IL134112A0 - Triazolo [4,5-d] pyrimidine compounds, their use anovel compounds s medicaments, compositions containing them and processes for their preparation - Google Patents
Triazolo [4,5-d] pyrimidine compounds, their use anovel compounds s medicaments, compositions containing them and processes for their preparationInfo
- Publication number
- IL134112A0 IL134112A0 IL13411298A IL13411298A IL134112A0 IL 134112 A0 IL134112 A0 IL 134112A0 IL 13411298 A IL13411298 A IL 13411298A IL 13411298 A IL13411298 A IL 13411298A IL 134112 A0 IL134112 A0 IL 134112A0
- Authority
- IL
- Israel
- Prior art keywords
- compounds
- medicaments
- processes
- preparation
- compositions containing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Vascular Medicine (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Use Of Switch Circuits For Exchanges And Methods Of Control Of Multiplex Exchanges (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9702772A SE9702772D0 (sv) | 1997-07-22 | 1997-07-22 | Novel compounds |
PCT/SE1998/001392 WO1999005142A1 (en) | 1997-07-22 | 1998-07-15 | Novel compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
IL134112A0 true IL134112A0 (en) | 2001-07-24 |
Family
ID=20407803
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL13411298A IL134112A0 (en) | 1997-07-22 | 1998-07-15 | Triazolo [4,5-d] pyrimidine compounds, their use anovel compounds s medicaments, compositions containing them and processes for their preparation |
Country Status (21)
Country | Link |
---|---|
US (1) | US6156756A (no) |
EP (1) | EP0996620B1 (no) |
JP (1) | JP2001510841A (no) |
KR (1) | KR20010022082A (no) |
CN (1) | CN1271359A (no) |
AT (1) | ATE216389T1 (no) |
AU (1) | AU8370598A (no) |
BR (1) | BR9811022A (no) |
CA (1) | CA2296648A1 (no) |
DE (1) | DE69804964T2 (no) |
EE (1) | EE200000042A (no) |
HU (1) | HUP0100202A3 (no) |
ID (1) | ID24837A (no) |
IL (1) | IL134112A0 (no) |
IS (1) | IS5351A (no) |
NO (1) | NO20000311L (no) |
PL (1) | PL338518A1 (no) |
SE (1) | SE9702772D0 (no) |
SK (1) | SK188099A3 (no) |
TR (1) | TR200000151T2 (no) |
WO (1) | WO1999005142A1 (no) |
Families Citing this family (51)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE9702773D0 (sv) * | 1997-07-22 | 1997-07-22 | Astra Pharma Prod | Novel compounds |
KR20010078696A (ko) * | 1998-02-17 | 2001-08-21 | 다비드 에 질레스 | 신규한 트리아졸로[4,5-d]피리미딘 화합물 |
SE9802574D0 (sv) * | 1998-07-17 | 1998-07-17 | Astra Pharma Prod | Novel compounds |
TWI229674B (en) | 1998-12-04 | 2005-03-21 | Astra Pharma Prod | Novel triazolo[4,5-d]pyrimidine compounds, pharmaceutical composition containing the same, their process for preparation and uses |
SE9904129D0 (sv) * | 1999-11-15 | 1999-11-15 | Astra Pharma Prod | Novel compounds |
SE9904128D0 (sv) * | 1999-11-15 | 1999-11-15 | Astra Pharma Prod | Novel compounds |
US6867199B2 (en) | 2000-08-21 | 2005-03-15 | Inspire Pharmaceuticals, Inc. | Dinucleoside polyphosphate compositions and their therapeutic use |
