IL134702A - High density arrays and methods of making the same - Google Patents
High density arrays and methods of making the sameInfo
- Publication number
- IL134702A IL134702A IL13470298A IL13470298A IL134702A IL 134702 A IL134702 A IL 134702A IL 13470298 A IL13470298 A IL 13470298A IL 13470298 A IL13470298 A IL 13470298A IL 134702 A IL134702 A IL 134702A
- Authority
- IL
- Israel
- Prior art keywords
- target
- high density
- target substance
- bundle
- target substances
- Prior art date
Links
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Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL15142198A IL151421A (en) | 1997-09-11 | 1998-05-19 | High density arrays and methods of making the same |
| IL15142298A IL151422A (en) | 1997-09-11 | 1998-05-19 | Methods of making high density arrays and high density arrays produced thereby |
| IL15142098A IL151420A (en) | 1997-09-11 | 1998-05-19 | High density arrays and method of making the same |
| IL15142398A IL151423A (en) | 1997-09-11 | 1998-05-19 | Methods of making high density arrays and high density arrays produced thereby |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US92797497A | 1997-09-11 | 1997-09-11 | |
| PCT/US1998/010243 WO1999013313A1 (en) | 1997-09-11 | 1998-05-19 | Method of making high density arrays |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL134702A0 IL134702A0 (en) | 2001-04-30 |
| IL134702A true IL134702A (en) | 2004-03-28 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL13470298A IL134702A (en) | 1997-09-11 | 1998-05-19 | High density arrays and methods of making the same |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US20010019827A1 (de) |
| EP (3) | EP1207383B1 (de) |
| JP (2) | JP2001515735A (de) |
| CN (5) | CN1677076A (de) |
| AT (3) | ATE272833T1 (de) |
| AU (1) | AU733589B2 (de) |
| CA (1) | CA2301539C (de) |
| DE (3) | DE69833698T2 (de) |
| DK (1) | DK1012564T3 (de) |
| ES (3) | ES2190591T3 (de) |
| IL (1) | IL134702A (de) |
| PT (1) | PT1012564E (de) |
| WO (1) | WO1999013313A1 (de) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020155495A1 (en) * | 2000-04-17 | 2002-10-24 | Millstein Larry S. | Method for producing arrays and devices relating thereto |
| CA2318984C (en) * | 1998-02-25 | 2009-04-28 | The United States Of America As Represented By The Secretary Department Of Health And Human Services | Tumor tissue microarrays for rapid molecular profiling |
| JP3562968B2 (ja) | 1998-08-14 | 2004-09-08 | 富士写真フイルム株式会社 | 試験片、その製造方法および装置並びにその読取方法および装置 |
| JP3445501B2 (ja) | 1998-09-04 | 2003-09-08 | 日立ソフトウエアエンジニアリング株式会社 | シート状部材積層体及びシート状プローブ保持体の製造方法 |
| EP1595948A3 (de) | 1999-03-05 | 2006-03-01 | Mitsubishi Rayon Co., Ltd. | Träger mit einer biologischen Substanz |
| US6713309B1 (en) * | 1999-07-30 | 2004-03-30 | Large Scale Proteomics Corporation | Microarrays and their manufacture |
| WO2001026799A1 (en) * | 1999-10-08 | 2001-04-19 | Bio-Informatics Group, Inc. | Biochip defining a channeled capillary array and associated methods |
| US6406840B1 (en) * | 1999-12-17 | 2002-06-18 | Biomosaic Systems, Inc. | Cell arrays and the uses thereof |
| DE10001136C2 (de) * | 2000-01-13 | 2003-09-04 | Michael Mengel | Verfahren zur Herstellung von Materialblöcken mit multiplen Untersuchungsproben |
