IL133809A0 - Steroidal alkaloids and pharmaceutical compositions comprising them - Google Patents

Steroidal alkaloids and pharmaceutical compositions comprising them

Info

Publication number
IL133809A0
IL133809A0 IL13380999A IL13380999A IL133809A0 IL 133809 A0 IL133809 A0 IL 133809A0 IL 13380999 A IL13380999 A IL 13380999A IL 13380999 A IL13380999 A IL 13380999A IL 133809 A0 IL133809 A0 IL 133809A0
Authority
IL
Israel
Prior art keywords
steroidal alkaloids
steroidal
pharmaceutical compositions
families
alkaloids
Prior art date
Application number
IL13380999A
Other languages
English (en)
Original Assignee
Yeda Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yeda Res & Dev filed Critical Yeda Res & Dev
Priority to IL13380999A priority Critical patent/IL133809A0/xx
Priority to DE60022687T priority patent/DE60022687T2/de
Priority to US10/169,353 priority patent/US20030114393A1/en
Priority to EP00983471A priority patent/EP1274445B1/de
Priority to AT00983471T priority patent/ATE304360T1/de
Priority to CA002395642A priority patent/CA2395642A1/en
Priority to AU20229/01A priority patent/AU2022901A/en
Priority to JP2001549647A priority patent/JP2003519178A/ja
Priority to IL14991300A priority patent/IL149913A0/xx
Priority to PCT/IL2000/000866 priority patent/WO2001049279A2/en
Publication of IL133809A0 publication Critical patent/IL133809A0/xx
Priority to IL149913A priority patent/IL149913A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL13380999A 1999-12-30 1999-12-30 Steroidal alkaloids and pharmaceutical compositions comprising them IL133809A0 (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
IL13380999A IL133809A0 (en) 1999-12-30 1999-12-30 Steroidal alkaloids and pharmaceutical compositions comprising them
CA002395642A CA2395642A1 (en) 1999-12-30 2000-12-28 Use of steroidal alkaloids to reverse multidrug resistance
US10/169,353 US20030114393A1 (en) 1999-12-30 2000-12-28 Use of steroidal alkaloids to reverse multidrug resistance
EP00983471A EP1274445B1 (de) 1999-12-30 2000-12-28 Verwendung von steroid-alkaloidderivaten zur umkehrung multipler medikamentenresistenz
AT00983471T ATE304360T1 (de) 1999-12-30 2000-12-28 Verwendung von steroid-alkaloidderivaten zur umkehrung multipler medikamentenresistenz
DE60022687T DE60022687T2 (de) 1999-12-30 2000-12-28 Verwendung von steroid-alkaloidderivaten zur umkehrung multipler medikamentenresistenz
AU20229/01A AU2022901A (en) 1999-12-30 2000-12-28 Use of steroidal alkaloids to reverse multidrug resistance
JP2001549647A JP2003519178A (ja) 1999-12-30 2000-12-28 多剤耐性を転換するためのステロイドアルカロイドの使用
IL14991300A IL149913A0 (en) 1999-12-30 2000-12-28 Use of steroidal alkaloids to reverse multidrug resistance
PCT/IL2000/000866 WO2001049279A2 (en) 1999-12-30 2000-12-28 Use of steroidal alkaloids to reverse multidrug resistance
IL149913A IL149913A (en) 1999-12-30 2004-01-01 Use of steroidal alkaloids for the manufacture of a composition for reverse of multi-drug resistance

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IL13380999A IL133809A0 (en) 1999-12-30 1999-12-30 Steroidal alkaloids and pharmaceutical compositions comprising them

Publications (1)

Publication Number Publication Date
IL133809A0 true IL133809A0 (en) 2001-04-30

Family

ID=11073663

Family Applications (2)

Application Number Title Priority Date Filing Date
IL13380999A IL133809A0 (en) 1999-12-30 1999-12-30 Steroidal alkaloids and pharmaceutical compositions comprising them
IL149913A IL149913A (en) 1999-12-30 2004-01-01 Use of steroidal alkaloids for the manufacture of a composition for reverse of multi-drug resistance

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL149913A IL149913A (en) 1999-12-30 2004-01-01 Use of steroidal alkaloids for the manufacture of a composition for reverse of multi-drug resistance

Country Status (9)

