross-reactivity profiling
US5300425A (en) 1987-10-13 1994-04-05 Terrapin Technologies, Inc. Method to produce immunodiagnostic reagents
US5133866A (en) 1988-03-24 1992-07-28 Terrapin Technologies, Inc. Method to identify analyte-bending ligands
US5340474A (en) 1988-03-24 1994-08-23 Terrapin Technologies, Inc. Panels of analyte-binding ligands
US5409611A (en) 1988-03-24 1995-04-25 Terrapin Technoogies, Inc. Method to identify analyte-binding ligands
JP2656564B2 (ja) 1988-08-26 1997-09-24 株式会社日立製作所 免疫分析方法
US5325295A (en) 1989-05-04 1994-06-28 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Adaptation of microtiter plate technology to measurement of platelet aggregation
JPH06503948A (ja) 1990-08-17 1994-05-12 ボストン・ユニヴァーシティー アミロイドβ―蛋白質のプレカーサーの異常分解をひき起こすプロテアーゼ
US5506097A (en) 1990-08-24 1996-04-09 President And Fellows Of Harvard College Method for inhibiting β-protein enzymatic activity
US5200504A (en) 1990-10-02 1993-04-06 The Scripps Research Institute Metallopeptides having stabilized secondary structures
US5994056A (en) 1991-05-02 1999-11-30 Roche Molecular Systems, Inc. Homogeneous methods for nucleic acid amplification and detection
DE4123817C2 (de) 1991-07-18 1994-06-09 Berthold Lab Prof Dr Strahlungsmeßgerät, insbesondere zur Messung der Lumineszenz
WO1993014781A1 (en) 1992-01-24 1993-08-05 The Regents Of The University Of California Novel peptides and method for altering the activity of allosteric proteins
EP0592624B1 (en) 1992-03-09 2001-09-19 Accumed International Inc. Diagnostic microbiological testing apparatus and method
CA2093481A1 (en) 1992-04-30 1993-10-31 Gottlieb Schacher Processing station for carrying out fluorescence polarization measurements in an analyzer
US5255976A (en) 1992-07-10 1993-10-26 Vertex Pharmaceuticals Incorporated Temperature gradient calorimeter
US5314825A (en) 1992-07-16 1994-05-24 Schiapparelli Biosystems, Inc. Chemical analyzer
US5585275A (en) 1992-09-02 1996-12-17 Arris Pharmaceutical Corporation Pilot apparatus for peptide synthesis and screening
US5355215A (en) 1992-09-30 1994-10-11 Environmental Research Institute Of Michigan Method and apparatus for quantitative fluorescence measurements
CA2115900A1 (en) 1993-02-22 1994-08-23 Gerald W. Becker Pharmaceutical screens and antibodies
US5383023A (en) 1993-03-01 1995-01-17 Walleczek; Jan Method and apparatus for performing dual-beam dual-wavelength fluorescence spectrophotometric evaluation of a biological specimen
US5356784A (en) 1993-03-30 1994-10-18 Terrapin Technologies, Inc. Determination of concentration by affinity titration
US5585277A (en) * 1993-06-21 1996-12-17 Scriptgen Pharmaceuticals, Inc. Screening method for identifying ligands for target proteins
US5679582A (en) 1993-06-21 1997-10-21 Scriptgen Pharmaceuticals, Inc. Screening method for identifying ligands for target proteins
JP3598123B2 (ja) 1993-07-15 2004-12-08 浜松ホトニクス株式会社 核酸の変性検出装置
US5436718A (en) 1993-07-30 1995-07-25 Biolumin Corporation Mutli-functional photometer with movable linkage for routing optical fibers
CA2129787A1 (en) 1993-08-27 1995-02-28 Russell G. Higuchi Monitoring multiple amplification reactions simultaneously and analyzing same
US5525300A (en) 1993-10-20 1996-06-11 Stratagene Thermal cycler including a temperature gradient block
US5415839A (en) 1993-10-21 1995-05-16 Abbott Laboratories Apparatus and method for amplifying and detecting target nucleic acids
ATE359509T1 (de) 1994-01-06 2007-05-15 Telik Inc Ersatz für zielobjekte und verbesserten referenzplatten
US5587293A (en) 1994-01-06 1996-12-24 Terrapin Technologies, Inc. Method to identify binding partners
US5935803A (en) 1994-02-01 1999-08-10 Terrapin Technologies, Inc. Methods to identify immunomodulators using cognate interaction of PKC-theta
US5631734A (en) 1994-02-10 1997-05-20 Affymetrix, Inc. Method and apparatus for detection of fluorescently labeled materials
US5557398A (en) 1994-04-15 1996-09-17 Molecular Devices Corporation Photometric device
US5463564A (en) 1994-09-16 1995-10-31 3-Dimensional Pharmaceuticals, Inc. System and method of automatically generating chemical compounds with desired properties
US5589351A (en) 1994-12-06 1996-12-31 Nps Pharmaceuticals, Inc. Fluorescence detection apparatus
AU5132096A (en) 1995-01-30 1996-08-21 Terrapin Technologies, Inc. Glubodies - multiplicities of proteins capable of binding a variety of small molecules
CA2203832A1 (en) 1995-09-08 1997-03-13 Jaime E. Arenas Screen for compounds with affinity for rna
US5633762A (en) * 1995-10-23 1997-05-27 Motorola Dual image manifestation apparatus with integrated electro-optical package
CA2184195C (en) 1995-10-25 2002-04-16 Andrew Pakula Screening method for identifying ligands for target proteins
JP2000502440A (ja) * 1995-12-07 2000-02-29 スクリプトジェン・ファーマスーティカルズ,インコーポレイテッド リガンドを識別するための蛍光に基づくスクリーニング方法
AU741049B2 (en) 1996-05-09 2001-11-22 Life Technologies Corporation Microplate thermal shift assay and apparatus for ligand development and multi-variable protein chemistry optimization
EP1669738A3 (en) 1996-10-09 2007-12-12 Symyx Technologies, Inc. Infrared spectroscopy and imaging of libraries
JP2001514511A (ja) 1997-03-05 2001-09-11 スクリプトゲン ファーマシューティカルズ インク 核酸への親和性を持つ化合物同定のための蛍光異方性を用いたスクリーニング
HU225767B1 (en) 1997-11-12 2007-08-28 Dimensional Pharmaceuticals 3 High throughput method for functionally classifying proteins identified using a genomics approach
US6376180B1 (en) 1999-12-09 2002-04-23 Pharmacia & Upjohn Company Methods of identifying compounds that bind to target species under isothermal denaturing conditions