| WO2001053831A1 (en) * | 2000-01-17 | 2001-07-26 | Unitec Co., Ltd. | Integrated support, integrated micro-container and permeable membrane, and method for production thereof and use thereof |
| AU2001274571B2 (en) * | 2000-06-20 | 2007-02-08 | Mitsubishi Chemical Corporation | Micro-array of organism-associated substance |
| DE10034570A1 (de) * | 2000-07-14 | 2002-01-31 | Max Delbrueck Centrum | Verfahren zur Herstellung von Mikroarray-Chips mit Nukleinsäuren, Proteinen oder anderen Testsubstanzen |
| DE10042871A1 (de) * | 2000-08-31 | 2002-05-16 | Hte Ag The High Throughput Exp | Dreidimensionale Materialbibliothek und Verfahren zur Herstellung einer dreidimensionalen Materialbibliothek |
| JP2004537712A (ja) | 2000-10-18 | 2004-12-16 | バーチャル・アレイズ・インコーポレーテッド | 多重細胞分析システム |
| US6905816B2 (en) | 2000-11-27 | 2005-06-14 | Intelligent Medical Devices, Inc. | Clinically intelligent diagnostic devices and methods |
| DE10110511C1 (de) * | 2001-02-28 | 2002-10-10 | Attomol Gmbh Molekulare Diagno | Verfahren zur Herstellung eines Arrays zur Detektion von Komponenten aus einer biologischen Probe |
| DE10117135A1 (de) * | 2001-04-05 | 2002-10-17 | Biotechnolog Forschung Gmbh | Verfahren zur Herstellung einer Vielzahl identischer Kopien einer planaren Testanordnung von Sondenmolekülen |
| US20030148380A1 (en) | 2001-06-05 | 2003-08-07 | Belcher Angela M. | Molecular recognition of materials |
| US20030113714A1 (en) * | 2001-09-28 | 2003-06-19 | Belcher Angela M. | Biological control of nanoparticles |
| GB0124338D0 (en) | 2001-10-10 | 2001-11-28 | Randox Lab Ltd | Biochips |
| US7439346B2 (en) | 2001-10-12 | 2008-10-21 | Perkinelmer Las Inc. | Nucleic acids arrays and methods of use therefor |
| CA2463725A1 (en) | 2001-10-12 | 2003-11-06 | Spectral Genomics, Inc. | Compilations of nucleic acids and arrays and methods of using them |
| AU2002368207A1 (en) * | 2001-10-18 | 2004-05-04 | Virtual Arrays, Inc. | Coded particles for multiplexed analysis of biological samples |
| US6924107B2 (en) | 2002-01-28 | 2005-08-02 | Bio-Informatics Group, Inc. | Four dimensional biochip design for high throughput applications and methods of using the four dimensional biochip |
| DE10208952B4 (de) * | 2002-02-28 | 2004-04-08 | Bayer Ag | Screeningverfahren zur Herstellung und Charakterisierung von Polyurethan-Schaumstoffen |
| AU2003243157C1 (en) | 2002-04-19 | 2008-09-04 | Verenium Corporation | Phospholipases, nucleic acids encoding them and methods for making and using them |
| US7226771B2 (en) | 2002-04-19 | 2007-06-05 | Diversa Corporation | Phospholipases, nucleic acids encoding them and methods for making and using them |
| AU2003272548A1 (en) * | 2002-09-16 | 2004-04-30 | Plexxikon, Inc. | Crystal structure of pim-1 kinase |
| US20050064508A1 (en) | 2003-09-22 | 2005-03-24 | Semzyme | Peptide mediated synthesis of metallic and magnetic materials |
| WO2004078923A2 (en) * | 2003-02-28 | 2004-09-16 | Plexxikon, Inc. | Pyk2 crystal structure and uses |
| DK2194133T3 (en) | 2003-03-06 | 2016-02-29 | Basf Enzymes Llc | Amylases, nucleic acids encoding them, and methods of making and using the same |