Country Link
US (1) US20030114393A1 (de)
EP (1) EP1274445B1 (de)
JP (1) JP2003519178A (de)
AT (1) ATE304360T1 (de)
AU (1) AU2022901A (de)
CA (1) CA2395642A1 (de)
DE (1) DE60022687T2 (de)
IL (2) IL133809A0 (de)
WO (1) WO2001049279A2 (de)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2578728T3 (es) * 2004-08-27 2016-07-29 Infinity Pharmaceuticals, Inc. Proceso para la preparación de compuestos análogos de ciclopamina
WO2006039569A1 (en) * 2004-09-30 2006-04-13 The University Of Chicago Combination therapy of hedgehog inhibitors, radiation and chemotherapeutic agents
TWI433674B (zh) 2006-12-28 2014-04-11 Infinity Discovery Inc 環杷明（ｃｙｃｌｏｐａｍｉｎｅ）類似物類
MX2009009429A (es) 2007-03-07 2010-07-05 Infinity Discovery Inc Analogos de ciclopamina lactama y metodos de uso de los mismos.
RU2009137014A (ru) 2007-03-07 2011-04-20 Инфинити Дискавери, Инк. (Us) Гетероциклические аналоги циклопамина и способы их применения
MX2010006991A (es) * 2007-12-27 2010-09-30 Infinity Pharmaceuticals Inc Tratamientos de cancer terapeuticos.
CA2710858A1 (en) * 2007-12-27 2009-07-09 Infinity Pharmaceuticals, Inc. Methods for stereoselective reduction
US20100297118A1 (en) * 2007-12-27 2010-11-25 Macdougall John Therapeutic Cancer Treatments
US8193182B2 (en) 2008-01-04 2012-06-05 Intellikine, Inc. Substituted isoquinolin-1(2H)-ones, and methods of use thereof
JP6141015B2 (ja) 2009-08-05 2017-06-07 インフィニティ ファーマスーティカルズ、インク． シクロパミン類似体の酵素によるアミノ基転移
US20110135739A1 (en) * 2009-11-06 2011-06-09 Bennett Carter Oral Formulations of a Hedgehog Pathway Inhibitor
WO2011088404A1 (en) * 2010-01-15 2011-07-21 Infinity Pharmaceuticals , Inc Treatment of fibrotic conditions using hedgehog inhibitors
AU2011255218B2 (en) 2010-05-21 2015-03-12 Infinity Pharmaceuticals, Inc. Chemical compounds, compositions and methods for kinase modulation
US9376447B2 (en) 2010-09-14 2016-06-28 Infinity Pharmaceuticals, Inc. Transfer hydrogenation of cyclopamine analogs
JP2013545749A (ja) 2010-11-10 2013-12-26 インフィニティー ファーマシューティカルズ， インコーポレイテッド 複素環化合物及びその使用
CA2824197C (en) 2011-01-10 2020-02-25 Michael Martin Processes for preparing isoquinolinones and solid forms of isoquinolinones
US9457033B2 (en) 2011-02-15 2016-10-04 Socpra Sciences Et Genie, S.E.C. Steroid alkaloids and uses thereof as antimicrobial agents against electron transport-deficient microbes and as potentiators for antimicrobial agents against pathogenic bacteria
AU2012268036B2 (en) * 2011-06-06 2017-04-06 THE UNITED STATES OF AMERICA as represented by THE SECRETARY OF STATE OF THE DEPARTMENT OF VETERANS AFFAIRS Methods of inhibiting muscle atrophy
CA2842190A1 (en) 2011-07-19 2013-01-24 Infinity Pharmaceuticals Inc. Heterocyclic compounds and uses thereof
CN103930422A (zh) 2011-07-19 2014-07-16 无限药品股份有限公司 杂环化合物及其用途
AR091790A1 (es) 2011-08-29 2015-03-04 Infinity Pharmaceuticals Inc Derivados de isoquinolin-1-ona y sus usos
WO2013049332A1 (en) 2011-09-29 2013-04-04 Infinity Pharmaceuticals, Inc. Inhibitors of monoacylglycerol lipase and methods of their use
US8940742B2 (en) 2012-04-10 2015-01-27 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
AU2013337717B2 (en) 2012-11-01 2018-10-25 Infinity Pharmaceuticals, Inc. Treatment of cancers using PI3 kinase isoform modulators
US9844541B2 (en) 2012-11-29 2017-12-19 Strasspharma, Llc Methods of modulating follicle stimulating hormone activity
CN103043635B (zh) * 2012-12-25 2015-04-22 浙江大学 一种抗耐药性的顺铂矿化液及其制备方法和应用
NZ629037A (en) 2013-03-15 2017-04-28 Infinity Pharmaceuticals Inc Salts and solid forms of isoquinolinones and composition comprising and methods of using the same
US9192609B2 (en) 2013-04-17 2015-11-24 Hedgepath Pharmaceuticals, Inc. Treatment and prognostic monitoring of proliferation disorders using hedgehog pathway inhibitors
RU2019134551A (ru) 2013-05-30 2019-11-22 Инфинити Фармасьютикалз, Инк. Лечение злокачественных опухолей с использованием модуляторов изоформ pi3-киназы
CN104224815A (zh) * 2013-06-18 2014-12-24 复旦大学 澳洲茄胺在制备抗肿瘤药物中的应用
FR3008699B1 (fr) 2013-07-19 2015-08-21 Univ Picardie Nouveaux composes derives de la solanidine
WO2015051241A1 (en) 2013-10-04 2015-04-09 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
MX2016004340A (es) 2013-10-04 2016-08-08 Infinity Pharmaceuticals Inc Compuestos heterociclicos y usos de los mismos.
WO2015061204A1 (en) 2013-10-21 2015-04-30 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
WO2015095971A1 (en) * 2013-12-23 2015-07-02 Socpra Sciences Et Génie S.E.C. Atp synthase inhibitors and steroid alkaloids and uses thereof as antimicrobial agents and as potentiators for aminoglycosides against pathogenic bacteria
PT3119397T (pt) 2014-03-19 2022-04-11 Infinity Pharmaceuticals Inc Compostos heterocíclicos para utilização no tratamento de distúrbios mediados por pi3k-gama
WO2015160986A2 (en) 2014-04-16 2015-10-22 Infinity Pharmaceuticals, Inc. Combination therapies
WO2015168079A1 (en) 2014-04-29 2015-11-05 Infinity Pharmaceuticals, Inc. Pyrimidine or pyridine derivatives useful as pi3k inhibitors
US9708348B2 (en) 2014-10-03 2017-07-18 Infinity Pharmaceuticals, Inc. Trisubstituted bicyclic heterocyclic compounds with kinase activities and uses thereof
EP3302428A1 (de) 2015-06-04 2018-04-11 Pellepharm Inc. Topische formulierungen zur freisetzung von hedgehog-inhibitorverbindungen und verwendung davon
CN105911176A (zh) * 2016-04-15 2016-08-31 广西壮族自治区梧州食品药品检验所 一种浙贝母中贝母素甲、贝母素乙的测定方法
US10919914B2 (en) 2016-06-08 2021-02-16 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
MX2018016227A (es) 2016-06-24 2019-07-08 Infinity Pharmaceuticals Inc Terapias de combinacion.
CN108853120B (zh) * 2018-07-23 2021-02-19 华南农业大学 贝母辛在制备抗白色念珠菌药物中的应用
CN110613720B (zh) * 2019-09-24 2022-06-03 华南农业大学 蒜藜芦碱用于制备防治白色念珠菌感染的药物中的应用
CN112138066B (zh) * 2020-09-09 2022-02-25 中南大学湘雅医院 龙葵或龙葵提取物在增加抗生素或抗肿瘤药物敏感性中的应用
CN112121059B (zh) * 2020-09-28 2022-02-11 郑州大学第一附属医院 一种中药单体组合物及用于治疗食管癌的用途