Also Published As

Publication number Publication date
HUP0100037A2 (hu) 2001-05-28
NZ504483A (en) 2002-11-26
KR20010032048A (ko) 2001-04-16
CA2309345A1 (en) 1999-05-20
JP2002514571A (ja) 2002-05-21
US7122321B2 (en) 2006-10-17
US20020168686A1 (en) 2002-11-14
WO1999024050A9 (en) 1999-08-12
ATE335498T1 (de) 2006-09-15
AU750501B2 (en) 2002-07-18
EP1030678A4 (en) 2002-10-09
HUP0100037A3 (en) 2003-08-28
AU1398099A (en) 1999-05-31
CA2309345C (en) 2007-01-23
WO1999024050A1 (en) 1999-05-20
DE69835531T2 (de) 2007-04-05
DE69835531D1 (de) 2006-09-21
KR20030040425A (ko) 2003-05-22
EP1030678B1 (en) 2006-08-09
HU225767B1 (en) 2007-08-28
EP1030678A1 (en) 2000-08-30
KR100406310B1 (ko) 2003-11-19
PL194483B1 (pl) 2007-06-29
PL340449A1 (en) 2001-02-12
US20010003648A1 (en) 2001-06-14
ES2273442T3 (es) 2007-05-01
DK1030678T3 (da) 2006-12-11

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