| EP2853593B1 (de) | 2003-03-07 | 2017-10-04 | DSM IP Assets B.V. | Hydrolasen, Nucleinsäuren zur Codierung davon sowie Verfahren zur Herstellung und Verwendung davon |
| US7592434B2 (en) | 2003-04-04 | 2009-09-22 | Verenium Corporation | Pectate lyases, nucleic encoding them and methods for making and using them |
| DE10316689A1 (de) * | 2003-04-10 | 2004-10-28 | Dimitrij Dr. Plachov | Dreidimensionaler Chip |
| CN103484486B (zh) | 2003-07-02 | 2018-04-24 | 维莱尼姆公司 | 葡聚糖酶,编码它们的核酸以及制备和使用它们的方法 |
| US20050079548A1 (en) * | 2003-07-07 | 2005-04-14 | Plexxikon, Inc. | Ligand development using PDE4B crystal structures |
| EP1668113B1 (de) | 2003-08-11 | 2013-06-19 | Verenium Corporation | Laccasen, diese codierende nukleinsäuren und verfahren zur herstellung und verwendung davon |
| US20050164300A1 (en) * | 2003-09-15 | 2005-07-28 | Plexxikon, Inc. | Molecular scaffolds for kinase ligand development |
| US7488451B2 (en) | 2003-09-15 | 2009-02-10 | Millipore Corporation | Systems for particle manipulation |
| GB2408331A (en) * | 2003-11-24 | 2005-05-25 | Asahi Chemical Ind | Arrays for screening polymeric materials |
| US20070066641A1 (en) * | 2003-12-19 | 2007-03-22 | Prabha Ibrahim | Compounds and methods for development of RET modulators |
| CA2550361C (en) | 2003-12-19 | 2014-04-29 | Prabha Ibrahim | Compounds and methods for development of ret modulators |
| US8168142B2 (en) | 2004-04-20 | 2012-05-01 | Universal Bio Research Co., Ltd. | Cassette for stacking specimen, spotting device, and specimen stacking device |
| WO2006078287A2 (en) | 2004-05-06 | 2006-07-27 | Plexxikon, Inc. | Pde4b inhibitors and uses therefor |
| EP1766061B1 (de) * | 2004-05-20 | 2013-07-17 | Quest Diagnostics Investments Incorporated | Vergleichende einfachmarkierung-hybridisierung |
| CN101432292B (zh) | 2004-06-16 | 2013-03-13 | 维莱尼姆公司 | 对叶绿素进行酶促脱色的组合物和方法 |
| CA2570817A1 (en) * | 2004-06-17 | 2006-01-26 | Plexxikon, Inc. | Azaindoles modulating c-kit activity and uses therefor |
| US7498342B2 (en) * | 2004-06-17 | 2009-03-03 | Plexxikon, Inc. | Compounds modulating c-kit activity |
| DE102004031167A1 (de) * | 2004-06-28 | 2006-01-12 | Infineon Technologies Ag | Verfahren zur Herstellung von Biochips aus porösen Substraten |
| US7605168B2 (en) * | 2004-09-03 | 2009-10-20 | Plexxikon, Inc. | PDE4B inhibitors |
| EP1846760B1 (de) * | 2005-01-27 | 2010-12-15 | Quest Diagnostics Investments Incorporated | Schnelle komparative genomhybridisierung |
| EP2886658A1 (de) | 2005-03-10 | 2015-06-24 | BASF Enzymes LLC | Lyaseenzyme, Nukleinsäuren zur Codierung davon und Verfahren zur Herstellung und Verwendung davon |
| MX300732B (es) | 2005-03-15 | 2012-06-28 | Verenium Corp | Celulasas, acidos nucleicos que las codifican y metodos para hacerlas y usarlas. |
| AU2006272951A1 (en) * | 2005-05-17 | 2007-02-01 | Plexxikon, Inc. | Pyrrol (2,3-b) pyridine derivatives protein kinase inhibitors |
| CN102206216B (zh) * | 2005-06-22 | 2014-11-12 | 普莱希科公司 | 作为蛋白质激酶抑制剂的吡咯并[2,3-b]吡啶衍生物 |
| US8076074B2 (en) | 2005-11-29 | 2011-12-13 | Quest Diagnostics Investments Incorporated | Balanced translocation in comparative hybridization |
