IL134418A - A medical system containing scopolamine for administration through the skin - Google Patents
A medical system containing scopolamine for administration through the skinInfo
- Publication number
- IL134418A IL134418A IL13441898A IL13441898A IL134418A IL 134418 A IL134418 A IL 134418A IL 13441898 A IL13441898 A IL 13441898A IL 13441898 A IL13441898 A IL 13441898A IL 134418 A IL134418 A IL 134418A
- Authority
- IL
- Israel
- Prior art keywords
- active substance
- transdermal therapeutic
- therapeutic system
- layer
- scopolamine
- Prior art date
Links
- 229930000680 A04AD01 - Scopolamine Natural products 0.000 title claims abstract description 28
- STECJAGHUSJQJN-GAUPFVANSA-N Hyoscine Natural products C1([C@H](CO)C(=O)OC2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-GAUPFVANSA-N 0.000 title claims abstract description 28
- STECJAGHUSJQJN-UHFFFAOYSA-N N-Methyl-scopolamin Natural products C1C(C2C3O2)N(C)C3CC1OC(=O)C(CO)C1=CC=CC=C1 STECJAGHUSJQJN-UHFFFAOYSA-N 0.000 title claims abstract description 28
- 229960002646 scopolamine Drugs 0.000 title claims abstract description 28
- STECJAGHUSJQJN-FWXGHANASA-N scopolamine Chemical compound C1([C@@H](CO)C(=O)O[C@H]2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-FWXGHANASA-N 0.000 title claims abstract description 27
- 230000001225 therapeutic effect Effects 0.000 title claims abstract description 17
- 239000013543 active substance Substances 0.000 claims abstract description 37
- 239000010410 layer Substances 0.000 claims abstract description 31
- 239000012528 membrane Substances 0.000 claims abstract description 13
- 239000004820 Pressure-sensitive adhesive Substances 0.000 claims abstract description 8
- 239000000853 adhesive Substances 0.000 claims abstract description 7
- 229920005601 base polymer Polymers 0.000 claims abstract description 5
- 230000001681 protective effect Effects 0.000 claims abstract description 4
- 229920005573 silicon-containing polymer Polymers 0.000 claims abstract description 3
- 239000013464 silicone adhesive Substances 0.000 claims description 16
- 238000004519 manufacturing process Methods 0.000 claims description 10
- 239000002904 solvent Substances 0.000 claims description 8
- 239000000126 substance Substances 0.000 claims description 6
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 claims description 4
- 238000000576 coating method Methods 0.000 claims description 4
- ALSTYHKOOCGGFT-KTKRTIGZSA-N (9Z)-octadecen-1-ol Chemical group CCCCCCCC\C=C/CCCCCCCCO ALSTYHKOOCGGFT-KTKRTIGZSA-N 0.000 claims description 3
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims description 3
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims description 3
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims description 3
- 239000005642 Oleic acid Substances 0.000 claims description 3
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims description 3
- 239000011248 coating agent Substances 0.000 claims description 3
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 3
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid group Chemical group C(CCCCCCC\C=C/CCCCCCCC)(=O)O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims description 3
- 229940055577 oleyl alcohol Drugs 0.000 claims description 3
- XMLQWXUVTXCDDL-UHFFFAOYSA-N oleyl alcohol Natural products CCCCCCC=CCCCCCCCCCCO XMLQWXUVTXCDDL-UHFFFAOYSA-N 0.000 claims description 3
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 2
- 239000000194 fatty acid Substances 0.000 claims description 2
- 229930195729 fatty acid Natural products 0.000 claims description 2