US7335648B2 (en) | 2003-10-21 | 2008-02-26 | Inspire Pharmaceuticals, Inc. | Non-nucleotide composition and method for inhibiting platelet aggregation |
US7504497B2 (en) | 2003-10-21 | 2009-03-17 | Inspire Pharmaceuticals, Inc. | Orally bioavailable compounds and methods for inhibiting platelet aggregation |
JP2007514647A (ja) | 2003-10-21 | 2007-06-07 | インスパイアー ファーマシューティカルズ,インコーポレイティド | テトラヒドロ−フロ[3,4−d]ジオキソール化合物並びに血小板凝集を阻害する組成物及び方法 |
US7749981B2 (en) | 2003-10-21 | 2010-07-06 | Inspire Pharmaceuticals, Inc. | Drug-eluting stents coated with non-nucleotide P2Y12 receptor antagonist compound |
US7932376B2 (en) | 2005-05-05 | 2011-04-26 | Inspire Pharmaceuticals, Inc. | Pyrimidine-based non-nucleotide composition and method for inhibiting platelet aggregation |
US7566722B2 (en) | 2006-10-31 | 2009-07-28 | Janssen Pharmaceutica, N.V. | Triazolopyrimidine derivatives as ADP P2Y12 receptor antagonists |
US8148385B2 (en) | 2006-10-31 | 2012-04-03 | Janssen Pharmaceutica N.V. | Substituted [1,2,3] triazolo[4,5-d]pyrimidine derivatives as ADP P2Y12 receptor antagonists |
TWI496776B (zh) * | 2007-11-15 | 2015-08-21 | Astrazeneca Ab | 製備(3aR,4S,6R,6aS)-6-胺基-2,2-二甲基四氫-3aH-環戊并[d][1,3]二氧雜環戊烯-4-醇之純非對映異構性之二苯甲醯-L-酒石酸鹽之方法 |
WO2010043721A1 (en) | 2008-10-17 | 2010-04-22 | Oryzon Genomics, S.A. | Oxidase inhibitors and their use |
US8993808B2 (en) | 2009-01-21 | 2015-03-31 | Oryzon Genomics, S.A. | Phenylcyclopropylamine derivatives and their medical use |
US8802850B2 (en) | 2009-07-27 | 2014-08-12 | Auspex Pharmaceuticals, Inc. | Cyclopropyl modulators of P2Y12 receptor |
EP2480528B1 (en) | 2009-09-25 | 2018-08-29 | Oryzon Genomics, S.A. | Lysine specific demethylase-1 inhibitors and their use |
US8946296B2 (en) | 2009-10-09 | 2015-02-03 | Oryzon Genomics S.A. | Substituted heteroaryl- and aryl-cyclopropylamine acetamides and their use |
EP2536695A1 (en) | 2010-02-16 | 2012-12-26 | Actavis Group Ptc Ehf | Improved processes for preparing ticagrelor intermediate, 4,6-dichloro-5-nitro-2-(propylthio)pyrimidine |
WO2011106573A2 (en) | 2010-02-24 | 2011-09-01 | Oryzon Genomics, S.A. | Lysine demethylase inhibitors for diseases and disorders associated with hepadnaviridae |
US9616058B2 (en) | 2010-02-24 | 2017-04-11 | Oryzon Genomics, S.A. | Potent selective LSD1 inhibitors and dual LSD1/MAO-B inhibitors for antiviral use |
EP3133059A1 (en) | 2010-04-19 | 2017-02-22 | Oryzon Genomics, S.A. | Lysine specific demethylase-1 inhibitors and their use |
EP2598480B1 (en) | 2010-07-29 | 2019-04-24 | Oryzon Genomics, S.A. | Cyclopropylamine derivatives useful as lsd1 inhibitors |
RU2611437C2 (ru) | 2010-07-29 | 2017-02-22 | Оризон Дженомикс С.А. | Ингибиторы деметилазы lsd1 на основе арилциклопропиламина и их применение в медицине |
US9061966B2 (en) | 2010-10-08 | 2015-06-23 | Oryzon Genomics S.A. | Cyclopropylamine inhibitors of oxidases |