| US20090324574A1 (en) | 2006-02-02 | 2009-12-31 | Verenium Corporation | Esterases and Related Nucleic Acids and Methods |
| WO2007094852A2 (en) | 2006-02-10 | 2007-08-23 | Verenium Corporation | Cellulolytic enzymes, nucleic acids encoding them and methods for making and using them |
| EP2548955A1 (de) | 2006-02-14 | 2013-01-23 | Verenium Corporation | Xylanasen, Nukleinsäuren, die diese codieren, und Verfahren zu deren Herstellung und Verwendung |
| MX2008011477A (es) | 2006-03-07 | 2008-09-23 | Cargill Inc | Aldolasas, acidos nucleicos que las codifican y metodos para hacerlas y usarlas. |
| BRPI0708614A2 (pt) | 2006-03-07 | 2011-06-07 | Verenium Corp | aldolases, ácidos nucléicos codificando as mesmas e métodos para produzir e usar as mesmas |
| US20070232556A1 (en) * | 2006-03-31 | 2007-10-04 | Montine Thomas J | Methods and compositions for the treatment of neurological diseases and disorders |
| WO2007140294A2 (en) * | 2006-05-30 | 2007-12-06 | Pall Corporation | Analysis device |
| JPWO2007145228A1 (ja) * | 2006-06-13 | 2009-11-05 | 独立行政法人産業技術総合研究所 | マイクロアレイの作製方法 |
| BRPI0714876B1 (pt) | 2006-08-04 | 2022-04-19 | Verenium Corporation | Ácido nucleico isolado, sintético ou recombinante, cassete de expressão, vetor ou veículo de clonagem, célula bacteriana, fúngica ou de levedura transformada, polipeptídeo isolado, sintético ou recombinante, composição, bem como métodos de produção e de usos dos mesmos |
| AR062947A1 (es) | 2006-09-21 | 2008-12-17 | Verenium Corp | Fosfolipasas acidos nucleicos que las codifican y metodos para prepararlas y usarlas |
| JP5307013B2 (ja) | 2006-09-21 | 2013-10-02 | ヴェレニウム コーポレイション | フィターゼ、フィターゼをコードする核酸、並びにフィターゼを製造および使用する方法 |
| US8618248B2 (en) | 2006-10-31 | 2013-12-31 | President And Fellows Of Harvard College | Phosphopeptide compositions and anti-phosphopeptide antibody compositions and methods of detecting phosphorylated peptides |
| WO2008063888A2 (en) | 2006-11-22 | 2008-05-29 | Plexxikon, Inc. | Compounds modulating c-fms and/or c-kit activity and uses therefor |
| WO2008079909A1 (en) * | 2006-12-21 | 2008-07-03 | Plexxikon, Inc. | Pyrrolo [2,3-b] pyridines as kinase modulators |
| AU2007336811A1 (en) | 2006-12-21 | 2008-07-03 | Plexxikon, Inc. | Compounds and methods for kinase modulation, and indications therefor |
| PE20081581A1 (es) * | 2006-12-21 | 2008-11-12 | Plexxikon Inc | COMPUESTOS PIRROLO[2,3-b]PIRIDINAS COMO MODULADORES DE QUINASA |
| PL2069490T5 (pl) | 2006-12-21 | 2018-09-28 | Basf Enzymes Llc | Amylazy i glukoamylazy, kwasy nukleinowe kodujące te związki oraz sposoby wytwarzania tych związków oraz stosowania ich |
| NZ578309A (en) | 2007-01-30 | 2012-06-29 | Verenium Corp | Enzymes for the treatment of lignocellulosics, nucleic acids encoding them and methods for making and using them |
| US20100087333A1 (en) * | 2007-03-07 | 2010-04-08 | National University Corporation University Of Toyama | Process of fabricating tissue array block, process of fabricating tissue array sheet, tissue array block, tissue array chip, system of fabricating tissue array block and system of fabricating tissue array sheet |
| AU2008245611B2 (en) | 2007-04-27 | 2014-09-18 | University Of California | Plant CO2 sensors, nucleic acids encoding them, and methods for making and using them |