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ193564A (en) * 1979-05-02 1985-01-31 Aruba Pty Ltd Steroid alkaloids from solanum sodomeum and pharmaceutical compositions
US5104858A (en) * 1988-09-29 1992-04-14 Yale University Sensitizing multidrug resistant cells to antitumor agents
US5005588A (en) * 1989-10-13 1991-04-09 David Rubin Method for increasing tumor sensitivity to chemotherapy
SE9600229D0 (sv) * 1996-01-23 1996-01-23 Pharmacia Ab Novel potentiating agents
WO1998058543A1 (en) * 1997-06-20 1998-12-30 Gubarev Michael J Method to enhance innate immunity defense mechanisms by treatment with plant-derived alkaloids
US6616925B1 (en) * 1998-04-02 2003-09-09 I.D.M. Immuno-Designed Molecules Combined preparation for the treatment of neoplasic diseases or of infectious diseases
IL138645A0 (en) * 1998-04-09 2001-10-31 Univ Johns Hopkins Med Use of steroidal alkaloid derivatives as inhibitors of hedghog signalling pathways
US6291516B1 (en) * 1999-01-13 2001-09-18 Curis, Inc. Regulators of the hedgehog pathway, compositions and uses related thereto

Also Published As

Publication number Publication date
JP2003519178A (ja) 2003-06-17
CA2395642A1 (en) 2001-07-12
US20030114393A1 (en) 2003-06-19
EP1274445B1 (de) 2005-09-14
DE60022687D1 (de) 2005-10-20
WO2001049279A3 (en) 2002-10-17
EP1274445A2 (de) 2003-01-15
AU2022901A (en) 2001-07-16
DE60022687T2 (de) 2006-07-06
IL149913A (en) 2006-08-01
WO2001049279A2 (en) 2001-07-12
ATE304360T1 (de) 2005-09-15

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