WO2012063126A2 (en) | 2010-11-09 | 2012-05-18 | Actavis Group Ptc Ehf | Improved processes for preparing pure (3ar,4s,6r,6as)-6-amino-2,2-dimethyltetrahdro-3ah-cyclopenta[d] [1,3]-dioxol-4-ol and its key starting material |
WO2012072713A2 (en) | 2010-11-30 | 2012-06-07 | Oryzon Genomics, S.A. | Lysine demethylase inhibitors for diseases and disorders associated with flaviviridae |
WO2012085665A2 (en) | 2010-12-20 | 2012-06-28 | Actavis Group Patc Ehf | Novel processes for preparing triazolo[4,5-d]pyrimidine derivatives and intermediates thereof |
EP3981395A1 (en) | 2011-02-08 | 2022-04-13 | Oryzon Genomics, S.A. | Lysine demethylase inhibitors for myeloproliferative disorders |
CZ2011229A3 (cs) | 2011-04-19 | 2012-08-15 | Zentiva, K.S. | Opticky aktivní soli (3aR,4S,6R,6aS)-6-amino-2,2-dimethyltetrahydro-3aH-cyklopenta-[d][1,3]dioxol-4-olu a zpusob jejich prípravy |
TWI537256B (zh) * | 2011-05-13 | 2016-06-11 | 阿斯特捷利康公司 | 製備[(3aS,4R,6S,6aR)-6-羥基-2,2-二甲基四氫-3aH-環戊并[d][1,3]二氧戊環-4-基]胺甲酸苄基酯之方法及該方法中的中間體 |
US20140206867A1 (en) | 2011-06-15 | 2014-07-24 | Actavis Group Ptc Ehf | Process for Preparing Cyclopentylamine Derivatives and Intermediates Thereof |
CN102924457A (zh) * | 2011-08-12 | 2013-02-13 | 上海恒瑞医药有限公司 | 三唑并嘧啶类衍生物、其制备方法及其用途 |
EP2776394B1 (en) | 2011-10-20 | 2018-12-26 | Oryzon Genomics, S.A. | (hetero)aryl cyclopropylamine compounds as lsd1 inhibitors |
CN104203914B (zh) | 2011-10-20 | 2017-07-11 | 奥瑞泽恩基因组学股份有限公司 | 作为lsd1抑制剂的(杂)芳基环丙胺化合物 |
CN102659691B (zh) * | 2012-05-23 | 2014-04-02 | 山东诚创医药技术开发有限公司 | 一种4,6-二氯-5-氨基-2-丙硫基嘧啶的制备方法 |
UA114351C2 (uk) | 2012-12-21 | 2017-05-25 | Гіліад Сайєнсіз, Інк. | Поліциклічні карбамоїлпіридонові сполуки та їх фармацевтичне застосування |
WO2014206187A1 (zh) | 2013-06-24 | 2014-12-31 | 苏州明锐医药科技有限公司 | 替卡格雷及其中间体的制备方法 |
PL3019503T3 (pl) | 2013-07-12 | 2018-01-31 | Gilead Sciences Inc | Policykliczne związki karbamoilopirydonowe i ich zastosowanie do leczenia infekcji hiv |
NO2865735T3 (no) | 2013-07-12 | 2018-07-21 | ||
WO2015162630A1 (en) | 2014-04-25 | 2015-10-29 | Anlon Chemical Research Organization | Novel processes for preparing triazolo [4,5-d]- pyrimidines, including ticagrelor, vianew intermediates and new route of synthesis. |
NO2717902T3 (no) | 2014-06-20 | 2018-06-23 | ||
TWI677489B (zh) | 2014-06-20 | 2019-11-21 | 美商基利科學股份有限公司 | 多環型胺甲醯基吡啶酮化合物之合成 |
TW201613936A (en) | 2014-06-20 | 2016-04-16 | Gilead Sciences Inc | Crystalline forms of(2R,5S,13aR)-8-hydroxy-7,9-dioxo-n-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide |
US10654825B2 (en) | 2017-03-30 | 2020-05-19 | Corvus Pharmaceuticals, Inc. | Processes for making triazolo[4,5D] pyramidine derivatives and intermediates thereof |
JP6722365B1 (ja) * | 2017-07-18 | 2020-07-15 | ロンザ リミテッドLonza Limited | 塩素化s−プロピル−チオバルビツル酸の製造方法 |
WO2020068583A1 (en) * | 2018-09-27 | 2020-04-02 | Corvus Pharmaceuticals, Inc. | Processes for making triazolo [4,5d] pyramidine derivatives and intermediates thereof |
CN111116592A (zh) * | 2019-11-27 | 2020-05-08 | 杭州沧海帆医药科技有限公司 | 嘧啶并三氮唑类化合物及其医药用途 |