| JP2010533729A (ja) | 2007-07-17 | 2010-10-28 | プレキシコン,インコーポレーテッド | キナーゼ調節のための化合物と方法、及びそのための適応 |
| US7507539B2 (en) * | 2007-07-30 | 2009-03-24 | Quest Diagnostics Investments Incorporated | Substractive single label comparative hybridization |
| WO2009045627A2 (en) | 2007-10-03 | 2009-04-09 | Verenium Corporation | Xylanases, nucleic acids encoding them and methods for making and using them |
| CA2710683A1 (en) | 2008-01-03 | 2009-07-16 | Verenium Corporation | Transferases and oxidoreductases, nucleic acids encoding them and methods for making and using them |
| US8153391B2 (en) | 2008-08-29 | 2012-04-10 | Bunge Oils, Inc. | Hydrolases, nucleic acids encoding them and methods for making and using them |
| US8357503B2 (en) | 2008-08-29 | 2013-01-22 | Bunge Oils, Inc. | Hydrolases, nucleic acids encoding them and methods for making and using them |
| US8198062B2 (en) | 2008-08-29 | 2012-06-12 | Dsm Ip Assets B.V. | Hydrolases, nucleic acids encoding them and methods for making and using them |
| JP4793707B2 (ja) * | 2008-09-03 | 2011-10-12 | 国立大学法人富山大学 | 組織片成形装置及び組織片成形方法 |
| CN102639552B (zh) * | 2008-09-05 | 2016-05-25 | 高端学术皇家研究会/麦吉尔大学 | 含有O-缩醛乙酰丙酸酯基团(O-acetal levulinyl ester)的RNA单体及其在RNA微阵列中的应用 |
| US9464284B2 (en) * | 2009-03-09 | 2016-10-11 | Bioatla, Llc | Mirac proteins |
| KR101739994B1 (ko) | 2009-04-03 | 2017-05-25 | 에프. 호프만-라 로슈 아게 | 프로판-1-술폰산 {3-[5-(4-클로로-페닐)-1H-피롤로[2,3-b]피리딘-3-카르보닐]-2,4-디플루오로-페닐}-아미드 조성물 및 그의 용도 |
| WO2010135588A2 (en) | 2009-05-21 | 2010-11-25 | Verenium Corporation | Phytases, nucleic acids encoding them and methods for making and using them |
| US8329724B2 (en) | 2009-08-03 | 2012-12-11 | Hoffmann-La Roche Inc. | Process for the manufacture of pharmaceutically active compounds |
| CN102630250A (zh) * | 2009-09-25 | 2012-08-08 | 基因诊断测试公司 | 用于检测与癌症和其他疾病相关的染色体异常的多重(+/-)链阵列和测试 |
| UA111708C2 (uk) | 2009-10-16 | 2016-06-10 | Бандж Ойлз, Інк. | Спосіб рафінування олії |
| UA109884C2 (uk) | 2009-10-16 | 2015-10-26 | Поліпептид, що має активність ферменту фосфатидилінозитол-специфічної фосфоліпази с, нуклеїнова кислота, що його кодує, та спосіб його виробництва і застосування | |
| NZ599866A (en) | 2009-11-06 | 2014-09-26 | Plexxikon Inc | Compounds and methods for kinase modulation, and indications therefor |
| JP5761732B2 (ja) * | 2010-07-29 | 2015-08-12 | サクラ精機株式会社 | 組織アレイの組織片形成方法及び組織アレイの組織片形成装置 |
| WO2012051055A2 (en) | 2010-10-06 | 2012-04-19 | Bp Corporation North America Inc. | Variant cbh i polypeptides |
| KR101911972B1 (ko) | 2011-02-07 | 2018-10-25 | 플렉시콘 인코퍼레이티드 | 키나제 조절을 위한 화합물 및 방법, 및 그에 대한 적응증 |
| TWI558702B (zh) | 2011-02-21 | 2016-11-21 | 普雷辛肯公司 | 醫藥活性物質的固態形式 |
| JP5660468B2 (ja) * | 2011-03-15 | 2015-01-28 | 三菱レイヨン株式会社 | 生体関連物質検出用ゲルマイクロアレイの製造方法 |
| US9150570B2 (en) | 2012-05-31 | 2015-10-06 | Plexxikon Inc. | Synthesis of heterocyclic compounds |
| US9267171B2 (en) | 2013-02-28 | 2016-02-23 | New York University | DNA photolithography with cinnamate crosslinkers |
| US20160097771A1 (en) | 2013-05-21 | 2016-04-07 | NX Pharmagen | Use of tenascin-c as an extracellular marker of tumor-derived microparticles |
