DK0973806T3 - Sted-beskyttet proteinmodificering - Google Patents
Sted-beskyttet proteinmodificeringInfo
- Publication number
- DK0973806T3 DK0973806T3 DK98911482T DK98911482T DK0973806T3 DK 0973806 T3 DK0973806 T3 DK 0973806T3 DK 98911482 T DK98911482 T DK 98911482T DK 98911482 T DK98911482 T DK 98911482T DK 0973806 T3 DK0973806 T3 DK 0973806T3
- Authority
- DK
- Denmark
- Prior art keywords
- protein
- polyethylene glycol
- site
- activity
- conjugating
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/642—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a cytokine, e.g. IL2, chemokine, growth factors or interferons being the inactive part of the conjugate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/814,305 US6548644B1 (en) | 1997-03-10 | 1997-03-10 | Site protected protein modification |
EP98911482A EP0973806B1 (en) | 1997-03-10 | 1998-03-05 | Site protected protein modification |
PCT/US1998/004301 WO1998040409A1 (en) | 1997-03-10 | 1998-03-05 | Site protected protein modification |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0973806T3 true DK0973806T3 (da) | 2005-01-31 |
Family
ID=25214667
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK98911482T DK0973806T3 (da) | 1997-03-10 | 1998-03-05 | Sted-beskyttet proteinmodificering |
Country Status (10)
Country | Link |
---|---|
US (1) | US6548644B1 (da) |
EP (1) | EP0973806B1 (da) |
JP (1) | JP3708134B2 (da) |
AT (1) | ATE277084T1 (da) |
AU (1) | AU6542598A (da) |
DE (1) | DE69826452T2 (da) |
DK (1) | DK0973806T3 (da) |
ES (1) | ES2229485T3 (da) |
PT (1) | PT973806E (da) |
WO (1) | WO1998040409A1 (da) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100353392B1 (ko) * | 2000-03-13 | 2002-09-18 | 선바이오(주) | 높은 생체 활성도를 갖는 생체 활성 단백질과 peg의결합체 제조방법 |
WO2003072714A2 (en) * | 2002-02-21 | 2003-09-04 | Wyeth | Follistatin domain containing proteins |
DE102004005710A1 (de) * | 2004-02-05 | 2006-05-04 | Siemens Ag | Biosensor und Verfahren zu dessen Betrieb |
DE102004005711A1 (de) * | 2004-02-05 | 2006-05-11 | Siemens Ag | Biosensor zur Bestimmung eines Allergenes mit Betriebsverfahren |
ES2355642T3 (es) * | 2004-07-16 | 2011-03-29 | Nektar Therapeutics | Conjugados que comprenden una porcion de gm-csf y un polimero. |
KR100754667B1 (ko) | 2005-04-08 | 2007-09-03 | 한미약품 주식회사 | 비펩타이드성 중합체로 개질된 면역글로불린 Fc 단편 및이를 포함하는 약제학적 조성물 |
US7833979B2 (en) * | 2005-04-22 | 2010-11-16 | Amgen Inc. | Toxin peptide therapeutic agents |
US8008453B2 (en) | 2005-08-12 | 2011-08-30 | Amgen Inc. | Modified Fc molecules |
US8168592B2 (en) * | 2005-10-21 | 2012-05-01 | Amgen Inc. | CGRP peptide antagonists and conjugates |
US7534595B2 (en) * | 2006-06-12 | 2009-05-19 | Biomarin Pharmaceutical Inc. | Compositions of prokaryotic phenylalanine ammonia-lyase and methods of using compositions thereof |
US7531341B1 (en) | 2006-06-12 | 2009-05-12 | Biomarin Pharmaceutical Inc. | Compositions of prokaryotic phenylalanine ammonia-lyase and methods of using compositions thereof |
PE20081140A1 (es) * | 2006-10-25 | 2008-09-22 | Amgen Inc | Agentes terapeuticos a base de peptidos derivados de toxinas |