- 150000004665 fatty acids Chemical class 0.000 claims description 2
- 150000002191 fatty alcohols Chemical class 0.000 claims description 2
- 238000002844 melting Methods 0.000 claims description 2
- 230000008018 melting Effects 0.000 claims description 2
- 239000003961 penetration enhancing agent Substances 0.000 claims 2
- 229920001577 copolymer Polymers 0.000 claims 1
- 230000002708 enhancing effect Effects 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 229920002554 vinyl polymer Polymers 0.000 claims 1
- 239000005038 ethylene vinyl acetate Substances 0.000 abstract description 5
- 229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 abstract description 5
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract description 3
- 210000003491 skin Anatomy 0.000 description 8
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 239000012790 adhesive layer Substances 0.000 description 5
- 230000001070 adhesive effect Effects 0.000 description 4
- 230000036470 plasma concentration Effects 0.000 description 4
- 229920006267 polyester film Polymers 0.000 description 4
- 239000007787 solid Substances 0.000 description 4
- 230000008901 benefit Effects 0.000 description 3
- 238000002425 crystallisation Methods 0.000 description 3
- 230000008025 crystallization Effects 0.000 description 3
- 238000001953 recrystallisation Methods 0.000 description 3
- 206010028813 Nausea Diseases 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 229910006283 Si—O—H Inorganic materials 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 238000009792 diffusion process Methods 0.000 description 2
- 239000003623 enhancer Substances 0.000 description 2
- -1 for example Substances 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 230000008693 nausea Effects 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 230000009885 systemic effect Effects 0.000 description 2
- 229940100640 transdermal system Drugs 0.000 description 2
- 206010040880 Skin irritation Diseases 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 230000003474 anti-emetic effect Effects 0.000 description 1
- 239000002111 antiemetic agent Substances 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- DQXBYHZEEUGOBF-UHFFFAOYSA-N but-3-enoic acid;ethene Chemical compound C=C.OC(=O)CC=C DQXBYHZEEUGOBF-UHFFFAOYSA-N 0.000 description 1
- STECJAGHUSJQJN-VJQRDGCPSA-N chembl3084722 Chemical compound C1([C@@H](CO)C(=O)O[C@@H]2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-VJQRDGCPSA-N 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 230000004313 glare Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000012982 microporous membrane Substances 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 235000010446 mineral oil Nutrition 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 229940070721 polyacrylate Drugs 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
- A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Anesthesiology (AREA)
- Emergency Medicine (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Otolaryngology (AREA)
- Hospice & Palliative Care (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19738643A DE19738643C2 (de) | 1997-09-04 | 1997-09-04 | Transdermales therapeutisches System mit dem Wirkstoff Scopolaminbase und Verfahren zu seiner Herstellung |
| PCT/EP1998/005224 WO1999011265A1 (de) | 1997-09-04 | 1998-08-18 | Transdermales therapeutisches system mit dem wirkstoff scopolaminbase |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL134418A0 IL134418A0 (en) | 2001-04-30 |
| IL134418A true IL134418A (en) | 2004-02-19 |