| CA2947605A1 (en) | 2014-05-13 | 2015-11-19 | Bioatla, Llc | Conditionally active biological proteins |
| WO2016033331A1 (en) | 2014-08-28 | 2016-03-03 | Bioatla, Llc | Conditionally active chimeric antigen receptors for modified t-cells |
| US11111288B2 (en) | 2014-08-28 | 2021-09-07 | Bioatla, Inc. | Conditionally active chimeric antigen receptors for modified t-cells |
| WO2016036916A1 (en) | 2014-09-03 | 2016-03-10 | Bioatla, Llc | Discovering and producing conditionally active biologic proteins in the same eukaryotic cell production hosts |
| EP2995703B1 (de) | 2014-09-09 | 2019-08-28 | Christian-Albrechts-Universität zu Kiel | Verfahren zur Herstellung von Flächenableitelektroden und Halbzeug zur Durchführung des Verfahrens |
| AU2016222830B2 (en) | 2015-02-24 | 2021-02-25 | Bioatla Llc | Conditionally active biological proteins |
| JP6367741B2 (ja) * | 2015-03-12 | 2018-08-01 | 学校法人北里研究所 | 生体組織標本アレイ切片、生体組織標本アレイ、シート状生体組織標本アレイ、生体組織標本ブロック及びそれらの製造方法 |
| US10829484B2 (en) | 2015-07-28 | 2020-11-10 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
| RU2018123825A (ru) | 2015-12-07 | 2020-01-15 | Плексксикон Инк. | Соединения и способы для модуляции киназ, и показания для этого |
| CN116751298A (zh) | 2016-05-13 | 2023-09-15 | 生物蛋白有限公司 | 抗ror2抗体、抗体片段和它们的免疫缀合物以及其用途 |
| TW201815766A (zh) | 2016-09-22 | 2018-05-01 | 美商普雷辛肯公司 | 用於ido及tdo調節之化合物及方法以及其適應症 |
| KR20180061979A (ko) * | 2016-11-30 | 2018-06-08 | 한국전자통신연구원 | 표적물질 검출용 키트 및 이를 이용한 검출방법 |
| US10703757B2 (en) | 2016-12-23 | 2020-07-07 | Plexxikon Inc. | Compounds and methods for CDK8 modulation and indications therefor |
| US10428067B2 (en) | 2017-06-07 | 2019-10-01 | Plexxikon Inc. | Compounds and methods for kinase modulation |
| CN110898672A (zh) * | 2019-10-22 | 2020-03-24 | 浙江省北大信息技术高等研究院 | 多孔薄膜、多孔薄膜的制作方法及电渗微泵装置 |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4084308A (en) * | 1976-11-22 | 1978-04-18 | Bell Telephone Laboratories, Incorporated | Slicing method in fiber end preparation |
| US4271139A (en) * | 1978-03-27 | 1981-06-02 | Hiram Hart | Scintillation proximity assay |
| US4382074A (en) * | 1978-03-27 | 1983-05-03 | Hiram Hart | Scintillation proximity assay |
| US4568649A (en) * | 1983-02-22 | 1986-02-04 | Immunex Corporation | Immediate ligand detection assay |
| US4673657A (en) * | 1983-08-26 | 1987-06-16 | The Regents Of The University Of California | Multiple assay card and system |
| US4689310A (en) * | 1984-09-21 | 1987-08-25 | Ortho Diagnostic Systems Inc. | Methods for attaching ligands or anti-ligands to a solid phase |
| US4948442A (en) * | 1985-06-18 | 1990-08-14 | Polyfiltronics, Inc. | Method of making a multiwell test plate |
| US4820504A (en) * | 1986-02-12 | 1989-04-11 | City Of Hope | Multi-specimen tissue blocks and slides |
| US5192507A (en) * | 1987-06-05 | 1993-03-09 | Arthur D. Little, Inc. | Receptor-based biosensors |
| US5001048A (en) * | 1987-06-05 | 1991-03-19 | Aurthur D. Little, Inc. | Electrical biosensor containing a biological receptor immobilized and stabilized in a protein film |
| US4914022A (en) * | 1987-10-21 | 1990-04-03 | Amc Cancer Research Center | Method for preparing multiple tissue samples for microscopic investigation and testing |