MX2009012609A (es) | 2007-05-22 | 2009-12-07 | Amgen Inc | Composiciones y metodos para producir proteinas de fusion bioactivas. |
US7560263B2 (en) * | 2007-08-17 | 2009-07-14 | Biomarin Pharmaceutical Inc. | Compositions of prokaryotic phenylalanine ammonia-lyase and methods of treating cancer using compositions thereof |
EP2285350B1 (en) * | 2008-06-16 | 2017-11-15 | Pfizer Inc | Methods for the preparation of targeting agent functionalized diblock copolymers for use in fabrication of therapeutic nanoparticles |
WO2010014225A2 (en) | 2008-07-30 | 2010-02-04 | Biomarin Pharmaceutical Inc. | Assays for detection of phenylalanine ammonia-lyase and antibodies to phenylalanine ammonia-lyase |
ES2441941T3 (es) * | 2008-10-15 | 2014-02-07 | Baxter Healthcare Sa | Pegilación de factores de coagulación sanguínea recombinantes en presencia de anticuerpos enlazados |
US9238878B2 (en) | 2009-02-17 | 2016-01-19 | Redwood Bioscience, Inc. | Aldehyde-tagged protein-based drug carriers and methods of use |
WO2011068993A1 (en) * | 2009-12-02 | 2011-06-09 | Acceleron Pharma Inc. | Compositions and methods for increasing serum half-life of fc fusion proteins. |
WO2011097335A2 (en) | 2010-02-04 | 2011-08-11 | Biomarin Pharmaceutical Inc. | Compositions of prokaryotic phenylalanine ammonia-lyase variants and methods of using compositions thereof |
RU2606016C2 (ru) | 2011-01-14 | 2017-01-10 | Редвуд Байосайнс, Инк. | Меченые альдегидом полипептиды иммуноглобулина и способы их применения |
CN103930437A (zh) | 2011-03-16 | 2014-07-16 | 安姆根有限公司 | Nav1.3和Nav1.7的强效及选择性抑制剂 |
WO2012170938A1 (en) | 2011-06-08 | 2012-12-13 | Acceleron Pharma Inc. | Compositions and methods for increasing serum half-life |
JP6426107B2 (ja) | 2012-12-20 | 2018-11-21 | アムジエン・インコーポレーテツド | Apj受容体アゴニストおよびその使用 |
UY35397A (es) | 2013-03-12 | 2014-10-31 | Amgen Inc | INHIBIDORES POTENTES Y SELECTIVOS DE NaV1.7 |
JP6803236B2 (ja) | 2014-06-10 | 2020-12-23 | アムジェン インコーポレイテッド | アペリンポリペプチド |
CA3019398A1 (en) | 2016-04-26 | 2017-11-02 | R.P. Scherer Technologies, Llc | Antibody conjugates and methods of making and using the same |
CN111378026A (zh) * | 2018-12-27 | 2020-07-07 | 天津键凯科技有限公司 | 一种制备结合位点可控的peg化生物分子的方法 |
US20230102464A1 (en) * | 2020-01-15 | 2023-03-30 | Jenkem Technology Co., Ltd. (Tianjin) | Method for preparing pegylated biomolecule with controllable binding sites |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4179337A (en) * | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
US5235028A (en) * | 1990-08-31 | 1993-08-10 | University Of Minnesota | Polyethylene glycol derivatives for solid-phase applications |
US6565841B1 (en) * | 1991-03-15 | 2003-05-20 | Amgen, Inc. | Pulmonary administration of granulocyte colony stimulating factor |
IT1260468B (it) * | 1992-01-29 | 1996-04-09 | Metodo per mantenere l'attivita' di enzimi proteolitici modificati con polietilenglicole | |
GB9225448D0 (en) * | 1992-12-04 | 1993-01-27 | Erba Carlo Spa | Improved synthesis of polymer bioactive conjugates |
AU3830895A (en) * | 1994-10-07 | 1996-05-02 | Amgen Boulder Inc. | Dimeric il-4 inhibitors |