Family
ID=7841162
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL13441898A IL134418A (en) | 1997-09-04 | 1998-08-18 | A medical system containing scopolamine for administration through the skin |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US6537571B1 (ja) |
| EP (1) | EP1011674B1 (ja) |
| JP (1) | JP3834202B2 (ja) |
| KR (1) | KR100549846B1 (ja) |
| AT (1) | ATE214606T1 (ja) |
| AU (1) | AU738009B2 (ja) |
| CA (1) | CA2300339C (ja) |
| DE (2) | DE19738643C2 (ja) |
| DK (1) | DK1011674T3 (ja) |
| ES (1) | ES2174492T3 (ja) |
| HK (1) | HK1032194A1 (ja) |
| HU (1) | HUP0003480A3 (ja) |
| ID (1) | ID24266A (ja) |
| IL (1) | IL134418A (ja) |
| NO (1) | NO20000894D0 (ja) |
| NZ (1) | NZ502873A (ja) |
| PL (1) | PL339226A1 (ja) |
| PT (1) | PT1011674E (ja) |
| SK (1) | SK3052000A3 (ja) |
| TR (1) | TR200000407T2 (ja) |
| WO (1) | WO1999011265A1 (ja) |
| ZA (1) | ZA988052B (ja) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050013957A1 (en) * | 2003-07-15 | 2005-01-20 | Boris Leschinsky | Disposable medical article with multiple adhesives for skin attachment |
| DE102004020463A1 (de) * | 2004-04-26 | 2005-11-10 | Grünenthal GmbH | Wirkstoffabgabesystem aus einem wirkstoffhaltigen Pflaster und mindestens einem Wirkstoffabgaberegulierungsmittel |
| DE102004044578A1 (de) * | 2004-09-13 | 2006-03-30 | Lts Lohmann Therapie-Systeme Ag | Transdermales therapeutisches System mit einer Haftschicht, Verfahren zum Silikonisieren einer Rückschicht des Systems und Verwendung der Rückschicht |
| US20070010550A1 (en) * | 2005-07-08 | 2007-01-11 | The Board Of Regents Of The University Of Texas | Scopolamine to Reduce or Eliminate Hot Flashes, Night Sweats, and Insomnia |
| EP1998756A2 (en) * | 2006-02-27 | 2008-12-10 | Noven Pharmaceuticals, Inc. | Compositions and methods for delivery of amino-functional drugs |
| DE102006054732B4 (de) * | 2006-11-21 | 2010-12-30 | Lts Lohmann Therapie-Systeme Ag | Transdermales therapeutisches System mit Ionenpaar-Mikroreservoiren |
| KR101572721B1 (ko) | 2013-10-14 | 2015-11-27 | 주식회사 엘지생활건강 | 히오신을 유효 성분으로 함유하는 피부 건조증 또는 피부 장벽 기능 개선용 조성물 |
| US20180049999A1 (en) * | 2015-04-14 | 2018-02-22 | Atossa Genetics Inc. | Compositions and methods of treatment of breast disorders and estrogen-related disorders |
| CA3061284A1 (en) * | 2017-06-26 | 2019-01-03 | Lts Lohmann Therapie-Systeme Ag | Transdermal therapeutic system containing scopolamine and silicone acrylic hybrid polymer |
| DE102018118507A1 (de) * | 2018-07-31 | 2020-02-06 | Lts Lohmann Therapie-Systeme Ag | Transdermales therapeutisches System zur Abgabe von Scopolamin ohne Membran |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US35474A (en) * | 1862-06-03 | Improved rocket-harpoon | ||
| US3797494A (en) | 1969-04-01 | 1974-03-19 | Alza Corp | Bandage for the administration of drug by controlled metering through microporous materials |
| US3903880A (en) * | 1972-08-17 | 1975-09-09 | Alza Corp | Intrauterine device for managing the reproductive process |
| US4573996A (en) * | 1984-01-03 | 1986-03-04 | Jonergin, Inc. | Device for the administration of an active agent to the skin or mucosa |
| US4655767A (en) * | 1984-10-29 | 1987-04-07 | Dow Corning Corporation | Transdermal drug delivery devices with amine-resistant silicone adhesives |
| US4832953A (en) * | 1987-08-13 | 1989-05-23 | Alza Corporation | Method for preventing the formation of a crystalline hydrate in a dispersion of a liquid in a monaqueous matrix |
| US5656286A (en) * | 1988-03-04 | 1997-08-12 | Noven Pharmaceuticals, Inc. | Solubility parameter based drug delivery system and method for altering drug saturation concentration |