| US5002377A (en) * | 1988-07-07 | 1991-03-26 | City Of Hope | Multi-specimen slides for immunohistologic procedures |
| GB8822228D0 (en) * | 1988-09-21 | 1988-10-26 | Southern E M | Support-bound oligonucleotides |
| FI82144C (fi) * | 1989-03-22 | 1991-01-10 | Wallac Oy | Foerfarande foer samtidig bestaemning av flera ligander. |
| US5527681A (en) * | 1989-06-07 | 1996-06-18 | Affymax Technologies N.V. | Immobilized molecular synthesis of systematically substituted compounds |
| US5143854A (en) * | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
| US5474796A (en) * | 1991-09-04 | 1995-12-12 | Protogene Laboratories, Inc. | Method and apparatus for conducting an array of chemical reactions on a support surface |
| US5605662A (en) * | 1993-11-01 | 1997-02-25 | Nanogen, Inc. | Active programmable electronic devices for molecular biological analysis and diagnostics |
| US5326691A (en) * | 1991-11-21 | 1994-07-05 | John Hozier | Micro-libraries and methods of making and manipulating them methods for generating and analyzing micro-libraries |
| US5384261A (en) * | 1991-11-22 | 1995-01-24 | Affymax Technologies N.V. | Very large scale immobilized polymer synthesis using mechanically directed flow paths |
| DE69233501T2 (de) * | 1991-11-22 | 2006-02-23 | Affymetrix, Inc. (n.d.Ges.d.Staates Delaware), Santa Clara | Kombinatorische Strategien für die Polymersynthese |
| US5541061A (en) * | 1992-04-29 | 1996-07-30 | Affymax Technologies N.V. | Methods for screening factorial chemical libraries |
| ES2176588T3 (es) * | 1993-02-03 | 2002-12-01 | Histaggen Inc | Procedimiento para almacenar un ligando dentro de un medio contencion liberable y procedimiento para liberar un ligando del mismo. |
| US5429807A (en) * | 1993-10-28 | 1995-07-04 | Beckman Instruments, Inc. | Method and apparatus for creating biopolymer arrays on a solid support surface |
| US5985356A (en) * | 1994-10-18 | 1999-11-16 | The Regents Of The University Of California | Combinatorial synthesis of novel materials |
| US5556752A (en) * | 1994-10-24 | 1996-09-17 | Affymetrix, Inc. | Surface-bound, unimolecular, double-stranded DNA |
| US5585069A (en) * | 1994-11-10 | 1996-12-17 | David Sarnoff Research Center, Inc. | Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis |
| SE9404166D0 (sv) * | 1994-11-30 | 1994-11-30 | Pharmacia Biotech Ab | Multifunctional surfaces |
| US5688696A (en) * | 1994-12-12 | 1997-11-18 | Selectide Corporation | Combinatorial libraries having a predetermined frequency of each species of test compound |
| US5787572A (en) * | 1995-02-14 | 1998-08-04 | Schott Fibre Optics (Uk) Limited | Apparatus for terminating a fibre optic bundle |
| US5690894A (en) * | 1995-05-23 | 1997-11-25 | The Regents Of The University Of California | High density array fabrication and readout method for a fiber optic biosensor |
| US6037186A (en) * | 1997-07-16 | 2000-03-14 | Stimpson; Don | Parallel production of high density arrays |
| US6521485B2 (en) * | 2001-01-17 | 2003-02-18 | Walsin Advanced Electronics Ltd | Method for manufacturing wafer level chip size package |
-
1998
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2002
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