-
1997
- 1997-03-10 US US08/814,305 patent/US6548644B1/en not_active Expired - Lifetime
-
1998
- 1998-03-05 DK DK98911482T patent/DK0973806T3/da active
- 1998-03-05 DE DE69826452T patent/DE69826452T2/de not_active Expired - Lifetime
- 1998-03-05 JP JP53962998A patent/JP3708134B2/ja not_active Expired - Fee Related
- 1998-03-05 WO PCT/US1998/004301 patent/WO1998040409A1/en active IP Right Grant
- 1998-03-05 AT AT98911482T patent/ATE277084T1/de active
- 1998-03-05 PT PT98911482T patent/PT973806E/pt unknown
- 1998-03-05 ES ES98911482T patent/ES2229485T3/es not_active Expired - Lifetime
- 1998-03-05 EP EP98911482A patent/EP0973806B1/en not_active Expired - Lifetime
- 1998-03-05 AU AU65425/98A patent/AU6542598A/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP0973806B1 (en) | 2004-09-22 |
EP0973806A1 (en) | 2000-01-26 |
AU6542598A (en) | 1998-09-29 |
PT973806E (pt) | 2005-01-31 |
US6548644B1 (en) | 2003-04-15 |
ATE277084T1 (de) | 2004-10-15 |
ES2229485T3 (es) | 2005-04-16 |
JP3708134B2 (ja) | 2005-10-19 |
DE69826452D1 (de) | 2004-10-28 |
WO1998040409A1 (en) | 1998-09-17 |
DE69826452T2 (de) | 2006-02-16 |
JP2001506670A (ja) | 2001-05-22 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK0973806T3 (da) | Sted-beskyttet proteinmodificering | |
WO1999067291A3 (en) | Site specific protein modification by mutagenesis | |
AU9174398A (en) | Peptides | |
NO20020641D0 (no) | Multiple cytokin-antistoff komplekser | |
DE614989T1 (de) | Verfahren für in vivo Selektion von Ligandenbindende Proteine. | |
DK1088084T3 (da) | Erythropoietin analog-humant serumalbumin fusionsprotein | |
TR200102703T2 (tr) | Katı nesnelerin hat üzerinde üretimi. | |
DK0973819T3 (da) | Ikke-antigene forgrenede polymerkonjugater | |
TR199600357A2 (tr) | Rekombinant simanlik (Ob) proteinleri. | |
ATE476192T1 (de) | Ligandenbindungsstelle von rage und deren verwendungen | |
ATE513056T1 (de) | Stabilisierte proteine | |
DE69840150D1 (de) | Verfahren, basierend auf affinitätskreuzbindung, der interaktion von biologisch aktiven peptiden an antikörper | |
TR199802394A3 (tr) | Proteinleri stabilize etmek için gelistirilmis proses. | |
IT1282762B1 (it) | Telaio per veicoli cingolati, in particolare per veicoli con cingoli o nastri di materiale elastico. | |
DE69731463D1 (de) | Rekombinante ribonuklease proteine | |
DK0754229T3 (da) | Afamin: et humant serum albumin-lignende protein | |
DE69619257T2 (de) | Die konjugation von liganden an immobilisierte proteine in einem organischen lösungsmittel | |
DE69634077D1 (de) | Haemophilus adhäsionsproteinen | |
IL187595A0 (en) | Antitumor antibodies, proteins, and uses thereof | |
WO2000018909A3 (en) | NUCLEIC ACIDS AND PROTEINS FROM $i(CENARCHAEUM SYMBIOSUM) | |
DK0782456T3 (da) | Konjugat bestående af et virksomt materiale og et nativt, ikke-kropsfremmed protein | |
DE68911599T2 (de) | GTP bindendes Protein und Verfahren zu dessen Herstellung. | |
ES1010588U (es) | Fijador de parasoles para automoviles. | |
DE3888078D1 (de) | Veränderungsverfahren für Peptide und Proteine. |