CN115710275B (zh) * | 2022-11-21 | 2024-02-02 | 河南中医药大学 | 一种嘧啶-tcp类化合物、制备方法和医药用途 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4742064A (en) * | 1985-09-10 | 1988-05-03 | Regents Of The University Of Minnesota | Antiviral carbocyclic analogs of xylofuranosylpurines |
GB8826205D0 (en) * | 1988-11-09 | 1988-12-14 | Wellcome Found | Heterocyclic compounds |
HU221880B1 (hu) * | 1995-07-11 | 2003-02-28 | Astrazeneca Ab, | Vérlemezke-aggregáció inhibitorok, ezeket tartalmazó gyógyszerkészítmények és előállításuk |
JP4125790B2 (ja) * | 1996-12-20 | 2008-07-30 | アストラゼネカ・アクチエボラーグ | トリアゾロ[4,5−d]ピリミジニル誘導体および医薬としてのその使用 |
-
1997
- 1997-07-22 SE SE9702772A patent/SE9702772D0/xx unknown
- 1997-07-24 ID IDW20000146A patent/ID24837A/id unknown
-
1998
- 1998-07-15 DE DE69804964T patent/DE69804964T2/de not_active Expired - Fee Related
- 1998-07-15 IL IL13411298A patent/IL134112A0/xx unknown
- 1998-07-15 AT AT98934106T patent/ATE216389T1/de active
- 1998-07-15 HU HU0100202A patent/HUP0100202A3/hu unknown
- 1998-07-15 SK SK1880-99A patent/SK188099A3/sk unknown
- 1998-07-15 PL PL98338518A patent/PL338518A1/xx not_active Application Discontinuation
- 1998-07-15 US US09/155,562 patent/US6156756A/en not_active Expired - Fee Related
- 1998-07-15 TR TR2000/00151T patent/TR200000151T2/xx unknown
- 1998-07-15 KR KR1020007000651A patent/KR20010022082A/ko not_active Application Discontinuation
- 1998-07-15 BR BR9811022-5A patent/BR9811022A/pt not_active IP Right Cessation
- 1998-07-15 WO PCT/SE1998/001392 patent/WO1999005142A1/en not_active Application Discontinuation
- 1998-07-15 CA CA002296648A patent/CA2296648A1/en not_active Abandoned
- 1998-07-15 CN CN98809135A patent/CN1271359A/zh active Pending
- 1998-07-15 EE EEP200000042A patent/EE200000042A/xx unknown
- 1998-07-15 EP EP98934106A patent/EP0996620B1/en not_active Expired - Lifetime
- 1998-07-15 AU AU83705/98A patent/AU8370598A/en not_active Abandoned
- 1998-07-15 JP JP2000504138A patent/JP2001510841A/ja active Pending
-
2000
- 2000-01-19 IS IS5351A patent/IS5351A/is unknown
- 2000-01-21 NO NO20000311A patent/NO20000311L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
JP2001510841A (ja) | 2001-08-07 |
ATE216389T1 (de) | 2002-05-15 |
CA2296648A1 (en) | 1999-02-04 |
US6156756A (en) | 2000-12-05 |
TR200000151T2 (tr) | 2000-09-21 |
SE9702772D0 (sv) | 1997-07-22 |
EE200000042A (et) | 2000-10-16 |
ID24837A (id) | 2000-08-24 |
EP0996620A1 (en) | 2000-05-03 |
PL338518A1 (en) | 2000-11-06 |
CN1271359A (zh) | 2000-10-25 |
EP0996620B1 (en) | 2002-04-17 |
IS5351A (is) | 2000-01-19 |
DE69804964T2 (de) | 2002-11-07 |
HUP0100202A3 (en) | 2001-10-29 |
WO1999005142A1 (en) | 1999-02-04 |
AU8370598A (en) | 1999-02-16 |
KR20010022082A (ko) | 2001-03-15 |
NO20000311L (no) | 2000-03-21 |
SK188099A3 (en) | 2000-08-14 |
NO20000311D0 (no) | 2000-01-21 |
DE69804964D1 (de) | 2002-05-23 |
HUP0100202A2 (hu) | 2001-08-28 |
BR9811022A (pt) | 2000-09-12 |
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