| DE3908431A1 (de) * | 1989-03-15 | 1990-09-27 | Lohmann Therapie Syst Lts | Transdermales system mit gestufter wirkstoffabgabe und verwendung fuer die lokale oder systemische wirkstoffverabreichung |
| DE69427391T2 (de) * | 1993-09-30 | 2001-10-31 | Takiron Co. Ltd., Osaka | Perkutan absorbierbare zubereitung |
| US5714162A (en) * | 1994-09-16 | 1998-02-03 | Lts Lohmann Therapie-Systeme Gmbh & Co. Kg | Scopolamine patch |
| DE4438989C2 (de) * | 1994-09-16 | 1999-02-25 | Lohmann Therapie Syst Lts | Scopolaminpflaster |
| DE69616370T2 (de) * | 1995-12-01 | 2002-07-11 | Alza Corp., Palo Alto | Verbessertes verfahren zur verhinderung der kristallbildung in einer dispersion eines flüssigen stoffes in einer matrix |
-
1997
- 1997-09-04 DE DE19738643A patent/DE19738643C2/de not_active Expired - Fee Related
-
1998
- 1998-08-18 DE DE59803454T patent/DE59803454D1/de not_active Expired - Lifetime
- 1998-08-18 TR TR2000/00407T patent/TR200000407T2/xx unknown
- 1998-08-18 NZ NZ502873A patent/NZ502873A/en unknown
- 1998-08-18 PT PT98946364T patent/PT1011674E/pt unknown
- 1998-08-18 ID IDW20000299A patent/ID24266A/id unknown
- 1998-08-18 DK DK98946364T patent/DK1011674T3/da active
- 1998-08-18 KR KR1020007002299A patent/KR100549846B1/ko not_active IP Right Cessation
- 1998-08-18 HU HU0003480A patent/HUP0003480A3/hu unknown
- 1998-08-18 SK SK305-2000A patent/SK3052000A3/sk unknown
- 1998-08-18 EP EP98946364A patent/EP1011674B1/de not_active Expired - Lifetime
- 1998-08-18 AU AU93434/98A patent/AU738009B2/en not_active Ceased
- 1998-08-18 PL PL98339226A patent/PL339226A1/xx unknown
- 1998-08-18 US US09/485,912 patent/US6537571B1/en not_active Expired - Lifetime
- 1998-08-18 WO PCT/EP1998/005224 patent/WO1999011265A1/de active IP Right Grant
- 1998-08-18 CA CA002300339A patent/CA2300339C/en not_active Expired - Lifetime
- 1998-08-18 AT AT98946364T patent/ATE214606T1/de active
- 1998-08-18 IL IL13441898A patent/IL134418A/en not_active IP Right Cessation
- 1998-08-18 ES ES98946364T patent/ES2174492T3/es not_active Expired - Lifetime
- 1998-08-18 JP JP2000508368A patent/JP3834202B2/ja not_active Expired - Lifetime
- 1998-09-03 ZA ZA988052A patent/ZA988052B/xx unknown
-
2000
- 2000-02-23 NO NO20000894A patent/NO20000894D0/no not_active Application Discontinuation
- 2000-12-23 HK HK00108393A patent/HK1032194A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| HK1032194A1 (en) | 2001-07-13 |
| DK1011674T3 (da) | 2002-07-08 |
| ES2174492T3 (es) | 2002-11-01 |
| AU738009B2 (en) | 2001-09-06 |
| HUP0003480A3 (en) | 2001-03-28 |
| IL134418A0 (en) | 2001-04-30 |
| ZA988052B (en) | 1999-03-05 |
| JP3834202B2 (ja) | 2006-10-18 |
| NZ502873A (en) | 2001-07-27 |
| TR200000407T2 (tr) | 2000-08-21 |
| SK3052000A3 (en) | 2000-12-11 |
| CA2300339A1 (en) | 1999-03-11 |
| KR100549846B1 (ko) | 2006-02-06 |
| ATE214606T1 (de) | 2002-04-15 |
| PT1011674E (pt) | 2002-08-30 |
| AU9343498A (en) | 1999-03-22 |
| US6537571B1 (en) | 2003-03-25 |
| EP1011674B1 (de) | 2002-03-20 |
| CA2300339C (en) | 2007-07-17 |
| ID24266A (id) | 2000-07-13 |
| EP1011674A1 (de) | 2000-06-28 |
| WO1999011265A1 (de) | 1999-03-11 |
| JP2001514226A (ja) | 2001-09-11 |
| NO20000894L (no) | 2000-02-23 |
| KR20010023647A (ko) | 2001-03-26 |
| DE59803454D1 (de) | 2002-04-25 |
| DE19738643A1 (de) | 1999-03-11 |
| HUP0003480A2 (hu) | 2001-02-28 |
| PL339226A1 (en) | 2000-12-04 |
| DE19738643C2 (de) | 2001-10-04 |
| NO20000894D0 (no) | 2000-02-23 |
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